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indirect
PMID: 15691589,7528106
For example, moderate NO concentrations
inhibit basal apoptosis in B lymphocytes, apoptosis induced by the potent
cytokine TGF-beta in hepatocytes, and Fas-dependent
apoptosis in several cellular models of inflammation
indirect
PMID: 15691589,7528106
For example, moderate NO concentrations
inhibit basal apoptosis in B lymphocytes, apoptosis induced by the potent
cytokine TGF-beta in hepatocytes, and Fas-dependent
apoptosis in several cellular models of inflammation
PMID: 15691589,12605597,9733516
These include the
‘desensitization’ of the initial pro-apoptotic signaling
pathway (although the mechanisms of this have been little studied), the inhibition of procaspase processing
and caspase activity and the expression
of anti-apoptotic genes of the Inhibitor of Apoptosis
(IAP) family
PMID: 15691589,12605597,9733516
These include the
‘desensitization’ of the initial pro-apoptotic signaling
pathway (although the mechanisms of this have been little studied), the inhibition of procaspase processing
and caspase activity and the expression
of anti-apoptotic genes of the Inhibitor of Apoptosis
(IAP) family
indirect
PMID: 15691589
Elevated
nitric oxide synthesis after the induced expression
of NOS-2 by activated macrophages is one of the
main cytostatic, cytotoxic, and pro-apoptotic mechanisms
participating in the innate response in many mammals
PMID: 15691589
A process that can be
demonstrated when NO synthesis is suppressed via
treatment of cells with a selective NOS-2 inhibitor such
as N-(3-aminomethylbenzyl)acetamidine (1400 W) or
l-N6-(1-iminoethyl)lysine (l-NIL).
indirect
PMID: 15691589,11129661
The pro-apoptotic activity of NO has
been well documented and involves the release of cytochrome c from the mitochondria,
increased expression of the tumor suppressor
p53 and accumulation and targeting
of pro-apoptotic members of the Bcl-2 family,
in particular Bax, which is translocated to the mitochondria
indirect
PMID: 15691589
In contrast, molecules that release NO
in a sustained way, or induction of NOS-2 expression
by treatment with lipopolysaccharide (LPS) and IFN-
gamma, do not provoke this response
indirect
PMID: 15691589
In contrast, molecules that release NO
in a sustained way, or induction of NOS-2 expression
by treatment with lipopolysaccharide (LPS) and IFN-
gamma, do not provoke this response
indirect
PMID: 15691589
The active sites of
caspase enzymes contain a cysteine residue that is susceptible
to S-nitrosylation by NO in the procaspase and
active forms of the proteins.
indirect
PMID: 15691589
The active sites of
caspase enzymes contain a cysteine residue that is susceptible
to S-nitrosylation by NO in the procaspase and
active forms of the proteins.
indirect
PMID: 15691589
This occurs
through a mechanism that involves nitrosylation of the
proteasome and of the p50 and p65 subunits at their
DNA binding domains; inhibiting their transcriptional
activity.
indirect
PMID: 15691589
This occurs
through a mechanism that involves nitrosylation of the
proteasome and of the p50 and p65 subunits at their
DNA binding domains; inhibiting their transcriptional
activity.
indirect
PMID: 15691589,9422508
This potent anti-inflammatory
molecule efficiently inhibits IKappaB kinase (IKK) activation,
as well as the transcriptional activity of several factors such as NF-KappaB, AP-1 and Stat-1alpha
indirect
indirect
PMID: 15691589
Moreover, 15-dPGJ2 synergizes with NO by enhancing
the synthesis of reactive oxygen species, in particular
oxygen superoxide.
PMID: 15691589,11086094,10593878,11175752,12893946,12727142
Superoxide rapidly reacts withNO
to produce peroxynitrite, one of the most potent oxidants
released by cells, and exhibits both pro-apoptotic
and necrotic effects
PMID: 15691589,10669746,12612088,12524534
These nuclear receptors – respectively activated by
fatty acids/prostanoids and oxysterols – exert an important
down-regulatory control on the transcriptional activity of pro-inflammatory genes and on transcription
factors such as NF-KappaB, Stat-1alpha, and AP-1
PMID: 15691589,10669746,12612088,12524534
These nuclear receptors – respectively activated by
fatty acids/prostanoids and oxysterols – exert an important
down-regulatory control on the transcriptional activity of pro-inflammatory genes and on transcription
factors such as NF-KappaB, Stat-1alpha, and AP-1
PMID: 15691589,10669746,12612088,12524534
These nuclear receptors – respectively activated by
fatty acids/prostanoids and oxysterols – exert an important
down-regulatory control on the transcriptional activity of pro-inflammatory genes and on transcription
factors such as NF-KappaB, Stat-1alpha, and AP-1
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3
indirect
PMID: 15691589
Figure 3