Entity
NF-kappaB
--
MO000000058
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m15
10
infinite
0
TRANSPATH | MO000000058 |
--
TLR4
--
MO000019394
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m3961
10
infinite
0
InterPro | IPR000157 |
TRANSPATH | MO000019394 |
--
TLR2
--
MO000019397
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m3964
10
infinite
0
InterPro | IPR000157 |
TRANSPATH | MO000019397 |
--
dsRNA:TLR3
--
MO000041446
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m19314
10
infinite
0
TRANSPATH | MO000041446 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
LPS:MD-2:TLR4: MyD88: MAL: TIRAP
--
e11
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m11
0
infinite
0
--
MAL
--
e12
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m12
0
infinite
0
--
LPS:MD-2:TLR4: MyD88: MAL: TIRAP: IRAK
--
e13
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m13
0
infinite
0
--
IkappaB {actiavted}
--
e14
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m14
10
infinite
0
TRANSPATH | MO000000215 |
--
NF-kappaB {activated}
--
e15
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m16
10
infinite
0
TRANSPATH | MO000000058 |
--
NF-kappaB {nucleus}
--
e16
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m17
10
infinite
0
TRANSPATH | MO000000058 |
--
csml-variable:Double
m18
10
infinite
0
Affymetrix | 1520_s_at |
Ensembl | ENSG00000125538 |
HGNC | IL1B |
OMIM | 137215 |
Proteome | HumanPSD/IL1B |
RefSeq | NM_000576 |
TRANSFAC | G000311 |
Unigene | Hs.126256 |
--
IL-8
--
e18
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m19
0
infinite
0
--
TLR1: TLR2
--
e19
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m20
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
TLR6:TLR2
--
e20
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m21
0
infinite
0
--
PGN: TLR2
--
e21
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m22
0
infinite
0
--
lipopeptide: TLR6:TLR2
--
e22
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m23
0
infinite
0
--
lipopeptides: TLR1: TLR2
--
e23
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m24
0
infinite
0
--
csml-variable:Double
m25
0
infinite
0
--
LPS: TLR2
--
e25
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m26
0
infinite
0
--
flagellin: TLR5
--
e26
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m27
0
infinite
0
--
type I IFN
--
e29
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m30
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
RSV F: CD14
--
e30
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m31
0
infinite
0
--
RSV F
--
e31
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m32
0
infinite
0
--
RSV F: CD14: TLR4
--
e32
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m33
0
infinite
0
--
csml-variable:Double
m34
0
infinite
0
--
CpG DNA: TLR9
--
e34
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m35
0
infinite
0
--
Ligand: TLR
--
e35
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m36
0
infinite
0
--
pneumolysin
--
e36
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m37
0
infinite
0
--
pneumolysin: TLR4
--
e37
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m38
0
infinite
0
--
csml-variable:Double
m39
0
infinite
0
--
TGF-beta
--
e39
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m40
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
TGF-beta
--
e41
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m42
0
infinite
0
--
IFN-beta
--
e42
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m43
0
infinite
0
--
LPS:MD-2
--
e5
cso30:c:Complex
cso30:i:CC_Extracellular
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
LPS:MD-2:TLR4
--
e6
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
p1
p1
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m155666*m6438*0.1
nodelay
--
0
PMID: 15069387, 11593030, 11500507 MD-2 is a secreted protein that may function by binding to LPS and to the extracellular domain of TLR4, where it facilitates LPS responsiveness.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
m17*0.1
nodelay
--
0
PMID: 15069387, 9237759 Interaction of LPS with its receptor TLR4 triggers a complex signaling pathway that leads to the activation of transcription actors, such as nuclear factor- jB (NF-jB), which then induce the activation of the inflammatory genes, such as tumor necrosis factor (TNF)-a, interleukin (IL)-1, IL-6, and IL-8.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
m17*0.1
nodelay
--
0
PMID: 15069387, 9237759 Interaction of LPS with its receptor TLR4 triggers a complex signaling pathway that leads to the activation of transcription actors, such as nuclear factor- jB (NF-jB), which then induce the activation of the inflammatory genes, such as tumor necrosis factor (TNF)-a, interleukin (IL)-1, IL-6, and IL-8.
p12
p12
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1
m3964*m3963*0.1
nodelay
--
0
PMID: 15069387 Toll-like receptor 2, in combination with TLR6 or TLR1, mediates responses to multiple other microbial pathogens.
p13
p13
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1
m3987*m3964*0.1
nodelay
--
0
PMID: 15069387 Toll-like receptor 2, in combination with TLR6 or TLR1, mediates responses to multiple other microbial pathogens.
p14
p14
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1
m3964*m155701*0.1
nodelay
--
0
PMID: 15069387, 10384090 Pathogen-associated molecular patterns of gram-positive organisms, such as peptidoglycan and lipopeptides, are recognized by TLR2.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1
m25*m20*0.1
nodelay
--
0
PMID: 15069387, 10384090 Pathogen-associated molecular patterns of gram-positive organisms, such as peptidoglycan and lipopeptides, are recognized by TLR2.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c45 : 1
m25*m21*0.1
nodelay
--
0
PMID: 15069387, 10384090 Pathogen-associated molecular patterns of gram-positive organisms, such as peptidoglycan and lipopeptides, are recognized by TLR2.
p17
p17
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1
m155666*m3964*0.1
nodelay
--
0
PMID: 15069387, 10816537 LPS from Leptospira interogans30 and Porphyromonas gingivalis (periodontal disease) activates macrophages through TLR2.
p18
p18
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1
m6485*m3966*0.1
nodelay
--
0
PMID: 15069387, 11323673 Toll-like receptor 5 has been found to be the receptor for monomeric flagellin.
p19
p19
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1
m1055*m119368*0.1
nodelay
--
0
PMID: 15069387, 7568028 dsRNA is known to bind only intracellular targets, including the dsRNA-dependent protein kinase (PKR).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m5*m3961*0.1
nodelay
--
0
PMID: 15069387, 11593030, 11500507 MD-2 is a secreted protein that may function by binding to LPS and to the extracellular domain of TLR4, where it facilitates LPS responsiveness.
p20
p20
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1
m119368*m3965*0.1
nodelay
--
0
PMID: 15069387, 11607032, 12646618 Studies have shown that mammalian TLR3 recognizes dsRNA, and that activation of the receptor induces NF-kappaB and the production of type I IFNs.
p21
p21
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c60 : 1
stoichiometry:c59 : 1
m15*m19314*0.1
nodelay
--
0
PMID: 15069387, 11607032, 12646618 Studies have shown that mammalian TLR3 recognizes dsRNA, and that activation of the receptor induces NF-kappaB and the production of type I IFNs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
m19314*0.1
nodelay
--
0
PMID: 15069387, 11607032, 12646618 Studies have shown that mammalian TLR3 recognizes dsRNA, and that activation of the receptor induces NF-kappaB and the production of type I IFNs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
m29*0.1
nodelay
--
0
PMID: 15069387, 11607032, 12646618 Studies have shown that mammalian TLR3 recognizes dsRNA, and that activation of the receptor induces NF-kappaB and the production of type I IFNs.
p24
p24
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1
m2828*m32*0.1
nodelay
--
0
PMID: 15069387, 11062499 The innate immune response to fusion protein F of respiratory syncytial virus (RSV) is mediated by TLR4 and CD14.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1
m3961*m31*0.1
nodelay
--
0
PMID: 15069387, 11062499 The innate immune response to fusion protein F of respiratory syncytial virus (RSV) is mediated by TLR4 and CD14.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c75 : 1
stoichiometry:c73 : 1
m34*m19828*0.1
nodelay
--
0
PMID: 15069387, 11470918 Toll-like receptor 9 has been shown to be the receptor for CpG DNA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c76 : 1
m36*0.1
nodelay
--
0
PMID: 15069387, 9237759 Pathogen-associated molecular pattern recognition by TLRs in macrophages and antigen-presenting cells also leads to the expression of costimulatory molecules such as CD80 (B7.1) and CD86 (B7.2), which bind to CD28 on T lymphocytes to assist in antigen presentation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c77 : 1
m36*0.1
nodelay
--
0
PMID: 15069387, 9237759 Pathogen-associated molecular pattern recognition by TLRs in macrophages and antigen-presenting cells also leads to the expression of costimulatory molecules such as CD80 (B7.1) and CD86 (B7.2), which bind to CD28 on T lymphocytes to assist in antigen presentation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c80 : 1
m95018*0.1
nodelay
--
0
PMID: 15069387, 9237759 Pathogen-associated molecular pattern recognition by TLRs in macrophages and antigen-presenting cells also leads to the expression of costimulatory molecules such as CD80 (B7.1) and CD86 (B7.2), which bind to CD28 on T lymphocytes to assist in antigen presentation.
p3
p3
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
stoichiometry:c11 : 1
stoichiometry:c10 : 1
m6*m1572*m12*m6810*0.1
nodelay
--
0
PMID: 15069387 The adapter proteins MyD88 and TIRAP/MAL associate via TIRmediated interactions with the TLR, and initiate the formation of a signaling complex involving interleukinreceptor?associated kinases (IRAKs).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c81 : 1
m93745*0.1
nodelay
--
0
PMID: 15069387, 9237759 Pathogen-associated molecular pattern recognition by TLRs in macrophages and antigen-presenting cells also leads to the expression of costimulatory molecules such as CD80 (B7.1) and CD86 (B7.2), which bind to CD28 on T lymphocytes to assist in antigen presentation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c82 : 1
m35*0.1
nodelay
--
0
PMID: 15069387 LPS- or CpGactivated dendritic cells produce IL-6.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1
m3961*m37*0.1
nodelay
--
0
PMID: 15069387, 12569171 a recent study found that pneumolysin, a pneumococcal virulence factor, is recognized by TLR4 and that this recognition confers resistance to pneumococcal infection.
p33
p33
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1
m2126*m387*m2125*0.1
nodelay
--
0
PMID: 15069387, 9237759 Pathogen-associated molecular pattern recognition by TLRs in macrophages and antigen-presenting cells also leads to the expression of costimulatory molecules such as CD80 (B7.1) and CD86 (B7.2), which bind to CD28 on T lymphocytes to assist in antigen presentation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
m36*0.1
nodelay
--
0
PMID: 15069387 Dendritic cell production of IL-12 shifts Th0 development towards Th1 differentiation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
m36*0.1
nodelay
--
0
PMID: 15069387 Dendritic cell production of IL-12 shifts Th0 development towards Th1 differentiation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c98 : 1
m41*0.1
nodelay
--
0
PMID: 15069387 Dendritic cell production of IL-12 shifts Th0 development towards Th1 differentiation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
m40*0.1
nodelay
--
0
PMID: 15069387 Dendritic cell production of IL-12 shifts Th0 development towards Th1 differentiation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c99 : 1
m26*0.1
nodelay
--
0
PMID: 15069387, 12646604 In vitro studies demonstrate that this polymorphism in TLR2 results in diminished TNF-a production in response toMtuberculosis andMleprae infection, providing a mechanistic explanation for the clinical findings.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
m93309*0.1
nodelay
--
0
12646604 In vitro studies demonstrate that this polymorphism in TLR2 results in diminished TNF-a production in response toMtuberculosis andMleprae infection, providing a mechanistic explanation for the clinical findings.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1
m11*m184*0.1
nodelay
--
0
PMID: 15069387 The adapter proteins MyD88 and TIRAP/MAL associate via TIRmediated interactions with the TLR, and initiate the formation of a signaling complex involving interleukinreceptor?associated kinases (IRAKs).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
m36*0.1
nodelay
--
0
PMID: 15069387 an alternative TLR-signaling pathway that leads to the production of the antiviral cytokine IFN-b has been reported in mice.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c105 : 1
m93217*0.1
nodelay
--
0
PMID: 15069387 an alternative TLR-signaling pathway that leads to the production of the antiviral cytokine IFN-b has been reported in mice.
p5
p5
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c17 : 1
m13*m186*0.1
nodelay
--
0
PMID: 15069387 TLR4 triggers a complex signaling pathway that leads to the activation of transcription factors, such as nuclear factor- jB (NF-kappaB).
p6
p6
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c20 : 1
stoichiometry:c19 : 1
m15*m14*0.1
nodelay
--
0
PMID: 15069387 TLR4 triggers a complex signaling pathway that leads to the activation of transcription factors, such as nuclear factor- jB (NF-kappaB).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
m16*0.1
nodelay
--
0
PMID: 15069387 Toll-like receptors share a common activation pathway mediated through their TIR signaling domains, resulting in the nuclear translocation and activation of the pro-inflammatory transcription factor NF-kappaB.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c23 : 1
m17*0.1
nodelay
--
0
PMID: 15069387, 9237759 Interaction of LPS with its receptor TLR4 triggers a complex signaling pathway that leads to the activation of transcription actors, such as nuclear factor- jB (NF-jB), which then induce the activation of the inflammatory genes, such as tumor necrosis factor (TNF)-a, interleukin (IL)-1, IL-6, and IL-8.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c24 : 1
m17*0.1
nodelay
--
0
PMID: 15069387, 9237759 Interaction of LPS with its receptor TLR4 triggers a complex signaling pathway that leads to the activation of transcription actors, such as nuclear factor- jB (NF-jB), which then induce the activation of the inflammatory genes, such as tumor necrosis factor (TNF)-a, interleukin (IL)-1, IL-6, and IL-8.
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--