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Our time-course studies show that plasma corticosterone levels are already maximally elevated 1 hour
after endotoxin administration.</csml:comment>
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</csml:processKinetic>
</csml:processSimulationProperty>
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<csml:comments>
<csml:comment type="text">PMID: 1315450, 2555127, 4719686, 3330674
endotoxin administration elevates plasma ACTH and glucocorticoid
levels in a variety of species including man.</csml:comment>
</csml:comments>
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<csml:comment type="text">PMID: 1315450, 3543052
The most predominant cytokines released by macrophages after endotoxin administration are interleukin-1 (ILl) and tumour necrosis factor (TNF)
which in turn induce other cytokines like interleukin 6.</csml:comment>
</csml:comments>
</csml:process>
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<csml:comment type="text">PMID: 1315450, 3543052
The most predominant cytokines released by macrophages after endotoxin administration are interleukin-1 (ILl) and tumour necrosis factor (TNF)
which in turn induce other cytokines like interleukin 6.</csml:comment>
</csml:comments>
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<csml:comment type="text">PMID: 1315450, 3543052
The most predominant cytokines released by macrophages after endotoxin administration are interleukin-1 (ILl) and tumour necrosis factor (TNF)
which in turn induce other cytokines like interleukin 6.</csml:comment>
</csml:comments>
</csml:process>
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The most predominant cytokines released by macrophages after endotoxin administration are interleukin-1 (ILl) and tumour necrosis factor (TNF)
which in turn induce other cytokines like interleukin 6.</csml:comment>
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The most predominant cytokines released by macrophages after endotoxin administration are interleukin-1 (ILl) and tumour necrosis factor (TNF)
which in turn induce other cytokines like interleukin 6.</csml:comment>
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The most predominant cytokines released by macrophages after endotoxin administration are interleukin-1 (ILl) and tumour necrosis factor (TNF)
which in turn induce other cytokines like interleukin 6.</csml:comment>
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The most predominant cytokines released by macrophages after endotoxin administration are interleukin-1 (ILl) and tumour necrosis factor (TNF)
which in turn induce other cytokines like interleukin 6.</csml:comment>
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The most predominant cytokines released by macrophages after endotoxin administration are interleukin-1 (ILl) and tumour necrosis factor (TNF)
which in turn induce other cytokines like interleukin 6.</csml:comment>
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The most predominant cytokines released by macrophages after endotoxin administration are interleukin-1 (ILl) and tumour necrosis factor (TNF)
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The most predominant cytokines released by macrophages after endotoxin administration are interleukin-1 (ILl) and tumour necrosis factor (TNF)
which in turn induce other cytokines like interleukin 6.</csml:comment>
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Injections of recombinant preparations of these 3 cytokines can induce the release of ACTH and corcorticosterone,
by an action involving the release of CRF from the hypothalamus.</csml:comment>
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Injections of recombinant preparations of these 3 cytokines can induce the release of ACTH and corcorticosterone,
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Injections of recombinant preparations of these 3 cytokines can induce the release of ACTH and corcorticosterone,
by an action involving the release of CRF from the hypothalamus.</csml:comment>
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Injections of recombinant preparations of these 3 cytokines can induce the release of ACTH and corcorticosterone,
by an action involving the release of CRF from the hypothalamus.</csml:comment>
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Injections of recombinant preparations of these 3 cytokines can induce the release of ACTH and corcorticosterone,
by an action involving the release of CRF from the hypothalamus.</csml:comment>
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Injections of recombinant preparations of these 3 cytokines can induce the release of ACTH and corcorticosterone,
by an action involving the release of CRF from the hypothalamus.</csml:comment>
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Injections of recombinant preparations of these 3 cytokines can induce the release of ACTH and corcorticosterone,
by an action involving the release of CRF from the hypothalamus.</csml:comment>
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endotoxin induces the activation of the complement system resulting in the
generation of C3a and CSa, which in turn can degranulate mast cells resulting in the release of vasoactive
substances, such as histamine.</csml:comment>
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<csml:comment type="text">PMID: 1315450
endotoxin induces the activation of the complement system resulting in the
generation of C3a and CSa, which in turn can degranulate mast cells resulting in the release of vasoactive
substances, such as histamine.</csml:comment>
</csml:comments>
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<csml:comment type="text">PMID: 1315450
endotoxin induces the activation of the complement system resulting in the
generation of C3a and CSa, which in turn can degranulate mast cells resulting in the release of vasoactive
substances, such as histamine.</csml:comment>
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