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style="fill:url(#MO_6ad24b);stroke:none;"/> </svg> PMID: 15283983,9041265,8591843 IFN-a also confers immunomodulatory benefits. For example, binding to its cognate cell-surface receptor on immune cells can result in: a reduction in inflammation by inhibiting production of IL-1, IL-8 and tumor necrosis factor (TNF)-a indirect PMID: 15283983,9041265,8591843 IFN-a also confers immunomodulatory benefits. For example, binding to its cognate cell-surface receptor on immune cells can result in: a reduction in inflammation by inhibiting production of IL-1, IL-8 and tumor necrosis factor (TNF)-a indirect PMID: 15283983,9041265,8591843 IFN-a also confers immunomodulatory benefits. For example, binding to its cognate cell-surface receptor on immune cells can result in: a reduction in inflammation by inhibiting production of IL-1, IL-8 and tumor necrosis factor (TNF)-a indirect PMID: 15283983,9041265,8591843 IFN-a also confers immunomodulatory benefits. For example, binding to its cognate cell-surface receptor on immune cells can result in: a reduction in inflammation by inhibiting production of IL-1, IL-8 and tumor necrosis factor (TNF)-a PMID:15283983,9857039,11427497 treatment ofcultured mammalian cells with IFN-a or TNF-a results in induction of SOCS1 and SOCS3 indirect PMID:15283983,9857039,11427497 treatment ofcultured mammalian cells with IFN-a or TNF-a results in induction of SOCS1 and SOCS3 indirect PMID: 15283983 TNF-a stimulates expression of SOCS3 and SHP2, which bind to the JAK –IFN receptor complex. indirect PMID:15283983,9857039,11427497 treatment ofcultured mammalian cells with IFN-a or TNF-a results in induction of SOCS1 and SOCS3 indirect PMID:15283983,9857039,11427497 treatment ofcultured mammalian cells with IFN-a or TNF-a results in induction of SOCS1 and SOCS3 indirect PMID: 15283983 TNF-a stimulates expression of SOCS3 and SHP2, which bind to the JAK –IFN receptor complex. PMID: 15283983 NS5A binds to PKR in a region that overlaps the ISDR domain, and would be expected to suppress its function in vivo. indirect PMID:15283983 Specifically, the signal transducer and activator of transcription (STAT) family of latent cytoplasmic transcription factors become tyrosine phosphorylated by the Janus family of tyrosine kinases (JAK) following binding of IFNs to their cognate multi-subunit transmembrane receptor PMID:15283983 This interaction prevents STAT activation and translocation to the nucleus, where it would otherwise induce antiviral response genes containing an ISRE. PMID: 15283983,9857039,11427497 treatment ofcultured mammalian cells with IFN-a or TNF-a results in induction of SOCS1 and SOCS3, the only two SOCS proteins reported to inhibit IFN-mediated antiviral and antiproliferative activities PMID: 15283983,12551851 Consistent with this observation, an initial report by Bode et al. claimed that overexpression of the HCV core protein inhibits IFN-a-induced tyrosine phosphorylation and activation of STAT1 in hepatic cells. PMID: 15283983 TNF-a stimulates expression of SOCS3 and SHP2, which bind to the JAK –IFN receptor complex. PMID:15283983 This interaction prevents STAT activation and translocation to the nucleus, where it would otherwise induce antiviral response genes containing an ISRE. PMID: 15283983 Specifically, they (STAT) recognize DNA promoter elements to modulate type I IFN (IFN-a and IFN-b) genes selectively, and also recognize the interferon-stimulated response element (ISRE) in some ISGs, leading to induction of an antiviral state. PMID:15283983 This interaction prevents STAT activation and translocation to the nucleus, where it would otherwise induce antiviral response genes containing an ISRE. indirect PMID: 15283983 Specifically, they (STAT) recognize DNA promoter elements to modulate type I IFN (IFN-a and IFN-b) genes selectively, and also recognize the interferon-stimulated response element (ISRE) in some ISGs, leading to induction of an antiviral state. PMID:15283983 This interaction prevents STAT activation and translocation to the nucleus, where it would otherwise induce antiviral response genes containing an ISRE. indirect PMID: 15283983 Specifically, they (STAT) recognize DNA promoter elements to modulate type I IFN (IFN-a and IFN-b) genes selectively, and also recognize the interferon-stimulated response element (ISRE) in some ISGs, leading to induction of an antiviral state. indirect PMID: 15283983 Specifically, they (STAT) recognize DNA promoter elements to modulate type I IFN (IFN-a and IFN-b) genes selectively, and also recognize the interferon-stimulated response element (ISRE) in some ISGs, leading to induction of an antiviral state. PMID: 15283983 Similar to NS5A, the HCV E2 protein was reported to contain a double-stranded (ds)RNA-activated protein kinase eukaryotic initiation factor 2a (PKR-eIF2a) homology domain, which might be capable of interacting with and inactivating PKR. indirect PMID: 15283983 TNF-a stimulates expression of SOCS3 and SHP2, which bind to the JAK –IFN receptor complex. PMID: 15283983 TNF-a stimulates expression of SOCS3 and SHP2, which bind to the JAK –IFN receptor complex. indirect PMID: 15283983 TNF-a stimulates expression of SOCS3 and SHP2, which bind to the JAK –IFN receptor complex. PMID: 15283983 TNF-a stimulates expression of SOCS3 and SHP2, which bind to the JAK –IFN receptor complex. PMID: 15283983,10048763 Characterization of IRF-3 showed regulatory activity by binding to the ISRE of ISG15 and interaction with the CBP/p300 coactivator PMID: 15283983,10048763 Characterization of IRF-3 showed regulatory activity by binding to the ISRE of ISG15 and interaction with the CBP/p300 coactivator PMID: 15283983,10048763 Characterization of IRF-3 showed regulatory activity by binding to the ISRE of ISG15 and interaction with the CBP/p300 coactivator indirect PMID: 15283983,9857039,11427497 treatment ofcultured mammalian cells with IFN-a or TNF-a results in induction of SOCS1 and SOCS3, the only two SOCS proteins reported to inhibit IFN-mediated antiviral and antiproliferative activities PMID: 15283983,9857039,11427497 treatment ofcultured mammalian cells with IFN-a or TNF-a results in induction of SOCS1 and SOCS3, the only two SOCS proteins reported to inhibit IFN-mediated antiviral and antiproliferative activities PMID: 15283983,14644140,10453004,11390452,12433373 SOCS1 and SOCS3 expression can be induced by various cytokines, and can also be induced by, and negatively regulate, LPS and CpG DNA, which are conserved bacterial components characterized as structural correlates of PAMP indirect PMID: 15283983,14644140,10453004,11390452,12433373 SOCS1 and SOCS3 expression can be induced by various cytokines, and can also be induced by, and negatively regulate, LPS and CpG DNA, which are conserved bacterial components characterized as structural correlates of PAMP indirect PMID: 15283983,14644140,10453004,11390452,12433373 SOCS1 and SOCS3 expression can be induced by various cytokines, and can also be induced by, and negatively regulate, LPS and CpG DNA, which are conserved bacterial components characterized as structural correlates of PAMP indirect PMID: 15283983,14644140,10453004,11390452,12433373 SOCS1 and SOCS3 expression can be induced by various cytokines, and can also be induced by, and negatively regulate, LPS and CpG DNA, which are conserved bacterial components characterized as structural correlates of PAMP indirect PMID: 15283983,14644140,10453004,11390452,12433373 SOCS1 and SOCS3 expression can be induced by various cytokines, and can also be induced by, and negatively regulate, LPS and CpG DNA, which are conserved bacterial components characterized as structural correlates of PAMP PMID: 15283983,14644140,10453004,11390452,12433373 SOCS1 and SOCS3 expression can be induced by various cytokines, and can also be induced by, and negatively regulate, LPS and CpG DNA, which are conserved bacterial components characterized as structural correlates of PAMP PMID: 15283983,14630206 This same pathway can be induced by activation of other cytokine receptors including those for IL-6 and IL-10 PMID: 15283983,14630206 This same pathway can be induced by activation of other cytokine receptors including those for IL-6 and IL-10 indirect PMID: 15283983,14630206 This same pathway can be induced by activation of other cytokine receptors including those for IL-6 and IL-10 PMID: 15283983,14630206 This same pathway can be induced by activation of other cytokine receptors including those for IL-6 and IL-10 PMID: 15283983,14630206 This same pathway can be induced by activation of other cytokine receptors including those for IL-6 and IL-10 indirect PMID: 15283983,14630206 This same pathway can be induced by activation of other cytokine receptors including those for IL-6 and IL-10 PMID: 15283983,10048763 Characterization of IRF-3 showed regulatory activity by binding to the ISRE of ISG15 and interaction with the CBP/p300 coactivator getElapsedTime(simulator)==0.1