Entity
Process
IkappaB-alpha
--
MO000000233
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m199
10
infinite
0
InterPro | IPR002110 |
TRANSPATH | MO000000233 |
--
IKK-alpha:IKK-beta
--
MO000033291
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m11981
10
infinite
0
TRANSPATH | MO000033291 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
csml-variable:Double
m10
0
infinite
0
--
PDGJ2:PPARG
--
e100
cso30:c:Complex
cso30:i:CC_Cell_WithoutCellWall_
--
--
csml-variable:Double
m104
0
infinite
0
--
LOX1
--
e101
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m105
0
infinite
0
--
FasL
--
e102
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m106
0
infinite
0
--
c-myc
--
e103
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m107
0
infinite
0
--
TF
--
e104
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m108
0
infinite
0
--
csml-variable:Double
m109
0
infinite
0
--
AT1
--
e106
cso30:c:Protein
cso30:i:CC_Cell_WithoutCellWall_
--
csml-variable:Double
m110
0
infinite
0
--
IKK-alpha:IKK-beta:(IKK-gamma)2
--
e17
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m17
0
infinite
0
--
MEKK3:IKK-alpha:IKK-beta:(IKK-gamma)2
--
e18
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m18
0
infinite
0
--
MEKK3:IKK-alpha:IKK-beta{p}:(IKK-gamma)2
--
e19
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
NIK:IKK-alpha:IKK-beta:(IKK-gamma)2
--
e20
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m20
0
infinite
0
--
NIK:IKK-alpha:IKK-beta{p}:(IKK-gamma)2
--
e21
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m21
0
infinite
0
--
PKC{active}:IKK-alpha:IKK-beta:(IKK-gamma)2
--
e22
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m22
0
infinite
0
--
PKC{active}:IKK-alpha:IKK-beta{p}:(IKK-gamma)2
--
e23
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m23
0
infinite
0
--
MEKK1:IKK-alpha:IKK-beta:(IKK-gamma)2
--
e24
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m24
0
infinite
0
--
MEKK1:IKK-alpha:IKK-beta:(IKK-gamma)2
--
e25
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m25
0
infinite
0
--
AKT:IKK-alpha:IKK-beta:(IKK-gamma)2
--
e26
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m26
0
infinite
0
--
AKT:IKKA:IKKB{p}:(IKKG)2
--
e27
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m27
0
infinite
0
--
MEKK2:IKK-alpha:IKK-beta:(IKK-gamma)2
--
e28
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m28
0
infinite
0
--
Mekk2:IKK-alpha:IKK-beta{p}:(IKK-gamma)2
--
e29
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
TBK1:IKKA:IKKb{p}:(IKKG)2
--
e30
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m30
0
infinite
0
--
TBK1:IKKA:IKKB{p}:(IKKG)2
--
e31
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m31
0
infinite
0
--
NF-kappaB:I-kappaB{alpha}
--
e32
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m32
0
infinite
0
--
NF-kappaB:I-kappaB{alpha}{p}
--
e33
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m33
0
infinite
0
--
NF-kappaB:I-kappaB{alpha}{p}{ub}
--
e34
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m34
0
infinite
0
--
protein remnants
--
e35
cso30:c:EntityBiological
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m35
0
infinite
0
--
NF-kappaB{active}
--
e36
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m36
0
infinite
0
--
NF-kappaB
--
e37
cso30:c:Protein
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m37
0
infinite
0
--
csml-variable:Double
m38
0
infinite
0
--
TNF-alpha:NF-kappaB
--
e39
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m39
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
csml-variable:Double
m40
0
infinite
0
--
IL-1:NF-kappaB
--
e41
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m41
0
infinite
0
--
IL-1
--
e42
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m42
0
infinite
0
--
csml-variable:Double
m43
0
infinite
0
--
ICAM1:NFkapapB
--
e44
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m46
0
infinite
0
--
ICAM1
--
e45
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m47
0
infinite
0
--
csml-variable:Double
m48
0
infinite
0
--
Eselectin:NFkappaB
--
e47
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m49
0
infinite
0
--
csml-variable:Double
m63
0
infinite
0
--
csml-variable:Double
m64
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
BCL-xL
--
e63
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m65
0
infinite
0
--
csml-variable:Double
m66
0
infinite
0
--
csml-variable:Double
m67
0
infinite
0
--
csml-variable:Double
m68
0
infinite
0
--
csml-variable:Double
m69
0
infinite
0
--
NF-kappaB:I-kappaB{alpha}
--
e69
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m71
0
infinite
0
--
csml-variable:Double
m7
0
infinite
0
--
UV
--
e70
cso30:c:EntityBiologicalEnvironment
cso30:i:CC_Cell_WithoutCellWall_
--
--
csml-variable:Double
m72
0
infinite
0
--
NF-kappaB
--
e71
cso30:c:Protein
cso30:i:CC_Cytoplasm
--
csml-variable:Double
m73
0
infinite
0
--
PI3K:NFkappaB:IkappaBalpha
--
e72
cso30:c:Complex
cso30:i:CC_Cell_WithoutCellWall_
--
csml-variable:Double
m75
0
infinite
0
--
PI3K:IKappaBalpha
--
e73
cso30:c:SmallMolecule
cso30:i:CC_Cell_WithoutCellWall_
--
--
csml-variable:Double
m76
0
infinite
0
--
H2O2
--
e74
cso30:c:SmallMolecule
cso30:i:CC_Cytoplasm
--
--
csml-variable:Double
m77
0
infinite
0
--
csml-variable:Double
m78
0
infinite
0
--
NAC
--
e76
cso30:c:SmallMolecule
cso30:i:CC_Cell_WithoutCellWall_
--
csml-variable:Double
m79
0
infinite
0
--
calphostin C
--
e77
cso30:c:SmallMolecule
cso30:i:CC_Cell_WithoutCellWall_
--
csml-variable:Double
m80
0
infinite
0
--
Lyso-PC
--
e78
cso30:c:SmallMolecule
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
csml-variable:Double
m81
0
infinite
0
--
Tyrosine kinase
--
e79
cso30:c:Protein
cso30:i:CC_Cytoplasm
--
--
csml-variable:Double
m82
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
Tyrosine kinase {active}
--
e80
cso30:c:Protein
cso30:i:CC_Cytoplasm
--
--
csml-variable:Double
m83
0
infinite
0
--
csml-variable:Double
m85
0
infinite
0
--
oxidised LDL
--
e83
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m86
0
infinite
0
--
sphingosine-1-phosphate
--
e84
cso30:c:Complex
cso30:i:CC_Cytoplasm
--
csml-variable:Double
m87
0
infinite
0
--
LOX1
--
e85
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m88
0
infinite
0
--
oxidized LDL:LOX1
--
e86
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m89
0
infinite
0
--
ROS
--
e87
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
csml-variable:Double
m90
0
infinite
0
--
LPS:TLRs
--
e88
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m91
0
infinite
0
--
csml-variable:Double
m93
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
phtohaemagglutinin
--
e90
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m94
0
infinite
0
--
IL-2R
--
e91
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m95
0
infinite
0
--
PPAR-gamma
--
e92
cso30:c:Protein
cso30:i:CC_Cell_WithoutCellWall_
--
csml-variable:Double
m96
0
infinite
0
--
9-HODE
--
e93
cso30:c:SmallMolecule
cso30:i:CC_Cell_WithoutCellWall_
--
--
csml-variable:Double
m97
0
infinite
0
--
9-HODE:PPARG
--
e94
cso30:c:Complex
cso30:i:CC_Cell_WithoutCellWall_
--
--
csml-variable:Double
m98
0
infinite
0
--
13-HODE
--
e95
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m99
0
infinite
0
--
13-HODE:PPARG
--
e96
cso30:c:Complex
cso30:i:CC_Cell_WithoutCellWall_
--
--
csml-variable:Double
m100
0
infinite
0
--
HETE
--
e97
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m101
0
infinite
0
--
HETE:PPARG
--
e98
cso30:c:Complex
cso30:i:CC_Cell_WithoutCellWall_
--
--
csml-variable:Double
m102
0
infinite
0
--
PDGJ2
--
e99
cso30:c:SmallMolecule
cso30:i:CC_Cell_WithoutCellWall_
--
--
csml-variable:Double
m103
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c149 : 1
stoichiometry:c2 : 1
m92*m81*0.1
nodelay
--
0
PMID: 15346645, 9555862, 1381720, 8622597, 9084506 Lysophosphatidylcholine (Lyso-PC) elicited PKC and tyrosine kinases activation and subsequent NF-kB activation and overexpression of ICAM-1, VCAM-1 and MCP-1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c24 : 1
m13*m17*0.1
nodelay
--
0
PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
m18*0.1
nodelay
--
0
PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
m6*m17*0.1
nodelay
--
0
PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
m20*0.1
nodelay
--
0
PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1
m5*m17*0.1
nodelay
--
0
PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
m22*0.1
nodelay
--
0
PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1
m12*m17*0.1
nodelay
--
0
PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
m24*0.1
nodelay
--
0
PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1
m17*m15*0.1
nodelay
--
0
PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
m26*0.1
nodelay
--
0
PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c250 : 1
stoichiometry:c4 : 1
m174*m86*0.1
nodelay
--
0
PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1
m14*m17*0.1
nodelay
--
0
PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
m28*0.1
nodelay
--
0
PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1
m11*m17*0.1
nodelay
--
0
PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
m30*0.1
nodelay
--
0
PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c57 : 1
stoichiometry:c56 : 1
m32*m29*0.1
nodelay
--
0
PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex, which in turn phosphorylates IkB. PMID: 15346645 Upon activation, IkB is rapidly phosphorylated on two serine residues (ser-32 and ser-36 in IkBa, ser-19 and ser-23 in IkBb).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c60 : 1
stoichiometry:c59 : 1
m32*m31*0.1
nodelay
--
0
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c63 : 1
stoichiometry:c62 : 1
m32*m27*0.1
nodelay
--
0
PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex, which in turn phosphorylates IkB. PMID: 15346645 Upon activation, IkB is rapidly phosphorylated on two serine residues (ser-32 and ser-36 in IkBa, ser-19 and ser-23 in IkBb).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c66 : 1
stoichiometry:c65 : 1
m32*m21*0.1
nodelay
--
0
PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex, which in turn phosphorylates IkB. PMID: 15346645 Upon activation, IkB is rapidly phosphorylated on two serine residues (ser-32 and ser-36 in IkBa, ser-19 and ser-23 in IkBb).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c69 : 1
stoichiometry:c68 : 1
m32*m19*0.1
nodelay
--
0
PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex, which in turn phosphorylates IkB. PMID: 15346645 Upon activation, IkB is rapidly phosphorylated on two serine residues (ser-32 and ser-36 in IkBa, ser-19 and ser-23 in IkBb).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c72 : 1
stoichiometry:c71 : 1
m32*m23*0.1
nodelay
--
0
PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex, which in turn phosphorylates IkB. PMID: 15346645 Upon activation, IkB is rapidly phosphorylated on two serine residues (ser-32 and ser-36 in IkBa, ser-19 and ser-23 in IkBb).
p3
p3
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c249 : 1
stoichiometry:c6 : 1
m3902*m86*0.1
nodelay
--
0
PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c75 : 1
stoichiometry:c74 : 1
m32*m25*0.1
nodelay
--
0
PMID: 15346645 Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex, which in turn phosphorylates IkB. PMID: 15346645 Upon activation, IkB is rapidly phosphorylated on two serine residues (ser-32 and ser-36 in IkBa, ser-19 and ser-23 in IkBb).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
m33*0.1
nodelay
--
0
PMID: 15346645 This leads to IkB ubiquitination and subsequent degradation by the 26S proteasome.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c168 : 1
stoichiometry:c82 : 1
m36*m86*0.1
nodelay
--
0
PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL)immunoreceptors. PMID: 15346645, 12586748 oxLDL-mediated NF-kB nuclear translocation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1
m37*m38*0.1
nodelay
--
0
PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
m39*0.1
nodelay
--
0
PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1
m40*m37*0.1
nodelay
--
0
PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c91 : 1
m41*0.1
nodelay
--
0
PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1
m43*m37*0.1
nodelay
--
0
PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
m46*0.1
nodelay
--
0
PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
p4
p4
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c247 : 1
stoichiometry:c8 : 1
m1115*m86*0.1
nodelay
--
0
PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
p40
p40
cso30:i:ME_DNABinding
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c100 : 1
m37*m7*0.1
nodelay
--
0
PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors. PMID: 15346645, 11557664 This effect is mediated by oxidative stress and PKC as assessed bythe inhibition of NF-kB DNA binding and transcriptionof VCAM-1 gene by the antioxidant NAC and calphostin C.
p41
p41
cso30:i:ME_Transcription
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c144 : 1
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c102 : 1
m10*m78*0.1
nodelay
--
0
PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1
m48*m37*0.1
nodelay
--
0
PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
m49*0.1
nodelay
--
0
PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c110 : 1
stoichiometry:c109 : 1
m63*m37*0.1
nodelay
--
0
PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
m64*0.1
nodelay
--
0
PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c113 : 1
m66*m37*0.1
nodelay
--
0
PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
m67*0.1
nodelay
--
0
PMID: 15346645, 11499717, 11795276 The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
m37*0.1
nodelay
--
0
PMID: 15346645 A second mechanism of autoregulation of the NF-kB/IkB system is also induced by NF-kB itself which elicits the synthesis of its own inhibitor IkB. The newly synthetized IkBa proteins enter the nucleus to bind activated NF-kB and carry it to the cytoplasm,thereby terminating the activation of gene expression.
p49
p49
cso30:i:ME_Translation
cso30:i:CC_Cell_WithoutCellWall_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1
m69*0.1
nodelay
--
0
PMID: 15346645 A second mechanism of autoregulation of the NF-kB/IkB system is also induced by NF-kB itself which elicits the synthesis of its own inhibitor IkB. The newly synthetized IkBa proteins enter the nucleus to bind activated NF-kB and carry it to the cytoplasm,thereby terminating the activation of gene expression.
p5
p5
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c248 : 1
stoichiometry:c10 : 1
m1116*m86*0.1
nodelay
--
0
PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
p50
p50
cso30:i:ME_Translocation
cso30:i:CC_Cell_WithoutCellWall_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
m199*0.1
nodelay
--
0
PMID: 15346645 A second mechanism of autoregulation of the NF-kB/IkB system is also induced by NF-kB itself which elicits the synthesis of its own inhibitor IkB. The newly synthetized IkBa proteins enter the nucleus to bind activated NF-kB and carry it to the cytoplasm,thereby terminating the activation of gene expression.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1
m37*m70*0.1
nodelay
--
0
PMID: 15346645 A second mechanism of autoregulation of the NF-kB/IkB system is also induced by NF-kB itself which elicits the synthesis of its own inhibitor IkB. The newly synthetized IkBa proteins enter the nucleus to bind activated NF-kB and carry it to the cytoplasm,thereby terminating the activation of gene expression.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1
m71*0.1
nodelay
--
0
PMID: 15346645 A second mechanism of autoregulation of the NF-kB/IkB system is also induced by NF-kB itself which elicits the synthesis of its own inhibitor IkB. The newly synthetized IkBa proteins enter the nucleus to bind activated NF-kB and carry it to the cytoplasm,thereby terminating the activation of gene expression.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c131 : 1
stoichiometry:c130 : 1
m73*m72*0.1
nodelay
--
0
PMID: 15346645 UV radiation-induced NF-kB activation does not involve IkBa phosphorylation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c133 : 1
stoichiometry:c134 : 1
m33*m74*0.1
nodelay
--
0
PMID: 15346645, 10488062, 10373503, 10723801 phosphorylation of IkBa at tyrosine 42, that may bind the SH2 domain ofPI3-kinase which pulls it away from NF-kB.
p55
p55
cso30:i:ME_Dissociation
cso30:i:CC_Cell_WithoutCellWall_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1
m75*0.1
nodelay
--
0
PMID: 15346645, 10488062, 10373503, 10723801 phosphorylation of IkBa at tyrosine 42, that may bind the SH2 domain ofPI3-kinase which pulls it away from NF-kB.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c140 : 1
stoichiometry:c139 : 1
m73*m77*0.1
nodelay
--
0
PMID: 15346645 NF-kB is a redox-sensitive transcription factorwhich is activated by intracellular reactive oxygen species (ROS), such as H2O2.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c143 : 1
stoichiometry:c142 : 1
m73*m78*0.1
nodelay
--
0
PMID: 15346645, 11557664 13-HPODE (13-hydroperoxyoctadecadienoic acid) induces NF-kB activation and subsequent overexpression of the vascular cell adhesion molecule-1 (VCAM-1) in porcine vascular SMCs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c152 : 1
stoichiometry:c151 : 1
m73*m81*0.1
nodelay
--
0
PMID: 15346645, 9555862, 1381720, 8622597, 9084506 Lysophosphatidylcholine (Lyso-PC) elicited PKC and tyrosine kinases activation and subsequent NF-kB activation and overexpression of ICAM-1, VCAM-1 and MCP-1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c153 : 1
m81*0.1
nodelay
--
0
PMID: 15346645, 9555862, 1381720, 8622597, 9084506 Lysophosphatidylcholine (Lyso-PC) elicited PKC and tyrosine kinases activation and subsequent NF-kB activation and overexpression of ICAM-1, VCAM-1 and MCP-1.
p6
p6
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c251 : 1
stoichiometry:c12 : 1
m44*m86*0.1
nodelay
--
0
PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c155 : 1
m81*0.1
nodelay
--
0
PMID: 15346645, 9555862, 1381720, 8622597, 9084506 Lysophosphatidylcholine (Lyso-PC) elicited PKC and tyrosine kinases activation and subsequent NF-kB activation and overexpression of ICAM-1, VCAM-1 and MCP-1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c157 : 1
m81*0.1
nodelay
--
0
PMID: 15346645, 9555862, 1381720, 8622597, 9084506 Lysophosphatidylcholine (Lyso-PC) elicited PKC and tyrosine kinases activation and subsequent NF-kB activation and overexpression of ICAM-1, VCAM-1 and MCP-1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c161 : 1
stoichiometry:c160 : 1
m82*m81*0.1
nodelay
--
0
PMID: 15346645, 9555862, 1381720, 8622597, 9084506 Lysophosphatidylcholine (Lyso-PC) elicited PKC and tyrosine kinases activation and subsequent NF-kB activation and overexpression of ICAM-1, VCAM-1 and MCP-1.
p63
p63
cso30:i:ME_UnknownActivation
cso30:i:CC_Cell_WithoutCellWall_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c164 : 1
stoichiometry:c163 : 1
m1812*m85*0.1
nodelay
--
0
PMID: 15346645 Low HNE concentration induces MAPK activation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c167 : 1
stoichiometry:c166 : 1
m73*m90*0.1
nodelay
--
0
PMID: 15346645, 8876974 Moderate concentrations of oxidized LDLs trigger a rapid and dose-dependent activation of NF-kB. PMID: 15346645 ROS are generated by a DPI-sensitive oxidase system activated through signaling triggered by binding ofoxidized LDLs to LOX-1 (lectin-like ox-LDL receptor-1) in endothelial cells.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1
m86*0.1
nodelay
--
0
PMID: 15346645, 8657285 Another survival mechanism that regulates cell death and proliferation induced by oxidized LDLs is the generation of bioactive sphingolipid metabolites, for instance sphingosine-1-phosphate (S1-P).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c173 : 1
stoichiometry:c172 : 1
m73*m87*0.1
nodelay
--
0
PMID: 15346645, 10567432, 9826677 S1-P is involved in NF-kB activation mediated by inflammatory cytokines
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c175 : 1
stoichiometry:c176 : 1
m86*m88*0.1
nodelay
--
0
PMID: 15346645 ROS are generated by a DPI-sensitive oxidase system activated through signaling triggered by binding ofoxidized LDLs to LOX-1 (lectin-like ox-LDL receptor-1) in endothelial cells.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c178 : 1
m89*0.1
nodelay
--
0
PMID: 15346645 ROS are generated by a DPI-sensitive oxidase system activated through signaling triggered by binding ofoxidized LDLs to LOX-1 (lectin-like ox-LDL receptor-1) in endothelial cells.
p69
p69
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c180 : 1
stoichiometry:c181 : 1
m157177*m3962*0.1
nodelay
--
0
PMID: 15346645, 9351352, 7583531, 8690807, 11502209, 13679995 oxidized LDLs inhibit the LPS-induced NF-kB activation and subsequent expression of TNF-a,IL-1b and PAF-receptor in macrophages.
p7
p7
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c252 : 1
stoichiometry:c14 : 1
m45*m86*0.1
nodelay
--
0
PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
p70
p70
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c184 : 1
stoichiometry:c188 : 1
stoichiometry:c240 : 1
stoichiometry:c183 : 1
m73*m91*0.1
nodelay
--
0
PMID: 15346645, 9351352, 7583531, 8690807, 11502209, 13679995 oxidized LDLs inhibit the LPS-induced NF-kB activation and subsequent expression of TNF-a,IL-1b and PAF-receptor in macrophages. PMID: 15346645, 9888865 oxidized LDLs significantly enhanced TF expression induced by LPS in human monocytes, whereas other reports have shown that lysoPC induce a decrease in both NFkB activation and TF expression induced by LPS.
p71
p71
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c187 : 1
stoichiometry:c189 : 1
stoichiometry:c186 : 1
m37*m91*0.1
nodelay
--
0
PMID: 15346645, 9351352, 7583531, 8690807, 11502209, 13679995 oxidized LDLs inhibit the LPS-induced NF-kB activation and subsequent expression of TNF-a,IL-1b and PAF-receptor in macrophages.
p72
p72
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c192 : 1
stoichiometry:c193 : 1
stoichiometry:c190 : 1
m37*m91*0.1
nodelay
--
0
PMID: 15346645, 9351352, 7583531, 8690807, 11502209, 13679995 oxidized LDLs inhibit the LPS-induced NF-kB activation and subsequent expression of TNF-a,IL-1b and PAF-receptor in macrophages.
p73
p73
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c196 : 1
stoichiometry:c197 : 1
stoichiometry:c194 : 1
m37*m91*0.1
nodelay
--
0
PMID: 15346645, 9351352, 7583531, 8690807, 11502209, 13679995 oxidized LDLs inhibit the LPS-induced NF-kB activation and subsequent expression of TNF-a,IL-1b and PAF-receptor in macrophages.
p74
p74
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c200 : 1
stoichiometry:c201 : 1
stoichiometry:c199 : 1
m73*m94*0.1
nodelay
--
0
PMID: 15346645, 9882624 phytohaemagglutinin (PHA)-induced NF-kB activation and subsequent IL-2 receptor expression in human T-lymphocytes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c204 : 1
stoichiometry:c205 : 1
stoichiometry:c202 : 1
m37*m94*0.1
nodelay
--
0
PMID: 15346645, 9882624 phytohaemagglutinin (PHA)-induced NF-kB activation and subsequent IL-2 receptor expression in human T-lymphocytes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c208 : 1
stoichiometry:c209 : 1
stoichiometry:c207 : 1
m32*m91*0.1
nodelay
--
0
PMID: 15346645, 10206970 HNE prevents the LPS-induced IkBa phosphorylation in THP-1 monocytic cells.
p77
p77
cso30:i:ME_ProteasomeDegradation
cso30:i:CC_Cell_WithoutCellWall_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c212 : 1
stoichiometry:c213 : 1
stoichiometry:c211 : 1
m34*m91*0.1
nodelay
--
0
PMID: 15346645, 10698969, 10446139 HNE (like oxidized LDLS) is also able to inhibit the proteasome activity and subsequent proteolysis of IkBa, possibly through a modification of proteasome proteins by 4-HNE.
p78
p78
cso30:i:ME_Binding
cso30:i:CC_Cell_WithoutCellWall_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c214 : 1
stoichiometry:c215 : 1
stoichiometry:c216 : 1
m96*m97*0.1
nodelay
--
0
PMID: 15346645, 9568715, 9422508, 12223313 Oxidized PUFAs, such as 9-HODE and 13-HODE, prostaglandin J2 and HETE, have been identified as endogenous ligands and activators of PPARg.
p79
p79
cso30:i:ME_Binding
cso30:i:CC_Cell_WithoutCellWall_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c217 : 1
stoichiometry:c218 : 1
stoichiometry:c219 : 1
m96*m99*0.1
nodelay
--
0
PMID: 15346645, 9568715, 9422508, 12223313 Oxidized PUFAs, such as 9-HODE and 13-HODE, prostaglandin J2 and HETE, have been identified as endogenous ligands and activators of PPARg.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1
m11981*m16*0.1
nodelay
--
0
PMID: 15346645 IKK is an heterodimer IKKa/IKKb associated with either dimer or trimer of IKKg.
p80
p80
cso30:i:ME_Binding
cso30:i:CC_Cell_WithoutCellWall_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c220 : 1
stoichiometry:c221 : 1
stoichiometry:c222 : 1
m96*m101*0.1
nodelay
--
0
PMID: 15346645, 9568715, 9422508, 12223313 Oxidized PUFAs, such as 9-HODE and 13-HODE, prostaglandin J2 and HETE, have been identified as endogenous ligands and activators of PPARg.
p81
p81
cso30:i:ME_Binding
cso30:i:CC_Cell_WithoutCellWall_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c223 : 1
stoichiometry:c224 : 1
stoichiometry:c225 : 1
m96*m103*0.1
nodelay
--
0
PMID: 15346645, 9568715, 9422508, 12223313 Oxidized PUFAs, such as 9-HODE and 13-HODE, prostaglandin J2 and HETE, have been identified as endogenous ligands and activators of PPARg.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c226 : 1
stoichiometry:c227 : 1
m37*0.1
nodelay
--
0
PMID: 15346645, 10764682, 10085242 NF-kB may enhance the pro-apoptotic effect of oxidized LDLs by up-regulating LOX-1 expression.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c229 : 1
m37*0.1
nodelay
--
0
PMID: 15346645, 10508269, 10022897, 10234031 NF-kB may also up-regulate the expression of pro-apoptotic genes such as Fas ligand, Fas (Cd95), c-myc and p53,thereby sensitizing cells to apoptotic stimuli
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c230 : 1
stoichiometry:c231 : 1
m37*0.1
nodelay
--
0
PMID: 15346645, 10508269, 10022897, 10234031 NF-kB may also up-regulate the expression of pro-apoptotic genes such as Fas ligand, Fas (Cd95), c-myc and p53,thereby sensitizing cells to apoptotic stimuli
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c232 : 1
stoichiometry:c233 : 1
m37*0.1
nodelay
--
0
PMID: 15346645, 10508269, 10022897, 10234031 NF-kB may also up-regulate the expression of pro-apoptotic genes such as Fas ligand, Fas (Cd95), c-myc and p53,thereby sensitizing cells to apoptotic stimuli
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c234 : 1
stoichiometry:c235 : 1
m37*0.1
nodelay
--
0
PMID: 15346645, 10508269, 10022897, 10234031 NF-kB may also up-regulate the expression of pro-apoptotic genes such as Fas ligand, Fas (Cd95), c-myc and p53,thereby sensitizing cells to apoptotic stimuli
p87
p87
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c238 : 1
stoichiometry:c239 : 1
stoichiometry:c237 : 1
m91*m86*0.1
nodelay
--
0
PMID: 15346645, 9888865 oxidized LDLs significantly enhanced TF expression induced by LPS in human monocytes, whereas other reports have shown that lysoPC induce a decrease in both NFkB activation and TF expression induced by LPS.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c242 : 1
stoichiometry:c241 : 1
m37*0.1
nodelay
--
0
PMID: 15346645, 11034947 NF-kB-mediated overexpression of Angiotensin Receptor-1 (AT1) which may up-regulate LOX-1 expression and enhances the toxicity of oxidized LDLs.
p89
p89
cso30:i:ME_Translation
cso30:i:CC_Cell_WithoutCellWall_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c244 : 1
stoichiometry:c243 : 1
m109*0.1
nodelay
--
0
PMID: 15346645, 11034947 NF-kB-mediated overexpression of Angiotensin Receptor-1 (AT1) which may up-regulate LOX-1 expression and enhances the toxicity of oxidized LDLs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
m1593*0.1
nodelay
--
0
PMID: 15346645 IKK is an heterodimer IKKa/IKKb associated with either dimer or trimer of IKKg.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c246 : 1
stoichiometry:c245 : 1
m110*0.1
nodelay
--
0
PMID: 15346645, 11034947 NF-kB-mediated overexpression of Angiotensin Receptor-1 (AT1) which may up-regulate LOX-1 expression and enhances the toxicity of oxidized LDLs.
p91
p91
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c253 : 1
stoichiometry:c255 : 1
stoichiometry:c254 : 1
m92*m86*0.1
nodelay
--
0
PMID: 15346645 In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--