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PMID: 14698224 To date, 10 TLRs (TLR1-TLR10) have been reportedly encoded in the human genome, and at least one ligand has been identified for each TLR, except for TLR8 and TLR10: triacylated lipoprotein for TLR1; peptidoglycan, the major gram-positive bacterial cell wall component, for TLR2; double-stranded RNA, which is considered to be generated in the lifecycle of RNA viruses, for TLR3; lipopolysaccharide (LPS), a gram-negative cell wall component, for TLR4; flagellin, a component of bacterial flagella, for TLR5; diacylated lipoprotein for TLR6; imidazoquinoline, an anti-viral drug, and its derivative R-848, for TLR7; and bacterial unmethylated CpG DNA for TLR9.

PMID: 14698224 To date, 10 TLRs (TLR1-TLR10) have been reportedly encoded in the human genome, and at least one ligand has been identified for each TLR, except for TLR8 and TLR10: triacylated lipoprotein for TLR1; peptidoglycan, the major gram-positive bacterial cell wall component, for TLR2; double-stranded RNA, which is considered to be generated in the lifecycle of RNA viruses, for TLR3; lipopolysaccharide (LPS), a gram-negative cell wall component, for TLR4; flagellin, a component of bacterial flagella, for TLR5; diacylated lipoprotein for TLR6; imidazoquinoline, an anti-viral drug, and its derivative R-848, for TLR7; and bacterial unmethylated CpG DNA for TLR9.

PMID: 14698224 To date, 10 TLRs (TLR1-TLR10) have been reportedly encoded in the human genome, and at least one ligand has been identified for each TLR, except for TLR8 and TLR10: triacylated lipoprotein for TLR1; peptidoglycan, the major gram-positive bacterial cell wall component, for TLR2; double-stranded RNA, which is considered to be generated in the lifecycle of RNA viruses, for TLR3; lipopolysaccharide (LPS), a gram-negative cell wall component, for TLR4; flagellin, a component of bacterial flagella, for TLR5; diacylated lipoprotein for TLR6; imidazoquinoline, an anti-viral drug, and its derivative R-848, for TLR7; and bacterial unmethylated CpG DNA for TLR9.

PMID: 14698224 To date, 10 TLRs (TLR1-TLR10) have been reportedly encoded in the human genome, and at least one ligand has been identified for each TLR, except for TLR8 and TLR10: triacylated lipoprotein for TLR1; peptidoglycan, the major gram-positive bacterial cell wall component, for TLR2; double-stranded RNA, which is considered to be generated in the lifecycle of RNA viruses, for TLR3; lipopolysaccharide (LPS), a gram-negative cell wall component, for TLR4; flagellin, a component of bacterial flagella, for TLR5; diacylated lipoprotein for TLR6; imidazoquinoline, an anti-viral drug, and its derivative R-848, for TLR7; and bacterial unmethylated CpG DNA for TLR9.

PMID: 14698224 To date, 10 TLRs (TLR1-TLR10) have been reportedly encoded in the human genome, and at least one ligand has been identified for each TLR, except for TLR8 and TLR10: triacylated lipoprotein for TLR1; peptidoglycan, the major gram-positive bacterial cell wall component, for TLR2; double-stranded RNA, which is considered to be generated in the lifecycle of RNA viruses, for TLR3; lipopolysaccharide (LPS), a gram-negative cell wall component, for TLR4; flagellin, a component of bacterial flagella, for TLR5; diacylated lipoprotein for TLR6; imidazoquinoline, an anti-viral drug, and its derivative R-848, for TLR7; and bacterial unmethylated CpG DNA for TLR9.

PMID: 14698224 To date, 10 TLRs (TLR1-TLR10) have been reportedly encoded in the human genome, and at least one ligand has been identified for each TLR, except for TLR8 and TLR10: triacylated lipoprotein for TLR1; peptidoglycan, the major gram-positive bacterial cell wall component, for TLR2; double-stranded RNA, which is considered to be generated in the lifecycle of RNA viruses, for TLR3; lipopolysaccharide (LPS), a gram-negative cell wall component, for TLR4; flagellin, a component of bacterial flagella, for TLR5; diacylated lipoprotein for TLR6; imidazoquinoline, an anti-viral drug, and its derivative R-848, for TLR7; and bacterial unmethylated CpG DNA for TLR9.

PMID: 14698224 To date, 10 TLRs (TLR1-TLR10) have been reportedly encoded in the human genome, and at least one ligand has been identified for each TLR, except for TLR8 and TLR10: triacylated lipoprotein for TLR1; peptidoglycan, the major gram-positive bacterial cell wall component, for TLR2; double-stranded RNA, which is considered to be generated in the lifecycle of RNA viruses, for TLR3; lipopolysaccharide (LPS), a gram-negative cell wall component, for TLR4; flagellin, a component of bacterial flagella, for TLR5; diacylated lipoprotein for TLR6; imidazoquinoline, an anti-viral drug, and its derivative R-848, for TLR7; and bacterial unmethylated CpG DNA for TLR9.

PMID: 14698224 To date, 10 TLRs (TLR1-TLR10) have been reportedly encoded in the human genome, and at least one ligand has been identified for each TLR, except for TLR8 and TLR10: triacylated lipoprotein for TLR1; peptidoglycan, the major gram-positive bacterial cell wall component, for TLR2; double-stranded RNA, which is considered to be generated in the lifecycle of RNA viruses, for TLR3; lipopolysaccharide (LPS), a gram-negative cell wall component, for TLR4; flagellin, a component of bacterial flagella, for TLR5; diacylated lipoprotein for TLR6; imidazoquinoline, an anti-viral drug, and its derivative R-848, for TLR7; and bacterial unmethylated CpG DNA for TLR9.

indirect

PMID: 14698224 To date, 10 TLRs (TLR1-TLR10) have been reportedly encoded in the human genome, and at least one ligand has been identified for each TLR, except for TLR8 and TLR10: triacylated lipoprotein for TLR1; peptidoglycan, the major gram-positive bacterial cell wall component, for TLR2; double-stranded RNA, which is considered to be generated in the lifecycle of RNA viruses, for TLR3; lipopolysaccharide (LPS), a gram-negative cell wall component, for TLR4; flagellin, a component of bacterial flagella, for TLR5; diacylated lipoprotein for TLR6; imidazoquinoline, an anti-viral drug, and its derivative R-848, for TLR7; and bacterial unmethylated CpG DNA for TLR9.

PMID: 14698224 To date, 10 TLRs (TLR1-TLR10) have been reportedly encoded in the human genome, and at least one ligand has been identified for each TLR, except for TLR8 and TLR10: triacylated lipoprotein for TLR1; peptidoglycan, the major gram-positive bacterial cell wall component, for TLR2; double-stranded RNA, which is considered to be generated in the lifecycle of RNA viruses, for TLR3; lipopolysaccharide (LPS), a gram-negative cell wall component, for TLR4; flagellin, a component of bacterial flagella, for TLR5; diacylated lipoprotein for TLR6; imidazoquinoline, an anti-viral drug, and its derivative R-848, for TLR7; and bacterial unmethylated CpG DNA for TLR9.

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

indirect

PMID: 14698224 Macrophages from MyD88-deficient mice are completely defective in the production of inflammatory cytokines such as TNF-alpha, IL-6, IL-1beta, and IL-12 p40 in response to bacterial components.

indirect

indirect

PMID: 14698224 Macrophages from MyD88-deficient mice are completely defective in the production of inflammatory cytokines such as TNF-alpha, IL-6, IL-1beta, and IL-12 p40 in response to bacterial components.

indirect

indirect

PMID: 14698224 Macrophages from MyD88-deficient mice are completely defective in the production of inflammatory cytokines such as TNF-alpha, IL-6, IL-1beta, and IL-12 p40 in response to bacterial components.

indirect

indirect

PMID: 14698224 Macrophages from MyD88-deficient mice are completely defective in the production of inflammatory cytokines such as TNF-alpha, IL-6, IL-1beta, and IL-12 p40 in response to bacterial components.

PMID: 14698224 Furthermore, epitope-tagged TIRAP interacted directly with MyD88 and the TIR domain of TLR4 but not TLR9, suggesting that, unlike MyD88 which participates in all of the TLR and IL-1 receptor signaling pathways, TIRAP is an adaptor molecule specific for TLR4 signaling.

PMID: 14698224 Furthermore, epitope-tagged TIRAP interacted directly with MyD88 and the TIR domain of TLR4 but not TLR9, suggesting that, unlike MyD88 which participates in all of the TLR and IL-1 receptor signaling pathways, TIRAP is an adaptor molecule specific for TLR4 signaling.

indirect

indirect

PMID: 14698224 Regarding cytokine production, LPS stimulation of wildtype macrophages resulted in the production of TNF-alpha, IL-6 and IL-12 p40 in a dose-dependent manner, whereas the production of these cytokines was completely abolished in TIRAP-deficient cells.

indirect

indirect

PMID: 14698224 Regarding cytokine production, LPS stimulation of wildtype macrophages resulted in the production of TNF-alpha, IL-6 and IL-12 p40 in a dose-dependent manner, whereas the production of these cytokines was completely abolished in TIRAP-deficient cells.

indirect

indirect

PMID: 14698224 Regarding cytokine production, LPS stimulation of wildtype macrophages resulted in the production of TNF-alpha, IL-6 and IL-12 p40 in a dose-dependent manner, whereas the production of these cytokines was completely abolished in TIRAP-deficient cells.

PMID: 14698224 Stimulation with MALP-2, a TLR2 ligand, showed NF-KappaB activation and MAPK phosphorylation in wild-type cells, but these were profoundly inhibited in TIRAP-deficient cells.

indirect

PMID: 14698224 Stimulation with MALP-2, a TLR2 ligand, showed NF-kappaB activation and MAPK phosphorylation in wild-type cells, but these were profoundly inhibited in TIRAP-deficient cells.

indirect

PMID: 14698224 Stimulation with MALP-2, a TLR2 ligand, showed NF-kappaB activation and MAPK phosphorylation in wild-type cells, but these were profoundly inhibited in TIRAP-deficient cells.

indirect

PMID: 14698224, 11070172, 10607756 IRF3 is a key transcription factor for LPS-mediated expression of IFN-beta and IRGs Activated IRF3 forms a homodimer after LPS stimulation and translocates into the nucleus to switch on the induction of IFN-beta and other IRGs

PMID: 14698224, 11070172, 10607756 IRF3 is a key transcription factor for LPS-mediated expression of IFN-beta and IRGs Activated IRF3 forms a homodimer after LPS stimulation and translocates into the nucleus to switch on the induction of IFN-beta and other IRGs

indirect

PMID: 14698224, 11070172, 10607756 IRF3 is a key transcription factor for LPS-mediated expression of IFN-beta and IRGs Activated IRF3 forms a homodimer after LPS stimulation and translocates into the nucleus to switch on the induction of IFN-beta and other IRGs

indirect

PMID: 14698224, 11070172, 10607756 IRF3 is a key transcription factor for LPS-mediated expression of IFN-beta and IRGs Activated IRF3 forms a homodimer after LPS stimulation and translocates into the nucleus to switch on the induction of IFN-beta and other IRGs

indirect

PMID: 14698224, 11070172, 10607756 IRF3 is a key transcription factor for LPS-mediated expression of IFN-beta and IRGs Activated IRF3 forms a homodimer after LPS stimulation and translocates into the nucleus to switch on the induction of IFN-beta and other IRGs

indirect

PMID: 14698224, 11070172, 10607756 IRF3 is a key transcription factor for LPS-mediated expression of IFN-beta and IRGs Activated IRF3 forms a homodimer after LPS stimulation and translocates into the nucleus to switch on the induction of IFN-beta and other IRGs

indirect

PMID: 14698224 As reported previously, overexpression of MyD88 or TIRAP in 293 cells strongly induced NF-kappaB activation as detected by a luciferase-mediated reporter assay

indirect

PMID: 14698224 As reported previously, overexpression of MyD88 or TIRAP in 293 cells strongly induced NF-kappaB activation as detected by a luciferase-mediated reporter assay

indirect

PMID: 14698224 Overexpression of TRIF activated NF-kappaB, albeit at a low level compared with MyD88- or TIRAP-induced activation

indirect

PMID: 14698224 TRIF overexpression culminated in activation of not only the NF-kappaB-responsive element but also the IFN-beta promoter.

PMID: 14698224 Coimmunoprecipitation analysis revealed that TRIF associated with the TIR domain of TLR3, indicating that TRIF may recognize TLR3 through homophilic interaction TRIF interacted with TLR3 through the TIR domain and endogenous IRF3.

PMID: 14698224 Coimmunoprecipitation analysis revealed that TRIF associated with the TIR domain of TLR3, indicating that TRIF may recognize TLR3 through homophilic interaction TRIF interacted with TLR3 through the TIR domain and endogenous IRF3.

indirect

indirect

PMID: 14698224 However, the production of type I interferon from certain cell types is stimulated by activation of TLR9 signaling but not by that of TLR2

PMID: 14698224 In addition, the latter group found that TRAM/TIRP associated with other TIR domain-containing adaptors, including TIRAP and TRIF, but not with MyD88.

PMID: 14698224 In addition, the latter group found that TRAM/TIRP associated with other TIR domain-containing adaptors, including TIRAP and TRIF, but not with MyD88.

indirect

PMID: 14698224, 12692549, 12702806 Recently, two groups reported that IKK-I/IKK-ε and TBK1/T2K act as molecules for mediating IRF3 phosphorylation

indirect

PMID: 14698224, 12692549, 12702806 Recently, two groups reported that IKK-I/IKK-ε and TBK1/T2K act as molecules for mediating IRF3 phosphorylation

indirect

PMID: 14698224, 12692549 Surprisingly, overexpression of both molecules led to strong activation of the IFN-beta and RANTES promoters as well as NF-kappaB

indirect

PMID: 14698224, 12692549 Surprisingly, overexpression of both molecules led to strong activation of the IFN-beta and RANTES promoters as well as NF-kappaB

indirect

PMID: 14698224, 12692549 Surprisingly, overexpression of both molecules led to strong activation of the IFN-beta and RANTES promoters as well as NF-kappaB

indirect

PMID: 14698224, 12692549 Surprisingly, overexpression of both molecules led to strong activation of the IFN-beta and RANTES promoters as well as NF-kappaB

indirect

PMID: 14698224, 12692549 Surprisingly, overexpression of both molecules led to strong activation of the IFN-beta and RANTES promoters as well as NF-kappaB

indirect

PMID: 14698224, 12692549 Surprisingly, overexpression of both molecules led to strong activation of the IFN-beta and RANTES promoters as well as NF-kappaB

PMID: 14698224, 12692549 TRIF bound to IKKI/ IKK-ε and TBK1/T2K through regions other than the TIR domain

PMID: 14698224, 12692549 TRIF bound to IKKI/ IKK-ε and TBK1/T2K through regions other than the TIR domain

indirect

indirect

PMID: 14698224 Instead, LPS-mediated production of type I interferons, such as IFN-beta and IFN-alpha4, was perturbed in Tyk2-deficient mice.

indirect

indirect

PMID: 14698224 Instead, LPS-mediated production of type I interferons, such as IFN-beta and IFN-alpha4, was perturbed in Tyk2-deficient mice.

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

PMID: 14698224, 11923871, 12297423, 12620219 , 11983155 , 12467243 MyD88, a common adaptor protein also harboring a TIR domain, is associated with the TIR domain of TLRs, and leads to the activation of IRAK-1/4 and TRAF-6, culminating in the activation of NF-kappaB, a transcription factor crucial for the expression of pro-inflammatory cytokines and various mediators

indirect

indirect

PMID: 14698224, 10435584 Although the activation of NF-KappaB and MAPK through almost all of the TLRs is abolished in MyD88-deficient cells, the TLR4 ligand LPS stimulation still activates NF-KappaB and MAPK in MyD88-deficient cells, but with delayed kinetics compared with those of wild-type cells PMID: 14698224 LPS stimulation activated the NF-KappaB responsive reporter in cells transfected with both TLR4 and MD-2,

indirect

PMID: 14698224, 10435584 Although the activation of NF-KappaB and MAPK through almost all of the TLRs is abolished in MyD88-deficient cells, the TLR4 ligand LPS stimulation still activates NF-KappaB and MAPK in MyD88-deficient cells, but with delayed kinetics compared with those of wild-type cells

indirect

PMID: 14698224, 11607032 TLR3 has also been shown to utilize the MyD88-independent pathway, since poly(I:C)-induced NF-KappaB activation and maturation of dendritic cells were observed normally in MyD88-deficient mice

indirect

PMID: 14698224, 12054664 293 cells stably transfected with TLR3 showed poly(I:C) stimulation-dependent activation of NF-KappaB and the IFN-beta promoter