Entity
p38
--
MO000000022
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m31
10
infinite
0
TRANSPATH | MO000000022 |
--
NF-kappaB
--
MO000000058
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m26
10
infinite
0
TRANSPATH | MO000000058 |
--
IL-12
--
MO000017265
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2121
10
infinite
0
TRANSPATH | MO000017265 |
--
PI3K family
--
MO000017608
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2387
10
infinite
0
TRANSPATH | MO000017608 |
--
protein remnants
--
MO000019479
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m360980
10
infinite
0
TRANSPATH | MO000019479 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
PI3K family
--
e11
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m11
10
infinite
0
TRANSPATH | MO000017608 |
--
peptidoglycan
--
e12
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m12
0
infinite
0
--
CD40L
--
e13
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m13
0
infinite
0
--
CpG ODN
--
e14
cso30:c:Dna
cso30:i:CC_Cytosol
--
csml-variable:Double
m14
0
infinite
0
--
LPS:TLR4:MyD88
--
e15
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m15
0
infinite
0
--
LPS:TLR4:MyD88:IRAK
--
e16
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m16
0
infinite
0
--
LPS:TLR4:MyD88:IRAK{p}
--
e17
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m17
0
infinite
0
--
LPS:TLR4:MyD88:IRAK{p}:Tollip
--
e18
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m18
0
infinite
0
--
LPS:TLR4:MyD88:IRAK{p}:Tollip:TRAF6
--
e19
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
TAK1{active}
--
e20
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m20
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000016574 |
--
TLR2 ligand
--
e22
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m22
0
infinite
0
--
TLR2 ligand: TLR2
--
e23
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m23
0
infinite
0
--
LPS:TLR4:MYD88:PI3K
--
e25
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m25
0
infinite
0
--
NF-kappaB{active}
--
e26
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m27
10
infinite
0
TRANSPATH | MO000000058 |
--
MAP3K
--
e27
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m28
0
infinite
0
--
MAP3K{active}
--
e28
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
p38{active}
--
e30
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m32
10
infinite
0
TRANSPATH | MO000000022 |
--
ASK1{p}
--
e33
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m35
0
infinite
0
--
RelA-p65
--
e35
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m37
0
infinite
0
--
IkappaB-alpha:NF-kappaB
--
e36
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m38
0
infinite
0
--
IkappaB-alpha{p}:NF-kappaB
--
e37
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m39
0
infinite
0
--
NF-kappaB{active}
--
e38
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m40
10
infinite
0
TRANSPATH | MO000000058 |
--
IL-12p40
--
e39
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m41
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
csml-variable:Double
m42
0
infinite
0
--
LPS:TLR4
--
e5
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
IL-12
--
e6
cso30:c:mRNA
cso30:i:CC_Cytosol
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m155666*m3961*0.1
nodelay
--
0
PMID: 12860525, 7612223, 10973276 Stimulation through TLRs by PAMPs, such as lipopolysaccharide (LPS) (endotoxin), triggers production of various cytokines, including interleukin-12 (IL-12), which is a crucial inducer of Th1 responses.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c29 : 1
stoichiometry:c28 : 1
m6*m14*0.1
nodelay
--
0
PMID: 12860525, 12154357, 11101877, 9195953, 10635328, 7507510, 11509631 PI3Ks are activated in DCs by many distinct stimuli, including LPS, peptidoglycan, CpG-oligodeoxynucleotide (CpG-ODN), CD40L and RANKL (receptor activator of NF-¦ÊB ligand), all of which induce IL-12 production.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1
m1572*m5*0.1
nodelay
--
0
PMID: 12860525, 16924467, 12524386 PI3K is activated after triggering of many TLR members, suggesting the presence of ¡Æshared¡Ç signaling pathway(s) for TLR-mediated activation of PI3K. MyD88, TOLLIP (Toll-interacting protein), IRAK and TRAF6 [tumor necrosis factor (TNF) receptor-associated factor 6] are involved in such ¡Æshared¡Ç signaling pathway(s).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1
m184*m15*0.1
nodelay
--
0
PMID: 12860525, 16924467, 12524386 PI3K is activated after triggering of many TLR members, suggesting the presence of ¡Æshared¡Ç signaling pathway(s) for TLR-mediated activation of PI3K. MyD88, TOLLIP (Toll-interacting protein), IRAK and TRAF6 [tumor necrosis factor (TNF) receptor-associated factor 6] are involved in such ¡Æshared¡Ç signaling pathway(s).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
m16*0.1
nodelay
--
0
PMID: 12860525, 16924467, 12524386 PI3K is activated after triggering of many TLR members, suggesting the presence of ¡Æshared¡Ç signaling pathway(s) for TLR-mediated activation of PI3K. MyD88, TOLLIP (Toll-interacting protein), IRAK and TRAF6 [tumor necrosis factor (TNF) receptor-associated factor 6] are involved in such ¡Æshared¡Ç signaling pathway(s).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1
m17*m3973*0.1
nodelay
--
0
PMID: 12860525, 16924467, 12524386 PI3K is activated after triggering of many TLR members, suggesting the presence of ¡Æshared¡Ç signaling pathway(s) for TLR-mediated activation of PI3K. MyD88, TOLLIP (Toll-interacting protein), IRAK and TRAF6 [tumor necrosis factor (TNF) receptor-associated factor 6] are involved in such ¡Æshared¡Ç signaling pathway(s).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1
m18*m183*0.1
nodelay
--
0
PMID: 12860525, 16924467, 12524386 PI3K is activated after triggering of many TLR members, suggesting the presence of ¡Æshared¡Ç signaling pathway(s) for TLR-mediated activation of PI3K. MyD88, TOLLIP (Toll-interacting protein), IRAK and TRAF6 [tumor necrosis factor (TNF) receptor-associated factor 6] are involved in such ¡Æshared¡Ç signaling pathway(s).
p16
p16
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c46 : 1
stoichiometry:c45 : 1
m1573*m19*0.1
nodelay
--
0
PMID: 12860525, 11129660, 11460167 In TLR4 signaling, TAK1 (transforming growth factor ¦Â-activated kinase 1) and TRAF6 pathways are operative in PI3K activation downstream of TLR4.
p17
p17
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c49 : 1
stoichiometry:c48 : 1
m2387*m20*0.1
nodelay
--
0
PMID: 12860525, 11129660, 11460167 In TLR4 signaling, TAK1 (transforming growth factor ¦Â-activated kinase 1) and TRAF6 pathways are operative in PI3K activation downstream of TLR4.
p18
p18
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c52 : 1
stoichiometry:c51 : 1
m207*m20*0.1
nodelay
--
0
PMID: 12860525 confirmed pathway from fig.1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1
m22*m3964*0.1
nodelay
--
0
PMID: 12860525 TLR2 binds TLR2 ligand
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c4 : 1
m5*0.1
nodelay
--
0
PMID: 12860525, 7612223, 10973276 Stimulation through TLRs by PAMPs, such as lipopolysaccharide (LPS) (endotoxin), triggers production of various cytokines, including interleukin-12 (IL-12), which is a crucial inducer of Th1 responses.
p20
p20
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c58 : 1
stoichiometry:c57 : 1
m146*m23*0.1
nodelay
--
0
PMID: 12860525, 11101877 activation of PI3K downstream of TLR2 is mediated in a Rac1-dependent manner.
p21
p21
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c61 : 1
stoichiometry:c60 : 1
m2387*m24*0.1
nodelay
--
0
PMID: 12860525, 11101877 activation of PI3K downstream of TLR2 is mediated in a Rac1-dependent manner.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1
m15*m2387*0.1
nodelay
--
0
PMID: 12860525, 12616480 interaction of PI3K with MyD88 in response to LPS has been reported, demonstrating the importance of such ¡Æshared¡Ç signaling in the PI3K pathway
p23
p23
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c67 : 1
stoichiometry:c66 : 1
m26*m21*0.1
nodelay
--
0
PMID: 12860525 confirmed pathway from fig.1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c70 : 1
stoichiometry:c69 : 1
m28*m20*0.1
nodelay
--
0
--
p25
p25
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c73 : 1
stoichiometry:c89 : 1
stoichiometry:c72 : 1
m1875*m29*0.1
nodelay
--
0
PMID: 12860525 confirmed pathway from fig.1 PMID: 12860525, 11154276 Protein kinase B (PKB)-mediated phosphorylation of apoptosis signal-regulating kinase 1 (ASK1), one of the MAPK kinase kinases (MAPKK-Ks), blocks ASK1 kinase activity, leading to suppression of MAPK kinase 3 (MKK3) or MKK6, upstream regulators of p38
p26
p26
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c82 : 1
stoichiometry:c78 : 1
m31*m33*0.1
nodelay
--
0
PMID: 12860525 confirmed pathway from fig.1
p27
p27
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c88 : 1
stoichiometry:c87 : 1
m71*m34*0.1
nodelay
--
0
PMID: 12860525, 11154276 Protein kinase B (PKB)-mediated phosphorylation of apoptosis signal-regulating kinase 1 (ASK1), one of the MAPK kinase kinases (MAPKK-Ks), blocks ASK1 kinase activity, leading to suppression of MAPK kinase 3 (MKK3) or MKK6, upstream regulators of p38
p28
p28
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c81 : 1
stoichiometry:c90 : 1
stoichiometry:c80 : 1
m3613*m29*0.1
nodelay
--
0
PMID: 12860525, 11154276 Protein kinase B (PKB)-mediated phosphorylation of apoptosis signal-regulating kinase 1 (ASK1), one of the MAPK kinase kinases (MAPKK-Ks), blocks ASK1 kinase activity, leading to suppression of MAPK kinase 3 (MKK3) or MKK6, upstream regulators of p38
p29
p29
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c85 : 1
stoichiometry:c84 : 1
m45*m11*0.1
nodelay
--
0
PMID: 12860525, 9192891 activation of PKB is positively regulated by PI3K.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c8 : 1
stoichiometry:c6 : 1
m6*m5*0.1
nodelay
--
0
PMID: 12860525, 7612223, 10973276 Stimulation through TLRs by PAMPs, such as lipopolysaccharide (LPS) (endotoxin), triggers production of various cytokines, including interleukin-12 (IL-12), which is a crucial inducer of Th1 responses.
p30
p30
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c76 : 1
stoichiometry:c75 : 1
m31*m30*0.1
nodelay
--
0
PMID: 12860525 confirmed pathway from fig.1
p31
p31
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c97 : 1
stoichiometry:c93 : 1
m166*m11*0.1
nodelay
--
0
PMID: 12860525, 11101877, 10373529 NF-¦ÊB transactivation by the PI3K cascade in TLR2-mediated signaling is independent of I¦ÊB¦Á (inhibitor of NF-¦ÊB¦Á) degradation and triggered by PI3K-pathway-mediated p65 phosphorylation.
p32
p32
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c96 : 1
stoichiometry:c91 : 1
stoichiometry:c95 : 1
m31*m36*0.1
nodelay
--
0
PMID: 12860525, 11387313 PKB blocks kinase activity of MEKK3, another MAPKK-K upstream of p38.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c100 : 1
stoichiometry:c106 : 1
stoichiometry:c99 : 1
m38*m21*0.1
nodelay
--
0
PMID: 12860525, 12052830 inhibition of PI3K augments the phosphorylation and degradation of I¦ÊB¦Á, resulting in nuclear localization of NF-¦ÊB in monocytes.
p34
p34
cso30:i:ME_UnknownDegradation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c107 : 1
stoichiometry:c101 : 1
stoichiometry:c103 : 1
m39*0.1
nodelay
--
0
PMID: 12860525, 12052830 inhibition of PI3K augments the phosphorylation and degradation of I¦ÊB¦Á, resulting in nuclear localization of NF-¦ÊB in monocytes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c108 : 1
stoichiometry:c105 : 1
m27*0.1
nodelay
--
0
PMID: 12860525, 12052830 inhibition of PI3K augments the phosphorylation and degradation of I¦ÊB¦Á, resulting in nuclear localization of NF-¦ÊB in monocytes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c109 : 1
m40*0.1
nodelay
--
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c110 : 1
m40*0.1
nodelay
--
0
PMID: 12860525, 7612223, 10973276 NF-¦ÊB activation is required for the transcription of both IL-12 p35 and p40
p4
p4
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c11 : 1
stoichiometry:c10 : 1
m2387*m12*0.1
nodelay
--
0
PMID: 12860525, 12154357, 11101877, 9195953, 10635328, 7507510, 11509631 PI3Ks are activated in DCs by many distinct stimuli, including LPS, peptidoglycan, CpG-oligodeoxynucleotide (CpG-ODN), CD40L and RANKL (receptor activator of NF-¦ÊB ligand), all of which induce IL-12 production.
p5
p5
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1
m13*m2387*0.1
nodelay
--
0
PMID: 12860525, 12154357, 11101877, 9195953, 10635328, 7507510, 11509631 PI3Ks are activated in DCs by many distinct stimuli, including LPS, peptidoglycan, CpG-oligodeoxynucleotide (CpG-ODN), CD40L and RANKL (receptor activator of NF-¦ÊB ligand), all of which induce IL-12 production.
p6
p6
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c17 : 1
stoichiometry:c16 : 1
m2387*m14*0.1
nodelay
--
0
PMID: 12860525, 12154357, 11101877, 9195953, 10635328, 7507510, 11509631 PI3Ks are activated in DCs by many distinct stimuli, including LPS, peptidoglycan, CpG-oligodeoxynucleotide (CpG-ODN), CD40L and RANKL (receptor activator of NF-¦ÊB ligand), all of which induce IL-12 production.
p7
p7
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c20 : 1
stoichiometry:c19 : 1
m2387*m3373*0.1
nodelay
--
0
PMID: 12860525, 12154357, 11101877, 9195953, 10635328, 7507510, 11509631 PI3Ks are activated in DCs by many distinct stimuli, including LPS, peptidoglycan, CpG-oligodeoxynucleotide (CpG-ODN), CD40L and RANKL (receptor activator of NF-¦ÊB ligand), all of which induce IL-12 production.
p8
p8
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c23 : 1
stoichiometry:c22 : 1
m6*m3373*0.1
nodelay
--
0
PMID: 12860525, 12154357, 11101877, 9195953, 10635328, 7507510, 11509631 PI3Ks are activated in DCs by many distinct stimuli, including LPS, peptidoglycan, CpG-oligodeoxynucleotide (CpG-ODN), CD40L and RANKL (receptor activator of NF-¦ÊB ligand), all of which induce IL-12 production.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c26 : 1
stoichiometry:c25 : 1
m6*m13*0.1
nodelay
--
0
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--