Entity
NF-kappaB {activated}
--
MO000000058
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m24
10
infinite
0
TRANSPATH | MO000000058 |
--
LPS:LBP:CD14
--
MO000021929
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m6255
10
infinite
0
TRANSPATH | MO000021929 |
--
LPS:LBP:CD14:TLR4:MD-2:MyD88
--
MO000038321
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m16536
10
infinite
0
TRANSPATH | MO000038321 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
LPS:LBP:CD14:TLR4:MD-2
--
e11
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m11
10
infinite
0
TRANSPATH | MO000022054 |
--
lipopeptide
--
e12
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m12
0
infinite
0
--
flagellin
--
e13
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m13
0
infinite
0
--
flagellin: TLR5
--
e14
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m14
0
infinite
0
--
ssDNA
--
e15
cso30:c:Dna
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m15
0
infinite
0
--
ssDNA:TLR9
--
e16
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m16
0
infinite
0
--
ssRNA: TLR7
--
e17
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m17
0
infinite
0
--
ssRNA
--
e18
cso30:c:Rna
cso30:i:CC_Extracellular
--
csml-variable:Double
m18
0
infinite
0
--
ssRNA: TLR9
--
e19
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
LPS:LBP:CD14:TLR4:MD-2:MyD88: IRAK: IRAK-4
--
e20
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m20
0
infinite
0
--
LPS:LBP:CD14:TLR4:MD-2:MyD88: IRAK: IRAK-4: TRAF6
--
e21
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m21
0
infinite
0
--
IKK-alpha:IKK-beta:IKK-gamma
--
e22
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m22
10
infinite
0
TRANSPATH | MO000021655 |
--
IKK-alpha:IKK-beta:IKK-gamma {p}
--
e23
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m23
0
infinite
0
--
IkappB: NFkappaB
--
e24
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m25
0
infinite
0
--
IkappB {p}: NFkappaB
--
e25
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m26
0
infinite
0
--
IkappaB {degraded}
--
e26
cso30:c:EntityBiological
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m27
0
infinite
0
--
NF-kappaB {nucleus}
--
e27
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m28
10
infinite
0
TRANSPATH | MO000000058 |
--
lipid IV A
--
e28
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m29
0
infinite
0
--
lipid IV A: TLR4
--
e29
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m30
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
lipopeptide: TLR2
--
e5
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
p1
p1
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m155666*m3985*0.1
nodelay
--
0
PMID: 15608698 Recognition of lipid A also requires an accessory protein ¡½ LPS-binding protein (LBP) ¡½ which converts oligomeric micelles of LPS to a monomer for delivery to CD14.
p10
p10
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1
m11*m1572*0.1
nodelay
--
0
PMID: 15608698 Upon ligand binding, this domain associates with the myeloid differentiation factor 88 (MyD88) adaptor protein.
p11
p11
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1
m184*m17258*m16536*0.1
nodelay
--
0
PMID: 15608698, 11905821 Upon ligand binding, this domain associates with the myeloid differentiation factor 88 (MyD88) adaptor protein, which is necessary for the recruitment of the protein kinases interleukin-1 receptor-associated kinase 1 (IRAK1) and IRAK4, and TNF-receptor-associated factor 6 (TRAF6) to the complex.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1
m20*m183*0.1
nodelay
--
0
PMID: 15608698, 11905821 Upon ligand binding, this domain associates with the myeloid differentiation factor 88 (MyD88) adaptor protein, which is necessary for the recruitment of the protein kinases interleukin-1 receptor-associated kinase 1 (IRAK1) and IRAK4, and TNF-receptor-associated factor 6 (TRAF6) to the complex.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1
m21*m22*0.1
nodelay
--
0
PMID: 15608698 Through a series of other intermediate compounds, the I¦ÊB kinase (IKK) complex is phosphorylated, and in turn phosphorylates I¦ÊB, which allows nuclear factor (NF)-¦ÊB to translocate to the nucleus.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1
m23*m25*0.1
nodelay
--
0
PMID: 15608698 Through a series of other intermediate compounds, the I¦ÊB kinase (IKK) complex is phosphorylated, and in turn phosphorylates I¦ÊB, which allows nuclear factor (NF)-¦ÊB to translocate to the nucleus.
p15
p15
cso30:i:ME_UnknownDegradation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1
m26*0.1
nodelay
--
0
PMID: 15608698 Through a series of other intermediate compounds, the I¦ÊB kinase (IKK) complex is phosphorylated, and in turn phosphorylates I¦ÊB, which allows nuclear factor (NF)-¦ÊB to translocate to the nucleus.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
m24*0.1
nodelay
--
0
PMID: 15608698 Through a series of other intermediate compounds, the I¦ÊB kinase (IKK) complex is phosphorylated, and in turn phosphorylates I¦ÊB, which allows nuclear factor (NF)-¦ÊB to translocate to the nucleus.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1
m29*m3961*0.1
nodelay
--
0
PMID: 15608698, 6361124, 1918061 lipidIVA, which is an intermediate in the biosynthetic pathway of lipid A and is the major component of Yersinia pestis lipid A, stimulates mouse TLR4 but is not recognized by human TLR4, even at very high concentrations.
p2
p2
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m6254*m2828*0.1
nodelay
--
0
PMID: 15608698 Recognition of lipid A also requires an accessory protein ¡½ LPS-binding protein (LBP) ¡½ which converts oligomeric micelles of LPS to a monomer for delivery to CD14.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c54 : 1
m28*0.1
nodelay
--
0
PMID: 15608698 Ligand binding to the extracellular domain of TLRs initiates a complex signal-transduction cascade,which ultimately leads to activation of the transcription factor nuclear factor-¦ÊB (NF-¦ÊB) and increased transcription of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumour-necrosis factor (TNF).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c53 : 1
m28*0.1
nodelay
--
0
PMID: 15608698 Ligand binding to the extracellular domain of TLRs initiates a complex signal-transduction cascade,which ultimately leads to activation of the transcription factor nuclear factor-¦ÊB (NF-¦ÊB) and increased transcription of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumour-necrosis factor (TNF).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
m6255*m6*0.1
nodelay
--
0
PMID: 15608698 CD14 concentrates LPS for binding to the TLR4?MD2 complex.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1
m12*m3964*0.1
nodelay
--
0
PMID: 15608698, 9851930, 11323673, 10426996 The ligands that are recognized by TLRs include lipopeptides (TLR2),lipopolysaccharide (TLR4), flagellin (TLR5)and CpG DNA (TLR9).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1
m13*m3966*0.1
nodelay
--
0
PMID: 15608698, 9851930, 11323673, 10426996 The ligands that are recognized by TLRs include lipopeptides (TLR2),lipopolysaccharide (TLR4), flagellin (TLR5)and CpG DNA (TLR9).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1
m15*m19828*0.1
nodelay
--
0
PMID: 15608698, 9851930, 11323673, 10426996 The ligands that are recognized by TLRs include lipopeptides (TLR2),lipopolysaccharide (TLR4), flagellin (TLR5)and CpG DNA (TLR9).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c19 : 1
stoichiometry:c21 : 1
m19940*m18*0.1
nodelay
--
0
PMID: 15608698, 14976262, 14976261, 15034168 viral products such as single-stranded and double-stranded RNA are recognized by TLR7 (human TLR8) and TLR3, respectively.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1
m19823*m18*0.1
nodelay
--
0
PMID: 15608698, 14976262, 14976261, 15034168 viral products such as single-stranded and double-stranded RNA are recognized by TLR7 (human TLR8) and TLR3, respectively.
p9
p9
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
m119368*m3965*0.1
nodelay
--
0
PMID: 15608698, 14976262, 14976261, 15034168 viral products such as single-stranded and double-stranded RNA are recognized by TLR7 (human TLR8) and TLR3, respectively.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--