Entity
iNOS
--
G010514
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m93479
10
infinite
0
TRANSFAC | G010514 |
--
IFNgamma
--
MO000016665
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1639
10
infinite
0
InterPro | IPR002069 |
TRANSPATH | MO000016665 |
--
LPS
--
MO000016882
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m155666
10
infinite
0
TRANSPATH | MO000016882 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
Fas
--
e11
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m11
0
infinite
0
--
Procaspase
--
e12
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m12
0
infinite
0
--
csml-variable:Double
m13
0
infinite
0
--
IAP family
--
e14
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m14
0
infinite
0
--
Procaspase{nitrosylated}
--
e15
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m15
0
infinite
0
--
Caspase{nitrosylated}
--
e16
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m16
0
infinite
0
--
proteosome
--
e17
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m17
0
infinite
0
--
proteosome{nitrosylated}
--
e18
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m18
0
infinite
0
--
p50:p65
--
e19
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
p50{nitrosylated}:p65{nitrosylated}
--
e20
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m20
0
infinite
0
--
15-dPGJ2
--
e21
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m21
0
infinite
0
--
IKK
--
e22
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m22
0
infinite
0
--
IKK{active}
--
e23
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m23
0
infinite
0
--
Oxygen superoxide
--
e24
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m24
0
infinite
0
--
Peroxynitrite
--
e25
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m25
0
infinite
0
--
PPAR
--
e26
cso30:c:Protein
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m26
0
infinite
0
--
LXRs
--
e27
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m27
0
infinite
0
--
Fatty acid
--
e28
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m28
0
infinite
0
--
PPAR:Fatty acid
--
e29
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
Prostanoids
--
e30
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m30
0
infinite
0
--
PPAR:Prostanoids
--
e31
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m31
0
infinite
0
--
Oxysterols
--
e32
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m32
0
infinite
0
--
LXRs:Oxysterols
--
e33
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m33
0
infinite
0
--
1400W
--
e34
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m34
0
infinite
0
--
1-NIL
--
e35
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m35
0
infinite
0
--
IL-1beta
--
e36
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m36
0
infinite
0
--
TNF-alpha
--
e37
cso30:c:Protein
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m37
0
infinite
0
--
AP-1
--
e38
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m38
0
infinite
0
--
AP-1{active}
--
e39
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m39
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
NF-KappaB{active}
--
e40
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m40
0
infinite
0
--
NF-kappaB
--
e41
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m41
0
infinite
0
--
STAT-1
--
e42
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m42
0
infinite
0
--
STAT-1{active}
--
e43
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m43
0
infinite
0
--
IRf-1
--
e44
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m44
0
infinite
0
--
IRf-1{active}
--
e45
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m45
0
infinite
0
--
MMps
--
e46
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m46
0
infinite
0
--
COX-2
--
e47
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m47
0
infinite
0
--
NO
--
e5
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
TGF-beta
--
e6
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c6 : 1
stoichiometry:c7 : 1
m12*0.1
nodelay
--
0
PMID: 15691589,12605597,9733516 These include the ¡Ædesensitization¡Ç of the initial pro-apoptotic signaling pathway (although the mechanisms of this have been little studied), the inhibition of procaspase processing and caspase activity and the expression of anti-apoptotic genes of the Inhibitor of Apoptosis (IAP) family
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1
m5*m13*0.1
nodelay
--
0
PMID: 15691589 The active sites of caspase enzymes contain a cysteine residue that is susceptible to S-nitrosylation by NO in the procaspase and active forms of the proteins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1
m5*m17*0.1
nodelay
--
0
PMID: 15691589 This occurs through a mechanism that involves nitrosylation of the proteasome and of the p50 and p65 subunits at their DNA binding domains; inhibiting their transcriptional activity.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
stoichiometry:c29 : 1
m5*m19*0.1
nodelay
--
0
PMID: 15691589 This occurs through a mechanism that involves nitrosylation of the proteasome and of the p50 and p65 subunits at their DNA binding domains; inhibiting their transcriptional activity.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1
m21*m22*0.1
nodelay
--
0
PMID: 15691589,9422508 This potent anti-inflammatory molecule efficiently inhibits IKappaB kinase (IKK) activation, as well as the transcriptional activity of several factors such as NF-KappaB, AP-1 and Stat-1alpha
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1
m5*m21*0.1
nodelay
--
0
PMID: 15691589 Moreover, 15-dPGJ2 synergizes with NO by enhancing the synthesis of reactive oxygen species, in particular oxygen superoxide.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1
m24*m5*0.1
nodelay
--
0
PMID: 15691589,11086094,10593878,11175752,12893946,12727142 Superoxide rapidly reacts withNO to produce peroxynitrite, one of the most potent oxidants released by cells, and exhibits both pro-apoptotic and necrotic effects
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1
m28*m26*0.1
nodelay
--
0
PMID: 15691589,10669746,12612088,12524534 These nuclear receptors ? respectively activated by fatty acids/prostanoids and oxysterols ? exert an important down-regulatory control on the transcriptional activity of pro-inflammatory genes and on transcription factors such as NF-KappaB, Stat-1alpha, and AP-1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1
m30*m26*0.1
nodelay
--
0
PMID: 15691589,10669746,12612088,12524534 These nuclear receptors ? respectively activated by fatty acids/prostanoids and oxysterols ? exert an important down-regulatory control on the transcriptional activity of pro-inflammatory genes and on transcription factors such as NF-KappaB, Stat-1alpha, and AP-1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1
m32*m27*0.1
nodelay
--
0
PMID: 15691589,10669746,12612088,12524534 These nuclear receptors ? respectively activated by fatty acids/prostanoids and oxysterols ? exert an important down-regulatory control on the transcriptional activity of pro-inflammatory genes and on transcription factors such as NF-KappaB, Stat-1alpha, and AP-1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1
m37*m38*0.1
nodelay
--
0
PMID: 15691589 Figure 3
p1
p2
cso30:i:CE_Apoptosis_InhibitionOfCellSurvival_
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m6*0.1
nodelay
--
0
PMID: 15691589,7528106 For example, moderate NO concentrations inhibit basal apoptosis in B lymphocytes, apoptosis induced by the potent cytokine TGF-beta in hepatocytes, and Fas-dependent apoptosis in several cellular models of inflammation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1
m37*m41*0.1
nodelay
--
0
PMID: 15691589 Figure 3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1
m37*m42*0.1
nodelay
--
0
PMID: 15691589 Figure 3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1
m37*m44*0.1
nodelay
--
0
PMID: 15691589 Figure 3
p19
p23
cso30:i:ME_UnknownActivation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1
m155666*m44*0.1
nodelay
--
0
PMID: 15691589 Figure 3
p19
p24
cso30:i:ME_UnknownActivation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1
m155666*m42*0.1
nodelay
--
0
PMID: 15691589 Figure 3
p19
p25
cso30:i:ME_UnknownActivation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1
m155666*m38*0.1
nodelay
--
0
PMID: 15691589 Figure 3
p19
p26
cso30:i:ME_UnknownActivation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
stoichiometry:c73 : 1
m155666*m41*0.1
nodelay
--
0
PMID: 15691589 Figure 3
p19
p27
cso30:i:ME_UnknownActivation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1
m1639*m42*0.1
nodelay
--
0
PMID: 15691589 Figure 3
p19
p28
cso30:i:ME_UnknownActivation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1
m1639*m44*0.1
nodelay
--
0
PMID: 15691589 Figure 3
p19
p29
cso30:i:ME_UnknownActivation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1
m1639*m41*0.1
nodelay
--
0
PMID: 15691589 Figure 3
p1
p3
cso30:i:CE_Apoptosis_InhibitionOfCellSurvival_
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
m11*0.1
nodelay
--
0
PMID: 15691589,7528106 For example, moderate NO concentrations inhibit basal apoptosis in B lymphocytes, apoptosis induced by the potent cytokine TGF-beta in hepatocytes, and Fas-dependent apoptosis in several cellular models of inflammation
p19
p30
cso30:i:ME_UnknownActivation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1
m1639*m38*0.1
nodelay
--
0
PMID: 15691589 Figure 3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1
m36*m38*0.1
nodelay
--
0
PMID: 15691589 Figure 3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1
m36*m41*0.1
nodelay
--
0
PMID: 15691589 Figure 3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1
m36*m42*0.1
nodelay
--
0
PMID: 15691589 Figure 3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1
m36*m44*0.1
nodelay
--
0
PMID: 15691589 Figure 3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
m43*0.1
nodelay
--
0
PMID: 15691589 Figure 3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
m45*0.1
nodelay
--
0
PMID: 15691589 Figure 3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
m40*0.1
nodelay
--
0
PMID: 15691589 Figure 3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
m39*0.1
nodelay
--
0
PMID: 15691589 Figure 3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
m40*0.1
nodelay
--
0
PMID: 15691589 Figure 3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c9 : 1
1.0*0.1
nodelay
--
0
PMID: 15691589,12605597,9733516 These include the ¡Ædesensitization¡Ç of the initial pro-apoptotic signaling pathway (although the mechanisms of this have been little studied), the inhibition of procaspase processing and caspase activity and the expression of anti-apoptotic genes of the Inhibitor of Apoptosis (IAP) family
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c109 : 1
m39*0.1
nodelay
--
0
PMID: 15691589 Figure 3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
m43*0.1
nodelay
--
0
PMID: 15691589 Figure 3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1
m45*0.1
nodelay
--
0
PMID: 15691589 Figure 3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
m40*0.1
nodelay
--
0
PMID: 15691589 Figure 3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
m39*0.1
nodelay
--
0
PMID: 15691589 Figure 3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
m43*0.1
nodelay
--
0
PMID: 15691589 Figure 3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1
m45*0.1
nodelay
--
0
PMID: 15691589 Figure 3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c11 : 1
m93479*0.1
nodelay
--
0
PMID: 15691589 Elevated nitric oxide synthesis after the induced expression of NOS-2 by activated macrophages is one of the main cytostatic, cytotoxic, and pro-apoptotic mechanisms participating in the innate response in many mammals PMID: 15691589 A process that can be demonstrated when NO synthesis is suppressed via treatment of cells with a selective NOS-2 inhibitor such as N-(3-aminomethylbenzyl)acetamidine (1400 W) or l-N6-(1-iminoethyl)lysine (l-NIL).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
m5*0.1
nodelay
--
0
PMID: 15691589,11129661 The pro-apoptotic activity of NO has been well documented and involves the release of cytochrome c from the mitochondria, increased expression of the tumor suppressor p53 and accumulation and targeting of pro-apoptotic members of the Bcl-2 family, in particular Bax, which is translocated to the mitochondria
p7
p7
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c15 : 1
m155666*0.1
nodelay
--
0
PMID: 15691589 In contrast, molecules that release NO in a sustained way, or induction of NOS-2 expression by treatment with lipopolysaccharide (LPS) and IFN- gamma, do not provoke this response
p7
p8
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c16 : 1
m1639*0.1
nodelay
--
0
PMID: 15691589 In contrast, molecules that release NO in a sustained way, or induction of NOS-2 expression by treatment with lipopolysaccharide (LPS) and IFN- gamma, do not provoke this response
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c20 : 1
stoichiometry:c19 : 1
m12*m5*0.1
nodelay
--
0
PMID: 15691589 The active sites of caspase enzymes contain a cysteine residue that is susceptible to S-nitrosylation by NO in the procaspase and active forms of the proteins.
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--