Entity
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
LPS:LBP
--
e11
cso30:c:Complex
cso30:i:CC_Extracellular
--
csml-variable:Double
m11
0
infinite
0
--
--
e12
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m12
0
infinite
0
--
--
e13
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m13
0
infinite
0
--
--
e14
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m14
0
infinite
0
--
--
e15
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m15
0
infinite
0
--
--
e16
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m16
0
infinite
0
--
--
e17
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m17
0
infinite
0
--
--
e18
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m18
0
infinite
0
--
--
e19
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
--
e20
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m20
0
infinite
0
--
--
e21
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m21
0
infinite
0
--
--
e22
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m22
0
infinite
0
--
--
e23
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m23
0
infinite
0
--
--
e24
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m24
0
infinite
0
--
TNF
--
e25
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m25
0
infinite
0
--
TNF
--
e26
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m26
0
infinite
0
--
CD14
--
e27
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m27
0
infinite
0
--
csml-variable:Double
m28
0
infinite
0
--
3C10
--
e29
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
60b
--
e30
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m30
0
infinite
0
--
albumin
--
e31
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m31
0
infinite
0
--
LPS:albumin
--
e32
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m32
0
infinite
0
--
ComplementC1
--
e33
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m33
0
infinite
0
--
LPS:complementC1
--
e34
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m34
0
infinite
0
--
complement C3
--
e35
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m35
0
infinite
0
--
CD11:CD18
--
e36
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m36
0
infinite
0
--
LPS:complement C3
--
e37
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m37
0
infinite
0
--
lipoproteins
--
e38
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m38
0
infinite
0
--
LPS:lipoproteins
--
e39
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m39
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
LPS:CD11:CD18
--
e40
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m40
0
infinite
0
--
Unknown protein
--
e41
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m41
0
infinite
0
--
LPS:unknown protein
--
e42
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m42
0
infinite
0
--
LPS
--
e5
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
csml-variable:Double
m5
0
infinite
0
--
csml-variable:Double
m6
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m6*m5*0.1
nodelay
--
0
PMID: 1373512 LBP, which does not have activity by itself, binds to LPS with high affinity.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
stoichiometry:c29 : 1
m35*m5*0.1
nodelay
--
0
PMID: 1373512, 2254981 Known serum proteins that bind to lipid A moiety of LPS include albumin, the complement proteins Cl and C3 and detoxifying as well as a down-modulating effect on LPS activities.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1
m38*m5*0.1
nodelay
--
0
PMID: 1373512, 2254981 Known serum proteins that bind to lipid A moiety of LPS include albumin, the complement proteins Cl and C3 and detoxifying as well as a down-modulating effect on LPS activities.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1
m36*m5*0.1
nodelay
--
0
PMID: 1373512, 3537192 Evidence exists that, on the cell surface, the CD1l/CD18 Leu-CAM complex also binds directly to LPS.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1
m41*m5*0.1
nodelay
--
0
PMID: 1373512, 2456339, 2345180, 3170565 A 73-kDa protein that is present on many cell types, an I8-kDa protein in the membrane of 702/3 cells and two proteins of 95 and 31 kDa in the membranes of RAW 263.1 cells have also recently been identified as binding to LPS.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c4 : 1
m11*0.1
nodelay
--
0
PMID: 1373512,2402637 LPS-induced TNF production and TNF-mRNA expression in rabbit peritoneal macrophages, for exampie, is enhanced strongly when LPS is complexed to LBP.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c7 : 1
stoichiometry:c39 : 1
stoichiometry:c19 : 1
stoichiometry:c6 : 1
m25*m11*0.1
nodelay
--
0
PMID: 1373512,2402637 LPS-induced TNF production and TNF-mRNA expression in rabbit peritoneal macrophages, for exampie, is enhanced strongly when LPS is complexed to LBP. PMID: 1373512, 1698311 In experiments that gave first evidence for CD14 being the receptor for LBP/LPS complexes, anti-CD 14 mAb 3C IO and 6Ob were able to inhibit LBP/LPS-mediated effects, including TNF production and opsonin function.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1
m27*m11*0.1
nodelay
--
0
PMID: 1373512, 1698311 Complexes of LPS and LBP now seem to be recognized and specifically bound by a cellular receptor on myeloid cells, the surface antigen CD14.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c14 : 1
stoichiometry:c40 : 1
stoichiometry:c18 : 1
stoichiometry:c13 : 1
m25*m28*0.1
nodelay
--
0
PMID: 1373512, 1698311 In experiments that gave first evidence for CD14 being the receptor for LBP/LPS complexes, anti-CD 14 mAb 3C IO and 6Ob were able to inhibit LBP/LPS-mediated effects, including TNF production and opsonin function.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1
m5*m31*0.1
nodelay
--
0
PMID: 1373512, 2254981 Known serum proteins that bind to lipid A moiety of LPS include albumin, the complement proteins Cl and C3 and detoxifying as well as a down-modulating effect on LPS activities.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1
m5*m33*0.1
nodelay
--
0
PMID: 1373512, 2254981 Known serum proteins that bind to lipid A moiety of LPS include albumin, the complement proteins Cl and C3 and detoxifying as well as a down-modulating effect on LPS activities.
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--