Entity
NF-kappaB
--
MO000000058
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m30
10
infinite
0
TRANSPATH | MO000000058 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
TLR2: TLR6
--
e12
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m12
0
infinite
0
--
diacylated lipopeptides
--
e13
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m13
0
infinite
0
--
diacylated lipoproteins: TLR2: TLR1
--
e14
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m14
0
infinite
0
--
triacylated lipoproteins: TLR2: TLR6
--
e15
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m15
0
infinite
0
--
triacylated lipoproteins
--
e16
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m16
0
infinite
0
--
csml-variable:Double
m17
0
infinite
0
--
CpG DNA: TLR9
--
e18
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m18
0
infinite
0
--
loxoribine
--
e19
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
imadazole quinoline
--
e20
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m20
0
infinite
0
--
loxoribine: TLR7
--
e21
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m21
0
infinite
0
--
imadazole quinoline: TLR8
--
e22
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m22
0
infinite
0
--
flagellin: TLR9
--
e23
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m23
0
infinite
0
--
LPS:CD14: TLR4: MD-2: MyD88
--
e24
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m24
0
infinite
0
--
Mal
--
e25
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m25
0
infinite
0
--
LPS:CD14: TLR4: MD-2: MyD88: TIRAP: Mal
--
e26
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m26
0
infinite
0
--
LPS:CD14: TLR4: MD-2: TRIF
--
e27
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m27
0
infinite
0
--
IRAK-4 {activated}
--
e28
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m28
10
infinite
0
TRANSPATH | MO000039077 |
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
NF-kappaB {activated}
--
e30
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m31
10
infinite
0
TRANSPATH | MO000000058 |
--
PGN: Nod1
--
e31
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m32
0
infinite
0
--
PGN: Nod2
--
e32
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m33
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
CD14: TLR4: MD-2
--
e5
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
LPS:CD14: TLR4: MD-2
--
e6
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m5*m155666*0.1
nodelay
--
0
PMID: 15576198 the lipopolysaccharide (LPS) receptor is made up of at least three proteins, CD14, MD-2 and TLR4.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1
m6*m1572*0.1
nodelay
--
0
PMID: 15576198, 12872135 MyD88 also contains a TIR domain, which associates with the TIR domain of the TLRs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1
m6810*m25*m24*0.1
nodelay
--
0
PMID: 15576198 A family of proteins with TIR domains that are structurally and functionally related to MyD88 has been identified. This family includes proteins named TIRAP and TRIF.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c35 : 1
stoichiometry:c37 : 1
m18998*m6*0.1
nodelay
--
0
PMID: 15576198 A family of proteins with TIR domains that are structurally and functionally related to MyD88 has been identified. This family includes proteins named TIRAP and TRIF.
p13
p13
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1
m26*m17258*0.1
nodelay
--
0
PMID: 15576198 A number of studies indicates roles of TRAF6 and members of the IRAK family (interleukin-1-associated receptor kinase), most notably IRAK-4, downstream of MyD88.
p14
p14
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c43 : 1
stoichiometry:c42 : 1
m183*m28*0.1
nodelay
--
0
PMID: 15576198 A number of studies indicates roles of TRAF6 and members of the IRAK family (interleukin-1-associated receptor kinase), most notably IRAK-4, downstream of MyD88.
p15
p15
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c46 : 1
stoichiometry:c45 : 1
m30*m29*0.1
nodelay
--
0
PMID: 15576198 This highly conserved pathway is linked to activation of the NF-kappaB pathway.
p16
p16
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1
m4923*m155701*0.1
nodelay
--
0
PMID: 15576198, 12791997, 12796777 both proteins recognize monomeric components of peptidoglycan.
p17
p17
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1
m155701*m4947*0.1
nodelay
--
0
PMID: 15576198, 12791997, 12796777 both proteins recognize monomeric components of peptidoglycan.
p18
p18
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c57 : 1
stoichiometry:c59 : 1
stoichiometry:c54 : 1
m30*m32*m2684*0.1
nodelay
--
0
PMID: 15576198 Binding of the cognate ligants to NOD1 or NOD2 leads to activation of NF-kappaB by a mechanism requiring the presence of the kinase known as RICK (Rip2).
p19
p19
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c58 : 1
stoichiometry:c60 : 1
stoichiometry:c56 : 1
m30*m33*m2684*0.1
nodelay
--
0
PMID: 15576198 Binding of the cognate ligants to NOD1 or NOD2 leads to activation of NF-kappaB by a mechanism requiring the presence of the kinase known as RICK (Rip2).
p2
p2
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m3964*m3963*0.1
nodelay
--
0
PMID: 15576198, 12524386, 14498823, 12960260 TLR2?TLR1 heterodimers recognize diacylated lipopeptides whereas TLR2?TLR6 heterodimers recognize triacylated lipopeptides.
p3
p3
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
m3987*m3964*0.1
nodelay
--
0
PMID: 15576198, 12524386, 14498823, 12960260 TLR2?TLR1 heterodimers recognize diacylated lipopeptides whereas TLR2?TLR6 heterodimers recognize triacylated lipopeptides.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1
m13*m11*0.1
nodelay
--
0
PMID: 15576198, 12524386, 14498823, 12960260 TLR2?TLR1 heterodimers recognize diacylated lipopeptides whereas TLR2?TLR6 heterodimers recognize triacylated lipopeptides.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1
m12*m16*0.1
nodelay
--
0
PMID: 15576198, 12524386, 14498823, 12960260 TLR2?TLR1 heterodimers recognize diacylated lipopeptides whereas TLR2?TLR6 heterodimers recognize triacylated lipopeptides.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1
m17*m19828*0.1
nodelay
--
0
PMID: 15576198, 12467249 It has been shown that TLR9, receptor for bacterial DNA containing sequences of non-methylated CpG sequences, is localized and acts in an intracellular compartment.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
m19940*m19*0.1
nodelay
--
0
PMID: 15576198, 12524386, 14498823, 12960260 More recently, synthetic nucleoside analogues loxoribine and imadazole quinolines have been identified as ligands for TLR7 and TLR8, respectively.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1
m19823*m20*0.1
nodelay
--
0
PMID: 15576198, 12524386, 14498823, 12960260 More recently, synthetic nucleoside analogues loxoribine and imadazole quinolines have been identified as ligands for TLR7 and TLR8, respectively.
p9
p9
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
m6485*m3966*0.1
nodelay
--
0
PMID: 15576198, 10963608 Biochemical studies have shown the direct binding of LPS-TLR4 and bacterial flagellin protein-TLR5.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--