majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:15031527.csml convertedTime:2009.07.01.10:44

Entity

G010227:IFNA1 G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010657:IL-12 p40 G010963:TLR3 MO000000058:NF-kappaB MO000000077:MAPKs MO000000099:GM-CSF MO000000212:TRAF6 MO000000213:IRAK MO000000289:TNF-alpha MO000007384:IL-6 MO000007694:IRF-3 MO000007702:IRF-7 MO000008179:PKR MO000016573:MyD88 MO000016608:IKK-i MO000016658:IFN Type I MO000016659:IFNalpha1 MO000016660:IFNbeta MO000016882:LPS MO000017053:IL-4 MO000017265:IL-12 MO000017269:CD80 MO000017270:CD86 MO000017793:Lp MO000019331:TBK1 MO000019387:cytokines MO000019394:TLR4 MO000019395:TLRs MO000019398:TLR3 MO000019399:TLR5 MO000022185:flagellin MO000022224:dsRNA MO000022225:dsRNA:PKR MO000038482:IFNalpha, IFNbeta MO000041125:TRIF MO000041132:TRAM MO000041437:dsRNA:TLR3:TRIF MO000041441:dsRNA:TLR3:TRIF:TBK1:IKK-i MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000041457:IRF-7{p} MO000042012:TLR9 MO000042126:TLR7 MO000066711:CD83 MO000068831:MAL e1: e10: e11: e12:LPS: TLR4 e13:flagellin: TLR5 e14:LPS: TLR4: TRAM e15:LPS: TLR4: MAL e16:LPS: TLR4: TRAM: TRIF e17:LPS: TLR4: MAL: MyD88 e18:IRAK {activated} e19:TRAF6 {activated} e2: e20:TLR2: TLR1 e21:TLR2: TLR6 e22:Lp: TLR2: TLR1 e23:Lp: TLR2: TLR6 e24:CpG DNA e25:CpG DNA: TLR9 e26:Peptidoglycan: TLR2: TLR1 e27:Peptidoglycan: TLR2: TLR6 e28:Peptidoglycan e29:Poly I: C e3: e30:Poly I: C: TLR3 e31:Type I IFN e32:IFN alpha/beta receptor e33:IFNalpha/beta e34:IFN alpha/beta: IFN alpha/beta receptor e35:IFNalpha,IFNbeta e36:IL-12p70 e37:IL-12p70 e38:cytokines e39:chloroquine e4: e40:Peptidoglycan: TLR2: TLR1: MAL e41:Peptidoglycan: TLR2: TLR1: MAL: MyD88 e42:CpG DNA: TLR9: MyD88 e43:flagellin: TLR5: MyD88 e44:TLR ligand e45:TLR ligand: TLR e46:TLR ligand: TLR: MyD88 e47:MAPKs {activated} e48:NF-kappaB {activated} e49:imidazoquinoline e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:imidazoquinoline: TLR7 e64:imidazoquinoline: TLR7: MyD88 e65:Poly I: C: TLR3: TRIF e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p8 p9
534.0, 1226.0
28.0, 28.0

IFNA1

--

G010227

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p29 p60 p61

true true true true

csml-variable:Double

m93216

10

false

infinite

0

unit false false false
TRANSFACG010227

--

Go back
782.0, 1035.0
28.0, 28.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p25 p62 p68

p26

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
518.0, 1122.0
27.0, 27.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p54

p51

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
501.0, 1073.0
30.0, 30.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p53

p50

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
537.0, 1173.0
30.0, 30.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p55

p52

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
708.0, 1248.0
32.0, 32.0

TLR3

--

G010963

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p21 p22 p31 p32

--

true true true true

csml-variable:Double

m93849

10

false

infinite

0

unit false false false
TRANSFACG010963

--

Go back
701.0, 641.0
30.0, 30.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
709.0, 553.0
30.0, 30.0

MAPKs

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
1182.0, 1291.0
28.0, 28.0

GM-CSF

--

MO000000099

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22 p23

true true true true

csml-variable:Double

m88

10

false

infinite

0

unit false false false
InterProIPR000773
TRANSPATHMO000000099

--

Go back
843.0, 499.0
26.0, 26.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p64 p10

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
774.0, 362.0
28.0, 28.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
357.0, 1073.0
30.0, 30.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p50

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
355.0, 1123.0
26.0, 26.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p51

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
941.0, 633.0
30.0, 30.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
978.0, 698.0
28.0, 28.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
1036.0, 741.0
32.0, 32.0

PKR

--

MO000008179

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m1055

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
733.0, 274.0
30.0, 30.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p41 p42 p43 p45 p59

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
992.0, 588.0
32.0, 32.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
1045.0, 1110.0
30.0, 30.0

IFN Type I

--

MO000016658

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28

--

true true true true

csml-variable:Double

m1634

10

false

infinite

0

unit false false false
TRANSPATHMO000016658

--

Go back
206.0, 1274.0
27.0, 27.0

IFNalpha1

--

MO000016659

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29 p60 p61

--

true true true true

csml-variable:Double

m1635

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016659

--

Go back
1179.0, 1023.0
26.0, 26.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26

--

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
963.0, 68.0
26.0, 26.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p32 p63

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1181.0, 1321.0
28.0, 28.0

IL-4

--

MO000017053

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p24

true true true true

csml-variable:Double

m1947

10

false

infinite

0

unit false false false
InterProIPR001325
TRANSPATHMO000017053

--

Go back
354.0, 1174.0
28.0, 28.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p52

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
890.0, 813.0
26.0, 26.0

CD80

--

MO000017269

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36

--

true true true true

csml-variable:Double

m2125

10

false

infinite

0

unit false false false
InterProIPR003599
TRANSPATHMO000017269

--

Go back
893.0, 888.0
28.0, 28.0

CD86

--

MO000017270

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

--

true true true true

csml-variable:Double

m2126

10

false

infinite

0

unit false false false
InterProIPR003596
TRANSPATHMO000017270

--

Go back
163.0, 348.0
30.0, 30.0

Lp

--

MO000017793

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p13

true true true true

csml-variable:Double

m2549

10

false

infinite

0

unit false false false
TRANSPATHMO000017793

--

Go back
985.0, 545.0
30.0, 30.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
1184.0, 969.0
31.5, 31.5

cytokines

--

MO000019387

cso30:c:Protein

cso30:i:CC_CellComponent

--

p39

--

true true true true

csml-variable:Double

m3957

10

false

infinite

0

unit false false false
TRANSPATHMO000019387

--

Go back
963.0, 199.0
26.5, 26.5

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
678.0, 206.0
28.0, 28.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
1111.0, 351.0
26.0, 26.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p20

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
279.0, 896.0
26.0, 26.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
189.0, 894.0
30.0, 30.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
1172.0, 469.0
32.0, 32.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p14

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1035.0, 784.0
34.0, 34.0

dsRNA:PKR

--

MO000022225

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14

p56

true true true true

csml-variable:Double

m6524

10

false

infinite

0

unit false false false
TRANSPATHMO000022225

--

Go back
1046.0, 1187.0
27.0, 27.0

IFNalpha, IFNbeta

--

MO000038482

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34

--

true true true true

csml-variable:Double

m16692

10

false

infinite

0

unit false false false
TRANSPATHMO000038482

--

Go back
957.0, 461.0
30.0, 30.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p8 p70

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
957.0, 313.0
29.0, 29.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p8

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
1100.0, 457.0
34.0, 34.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3

p6 p65 p66 p10

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
1104.0, 524.0
32.0, 32.0

dsRNA:TLR3:TRIF:TBK1:IKK-i

--

MO000041441

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p15 p16

true true true true

csml-variable:Double

m19309

10

false

infinite

0

unit false false false
TRANSPATHMO000041441

--

Go back
1110.0, 398.0
27.0, 27.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p3

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
935.0, 667.0
34.0, 34.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15

p62 p71

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
978.0, 742.0
28.0, 28.0

IRF-7{p}

--

MO000041457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16

p47

true true true true

csml-variable:Double

m19325

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
367.0, 767.0
26.0, 26.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
364.0, 572.0
23.0, 23.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
891.0, 850.0
24.0, 24.0

CD83

--

MO000066711

cso30:c:Protein

cso30:i:CC_CellComponent

--

p37

--

true true true true

csml-variable:Double

m41568

10

false

infinite

0

unit false false false
TRANSPATHMO000066711

--

Go back
884.0, 257.0
32.0, 32.0

MAL

--

MO000068831

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p40

true true true true

csml-variable:Double

m43675

10

false

infinite

0

unit false false false
TRANSPATHMO000068831

--

Go back
243.59813465686852, 169.13710181340392
907.7154769467401, 1301.3020622355357

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
252.34391007509853, 189.02690127395482
879.854263677535, 1222.024183441779

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
371.0, 482.0
209.5012989968329, 349.7606432404753

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
909.5, 187.0
29.591068155307447, 36.233961006498916

LPS: TLR4

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p1

p5 p7 p67

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
278.625, 948.5
27.457882019663387, 33.62189635060823

flagellin: TLR5

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p43

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1019.875, 182.5
32.25, 45.0

LPS: TLR4: TRAM

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p8

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
851.875, 194.5
32.25, 45.0

LPS: TLR4: MAL

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p5

p9

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1079.875, 169.5
32.25, 45.0

LPS: TLR4: TRAM: TRIF

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

p68

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
743.875, 178.5
32.25, 45.0

LPS: TLR4: MAL: MyD88

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

p69

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
778.0, 430.0
28.0, 28.0

IRAK {activated}

--

e18

cso30:c:Protein

cso30:i:CC_CellComponent

--

p46

p11

true true true true

csml-variable:Double

m18

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
820.0, 552.0
24.0, 24.0

TRAF6 {activated}

--

e19

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11 p64 p10

p48 p49

true true true true

csml-variable:Double

m19

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
243.59813465686852, 169.13710181340392
907.7154769467401, 1301.3020622355357

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
277.625, 311.5
28.249916680553238, 34.59173471088152

TLR2: TLR1

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p12 p18

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
279.625, 365.5
32.08761039826695, 39.29095150808198

TLR2: TLR6

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p13 p19

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
274.875, 257.5
34.21494769682511, 47.741787483942005

Lp: TLR2: TLR1

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
280.875, 415.5
31.08997063681409, 43.3813543769499

Lp: TLR2: TLR6

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p13

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
117.5, 809.125
45.0, 15.75

CpG DNA

--

e24

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p17

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
405.625, 815.5
28.478545242459585, 34.871688051991335

CpG DNA: TLR9

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p42

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
275.875, 202.5
32.25, 45.0

Peptidoglycan: TLR2: TLR1

--

e26

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p18

p40

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
275.875, 466.5
32.25, 45.0

Peptidoglycan: TLR2: TLR6

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
112.5, 355.375
35.36906854130052, 22.989894551845342

Peptidoglycan

--

e28

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p18 p19

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
1317.5, 898.25
36.597981497056345, 20.738856181665263

Poly I: C

--

e29

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p20

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
261.7524441958033, 187.06137264309456
871.4068578688705, 1265.4535205761554

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
1102.625, 892.5
27.359898350274957, 33.501916347275454

Poly I: C: TLR3

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p20

p25 p27 p29 p33 p34 p35 p36 p37 p38 p39 p70

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
823.5, 1113.0
41.52249134948097, 22.14532871972318

Type I IFN

--

e31

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p27 p56

p28

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
1103.375, 1170.5
24.26933216168717, 37.33743409490334

IFN alpha/beta receptor

--

e32

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p30

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
1244.0, 1179.5
31.96216542563896, 19.710002012477364

IFNalpha/beta

--

e33

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p30

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1104.375, 1250.5
23.25, 45.0

IFN alpha/beta: IFN alpha/beta receptor

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p30

p31

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
837.5, 1187.0
37.88927335640139, 20.207612456747405

IFNalpha,IFNbeta

--

e35

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p47 p71

p34

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
842.5, 1220.0
34.72318339100346, 18.519031141868513

IL-12p70

--

e36

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p35

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1031.5, 1223.125
32.84061179311733, 20.251710605755683

IL-12p70

--

e37

cso30:c:Protein

cso30:i:CC_Cytosol

--

p35

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
797.5, 982.0
37.88927335640139, 20.207612456747405

cytokines

--

e38

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p66 p69

p39

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
922.5, 935.25
35.48780487804878, 20.109756097560975

chloroquine

--

e39

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p39

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
295.3379168428328, 218.4288465950529
804.2359125748118, 1202.7185726722375

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
327.875, 190.5
32.25, 45.0

Peptidoglycan: TLR2: TLR1: MAL

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p40

p41

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
375.875, 178.5
32.25, 45.0

Peptidoglycan: TLR2: TLR1: MAL: MyD88

--

e41

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p41

p57

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
459.875, 801.5
32.25, 45.0

CpG DNA: TLR9: MyD88

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

p60

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
275.875, 989.5
32.25, 45.0

flagellin: TLR5: MyD88

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

p43

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
620.5, 25.375
31.994727592267132, 20.796572934973636

TLR ligand

--

e44

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p44

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
620.625, 197.5
31.009790034994168, 37.97117147142143

TLR ligand: TLR

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44

p45

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
555.875, 181.5
32.25, 45.0

TLR ligand: TLR: MyD88

--

e46

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p45

p46

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
713.0, 597.0
30.0, 30.0

MAPKs {activated}

--

e47

cso30:c:Protein

cso30:i:CC_CellComponent

--

p48

--

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
657.0, 669.0
30.0, 30.0

NF-kappaB {activated}

--

e48

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49

p53 p54 p55

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
195.5, 548.25
40.13036164844407, 22.74053826745164

imidazoquinoline

--

e49

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p58

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
371.0, 482.0
209.5012989968329, 349.7606432404753

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
435.74017036040595, 919.5964333335561
493.6328417247521, 441.99818160932847

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
489.0561942338427, 930.0711476734116
288.6419223492964, 428.3842745782403

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
442.17486289685525, 925.4957930470276
480.76345665185386, 430.19946218238533

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
443.0941046877765, 926.4033868491001
478.92497307001094, 428.3842745782403

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
435.74017036040595, 919.5964333335561
493.6328417247521, 441.99818160932847

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
435.74017036040595, 919.5964333335561
493.6328417247521, 441.99818160932847

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
443.0941046877765, 926.4033868491001
478.92497307001094, 428.3842745782403

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
796.0829524015655, 1101.1151937480647
30.839467683302654, 27.564078643615268

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
715.189674800489, 1228.1783260382206
87.32797013752595, 78.05306697823876

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
435.74017036040595, 919.5964333335561
493.6328417247521, 441.99818160932847

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
371.0, 482.0
209.5012989968329, 349.7606432404753

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
552.0866536741079, 1116.0167729797006
15.632626780152115, 7.431445700655182

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
551.564636016493, 1093.8544433314844
53.506809905514906, 95.09185628129863

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
574.0113952939289, 1155.7028051404595
8.352282521836463, 8.246448241196624

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
366.625, 524.5
25.898308615230793, 31.712214630894845

imidazoquinoline: TLR7

--

e63

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p58

p59

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
423.875, 469.5
32.25, 45.0

imidazoquinoline: TLR7: MyD88

--

e64

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p59

p61

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1099.875, 289.5
32.25, 45.0

Poly I: C: TLR3: TRIF

--

e65

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p70

p64

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
255.52419204536398, 174.37364418393415
890.1860853346323, 1245.3874822974904

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
258.7044740156294, 196.35352981896511
853.9661189144922, 1224.2469141989848

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
267.1852259363373, 218.3334154539961
850.0672951518607, 1208.191222687785

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
964.0, 121.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019394

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 15031527 TLR1, 2, 4, 5, and 6 are engaged in the recognition of bacterial PAMPs such as LPS, peptidoglycan, lipoprotein, and ?agellin.

Go back
919.0, 551.0
25.0, 25.0

p10

p10

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000212 MO000041437

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c178 : 1
stoichiometry:c29 : 1

m183*m19305*0.1

nodelay

--

true

0

false

PMID: 15031527 Although the downstream signaling path- way of TICAM-1 to activate NF-kappaB and MAP kinases remain largely unknown, TICAM-1 appears to bridge TLR3 and TRAF6 to activate NF-kappaB and MAP kinases.

Go back
781.0, 497.0
29.0, 29.0

p11

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e18 MO000000212

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m18*m183*0.1

nodelay

--

true

0

false

PMID: 15031527, 12893815 Upon stimulation, TLRs activate NF-kappaB and MAP kinases via MyD88-IRAK-TRAF6, leading to the production of in?ammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, and IL-12p40 (3).

Go back
213.0, 318.0
25.0, 25.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017793 e20

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m2549*m20*0.1

nodelay

--

true

0

false

PMID: 15031527 TLR1, 2, 4, 5, and 6 are engaged in the recognition of bacterial PAMPs such as LPS, peptidoglycan, lipoprotein, and ?agellin. PMID: 15031527 TLR2 recognizes various PAMPs in cooperation with TLR1 and TLR6.

Go back
213.0, 374.0
25.0, 25.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e21 MO000017793

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c46 : 1

m21*m2549*0.1

nodelay

--

true

0

false

PMID: 15031527 TLR1, 2, 4, 5, and 6 are engaged in the recognition of bacterial PAMPs such as LPS, peptidoglycan, lipoprotein, and ?agellin. PMID: 15031527 TLR2 recognizes various PAMPs in cooperation with TLR1 and TLR6.

Go back
1176.0, 789.0
23.0, 23.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022224 MO000008179

MO000022225

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m119368*m1055*0.1

nodelay

--

true

0

false

PMID: 15031527, 7568028, 7568028 dsRNA-activated protein kinase (PKR) recognizes intracellular dsRNA, a virus-associated molecular pattern, and induces anti-viral cellular responses including type I IFN production (8, 25).

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1032.0, 636.0
23.0, 23.0

p15

p15

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 MO000041441

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c41 : 1
stoichiometry:c38 : 1

m977*m19309*0.1

nodelay

--

true

0

false

PMID: 15031527 IKK-epsilon and TBK-1 are key kinases acting downstream of TICAM-1, which phosphorylate IRF-3, a main transcription factor for IFN-beta gene expression. PMID: 15031527, 11070172, 11244049 The transcription factors IRF-3 and IRF-7 are essential for virus-induced IFN-alpha/beta gene expression, which are activated by phosphorylation via virus-activated kinase(VAK) (41, 45).

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1031.0, 699.0
25.0, 25.0

p16

p16

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 MO000041441

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c42 : 1
stoichiometry:c40 : 1

m980*m19309*0.1

nodelay

--

true

0

false

PMID: 15031527, 11070172, 11244049 The transcription factors IRF-3 and IRF-7 are essential for virus-induced IFN-alpha/beta gene expression, which are activated by phosphorylation via virus-activated kinase(VAK) (41, 45).

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195.0, 804.0
25.0, 25.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042012 e24

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m19828*m25*0.1

nodelay

--

true

0

false

PMID: 15031527, 11561001, 12960343 In addition, the second type of DC precursor cell, pre-DC2 (previously known as plasmacytoid DC precursor), which expresses TLR7 and TLR9 and secretes large amounts of IFN-alpha in response to imidazoquinoline (TLR7 ligand) or CpG DNA (TLR9 ligand), does not express TLR3 (23, 29).

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214.0, 267.0
23.0, 23.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e28 e20

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m29*m20*0.1

nodelay

--

true

0

false

PMID: 15031527 TLR1, 2, 4, 5, and 6 are engaged in the recognition of bacterial PAMPs such as LPS, peptidoglycan, lipoprotein, and ?agellin. PMID: 15031527 TLR2 recognizes various PAMPs in cooperation with TLR1 and TLR6.

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211.0, 476.0
25.0, 25.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e28 e21

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c55 : 1
stoichiometry:c54 : 1

m29*m21*0.1

nodelay

--

true

0

false

PMID: 15031527 TLR1, 2, 4, 5, and 6 are engaged in the recognition of bacterial PAMPs such as LPS, peptidoglycan, lipoprotein, and ?agellin. PMID: 15031527 TLR2 recognizes various PAMPs in cooperation with TLR1 and TLR6.

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1175.0, 399.0
25.0, 25.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 15031527, 11607032, 12054664 Indeed, we and another group independently found that TLR3 is a receptor for dsRNA that transmits signals that activate NF-kappaB and the IFN-beta promoter (4, 28).

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1223.0, 896.0
25.0, 25.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019398 e29

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m3965*m30*0.1

nodelay

--

true

0

false

PMID: 15031527, 12609980 Recently, it has been reported that poly(I:C)-induced TLR3-mediated activation of NF-kappaB and MAP kinase is through an IRAK-independent and TRAF6-dependent pathway (54).

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744.0, 1312.0
23.0, 23.0

p21

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000017053

G010963

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c63 : 1

m1947*0.1

nodelay

--

true

0

false

PMID: 15031527 Such induction also is observed during iDCs differentiation with GM-CSF and IL-4.

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775.0, 1287.0
25.0, 25.0

p22

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000099

G010963

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c62 : 1

m88*0.1

nodelay

--

true

0

false

PMID: 15031527 The TLR3 expression is induced during differentiation from monocytes to macrophages with GM-CSF.

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1251.0, 1292.0
25.0, 25.0

p23

p23

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000000099

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1

m88*0.1

nodelay

--

true

0

false

PMID: 15031527 Such induction also is observed during iDCs differentiation with GM-CSF and IL-4.

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1250.0, 1322.0
25.0, 25.0

p24

p24

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000017053

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1

m1947*0.1

nodelay

--

true

0

false

PMID: 15031527 Such induction also is observed during iDCs differentiation with GM-CSF and IL-4.

Go back
832.0, 1013.0
24.0, 24.0

p25

p25

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e30

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c68 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 15031527, 12960343 These TLR3-positive cells produce type I IFN, particularly IFN-beta upon viral infection or treatment with poly(I:C).

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963.0, 1023.0
25.0, 25.0

p26

p26

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c69 : 1

m93217*0.1

nodelay

--

true

0

false

PMID: 15031527, 12960343 These TLR3-positive cells produce type I IFN, particularly IFN-beta upon viral infection or treatment with poly(I:C).

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832.0, 1064.0
23.0, 23.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e30

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c72 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 15031527, 12960343 These TLR3-positive cells produce type I IFN, particularly IFN-beta upon viral infection or treatment with poly(I:C).

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949.0, 1109.0
25.0, 25.0

p28

p28

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e31

MO000016658

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 15031527, 12960343 These TLR3-positive cells produce type I IFN, particularly IFN-beta upon viral infection or treatment with poly(I:C).

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467.0, 1295.0
25.0, 25.0

p29

p29

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

G010227 e30

MO000016659

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c78 : 1
stoichiometry:c77 : 1

m93216*m31*0.1

nodelay

--

true

0

false

PMID: 15031527 By using IFN-alpha/beta?receptor-null cells, it was revealed that poly(I:C) induces IFN-alpha/beta?secretion in DCs.

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1025.0, 462.0
24.0, 24.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000041446 MO000041125

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c9 : 1
stoichiometry:c8 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 15031527 Although the downstream signaling path- way of TICAM-1 to activate NF-kappaB and MAP kinases remain largely unknown, TICAM-1 appears to bridge TLR3 and TRAF6 to activate NF-kappaB and MAP kinases. PMID: 15031527, 12471095 Meanwhile, Yamamoto et al. identi?ed the same molecule from the database and named it TIR domain-containing adaptor-inducing IFN-beta (TRIF) (51).

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1185.0, 1178.0
21.0, 21.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e33 e32

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c83 : 1

m34*m33*0.1

nodelay

--

true

0

false

PMID: 15031527 Released IFN-alpha/beta acts on DCs in an autocline manner through IFN-alpha/beta?receptors to induce TLR3 expression.

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788.0, 1252.0
23.0, 23.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e34

G010963

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c81 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 15031527 Released IFN-alpha/beta acts on DCs in an autocline manner through IFN-alpha/beta?receptors to induce TLR3 expression. PMID: 15031527, 12672806, 14575692 The IFN-responsive element (ISRE) located around 30 bp of the human TLR3 promoter region is responsible for virus- and poly(I:C)-induced TLR3 gene expression (16,44). PMID: 15031527, 12672806 The sequences of the proximal promoter regions, as well as the non-cod-ing 5'-exons, are different in these two species (16).

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712.0, 1312.0
23.0, 23.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016882

G010963

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c84 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 15031527 LPS strongly up-regulates the TLR3 expression in mouse macrophages and DCs.

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1327.0, 947.0
25.0, 25.0

p33

p33

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e30

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 15031527, 10049946, 12960343 DC maturation is induced by poly(I:C) stimulation (7,29). PMID: 15031527, 11607032, 11286707 Poly(I:C) and LPS induce DC maturation even in MyD88-de?cient mice (4, 24).

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946.0, 1189.0
23.0, 23.0

p34

p34

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e30 e35

MO000038482

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c87 : 1

m31*m36*0.1

nodelay

--

true

0

false

PMID: 15031527 Upon poly(I:C) stimulation, DCs produce IFN-alpha/beta and IL-12p70 and up-regulate co-stimulatory molecules such as CD80, CD83, and CD86 via intracellular TLR3.

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963.0, 1220.0
25.0, 25.0

p35

p35

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e30 e36

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c90 : 1

m31*m37*0.1

nodelay

--

true

0

false

PMID: 15031527 Upon poly(I:C) stimulation, DCs produce IFN-alpha/beta and IL-12p70 and up-regulate co-stimulatory molecules such as CD80, CD83, and CD86 via intracellular TLR3.

Go back
951.0, 814.0
23.0, 23.0

p36

p36

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e30

MO000017269

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c96 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 15031527 Upon poly(I:C) stimulation, DCs produce IFN-alpha/beta and IL-12p70 and up-regulate co-stimulatory molecules such as CD80, CD83, and CD86 via intracellular TLR3.

Go back
951.0, 850.0
23.0, 23.0

p37

p37

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e30

MO000066711

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c97 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 15031527 Upon poly(I:C) stimulation, DCs produce IFN-alpha/beta and IL-12p70 and up-regulate co-stimulatory molecules such as CD80, CD83, and CD86 via intracellular TLR3.

Go back
951.0, 890.0
23.0, 23.0

p38

p38

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e30

MO000017270

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c98 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 15031527 Upon poly(I:C) stimulation, DCs produce IFN-alpha/beta and IL-12p70 and up-regulate co-stimulatory molecules such as CD80, CD83, and CD86 via intracellular TLR3.

Go back
1030.0, 970.0
27.0, 27.0

p39

p39

cso30:i:ME_Translation

cso30:i:CC_Extracellular

--

e30 e38 e39

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c102 : 1
stoichiometry:c101 : 1

m31*m39*0.1

nodelay

--

true

0

false

PMID: 15031527, 12960343 In monocyte-derived iDCs, poly(I:C)-induced cytokine secretion was markedly reduced by pretreatment of the cells with endosomal acidi?cation inhibitor, chloroquine (29).

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192.0, 953.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019399 MO000022185

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m3966*m6485*0.1

nodelay

--

true

0

false

PMID: 15031527 TLR1, 2, 4, 5, and 6 are engaged in the recognition of bacterial PAMPs such as LPS, peptidoglycan, lipoprotein, and ?agellin.

Go back
279.0, 128.0
25.0, 25.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000068831 e26

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m43675*m27*0.1

nodelay

--

true

0

false

PMID: 15031527, 11544529, 11526399, 12447442 Another adaptor protein, Mal/TIRAP cooperatively mediates TLR2 and TLR4 signal transduction and does not participate in a MyD88-independent pathway (11, 19, 20, 49). PMID: 15031527 TLR2 uses MyD88 and Mal/TIRAP to induce in?ammatory cytokines (TNF-alpha, IL-6, IL-12p40) and DC maturation.

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380.0, 101.0
24.0, 24.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e40

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m1572*m41*0.1

nodelay

--

true

0

false

PMID: 15031527, 11544529, 11526399, 12447442 Another adaptor protein, Mal/TIRAP cooperatively mediates TLR2 and TLR4 signal transduction and does not participate in a MyD88-independent pathway (11, 19, 20, 49). PMID: 15031527, 12524386 TLR2, TLR4, TLR5, TLR7, and TLR9 have been shown to transduce signals via MyD88 upon ligand stimulation (43). PMID: 15031527 TLR2 uses MyD88 and Mal/TIRAP to induce in?ammatory cytokines (TNF-alpha, IL-6, IL-12p40) and DC maturation.

Go back
407.0, 872.0
25.0, 25.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e25

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m1572*m26*0.1

nodelay

--

true

0

false

PMID: 15031527, 12524386 TLR2, TLR4, TLR5, TLR7, and TLR9 have been shown to transduce signals via MyD88 upon ligand stimulation (43).

Go back
187.0, 1000.0
25.0, 25.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e13

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c114 : 1
stoichiometry:c113 : 1

m1572*m13*0.1

nodelay

--

true

0

false

PMID: 15031527, 12524386 TLR2, TLR4, TLR5, TLR7, and TLR9 have been shown to transduce signals via MyD88 upon ligand stimulation (43).

Go back
623.0, 147.0
25.0, 25.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

MO000019395 e44

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m3962*m45*0.1

nodelay

--

true

0

false

PMID: 15031527, 12893815 Upon stimulation, TLRs activate NF-kappaB and MAP kinases via MyD88-IRAK-TRAF6, leading to the production of in?ammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, and IL-12p40 (3).

Go back
692.0, 280.0
23.0, 23.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e45 MO000016573

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m46*m1572*0.1

nodelay

--

true

0

false

PMID: 15031527, 12217523 The TIR domain that is responsible for signaling and recruiting the adaptor protein MyD88 is present in the cytoplasmic regions in all TLR proteins (22).

Go back
703.0, 363.0
25.0, 25.0

p46

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000213 e46

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c123 : 1
stoichiometry:c122 : 1

m184*m47*0.1

nodelay

--

true

0

false

PMID: 15031527, 12893815 Upon stimulation, TLRs activate NF-kappaB and MAP kinases via MyD88-IRAK-TRAF6, leading to the production of in?ammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, and IL-12p40 (3).

Go back
663.0, 1183.0
25.0, 25.0

p47

p47

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041457

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c124 : 1

m19325*0.1

nodelay

--

true

0

false

PMID: 15031527, 11070172, 11244049 The transcription factors IRF-3 and IRF-7 are essential for virus-induced IFN-alpha/beta gene expression, which are activated by phosphorylation via virus-activated kinase(VAK) (41, 45).

Go back
771.0, 599.0
25.0, 25.0

p48

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000077 e19

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c131 : 1
stoichiometry:c128 : 1

m69*m19*0.1

nodelay

--

true

0

false

PMID: 15031527, 12893815 Upon stimulation, TLRs activate NF-kappaB and MAP kinases via MyD88-IRAK-TRAF6, leading to the production of in?ammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, and IL-12p40 (3). PMID: 15031527, 12609980 Recently, it has been reported that poly(I:C)-induced TLR3-mediated activation of NF-kappaB and MAP kinase is through an IRAK-independent and TRAF6-dependent pathway (54).

Go back
770.0, 642.0
27.0, 27.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e19

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c132 : 1
stoichiometry:c130 : 1

m24*m19*0.1

nodelay

--

true

0

false

PMID: 15031527, 12893815 Upon stimulation, TLRs activate NF-kappaB and MAP kinases via MyD88-IRAK-TRAF6, leading to the production of in?ammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, and IL-12p40 (3). PMID: 15031527, 12609980 Recently, it has been reported that poly(I:C)-induced TLR3-mediated activation of NF-kappaB and MAP kinase is through an IRAK-independent and TRAF6-dependent pathway (54). PMID: 15031527, 11607032, 12054664 Indeed, we and another group independently found that TLR3 is a receptor for dsRNA that transmits signals that activate NF-kappaB and the IFN-beta promoter (4, 28).

Go back
887.0, 120.0
25.0, 25.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000068831 e12

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c21 : 1

m43675*m12*0.1

nodelay

--

true

0

false

PMID: 15031527, 11544529, 11526399, 12447442 Another adaptor protein, Mal/TIRAP cooperatively mediates TLR2 and TLR4 signal transduction and does not participate in a MyD88-independent pathway (11, 19, 20, 49).

Go back
415.0, 1075.0
25.0, 25.0

p50

p50

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

G010329

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c133 : 1

m93309*0.1

nodelay

--

true

0

false

PMID: 15031527, 12893815 Upon stimulation, TLRs activate NF-kappaB and MAP kinases via MyD88-IRAK-TRAF6, leading to the production of in?ammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, and IL-12p40 (3).

Go back
403.0, 1123.0
25.0, 25.0

p51

p51

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c134 : 1

m93248*0.1

nodelay

--

true

0

false

PMID: 15031527, 12893815 Upon stimulation, TLRs activate NF-kappaB and MAP kinases via MyD88-IRAK-TRAF6, leading to the production of in?ammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, and IL-12p40 (3).

Go back
408.0, 1176.0
23.0, 23.0

p52

p52

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010657

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c141 : 1

m93589*0.1

nodelay

--

true

0

false

PMID: 15031527, 12893815 Upon stimulation, TLRs activate NF-kappaB and MAP kinases via MyD88-IRAK-TRAF6, leading to the production of in?ammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, and IL-12p40 (3).

Go back
504.0, 1024.0
23.0, 23.0

p53

p53

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e48

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c138 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 15031527, 12893815 Upon stimulation, TLRs activate NF-kappaB and MAP kinases via MyD88-IRAK-TRAF6, leading to the production of in?ammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, and IL-12p40 (3). PMID: 15031527 TLR2 uses MyD88 and Mal/TIRAP to induce in?ammatory cytokines (TNF-alpha, IL-6, IL-12p40) and DC maturation.

Go back
532.0, 1056.0
23.0, 23.0

p54

p54

cso30:i:ME_GeneExpression

cso30:i:CC_Chromatin

--

e48

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c139 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 15031527, 12893815 Upon stimulation, TLRs activate NF-kappaB and MAP kinases via MyD88-IRAK-TRAF6, leading to the production of in?ammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, and IL-12p40 (3). PMID: 15031527 TLR2 uses MyD88 and Mal/TIRAP to induce in?ammatory cytokines (TNF-alpha, IL-6, IL-12p40) and DC maturation.

Go back
556.0, 1096.0
23.0, 23.0

p55

p55

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e48

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c140 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 15031527, 12893815 Upon stimulation, TLRs activate NF-kappaB and MAP kinases via MyD88-IRAK-TRAF6, leading to the production of in?ammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, and IL-12p40 (3). PMID: 15031527 TLR2 uses MyD88 and Mal/TIRAP to induce in?ammatory cytokines (TNF-alpha, IL-6, IL-12p40) and DC maturation.

Go back
763.0, 1111.0
25.0, 25.0

p56

p56

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000022225

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c145 : 1

m6524*0.1

nodelay

--

true

0

false

PMID: 15031527, 7568028, 7568028 dsRNA-activated protein kinase (PKR) recognizes intracellular dsRNA, a virus-associated molecular pattern, and induces anti-viral cellular responses including type I IFN production (8, 25).

Go back
433.0, 25.0
29.0, 29.0

p57

p57

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e41

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 15031527 TLR2 uses MyD88 and Mal/TIRAP to induce in?ammatory cytokines (TNF-alpha, IL-6, IL-12p40) and DC maturation.

Go back
277.0, 549.0
25.0, 25.0

p58

p58

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000042126 e49

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c149 : 1
stoichiometry:c150 : 1

m19940*m63*0.1

nodelay

--

true

0

false

PMID: 15031527, 11561001, 12960343 In addition, the second type of DC precursor cell, pre-DC2 (previously known as plasmacytoid DC precursor), which expresses TLR7 and TLR9 and secretes large amounts of IFN-alpha in response to imidazoquinoline (TLR7 ligand) or CpG DNA (TLR9 ligand), does not express TLR3 (23, 29).

Go back
367.0, 427.0
25.0, 25.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e63 MO000016573

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c153 : 1
stoichiometry:c152 : 1

m64*m1572*0.1

nodelay

--

true

0

false

PMID: 15031527, 12524386 TLR2, TLR4, TLR5, TLR7, and TLR9 have been shown to transduce signals via MyD88 upon ligand stimulation (43).

Go back
1048.0, 528.0
24.0, 24.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041441 MO000019331 MO000016608 MO000041437

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c19 : 1
stoichiometry:c61 : 1

m19309*m3902*m1599*m19305*0.1

nodelay

--

true

0

false

PMID: 15031527 IKK-epsilon and TBK-1 are key kinases acting downstream of TICAM-1, which phosphorylate IRF-3, a main transcription factor for IFN-beta gene expression. PMID: 15031527, 12692549 By employing co-immunoprecipitation experiments, Maniatis et al. showed that TBK-1 and IKK-epsilon are associated with TICAM-1, suggesting that these kinases may function downstream of TICAM-1.

Go back
446.0, 1258.0
27.0, 27.0

p60

p60

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e42 G010227

MO000016659

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1

m43*m93216*0.1

nodelay

--

true

0

false

PMID: 15031527, 11561001, 12960343 In addition, the second type of DC precursor cell, pre-DC2 (previously known as plasmacytoid DC precursor), which expresses TLR7 and TLR9 and secretes large amounts of IFN-alpha in response to imidazoquinoline (TLR7 ligand) or CpG DNA (TLR9 ligand), does not express TLR3 (23, 29).

Go back
428.0, 1224.0
23.0, 23.0

p61

p61

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e64 G010227

MO000016659

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c156 : 1
stoichiometry:c159 : 1

m65*m93216*0.1

nodelay

--

true

0

false

PMID: 15031527, 11561001, 12960343 In addition, the second type of DC precursor cell, pre-DC2 (previously known as plasmacytoid DC precursor), which expresses TLR7 and TLR9 and secretes large amounts of IFN-alpha in response to imidazoquinoline (TLR7 ligand) or CpG DNA (TLR9 ligand), does not express TLR3 (23, 29).

Go back
736.0, 980.0
23.0, 23.0

p62

p62

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041456

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c160 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 15031527 IKK-epsilon and TBK-1 are key kinases acting downstream of TICAM-1, which phosphorylate IRF-3, a main transcription factor for IFN-beta gene expression. PMID: 15031527 TLR3 uses TICAM-1 to induce IFN-beta, in?ammatory cytokines, and DC maturation. PMID: 15031527, 11607032, 12054664 Indeed, we and another group independently found that TLR3 is a receptor for dsRNA that transmits signals that activate NF-kappaB and the IFN-beta promoter (4, 28).

Go back
1107.0, 95.0
25.0, 25.0

p63

p63

cso30:i:CE_CellDeath

cso30:i:CC_Extracellular

--

MO000016882

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 15031527, 11607032, 11286707 Poly(I:C) and LPS induce DC maturation even in MyD88-de?cient mice (4, 24).

Go back
896.0, 500.0
24.0, 24.0

p64

p64

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000212 e65

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c30 : 1
stoichiometry:c164 : 1

m183*m66*0.1

nodelay

--

true

0

false

PMID: 15031527, 12609980 Recently, it has been reported that poly(I:C)-induced TLR3-mediated activation of NF-kappaB and MAP kinase is through an IRAK-independent and TRAF6-dependent pathway (54).

Go back
1203.0, 527.0
26.0, 26.0

p65

p65

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000041437

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1

m19305*0.1

nodelay

--

true

0

false

PMID: 15031527 TLR3 uses TICAM-1 to induce IFN-beta, in?ammatory cytokines, and DC maturation.

Go back
706.0, 946.0
26.0, 26.0

p66

p66

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041437

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c168 : 1

m19305*0.1

nodelay

--

true

0

false

PMID: 15031527 TLR3 uses TICAM-1 to induce IFN-beta, in?ammatory cytokines, and DC maturation.

Go back
909.0, 67.0
26.0, 26.0

p67

p67

cso30:i:CE_CellDeath

cso30:i:CC_Extracellular

--

e12

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 15031527 TLR4 uses MyD88, Mal/TIRAP, TICAM-1, and TICAM-2 to induce IFN-beta, in?ammatory cytokines, and DC maturation.

Go back
881.0, 1065.0
25.0, 25.0

p68

p68

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e16

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c172 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 15031527 TLR4 uses MyD88, Mal/TIRAP, TICAM-1, and TICAM-2 to induce IFN-beta, in?ammatory cytokines, and DC maturation.

Go back
699.0, 1151.0
25.0, 25.0

p69

p69

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e17

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c173 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 15031527 TLR4 uses MyD88, Mal/TIRAP, TICAM-1, and TICAM-2 to induce IFN-beta, in?ammatory cytokines, and DC maturation.

Go back
963.0, 256.0
25.0, 25.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 MO000041132

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c20 : 1

m12*m19005*0.1

nodelay

--

true

0

false

PMID: 15031527, 14517278, 14519765, 14556004 Recently, a novel adaptor molecule named TICAM-2 (also called TRAM) was identi?ed. It is involved in TLR4-mediated signaling leading to the production of IFN-beta (13, 37, 52).

Go back
1308.0, 300.0
23.0, 23.0

p70

p70

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e30 MO000041125

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c175 : 1

m31*m18998*0.1

nodelay

--

true

0

false

PMID: 15031527 Although the downstream signaling path- way of TICAM-1 to activate NF-kappaB and MAP kinases remain largely unknown, TICAM-1 appears to bridge TLR3 and TRAF6 to activate NF-kappaB and MAP kinases. PMID: 15031527, 12471095 Meanwhile, Yamamoto et al. identi?ed the same molecule from the database and named it TIR domain-containing adaptor-inducing IFN-beta (TRIF) (51).

Go back
644.0, 1228.0
23.0, 23.0

p71

p71

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041456

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c165 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 15031527, 11070172, 11244049 The transcription factors IRF-3 and IRF-7 are essential for virus-induced IFN-alpha/beta gene expression, which are activated by phosphorylation via virus-activated kinase(VAK) (41, 45).

Go back
960.0, 392.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041132 e14 MO000041125

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c170 : 1
stoichiometry:c24 : 1

m19005*m14*m18998*0.1

nodelay

--

true

0

false

PMID: 15031527 TLR4 uses MyD88, Mal/TIRAP, TICAM-1, and TICAM-2 to induce IFN-beta, in?ammatory cytokines, and DC maturation.

Go back
807.0, 276.0
25.0, 25.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 MO000016573

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m15*m1572*0.1

nodelay

--

true

0

false

PMID: 15031527, 11544529, 11526399, 12447442 Another adaptor protein, Mal/TIRAP cooperatively mediates TLR2 and TLR4 signal transduction and does not participate in a MyD88-independent pathway (11, 19, 20, 49). PMID: 15031527, 12524386 TLR2, TLR4, TLR5, TLR7, and TLR9 have been shown to transduce signals via MyD88 upon ligand stimulation (43).

Go back
1188.0, 432.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
221.7362590055862, 917.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
835.0, 984.2869946323538

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1057.0, 984.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
958.0, 952.0

c102

c102

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
311.9999995464778, 140.81685253507092

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
292.0, 161.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
301.0, 153.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
411.9999767016243, 112.2757692912993

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
355.0, 132.24103409467205

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.0, 125.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
75.50005298232938, 76.00534900555454

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
204.0, 924.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
95.91463673867213, 93.20275750943273

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
420.0, 850.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
432.0, 847.848442145943

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
212.0, 1012.1249847440043

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
219.09079078563866, 972.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
652.4829175920399, 177.82559994154244

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
636.0, 46.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
636.0, 172.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
652.0, 234.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
722.9876828256433, 290.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
215.0, 965.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
594.6662472316751, 219.42279864409215

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
736.0, 376.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
728.0, 387.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
588.0, 223.0

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
688.0, 1196.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1130.0, 330.9999987980701

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
981.0, 315.1386262109849

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
739.0, 579.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
751.0, 612.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
731.0, 656.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
900.0, 153.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
694.7556123233586, 659.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
801.6568542494924, 576.0

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
794.7480210390779, 576.0

c132

c132

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
395.0, 1088.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
389.0, 1136.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
448.0, 1088.0

c135

c135

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
436.0, 1136.0

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
439.0, 1188.0

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
516.0, 1047.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
535.463263329464, 1079.0

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
906.5298221281347, 152.58946638440412

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
556.5968358571538, 1119.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
390.0, 1188.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
524.2407531512001, 699.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
550.5298221281347, 699.0

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
572.8988037548377, 699.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
788.0, 1124.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
776.0090817304487, 800.1961879110365

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
400.0, 61.56491119735253

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
309.74621858967487, 566.9990241521741

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
236.0, 561.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1080.0, 540.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
302.0, 544.9121523769792

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
380.0, 460.0

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.0, 450.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
399.40056706827596, 295.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
127.5225655593211, 494.0

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
460.29177654679853, 847.0

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
458.9947793925485, 1236.2889679298512

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
480.5255253311717, 1245.0

c157

c157

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
240.98277526782678, 1273.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
240.7862887385181, 1239.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1015.0, 546.5298221281347

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
757.0, 1003.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
747.5205070657535, 691.0

c161

c161

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
989.0, 83.0

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
869.0, 512.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
850.5775375331502, 520.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
667.0, 1202.691842951061

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1134.0, 485.0

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
719.0477388350898, 479.0

c167

c167

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
732.0, 963.0

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
922.1701742519247, 100.99818984045652

c169

c169

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
939.0, 223.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
972.0, 423.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
913.9999483178524, 191.81508195463766

c171

c171

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
817.67147404649, 1055.2690275348773

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
720.0, 1008.8477480780765

c173

c173

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
731.9999977883152, 59.75617265581377

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1140.0, 312.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
656.0084181488209, 690.0

c176

c176

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
675.8353542315813, 761.0

c177

c177

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
951.1919189506982, 482.0

c178

c178

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
973.0, 288.98442062786313

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1021.0, 558.2300312726662

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1137.0, 374.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
988.0, 227.82559994154244

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
878.8417420849886, 145.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
972.0, 342.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
978.4600904678997, 228.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
979.0, 221.89747641699512

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
833.4376015698018, 240.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
763.0, 289.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
779.5536798306425, 230.57753753315023

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
869.0, 521.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
852.0, 564.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1145.0, 412.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
907.8839479430287, 317.0

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
793.0, 458.0

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
818.0, 512.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
806.0, 526.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1188.0, 501.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1068.0, 762.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1077.0, 801.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
971.0, 648.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
976.4759018794317, 653.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1006.0, 712.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
976.0, 94.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1012.1256389183169, 723.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1062.9998641480595, 556.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1063.9886504808746, 556.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
193.0, 344.35990680476334

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
245.997501171265, 330.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
238.0, 298.8275413614843

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
238.0, 396.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
245.99773338995308, 386.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
193.0, 371.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
227.82783282716542, 783.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
976.0, 152.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
163.0, 817.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
220.0, 818.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
143.0, 295.4020325375149

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
139.0, 378.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
236.0, 489.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
237.54403046270698, 405.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
243.3812746502559, 291.82486619897395

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
237.0, 243.0745328934242

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1137.0, 364.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1256.0, 909.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.6784126030082, 144.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1138.0, 909.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1075.2332154634528, 491.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
746.9459451369956, 1276.9691115068547

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
736.753241807694, 1287.0649257556593

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
807.999314799809, 1300.104703073296

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
774.9971776244225, 1324.212485395818

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1210.0, 1305.0

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1209.0, 1335.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
817.1554175279994, 1031.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
988.0, 1036.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1055.5387122302607, 422.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
863.3623790715685, 915.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
810.0, 1037.5736826406696

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
844.0, 1087.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
861.8208100192876, 917.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
865.0, 1122.1904222235703

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
974.0, 1122.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
497.65685424949237, 1254.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
240.97643588401266, 1289.6135719910778

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
479.8522754607915, 914.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1214.0, 1189.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1049.0, 474.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1128.0, 1189.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
748.0, 1264.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
818.996228600153, 1264.2456179433493

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1133.514906885181, 1199.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
724.0, 1288.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
725.4936861032184, 80.5988760459793

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1130.0, 912.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
969.0, 1201.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
968.8007768480796, 926.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
875.0, 1198.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
987.0, 474.21045345670586

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
988.0, 1233.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
985.1724451037694, 926.0

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
877.0, 1230.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
981.031480341847, 835.8155319684441

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
981.6410910662299, 867.3693305631721

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
981.9913606886246, 902.3716911948197

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
924.0, 826.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
923.0, 862.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
929.0, 902.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1062.5352429058848, 923.0

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back