majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:15075353.csml convertedTime:2009.07.01.10:45

Entity

G010329:TNF-alpha G029941:COX2 MO000000022:p38 MO000000074:14-3-3 MO000000289:TNF-alpha MO000000310:arachidonic acid MO000008179:PKR MO000016882:LPS MO000017266:COX-2 MO000021832:prostaglandins MO000069272:TIA1 e1: e10: e11:TTP e12:TTP e13:TLRs e14:LPS:TLRs e15:PKR{active} e16:PERK e17:PERK e18:GCN2 e19:GCN2{active} e2: e20:eIF2alpha e21:eIF2alpha{p} e22:TTP e23:TTP{p} e24:alkaline phosphatase e25:MK2 e26:TTP{p}:14-3-3 e27:TNF-alpha:TNFR e28:TNFR e29:p38 inhibitor e3: e30:intiation complex e31:mRNA e32:initiation complex:TIA1:mRNA e4: e5:MMP13 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:NTPs e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p3 p4 p5 p6 p7 p8 p9
492.0, 1076.0
32.0, 32.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p8

p3 p7

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
688.0, 1156.0
40.0, 40.0

COX2

--

G029941

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p21

--

true true true true

csml-variable:Double

m108639

10

false

infinite

0

unit false false false
TRANSFACG029941

--

Go back
872.0, 488.0
40.0, 40.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
789.0, 613.0
30.0, 30.0

14-3-3

--

MO000000074

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m66

10

false

infinite

0

unit false false false
TRANSPATHMO000000074

--

Go back
1194.0, 902.0
36.0, 36.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

p20

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
405.0, 449.0
29.0, 29.0

arachidonic acid

--

MO000000310

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m349736

10

false

infinite

0

unit false false false
TRANSPATHMO000000310

--

Go back
251.0, 535.0
33.0, 33.0

PKR

--

MO000008179

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m1055

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
1190.0, 670.0
36.0, 36.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
535.0, 567.0
34.0, 34.0

COX-2

--

MO000017266

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m2122

10

false

infinite

0

unit false false false
InterProIPR002016
TRANSPATHMO000017266

--

Go back
668.0, 448.0
32.0, 32.0

prostaglandins

--

MO000021832

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

--

true true true true

csml-variable:Double

m6166

10

false

infinite

0

unit false false false
EnsemblENSG00000035862
TRANSPATHMO000021832

--

Go back
399.0, 1103.0
33.0, 33.0

TIA1

--

MO000069272

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m44116

10

false

infinite

0

unit false false false
TRANSPATHMO000069272

--

Go back
76.82921726248895, 148.36241342287627
990.4056548041356, 1197.7987975084177

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
86.37170678684701, 166.67021340868712
960.0063679435196, 1124.8265409940095

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
561.0, 1154.06
37.919999999999995, 28.43999999999999

TTP

--

e11

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p6

p3

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
449.0, 1019.5017301038062
45.93425605536332, 24.498269896193772

TTP

--

e12

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p4

p6

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1008.5, 574.0
39.0, 60.0

TLRs

--

e13

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p5

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1016.5, 706.0
31.0, 60.0

LPS:TLRs

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

p4 p6 p7 p8

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
255.0, 687.0
33.0, 33.0

PKR{active}

--

e15

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

p12

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
385.0, 535.4677268475209
21.463985032740876, 49.53227315247894

PERK

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
386.0, 696.7408793264734
20.478952291861553, 47.25912067352666

PERK

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

p10

p13

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
684.0, 545.407828536929
47.176494264439526, 29.092171463071043

GCN2

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
684.0, 689.5120748641579
47.00744616623063, 28.98792513584222

GCN2{active}

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

p11

p14

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
76.82921726248895, 148.36241342287627
990.4056548041356, 1197.7987975084177

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
347.0, 785.0005031193399
49.45864359025961, 30.499496880660093

eIF2alpha

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p12 p13 p14

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
607.0, 783.7317073170732
41.58536585365853, 33.26829268292683

eIF2alpha{p}

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

p12 p13 p14

p15

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
901.0, 1226.06
37.919999999999995, 28.43999999999999

TTP

--

e22

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p16

p17 p18

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
921.0, 1037.8292682926826
46.46341463414634, 37.170731707317074

TTP{p}

--

e23

cso30:c:Protein

cso30:i:CC_Cytosol

--

p17 p18

p16 p19

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
829.5, 1229.5139867176495
28.049708190782855, 45.486013282350584

alkaline phosphatase

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p16

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
864.0, 713.407828536929
47.176494264439526, 29.092171463071043

MK2

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p18

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
928.5, 580.816530578237
31.999833361106482, 39.183469421763036

TTP{p}:14-3-3

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1016.5, 862.0
31.0, 60.0

TNF-alpha:TNFR

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p20

p2

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
1004.5, 990.0
39.0, 60.0

TNFR

--

e28

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p20

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
282.0, 851.0
60.0, 34.0

p38 inhibitor

--

e29

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p2 p8 p21

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
96.63733035857162, 164.86101944916305
950.7894286119699, 1164.8015854558453

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
350.5, 1118.0
43.0, 60.0

intiation complex

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p22

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
437.0, 1201.5432525951555
53.35640138408304, 28.456747404844293

mRNA

--

e31

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p22

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
518.0, 1174.0
36.0, 60.0

initiation complex:TIA1:mRNA

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
133.28233958632484, 193.73357999516475
877.4994101564643, 1107.0564643638404

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
642.0, 988.0
60.0, 32.0

MMP13

--

e5

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p2

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
286.474820449144, 839.1315368726387
538.6013241569034, 406.84242790105947

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
344.6477753860161, 848.773110958035
314.93634224444645, 394.3113469595483

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
293.4956943208354, 844.5616719472935
524.5595764135209, 395.9821577517497

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
294.49867630250566, 845.3970773433941
522.5536124501801, 394.3113469595483

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
286.474820449144, 839.1315368726387
538.6013241569034, 406.84242790105947

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
286.474820449144, 839.1315368726387
538.6013241569034, 406.84242790105947

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
294.49867630250566, 845.3970773433941
522.5536124501801, 394.3113469595483

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
679.6437572638666, 1006.2126160927861
33.64885138615356, 25.371680574324557

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
591.3813428768881, 1123.1693715468891
95.28328825867004, 71.8448640646635

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
286.474820449144, 839.1315368726387
538.6013241569034, 406.84242790105947

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
645.0, 1079.6497120921304
45.18234165067179, 24.850287907869482

NTPs

--

e6

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p3

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
413.42012205186904, 1019.9289500652118
17.056712544534104, 6.8403616518535335

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
412.85055013959044, 999.52937292398
58.38112100853964, 87.52841819900742

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
437.34214236756367, 1056.4584254111392
9.113150596454958, 7.590540331621236

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
89.84170297752273, 153.18245047388007
971.2793877977546, 1146.3315643758408

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
93.3116991681984, 173.41409487609064
931.759890256536, 1126.8724796776016

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
102.5650223433335, 193.64573927830125
927.5058952551688, 1112.0938294753241

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
538.0, 450.0
27.0, 27.0

p1

p1

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

MO000000310 MO000017266

MO000021832

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c3 : 1
stoichiometry:c1 : 1

m349736*m2122*0.1

nodelay

--

true

0

false

PMID: 15075353, 12086290, 11177775 COX-2 is an enzyme that converts arachidonic acid into proinflammatory prostaglandins.

Go back
384.0, 624.0
23.0, 23.0

p10

p10

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 15075353, 10557102, 10655230, 10882126, 11106749 Stress-induced translational arrest is characterized by the activation of one or more members of a family of serine/threonine kinases [e.g., double-stranded RNA-dependent protein kinase R (PKR), PKR-like endoplasmic reticulum kinase (PERK), GCN2.

Go back
696.0, 628.0
23.0, 23.0

p11

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 15075353, 10557102, 10655230, 10882126, 11106749 Stress-induced translational arrest is characterized by the activation of one or more members of a family of serine/threonine kinases [e.g., double-stranded RNA-dependent protein kinase R (PKR), PKR-like endoplasmic reticulum kinase (PERK), GCN2.

Go back
495.0, 787.0
26.0, 26.0

p12

p12

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e20 e15

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1

m20*m15*0.1

nodelay

--

true

0

false

PMID: 15075353, 11909525 These kinases phosphorylate eukaryotic initiation factor 2{alpha} (eIF2{alpha}), a component of the ternary complex that loads tRNAiMet onto the small ribosomal subunit to initiate protein synthesis

Go back
548.0, 748.0
23.0, 23.0

p13

p13

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e20 e17

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c33 : 1
stoichiometry:c32 : 1

m20*m17*0.1

nodelay

--

true

0

false

PMID: 15075353, 11909525 These kinases phosphorylate eukaryotic initiation factor 2{alpha} (eIF2{alpha}), a component of the ternary complex that loads tRNAiMet onto the small ribosomal subunit to initiate protein synthesis

Go back
436.0, 828.0
23.0, 23.0

p14

p14

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e20 e19

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c36 : 1
stoichiometry:c35 : 1

m20*m19*0.1

nodelay

--

true

0

false

PMID: 15075353, 11909525 These kinases phosphorylate eukaryotic initiation factor 2{alpha} (eIF2{alpha}), a component of the ternary complex that loads tRNAiMet onto the small ribosomal subunit to initiate protein synthesis

Go back
758.0, 786.0
27.0, 27.0

p15

p15

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e21

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 15075353, 11438658 Phosphorylation of eIF2{alpha} inhibits protein translation by reducing the availability of an active ternary complex.

Go back
908.0, 1152.0
23.0, 23.0

p16

p16

cso30:i:ME_Dephosphorylation

cso30:i:CC_Cytosol

--

e23 e24

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c40 : 1
stoichiometry:c39 : 1

m23*m24*0.1

nodelay

--

true

0

false

PMID: 15075353, 11546803 In extracts of 293 cells, calf intestinal alkaline phosphatase-induced dephosphorylation of recombinant TTP increases its affinity for AREs.

Go back
967.0, 1163.0
25.0, 25.0

p17

p17

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e22 MO000000022

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c43 : 1
stoichiometry:c42 : 1

m22*m25*0.1

nodelay

--

true

0

false

PMID: 15075353, 11546803, 11533235 One of the candidate substrates for p38MAPK is TTP.

Go back
871.0, 1115.0
25.0, 25.0

p18

p18

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e22 e25

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c46 : 1
stoichiometry:c45 : 1

m22*m26*0.1

nodelay

--

true

0

false

PMID: 15075353 We found that MK2-induced phosphorylation of TTP results in the assembly of 14-3-3:TTP complexes, which are actively excluded from SGs.

Go back
930.0, 842.0
27.0, 27.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000074 e23

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m66*m23*0.1

nodelay

--

true

0

false

PMID: 15075353 We identified serine residues 52 and 178 as sites that are phosphorylated following p38MAPK/MK2 activation to create 14-3-3-binding sites.

Go back
660.0, 912.0
23.0, 23.0

p2

p2

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e27 e29

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c55 : 1
stoichiometry:c4 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 15075353, 12010565, 11817610, 11040455, 10517187 MMP-13 is a TNF-{alpha}-induced collagenase that has been implicated in proinflammatory, angiogenic, and destructive processes within the joint of patients with rheumatoid arthritis. PMID: 15075353, 12767518, 12060661, 14516792, 12937622, 12852754, 12874238 pharmacological inhibitors of p38MAPK prevent the expression of TNF-{alpha}, COX-2, MMP-13, and other proinflammatory proteins.

Go back
1137.0, 981.0
21.0, 21.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e28 MO000000289

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m29*m230*0.1

nodelay

--

true

0

false

PMID: 15075353, 12010565, 11817610, 11040455, 10517187 MMP-13 is a TNF-{alpha}-induced collagenase that has been implicated in proinflammatory, angiogenic, and destructive processes within the joint of patients with rheumatoid arthritis.

Go back
763.0, 1091.0
25.0, 25.0

p21

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

G029941

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c53 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 15075353, 12767518, 12060661, 14516792, 12937622, 12852754, 12874238 pharmacological inhibitors of p38MAPK prevent the expression of TNF-{alpha}, COX-2, MMP-13, and other proinflammatory proteins.

Go back
455.0, 1131.0
25.0, 25.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e30 MO000069272 e31

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m31*m44116*m32*0.1

nodelay

--

true

0

false

PMID: 15075353 TIA-1 interacts with specific components of the initiation complex that are assembled at the 5'-end of the transcript.

Go back
572.0, 1079.5
24.5, 24.5

p3

p3

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

G010329 e11

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c8 : 1
stoichiometry:c7 : 1

m93309*m11*0.1

nodelay

--

true

0

false

PMID: 15075353, 10330172, 10751406, 11279239, 9703499 TTP is a zinc-finger protein that promotes the degradation of TNF-{alpha} transcripts.

Go back
459.0, 927.0
25.0, 25.0

p4

p4

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c9 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 15075353, 9703499 In macrophages, its induction by lipopolysaccharide (LPS) appears to prevent the pathological overexpression of this proinflammatory cytokine.

Go back
1126.0, 678.0
19.0, 19.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e13 MO000016882

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m13*m155666*0.1

nodelay

--

true

0

false

PMID: 15075353, 9703499 In macrophages, its induction by lipopolysaccharide (LPS) appears to prevent the pathological overexpression of this proinflammatory cytokine.

Go back
248.0, 1024.0
24.0, 24.0

p6

p6

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e12 e14

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c16 : 1
stoichiometry:c15 : 1

m12*m14*0.1

nodelay

--

true

0

false

PMID: 15075353, 9703499 In macrophages, its induction by lipopolysaccharide (LPS) appears to prevent the pathological overexpression of this proinflammatory cytokine.

Go back
897.0, 1009.0
21.0, 21.0

p7

p7

cso30:i:ME_Translation

cso30:i:CC_Extracellular

--

G010329 e14

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c17 : 1

m93309*m14*0.1

nodelay

--

true

0

false

PMID: 15075353, 10921895, 11762949 LPS-activated macrophages derived from wild-type and TIA-1?/? mice express similar amounts of TNF-{alpha} transcripts, macrophages lacking TIA-1 produce significantly more TNF-{alpha} protein than wild-type controls.

Go back
551.0, 1019.0
25.0, 25.0

p8

p8

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14 e29

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c56 : 1
stoichiometry:c20 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 15075353, 10921895, 11762949 LPS-activated macrophages derived from wild-type and TIA-1?/? mice express similar amounts of TNF-{alpha} transcripts, macrophages lacking TIA-1 produce significantly more TNF-{alpha} protein than wild-type controls. PMID: 15075353, 12767518, 12060661, 14516792, 12937622, 12852754, 12874238 pharmacological inhibitors of p38MAPK prevent the expression of TNF-{alpha}, COX-2, MMP-13, and other proinflammatory proteins.

Go back
259.0, 611.5
24.5, 24.5

p9

p9

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000008179

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m1055*0.1

nodelay

--

true

0

false

PMID: 15075353, 10557102, 10655230, 10882126, 11106749 Stress-induced translational arrest is characterized by the activation of one or more members of a family of serine/threonine kinases [e.g., double-stranded RNA-dependent protein kinase R (PKR), PKR-like endoplasmic reticulum kinase (PERK), GCN2.

Go back
565.0, 464.0

c1

c1

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1048.0, 619.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1153.0, 688.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1055.2636750760037, 693.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
491.5175234454968, 742.0

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
279.99795794642665, 1032.0

c14

c14

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
272.0, 1041.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
279.45847718143517, 742.0

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
918.0, 928.5050335913174

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
524.0, 1023.4143612604037

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
916.1986338408371, 766.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
434.0, 464.0

c2

c2

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
528.4715290310506, 1044.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
582.7675553177322, 746.0

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
269.0, 568.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
271.0, 636.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
396.0, 585.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
396.0, 647.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
708.0, 575.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
708.0, 651.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
396.0, 800.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
521.0, 800.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
552.0, 485.0

c3

c3

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
288.0, 711.0

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
396.0, 764.6480838483988

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
571.0, 766.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
406.0, 723.0

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
396.0, 813.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
459.0, 806.7410294091843

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
466.09773440987675, 717.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
649.0, 800.0

c37

c37

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
924.7246999450019, 1075.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
920.0, 1175.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
672.0, 935.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
858.0, 1181.0389749949209

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
933.0, 1193.8076214712466

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
952.2667691281392, 1082.6721416644712

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
895.0, 528.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
890.4766883796864, 1147.6069714518937

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
895.0, 1081.1709862283205

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
884.0860165328912, 743.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
813.0, 643.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
944.0, 877.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
944.0, 628.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
690.9679231718661, 893.0

c5

c5

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1044.0, 996.7620869714772

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1163.2975823717736, 938.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1054.049996270548, 910.234266436317

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
732.5099956953176, 1116.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
342.0, 883.0

c54

c54

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
342.0, 873.0

c55

c55

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
338.0, 885.0

c56

c56

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
394.0, 1145.2621542145662

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
432.0, 1127.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
465.0, 1163.9924492668404

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
524.0, 1092.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
480.0, 1155.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
597.0, 1092.0

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
581.0, 1111.9936076697743

c8

c8

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
472.0, 952.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back