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PMID: 15178705,12077222,10549626,11607032,11323673,11431423, 15034168,11130078
Since then, TLRs have been shown to recognize and mediate signals for a wide range of microbial components: TLR1 (in association with TLR2, TLR1/2) for triacyl lipopeptides; TLR2 for lipoproteins and peptidoglycans; TLR3 for double-stranded RNA; TLR5 for flagellin; TLR6 (in association with TLR2, TLR2/6) for diacyl lipopeptides; TLR7 for single-stranded RNA, and TLR9 for nonmethylated CpG DNA
PMID: 15178705,12077222,10549626,11607032,11323673,11431423, 15034168,11130078
Since then, TLRs have been shown to recognize and mediate signals for a wide range of microbial components: TLR1 (in association with TLR2, TLR1/2) for triacyl lipopeptides; TLR2 for lipoproteins and peptidoglycans; TLR3 for double-stranded RNA; TLR5 for flagellin; TLR6 (in association with TLR2, TLR2/6) for diacyl lipopeptides; TLR7 for single-stranded RNA, and TLR9 for nonmethylated CpG DNA
PMID: 15178705,12077222,10549626,11607032,11323673,11431423, 15034168,11130078
Since then, TLRs have been shown to recognize and mediate signals for a wide range of microbial components: TLR1 (in association with TLR2, TLR1/2) for triacyl lipopeptides; TLR2 for lipoproteins and peptidoglycans; TLR3 for double-stranded RNA; TLR5 for flagellin; TLR6 (in association with TLR2, TLR2/6) for diacyl lipopeptides; TLR7 for single-stranded RNA, and TLR9 for nonmethylated CpG DNA
PMID: 15178705,12077222,10549626,11607032,11323673,11431423, 15034168,11130078
Since then, TLRs have been shown to recognize and mediate signals for a wide range of microbial components: TLR1 (in association with TLR2, TLR1/2) for triacyl lipopeptides; TLR2 for lipoproteins and peptidoglycans; TLR3 for double-stranded RNA; TLR5 for flagellin; TLR6 (in association with TLR2, TLR2/6) for diacyl lipopeptides; TLR7 for single-stranded RNA, and TLR9 for nonmethylated CpG DNA
PMID: 15178705,9851930
In 1998, TLR4 was identified as the signal transducer for lipopolysaccharide (LPS), a major cell-wall component of Gram-negative bacteria
PMID: 15178705,12077222,10549626,11607032,11323673,11431423, 15034168,11130078
Since then, TLRs have been shown to recognize and mediate signals for a wide range of microbial components: TLR1 (in association with TLR2, TLR1/2) for triacyl lipopeptides; TLR2 for lipoproteins and peptidoglycans; TLR3 for double-stranded RNA; TLR5 for flagellin; TLR6 (in association with TLR2, TLR2/6) for diacyl lipopeptides; TLR7 for single-stranded RNA, and TLR9 for nonmethylated CpG DNA
PMID: 15178705,12077222,10549626,11607032,11323673,11431423, 15034168,11130078
Since then, TLRs have been shown to recognize and mediate signals for a wide range of microbial components: TLR1 (in association with TLR2, TLR1/2) for triacyl lipopeptides; TLR2 for lipoproteins and peptidoglycans; TLR3 for double-stranded RNA; TLR5 for flagellin; TLR6 (in association with TLR2, TLR2/6) for diacyl lipopeptides; TLR7 for single-stranded RNA, and TLR9 for nonmethylated CpG DNA
PMID: 15178705,11812998
TLR7 also appears to recognize several synthetic compounds that are structurally related to nucleic acids such as imidazoquinolines
PMID: 15178705,12032557
In human, but not in mouse, TLR8 also appears to recognize the imidazoquinoline, resiquimod (R-848)
PMID: 15178705,12032557
In human, but not in mouse, TLR8 also appears to recognize the imidazoquinoline, resiquimod (R-848)
PMID: 15178705,12077222,10549626,11607032,11323673,11431423, 15034168,11130078
Since then, TLRs have been shown to recognize and mediate signals for a wide range of microbial components: TLR1 (in association with TLR2, TLR1/2) for triacyl lipopeptides; TLR2 for lipoproteins and peptidoglycans; TLR3 for double-stranded RNA; TLR5 for flagellin; TLR6 (in association with TLR2, TLR2/6) for diacyl lipopeptides; TLR7 for single-stranded RNA, and TLR9 for nonmethylated CpG DNA
PMID: 15178705
Upon stimulation, TLRs recruit MyD88 through interaction of their respective TIR domains
PMID: 15178705
Upon stimulation, TLRs recruit MyD88 through interaction of their respective TIR domains
PMID: 15178705
Upon stimulation, TLRs recruit MyD88 through interaction of their respective TIR domains
PMID: 15178705
Upon stimulation, TLRs recruit MyD88 through interaction of their respective TIR domains
PMID: 15178705
Upon stimulation, TLRs recruit MyD88 through interaction of their respective TIR domains
PMID: 15178705
Upon stimulation, TLRs recruit MyD88 through interaction of their respective TIR domains
PMID: 15178705
Upon stimulation, TLRs recruit MyD88 through interaction of their respective TIR domains
PMID: 15178705
Upon stimulation, TLRs recruit MyD88 through interaction of their respective TIR domains
PMID: 15178705
Upon stimulation, TLRs recruit MyD88 through interaction of their respective TIR domains
PMID: 15178705
Upon stimulation, TLRs recruit MyD88 through interaction of their respective TIR domains
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
indirect
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
indirect
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
indirect
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
indirect
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
indirect
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
indirect
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
indirect
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
indirect
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
indirect
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
indirect
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
indirect
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
indirect
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
indirect
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
indirect
PMID: 15178705,12524386,12893815,12900270,14751757
The DD of MyD88 then binds the DD of IL-1R-associated kinase, and the signal is propagated via tumor necrosis factor (TNF) receptor-associated factor-6, leading to the activation of nuclear factor (NF)-{kappa}B and mitogen-activated protein kinases and the transcription of immunologically relevant genes
indirect
PMID: 15178705,11607032
Conversely, the TLR3 ligand, double-stranded RNA is able to induce NF-{kappa}B activation in MyD88 knockout (KO) mice, suggesting that TLR3 signaling is independent of MyD88
PMID: 15178705,12471095,12855817
In addition to the common MyD88-mediated signaling pathway, a MyD88-independent pathway has been identified that involves a third TIR-containing adaptor molecule, TIR domain-containing adaptor-inducing interferon-ß (IFN-ß; TRIF), which is essential for the TLR3 and TLR4 signaling, leading to the induction of transcription factor, IFN regulatory factor 3, and the subsequent production of IFN-ß and the activation and maturation of DCs
indirect
PMID: 15178705,12471095,12855817
In addition to the common MyD88-mediated signaling pathway, a MyD88-independent pathway has been identified that involves a third TIR-containing adaptor molecule, TIR domain-containing adaptor-inducing interferon-ß (IFN-ß; TRIF), which is essential for the TLR3 and TLR4 signaling, leading to the induction of transcription factor, IFN regulatory factor 3, and the subsequent production of IFN-ß and the activation and maturation of DCs
PMID: 15178705,12471095,12855817
In addition to the common MyD88-mediated signaling pathway, a MyD88-independent pathway has been identified that involves a third TIR-containing adaptor molecule, TIR domain-containing adaptor-inducing interferon-ß (IFN-ß; TRIF), which is essential for the TLR3 and TLR4 signaling, leading to the induction of transcription factor, IFN regulatory factor 3, and the subsequent production of IFN-ß and the activation and maturation of DCs
PMID: 15178705,12471095,12855817
In addition to the common MyD88-mediated signaling pathway, a MyD88-independent pathway has been identified that involves a third TIR-containing adaptor molecule, TIR domain-containing adaptor-inducing interferon-ß (IFN-ß; TRIF), which is essential for the TLR3 and TLR4 signaling, leading to the induction of transcription factor, IFN regulatory factor 3, and the subsequent production of IFN-ß and the activation and maturation of DCs
indirect
PMID: 15178705,12471095,12855817
In addition to the common MyD88-mediated signaling pathway, a MyD88-independent pathway has been identified that involves a third TIR-containing adaptor molecule, TIR domain-containing adaptor-inducing interferon-ß (IFN-ß; TRIF), which is essential for the TLR3 and TLR4 signaling, leading to the induction of transcription factor, IFN regulatory factor 3, and the subsequent production of IFN-ß and the activation and maturation of DCs
PMID: 15178705,14556004
Recently, a fourth TIR-containing adaptor molecule, TRIF-related adaptor molecule (TRAM), has been shown to be involved specifically in TLR4- but not TLR3-mediated, MyD88-independent IFN-ß production
indirect
PMID: 15178705,14556004
Recently, a fourth TIR-containing adaptor molecule, TRIF-related adaptor molecule (TRAM), has been shown to be involved specifically in TLR4- but not TLR3-mediated, MyD88-independent IFN-ß production
PMID: 15178705,12524386
TLR1 and TLR6 form heterodimers with TLR2
PMID: 15178705,12524386
TLR1 and TLR6 form heterodimers with TLR2