<?xml version="1.0" encoding="UTF-8" standalone="no"?>
<csml:project xmlns:csml="http://www.csml.org/csml/version3" majorVersion="3" minorVersion="0" projectID="local" projectVersionID="undef">
<csml:model modelID="undef" modelVersionID="undef">
<csml:entitySet>
<csml:entity id="MO000016882" name="LPS" refUnificationXrefID="ref748;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m155666">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="881.0" y="49.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="30.0" outlineColor="0 0 0 0" width="30.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_547081" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#547081;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_547081);stroke:none;" d="M 60 32.3743 l -33.6576 -5.4359 c -30.9833 -3.1573 6.111 -20.3941 -26.3424 15.4502 c -17.6949 -23.4208 -17.913 -2.7301 14.7891 -37.6391 l 12.3807 33.5667 c 12.9077 29.9752 -19.7446 4.5967 25.8135 16.4189 c -10.3176 27.9274 6.7221 17.7825 -38.1951 5.2648 l 21.2769 -28.1309 c 18.0746 -26.819 13.6337 15.7984 0.528 -31.8691 c 28.0124 -4.5076 11.1899 -15.0524 23.406 32.3743 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="MO000019394" name="TLR4" refUnificationXrefID="ref749;ref750;ref751;ref752;ref753;ref754;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m3961">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="973.0" y="221.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="30.0" outlineColor="0 0 0 0" width="30.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_932e3f" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#932e3f;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_932e3f);stroke:none;" d="M 60 48.54 l -0.3772 -11.808 c 13.6534 -12.4868 26.6272 14.8035 0.3772 -25.2737 l -11.9246 -3.3074 c -8.2669 -16.2079 23.0311 -19.5108 -25.1571 -8.1508 l -6.993 9.7635 c -18.7631 2.4691 -12.3928 -26.8612 -15.9253 20.2365 l 7.6025 9.3425 c -3.3288 17.7341 -30.6905 2.909 15.3149 20.6575 l 11.6914 -3.9898 c 16.7054 8.4916 -6.575 28.6596 25.3903 -7.4684 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e5" name="LPS:TLR4" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m5">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="917.5" y="220.9033106774831"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="39.096689322516994" outlineColor="0 0 0 0" resourceID="6" width="20.19995614996711"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="MO000017265" name="IL-12" refUnificationXrefID="ref755;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m2121">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1506.0" y="1202.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="36.0" outlineColor="0 0 0 0" width="36.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_517963" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#517963;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_517963);stroke:none;" d="M 60 42.4263 l -10.3315 -5.9498 c -7.3426 -1.6765 2.5901 -9.7445 8.9955 -7.5253 l -16.2377 -28.9512 l -5.9498 10.3315 c -1.6765 7.3426 -9.7445 -2.5901 -7.5253 -8.9955 l -28.9512 16.2377 l 10.3315 5.9498 c 7.3426 1.6765 -2.5901 9.7445 -8.9955 7.5253 l 16.2377 28.9512 l 5.9498 -10.3315 c 1.6765 -7.3426 9.7445 2.5901 7.5253 8.9955 l 28.9512 -16.2377 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e6" name="IL-12" type="cso30:c:mRNA">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m6">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="914.0" y="1336.5536332179931"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="23.446366782006923" outlineColor="0 0 0 0" resourceID="37" width="43.96193771626297"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="MO000017608" name="PI3K family" refUnificationXrefID="ref756;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m2387">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1086.0" y="406.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="28.0" outlineColor="0 0 0 0" width="28.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_b8a9e7" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#b8a9e7;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_b8a9e7);stroke:none;" d="M 60 42.4264 l -10.3098 -5.2865 l -7.2638 -37.1398 l -5.2865 10.3098 l -37.1398 7.2638 l 10.3098 5.2865 l 7.2638 37.1398 l 5.2865 -10.3098 l 37.1398 -7.2638 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e11" name="PI3K family" refUnificationXrefID="ref757;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m11">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1102.0" y="634.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="28.0" outlineColor="0 0 0 0" width="28.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_b8a9e7" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#b8a9e7;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_b8a9e7);stroke:none;" d="M 60 42.4264 l -10.3098 -5.2865 l -7.2638 -37.1398 l -5.2865 10.3098 l -37.1398 7.2638 l 10.3098 5.2865 l 7.2638 37.1398 l 5.2865 -10.3098 l 37.1398 -7.2638 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e12" name="peptidoglycan" type="cso30:c:SmallMolecule">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m12">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1122.0" y="83.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="34.0" outlineColor="0 0 0 0" resourceID="65" width="60.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Extracellular"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e13" name="CD40L" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m13">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1522.0" y="423.9674868189807"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="23.53251318101934" outlineColor="0 0 0 0" resourceID="5" width="36.20386643233744"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e14" name="CpG ODN" type="cso30:c:Dna">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m14">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1481.0" y="249.7589546298753"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="11.7410453701247" outlineColor="0 0 0 0" resourceID="3" width="54.18944016980632"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="MO000018743" name="RANKL" refUnificationXrefID="ref758;ref759;ref760;ref761;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m3373">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1471.0" y="567.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="34.0" outlineColor="0 0 0 0" width="34.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_6d8bf8" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#6d8bf8;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_6d8bf8);stroke:none;" d="M 58.6456 48.5412 l 1.3544 -14.6053 l -6.0764 -17.6637 c 1.5184 -5 -5.1273 -7.4507 4.722 -4.8131 l -13.8572 -5.7669 l -19.1427 0.1647 c -4.4181 -2.9501 -8.8669 2.4422 -3.2452 -5.8569 l -9.9186 11.0414 l -5.7542 17.7653 c -4.2488 3.1768 -0.3527 8.9601 -6.7276 1.1933 l 7.727 12.5907 l 15.5861 10.8149 c 1.792 4.9136 8.6489 3.0953 -0.9126 6.5944 l 14.6941 -3.2598 l 15.3872 -11.0816 c 5.3564 -0.14 5.698 -7.047 6.1634 2.8823 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e9" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m9">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="338.1290464948381" y="263.762512322074"/>
<csml:shape depth="81" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="1666.0816469283054" outlineColor="0 0 0 0" resourceID="20046" width="1039.7072281820178"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytoplasm"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e7" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m7">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="323.8665742250932" y="203.1424989161804"/>
<csml:shape depth="100" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="1717.3748564024186" outlineColor="0 0 0 0" resourceID="20004" width="1088.776044706119"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cell"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e10" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m10">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="319.97680906061726" y="223.34917005147813"/>
<csml:shape depth="72" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="1685.157138954838" outlineColor="0 0 0 0" resourceID="20045" width="1076.1393161571723"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e2" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m2">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="309.2799548583088" y="195.9213678790802"/>
<csml:shape depth="71" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="1794.4804119478729" outlineColor="0 0 0 0" resourceID="20064" width="1110.2160357146968"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e3" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m3">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="331.48427557260277" y="220.63872892519402"/>
<csml:shape depth="71" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="1745.0456898556456" outlineColor="0 0 0 0" resourceID="20065" width="1065.8073942861079"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e1" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m1">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="309.2799548583088" y="195.9213678790802"/>
<csml:shape depth="81" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="1794.4804119478729" outlineColor="0 0 0 0" resourceID="20003" width="1110.2160357146968"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_PlasmaMembrane"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e4" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m4">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="372.56226889404667" y="263.8941107558934"/>
<csml:shape depth="71" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="1658.5349261942463" outlineColor="0 0 0 0" resourceID="20066" width="983.6514076432215"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e54" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m54">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="544.2866002120593" y="1230.7960595113273"/>
<csml:shape depth="50" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="609.5103527707753" outlineColor="0 0 0 0" resourceID="20111" width="603.7564749712761"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_NuclearOuterMembrane"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e50" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m50">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="544.2866002120593" y="1230.7960595113273"/>
<csml:shape depth="50" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="609.5103527707753" outlineColor="0 0 0 0" resourceID="20112" width="603.7564749712761"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_NuclearEnvelopeLumen"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e56" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m56">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="553.2811100812778" y="1240.1827692562576"/>
<csml:shape depth="50" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="590.7369332809153" outlineColor="0 0 0 0" resourceID="20063" width="585.7674552328397"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Nucleoplasm"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e62" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m62">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="713.404495739711" y="1556.3840007274566"/>
<csml:shape depth="30" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="11.37175623278991" outlineColor="0 0 0 0" resourceID="20115" width="10.215577706963018"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_NuclearCentromere"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e60" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m60">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="686.5886042589324" y="1501.6574238571538"/>
<csml:shape depth="30" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="10.24787720644234" outlineColor="0 0 0 0" resourceID="20043" width="19.12008043538759"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Chromatin"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e61" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m61">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="685.9501306522473" y="1471.095828981531"/>
<csml:shape depth="40" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="131.13056405935882" outlineColor="0 0 0 0" resourceID="20114" width="65.44354468523198"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_NuclearChromosome"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e59" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m59">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="544.2866002120593" y="1230.7960595113273"/>
<csml:shape depth="60" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="609.5103527707753" outlineColor="0 0 0 0" resourceID="20022" width="603.7564749712761"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_NuclearEnvelope"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e53" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m53">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="553.2811100812778" y="1240.1827692562576"/>
<csml:shape depth="60" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="590.7369332809153" outlineColor="0 0 0 0" resourceID="20113" width="585.7674552328397"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_NuclearLumen"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e55" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m55">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="544.2866002120593" y="1230.7960595113273"/>
<csml:shape depth="70" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="609.5103527707753" outlineColor="0 0 0 0" resourceID="20025" width="603.7564749712761"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Nucleus"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e52" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m52">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="552.1567963476252" y="1238.9312079569327"/>
<csml:shape depth="50" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="593.2400558795632" outlineColor="0 0 0 0" resourceID="20110" width="588.0160827001447"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_NuclearInnerMembrane"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e51" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m51">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="609.4967967638918" y="1245.2405687833166"/>
<csml:shape depth="50" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="590.7369332809153" outlineColor="0 0 0 0" resourceID="20021" width="353.03451236681724"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_NuclearPore"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e57" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m57">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="985.0175838037542" y="1481.1083193761222"/>
<csml:shape depth="40" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="38.010543927352536" outlineColor="0 0 0 0" resourceID="20117" width="37.71938721379395"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_NuclearBody"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e58" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m58">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="886.0779752423531" y="1656.3269012814794"/>
<csml:shape depth="40" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="107.6342717418618" outlineColor="0 0 0 0" resourceID="20062" width="106.80980469696685"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Nucleolus"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e8" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m8">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="327.7563393895691" y="233.45250561912724"/>
<csml:shape depth="90" shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="system" fileType="resourceFile" height="1688.2222588225413" outlineColor="0 0 0 0" resourceID="20068" width="1044.4758332919132"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cell_WithoutCellWall_"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="MO000016573" name="MyD88" refUnificationXrefID="ref762;ref763;ref764;ref765;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m1572">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="827.0" y="367.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="26.0" outlineColor="0 0 0 0" width="26.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_d14d35" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#d14d35;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_d14d35);stroke:none;" d="M 45.6589 40.7351 c -12.8034 -17.2246 -3.4958 -15.396 14.3411 -6.9145 c -5.6247 -21.6076 15.286 -16.8559 -23.1584 -3.4266 l 8.8172 -14.5467 c -20.2529 6.9178 -15.6471 -1.4149 -2.1102 -15.8473 c -22.1809 -1.2997 -11.2242 -19.8223 -10.3989 21.0812 l -11.038 -12.9242 c 0.2862 21.4997 -6.1744 14.5214 -15.6455 -2.8798 c -8.0838 20.8041 -22.2224 4.6053 16.7319 16.4554 l -15.639 6.5589 c 20.4302 6.3701 11.8309 10.3902 -7.5593 14.0677 c 17.1848 14.1568 -2.5103 22.6686 20.7392 -10.9109 l 1.3726 16.9777 c 12.3399 -17.563 13.4865 -8.0998 10.9738 11.5738 c 18.7046 -12.0544 20.6709 9.4044 -3.9138 -23.1991 l 16.4871 3.9342 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e15" name="LPS:TLR4:MyD88" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m15">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="826.5" y="221.59699027344465"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="36.40300972655534" outlineColor="0 0 0 0" resourceID="30" width="26.08882363736466"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol"/>
</csml:entity>
<csml:entity id="MO000000213" name="IRAK" refUnificationXrefID="ref766;ref767;ref768;ref769;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m184">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="753.0" y="393.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="38.0" outlineColor="0 0 0 0" width="38.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_71653d" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#71653d;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_71653d);stroke:none;" d="M 53.1117 45.8329 c -1.171 -4.7103 0.7422 -4.435 6.8883 -9.5688 l -0.7383 -5.3439 l -1.9522 -9.4672 c -3.3869 -5.177 0.4165 -2.7857 -2.6392 -6.1659 l -1.5587 -3.7825 c -4.8658 -0.348 -4.0114 -2.0724 -7.0211 -9.4728 l -5.338 -0.953 l -9.6559 -1.0788 c -5.9968 1.6041 -2.5349 -1.2548 -6.7114 0.5909 l -4.0985 0.3055 c -1.8364 4.4953 -3.2214 3.1542 -11.2276 3.7144 l -2.5607 4.7549 l -4.0154 8.8004 c -0.3192 6.1685 -1.9833 2.0101 -1.5088 6.5312 l -0.9744 3.9714 c 3.731 3.1263 2.0205 4.022 0.0822 11.7684 l 3.7554 3.8917 l 7.1741 6.5178 c 5.7995 2.2082 1.3091 2.4973 5.7788 3.4456 l 3.4963 2.1488 c 4.1421 -2.5631 4.4699 -0.6685 11.2784 3.559 l 4.8816 -2.3497 l 8.4493 -4.7722 c 3.9035 -4.8036 2.7924 -0.4669 5.0805 -4.4018 l 3.135 -2.6432 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e16" name="LPS:TLR4:MyD88:IRAK" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m16">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="759.0" y="218.5"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="42.5" outlineColor="0 0 0 0" resourceID="31" width="25.499999999999996"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol"/>
</csml:entity>
<csml:entity id="e17" name="LPS:TLR4:MyD88:IRAK{p}" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m17">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="687.0" y="217.58823529411768"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="44.411764705882355" outlineColor="0 0 0 0" resourceID="31" width="26.647058823529417"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol"/>
</csml:entity>
<csml:entity id="MO000019406" name="Tollip" refUnificationXrefID="ref770;ref771;ref772;ref773;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m3973">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="651.0" y="303.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="26.0" outlineColor="0 0 0 0" width="26.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_38ba17" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#38ba17;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_38ba17);stroke:none;" d="M 60 48.5415 c 0.8103 -7.397 2.3214 -19.8066 -3.5398 -20.1631 c 9.5776 -10.3066 -2.5463 -7.5712 3.5398 -16.9193 c -7.1467 -3.0187 -19.0893 -8.2203 -21.2568 -3.0292 c -7.3468 -11.8479 -8.3579 -0.0366 -15.8253 -8.4299 c -5.2269 5.5315 -14.1193 14.7258 -9.5978 18.2907 c -14.118 2.984 -2.6193 7.5483 -13.3201 11.7096 c 3.9166 6.4373 10.3631 17.3217 15.3246 14.3334 c -1.3787 13.6923 6.7392 4.7019 7.5932 15.6663 c 7.6473 -1.5531 20.5241 -4.0206 19.0691 -9.4324 c 13.2666 5.4782 6.7842 -4.643 18.013 -2.0267 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e18" name="LPS:TLR4:MyD88:IRAK{p}:Tollip" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m18">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="613.0" y="225.82352941176464"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="36.1764705882353" outlineColor="0 0 0 0" resourceID="31" width="21.70588235294118"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol"/>
</csml:entity>
<csml:entity id="MO000000212" name="TRAF6" refUnificationXrefID="ref774;ref775;ref776;ref777;ref778;ref779;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m183">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="579.0" y="291.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="34.0" outlineColor="0 0 0 0" width="34.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_8b1f27" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#8b1f27;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_8b1f27);stroke:none;" d="M 52.8059 47.4706 c -7.7431 -3.717 11.6089 -12.322 7.1941 -19.4363 l -0.9501 -11.2137 l -6.244 -1.3273 c -5.8784 6.3193 -7.9683 -15.0039 -16.0049 -12.9444 l -10.8101 -2.5489 l -3.1742 5.6121 c 4.11 7.6223 -16.5332 3.0487 -17.0856 11.4363 l -5.7311 9.6382 l 4.2819 4.7956 c 8.4188 -1.6086 -2.2498 16.888 5.4452 20.0122 l 7.2681 8.5056 l 5.8205 -2.6483 c 1.0928 -8.6166 15.143 7.3886 20.4506 0.9322 l 10.2227 -4.3818 l -0.6848 -6.4321 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e19" name="LPS:TLR4:MyD88:IRAK{p}:Tollip:TRAF6" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m19">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="508.0" y="224.4411764705883"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="39.55882352941178" outlineColor="0 0 0 0" resourceID="31" width="23.73529411764706"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol"/>
</csml:entity>
<csml:entity id="MO000016574" name="TAK1" refUnificationXrefID="ref780;ref781;ref782;ref783;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m1573">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="626.0" y="484.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="38.0" outlineColor="0 0 0 0" width="38.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_734776" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#734776;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_734776);stroke:none;" d="M 60 48.5414 l -12.552 -4.3536 c -4.9628 -1.2539 -2.3244 2.5466 0.8986 -11.5109 c -3.4541 -4.4437 1.7713 -4.7089 3.4554 -7.3184 c -4.1185 -5.6583 -4.2367 -1.5987 2.5591 -5.747 c 1.8754 -2.5235 3.97 -6.1708 5.6388 -8.1524 l -8.2323 10.0079 c -2.7874 4.1014 1.8281 2.8894 -11.2333 -4.3698 c -5.511 1.7512 -4.1616 -3.0574 -6.2505 -5.3869 c -6.9309 1.9769 -2.908 3.3384 -4.9561 -4.0908 c -1.9438 -2.4761 -4.944 -5.4979 -6.4099 -7.6197 l 7.4641 10.5389 c 3.24 3.7887 3.4544 -0.7608 -7.8409 8.8103 c 0.0483 5.5259 -4.3434 2.8195 -7.3185 3.9889 c -0.165 6.88 2.4396 3.6618 -5.6223 3.2188 c -3.0769 0.9931 -7.0254 2.7728 -9.6003 3.4432 l 12.8455 -3.4945 c 4.7898 -1.7598 0.3068 -3.3597 6.3871 9.8147 c 5.5407 1.664 1.4772 4.7998 1.7274 7.8523 c 6.8289 2.2753 4.4157 -1.0751 1.4814 6.08 c 0.0423 3.0898 0.6019 7.2116 0.4764 9.7476 l 0.4749 -12.6987 c -0.2796 -4.8764 -3.2648 -1.3155 11.7884 -2.7443 c 3.3761 -4.4975 5.2562 0.1471 8.386 0.8639 c 4.3855 -5.4739 0.2895 -4.3263 6.5377 0.5388 c 3.1029 0.9165 7.3975 1.6842 9.895 2.5812 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e20" name="TAK1{active}" refUnificationXrefID="ref784;ref785;ref786;ref787;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m20">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="697.0" y="617.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="38.0" outlineColor="0 0 0 0" width="38.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_734776" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#734776;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_734776);stroke:none;" d="M 60 48.5414 l -12.552 -4.3536 c -4.9628 -1.2539 -2.3244 2.5466 0.8986 -11.5109 c -3.4541 -4.4437 1.7713 -4.7089 3.4554 -7.3184 c -4.1185 -5.6583 -4.2367 -1.5987 2.5591 -5.747 c 1.8754 -2.5235 3.97 -6.1708 5.6388 -8.1524 l -8.2323 10.0079 c -2.7874 4.1014 1.8281 2.8894 -11.2333 -4.3698 c -5.511 1.7512 -4.1616 -3.0574 -6.2505 -5.3869 c -6.9309 1.9769 -2.908 3.3384 -4.9561 -4.0908 c -1.9438 -2.4761 -4.944 -5.4979 -6.4099 -7.6197 l 7.4641 10.5389 c 3.24 3.7887 3.4544 -0.7608 -7.8409 8.8103 c 0.0483 5.5259 -4.3434 2.8195 -7.3185 3.9889 c -0.165 6.88 2.4396 3.6618 -5.6223 3.2188 c -3.0769 0.9931 -7.0254 2.7728 -9.6003 3.4432 l 12.8455 -3.4945 c 4.7898 -1.7598 0.3068 -3.3597 6.3871 9.8147 c 5.5407 1.664 1.4772 4.7998 1.7274 7.8523 c 6.8289 2.2753 4.4157 -1.0751 1.4814 6.08 c 0.0423 3.0898 0.6019 7.2116 0.4764 9.7476 l 0.4749 -12.6987 c -0.2796 -4.8764 -3.2648 -1.3155 11.7884 -2.7443 c 3.3761 -4.4975 5.2562 0.1471 8.386 0.8639 c 4.3855 -5.4739 0.2895 -4.3263 6.5377 0.5388 c 3.1029 0.9165 7.3975 1.6842 9.895 2.5812 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="MO000000248" name="IKK" refUnificationXrefID="ref788;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m207">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="782.0" y="734.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="28.0" outlineColor="0 0 0 0" width="28.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_11f29d" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#11f29d;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_11f29d);stroke:none;" d="M 60 42.4263 c -0.3693 -0.8655 8.2994 -5.4905 -7.9574 -3.6103 c -2.2005 -5.1493 6.1278 -2.0621 -11.4802 -10.6206 l 1.864 -28.1954 c -0.8655 0.3693 -5.4905 -8.2994 -3.6103 7.9574 c -5.1493 2.2005 -2.0621 -6.1278 -10.6206 11.4802 l -28.1954 -1.864 c 0.3693 0.8655 -8.2994 5.4905 7.9574 3.6103 c 2.2005 5.1493 -6.1278 2.0621 11.4802 10.6206 l -1.864 28.1954 c 0.8655 -0.3693 5.4905 8.2994 3.6103 -7.9574 c 5.1493 -2.2005 2.0621 6.1278 10.6206 -11.4802 l 28.1954 1.864 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e21" name="IKK{active}" refUnificationXrefID="ref789;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m21">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="790.0" y="878.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="28.0" outlineColor="0 0 0 0" width="28.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_11f29d" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#11f29d;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_11f29d);stroke:none;" d="M 60 42.4263 c -0.3693 -0.8655 8.2994 -5.4905 -7.9574 -3.6103 c -2.2005 -5.1493 6.1278 -2.0621 -11.4802 -10.6206 l 1.864 -28.1954 c -0.8655 0.3693 -5.4905 -8.2994 -3.6103 7.9574 c -5.1493 2.2005 -2.0621 -6.1278 -10.6206 11.4802 l -28.1954 -1.864 c 0.3693 0.8655 -8.2994 5.4905 7.9574 3.6103 c 2.2005 5.1493 -6.1278 2.0621 11.4802 10.6206 l -1.864 28.1954 c 0.8655 -0.3693 5.4905 8.2994 3.6103 -7.9574 c 5.1493 -2.2005 2.0621 6.1278 10.6206 -11.4802 l 28.1954 1.864 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="MO000019397" name="TLR2" refUnificationXrefID="ref790;ref791;ref792;ref793;ref794;ref795;ref796;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m3964">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="337.0" y="349.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="30.0" outlineColor="0 0 0 0" width="30.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_930942" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#930942;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_930942);stroke:none;" d="M 60 48.54 l -0.3772 -11.808 c 13.6534 -12.4868 26.6272 14.8035 0.3772 -25.2737 l -11.9246 -3.3074 c -8.2669 -16.2079 23.0311 -19.5108 -25.1571 -8.1508 l -6.993 9.7635 c -18.7631 2.4691 -12.3928 -26.8612 -15.9253 20.2365 l 7.6025 9.3425 c -3.3288 17.7341 -30.6905 2.909 15.3149 20.6575 l 11.6914 -3.9898 c 16.7054 8.4916 -6.575 28.6596 25.3903 -7.4684 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e22" name="TLR2 ligand" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m22">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="62.0" y="377.62126537785593"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="28.87873462214412" outlineColor="0 0 0 0" resourceID="5" width="44.42882249560633"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol"/>
</csml:entity>
<csml:entity id="e23" name="TLR2 ligand: TLR2" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m23">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="333.5" y="426.4698531023897"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="42.53014689761017" outlineColor="0 0 0 0" resourceID="6" width="21.973909230431925"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol"/>
</csml:entity>
<csml:entity id="MO000000166" name="Rac1" refUnificationXrefID="ref797;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m146">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="434.0" y="566.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="28.0" outlineColor="0 0 0 0" width="28.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_a95a36" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#a95a36;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_a95a36);stroke:none;" d="M 60 48.5409 c -1.0809 -5.6647 7.5121 -7.6315 -13.4071 -3.2725 c -3.7181 0.3841 6.3256 -8.7011 11.1947 -4.4078 l 2.212 -29.4019 c -5.9988 -0.773 -5.3099 -9.1533 -7.4155 11.1156 c -0.7646 3.4817 -6.7464 -8.4103 -0.9484 -11.488 l -28.7179 -11.0864 c -2.6267 5.187 -10.7938 1.9744 8.8238 10.1424 c 3.2455 1.7675 -10.4949 3.5034 -11.7809 -2.6923 l -19.9607 22.5499 c 4.3752 3.9787 -1.3613 10.3733 12.869 -4.8473 c 2.7704 -2.3894 0.2602 10.5756 -6.3328 9.824 l 16.3816 25.0233 c 5.3309 -2.7281 9.9528 4.4367 -0.8703 -13.1382 c -1.5332 -3.2443 10.6559 3.0326 7.8671 8.7637 l 30.0854 -7.085 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e24" name="Rac1{active}" refUnificationXrefID="ref798;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m24">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="502.0" y="650.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="28.0" outlineColor="0 0 0 0" width="28.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_a95a36" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#a95a36;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_a95a36);stroke:none;" d="M 60 48.5409 c -1.0809 -5.6647 7.5121 -7.6315 -13.4071 -3.2725 c -3.7181 0.3841 6.3256 -8.7011 11.1947 -4.4078 l 2.212 -29.4019 c -5.9988 -0.773 -5.3099 -9.1533 -7.4155 11.1156 c -0.7646 3.4817 -6.7464 -8.4103 -0.9484 -11.488 l -28.7179 -11.0864 c -2.6267 5.187 -10.7938 1.9744 8.8238 10.1424 c 3.2455 1.7675 -10.4949 3.5034 -11.7809 -2.6923 l -19.9607 22.5499 c 4.3752 3.9787 -1.3613 10.3733 12.869 -4.8473 c 2.7704 -2.3894 0.2602 10.5756 -6.3328 9.824 l 16.3816 25.0233 c 5.3309 -2.7281 9.9528 4.4367 -0.8703 -13.1382 c -1.5332 -3.2443 10.6559 3.0326 7.8671 8.7637 l 30.0854 -7.085 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e25" name="LPS:TLR4:MYD88:PI3K" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m25">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1032.0" y="219.67647058823525"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="41.32352941176471" outlineColor="0 0 0 0" resourceID="31" width="24.794117647058822"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol"/>
</csml:entity>
<csml:entity id="MO000000058" name="NF-kappaB" refUnificationXrefID="ref799;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m26">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1014.0" y="882.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="24.0" outlineColor="0 0 0 0" width="24.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_c0a85b" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#c0a85b;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_c0a85b);stroke:none;" d="M 59.9987 30 c -33.2435 0.7613 5.9036 22.2992 -25.8364 -16.4278 l -1.8953 25.5774 c -14.6426 13.9063 -31.9178 -9.3883 -29.5118 -39.1497 c 17.3491 25.7524 18.323 -15.7914 -2.7553 28.5239 l 25.3495 -11.2984 c 20.5888 4.5578 7.0015 29.7852 -22.5942 42.7745 c 15.8957 -26.5149 -24.2266 -6.5088 28.5917 -12.0961 l -23.4542 -14.2779 c -5.9449 -18.4641 24.9151 -20.397 52.1072 -3.6249 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e26" name="NF-kappaB{active}" refUnificationXrefID="ref800;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m27">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1024.0" y="1008.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="24.0" outlineColor="0 0 0 0" width="24.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_c0a85b" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#c0a85b;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_c0a85b);stroke:none;" d="M 59.9987 30 c -33.2435 0.7613 5.9036 22.2992 -25.8364 -16.4278 l -1.8953 25.5774 c -14.6426 13.9063 -31.9178 -9.3883 -29.5118 -39.1497 c 17.3491 25.7524 18.323 -15.7914 -2.7553 28.5239 l 25.3495 -11.2984 c 20.5888 4.5578 7.0015 29.7852 -22.5942 42.7745 c 15.8957 -26.5149 -24.2266 -6.5088 28.5917 -12.0961 l -23.4542 -14.2779 c -5.9449 -18.4641 24.9151 -20.397 52.1072 -3.6249 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e27" name="MAP3K" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m28">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="519.0" y="779.4682028577179"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="26.03179714228215" outlineColor="0 0 0 0" resourceID="11" width="42.21372509559267"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol"/>
</csml:entity>
<csml:entity id="e28" name="MAP3K{active}" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m29">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="482.0" y="841.1466089756489"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="22.353391024350977" outlineColor="0 0 0 0" resourceID="11" width="36.24874220165023"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol"/>
</csml:entity>
<csml:entity id="MO000016966" name="MKK3" refUnificationXrefID="ref801;ref802;ref803;ref804;ref805;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m1875">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="661.0" y="865.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="30.0" outlineColor="0 0 0 0" width="30.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_99954c" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#99954c;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_99954c);stroke:none;" d="M 59.9995 48.5413 c -3.667 -8.7159 -7.5004 -11.8246 -10.1344 -6.3316 l 10.1344 -30.7504 c -9.8488 0.6236 -14.1423 3.13 -9.4632 7.2098 l -27.6184 -18.669 c -2.4202 9.1014 -1.24 13.7592 4.2857 10.7878 l -27.2036 19.2122 c 8.3534 5.0015 13.3756 5.3735 12.1118 -0.5427 l 10.806 30.5427 c 7.5826 -6.0101 9.5066 -10.438 3.2001 -11.1233 l 33.882 -0.3359 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e29" name="MKK3{active}" refUnificationXrefID="ref806;ref807;ref808;ref809;ref810;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m30">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="661.0" y="1017.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="30.0" outlineColor="0 0 0 0" width="30.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_99954c" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#99954c;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_99954c);stroke:none;" d="M 59.9995 48.5413 c -3.667 -8.7159 -7.5004 -11.8246 -10.1344 -6.3316 l 10.1344 -30.7504 c -9.8488 0.6236 -14.1423 3.13 -9.4632 7.2098 l -27.6184 -18.669 c -2.4202 9.1014 -1.24 13.7592 4.2857 10.7878 l -27.2036 19.2122 c 8.3534 5.0015 13.3756 5.3735 12.1118 -0.5427 l 10.806 30.5427 c 7.5826 -6.0101 9.5066 -10.438 3.2001 -11.1233 l 33.882 -0.3359 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="MO000000022" name="p38" refUnificationXrefID="ref811;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m31">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="536.0" y="1072.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="24.0" outlineColor="0 0 0 0" width="24.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_108fbd" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#108fbd;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_108fbd);stroke:none;" d="M 58.5031 41.8065 c 2.0655 -1.1946 0.9878 -3.024 1.4969 -1.4202 l -2.3306 -16.7022 l -6.1006 -19.6178 c 1.7073 -4.6618 -1.0284 -5.2163 -9.7624 -2.5694 c -1.1946 -2.0655 -3.024 -0.9878 -1.4202 -1.4969 l -16.7022 2.3306 l -19.6178 6.1006 c -4.6618 -1.7073 -5.2163 1.0284 -2.5694 9.7624 c -2.0655 1.1946 -0.9878 3.024 -1.4969 1.4202 l 2.3306 16.7022 l 6.1006 19.6178 c -1.7073 4.6618 1.0284 5.2163 9.7624 2.5694 c 1.1946 2.0655 3.024 0.9878 1.4202 1.4969 l 16.7022 -2.3306 l 19.6178 -6.1006 c 4.6618 1.7073 5.2163 -1.0284 2.5694 -9.7624 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e30" name="p38{active}" refUnificationXrefID="ref812;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m32">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="536.0" y="1200.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="24.0" outlineColor="0 0 0 0" width="24.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_108fbd" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#108fbd;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_108fbd);stroke:none;" d="M 58.5031 41.8065 c 2.0655 -1.1946 0.9878 -3.024 1.4969 -1.4202 l -2.3306 -16.7022 l -6.1006 -19.6178 c 1.7073 -4.6618 -1.0284 -5.2163 -9.7624 -2.5694 c -1.1946 -2.0655 -3.024 -0.9878 -1.4202 -1.4969 l -16.7022 2.3306 l -19.6178 6.1006 c -4.6618 -1.7073 -5.2163 1.0284 -2.5694 9.7624 c -2.0655 1.1946 -0.9878 3.024 -1.4969 1.4202 l 2.3306 16.7022 l 6.1006 19.6178 c -1.7073 4.6618 1.0284 5.2163 9.7624 2.5694 c 1.1946 2.0655 3.024 0.9878 1.4202 1.4969 l 16.7022 -2.3306 l 19.6178 -6.1006 c 4.6618 1.7073 5.2163 -1.0284 2.5694 -9.7624 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="MO000019005" name="MKK6" refUnificationXrefID="ref813;ref814;ref815;ref816;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m3613">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="414.0" y="886.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="28.0" outlineColor="0 0 0 0" width="28.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_8e984c" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#8e984c;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_8e984c);stroke:none;" d="M 59.9995 48.5413 c -3.667 -8.7159 -7.5004 -11.8246 -10.1344 -6.3316 l 10.1344 -30.7504 c -9.8488 0.6236 -14.1423 3.13 -9.4632 7.2098 l -27.6184 -18.669 c -2.4202 9.1014 -1.24 13.7592 4.2857 10.7878 l -27.2036 19.2122 c 8.3534 5.0015 13.3756 5.3735 12.1118 -0.5427 l 10.806 30.5427 c 7.5826 -6.0101 9.5066 -10.438 3.2001 -11.1233 l 33.882 -0.3359 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e31" name="MKK6{active}" refUnificationXrefID="ref817;ref818;ref819;ref820;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m33">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="446.0" y="1018.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="28.0" outlineColor="0 0 0 0" width="28.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_8e984c" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#8e984c;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_8e984c);stroke:none;" d="M 59.9995 48.5413 c -3.667 -8.7159 -7.5004 -11.8246 -10.1344 -6.3316 l 10.1344 -30.7504 c -9.8488 0.6236 -14.1423 3.13 -9.4632 7.2098 l -27.6184 -18.669 c -2.4202 9.1014 -1.24 13.7592 4.2857 10.7878 l -27.2036 19.2122 c 8.3534 5.0015 13.3756 5.3735 12.1118 -0.5427 l 10.806 30.5427 c 7.5826 -6.0101 9.5066 -10.438 3.2001 -11.1233 l 33.882 -0.3359 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="MO000000048" name="AKT" refUnificationXrefID="ref821;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m45">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="868.0" y="604.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="32.0" outlineColor="0 0 0 0" width="32.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_2246f4" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#2246f4;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_2246f4);stroke:none;" d="M 60 42.4263 c 4.3954 -0.6872 5.4255 -3.2779 -10.8951 -10.4523 c -2.9003 -6.5545 3.4678 -5.7125 -6.1033 -4.2315 l -0.5754 -27.7424 c -0.6872 -4.3954 -3.2779 -5.4255 -10.4523 10.8951 c -6.5545 2.9003 -5.7125 -3.4678 -4.2315 6.1033 l -27.7424 0.5754 c -4.3954 0.6872 -5.4255 3.2779 10.8951 10.4523 c 2.9003 6.5545 -3.4678 5.7125 6.1033 4.2315 l 0.5754 27.7424 c 0.6872 4.3954 3.2779 5.4255 10.4523 -10.8951 c 6.5545 -2.9003 5.7125 3.4678 4.2315 -6.1033 l 27.7424 -0.5754 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e32" name="AKT{active}" refUnificationXrefID="ref822;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m34">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="872.0" y="732.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="32.0" outlineColor="0 0 0 0" width="32.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_2246f4" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#2246f4;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_2246f4);stroke:none;" d="M 60 42.4263 c 4.3954 -0.6872 5.4255 -3.2779 -10.8951 -10.4523 c -2.9003 -6.5545 3.4678 -5.7125 -6.1033 -4.2315 l -0.5754 -27.7424 c -0.6872 -4.3954 -3.2779 -5.4255 -10.4523 10.8951 c -6.5545 2.9003 -5.7125 -3.4678 -4.2315 6.1033 l -27.7424 0.5754 c -4.3954 0.6872 -5.4255 3.2779 10.8951 10.4523 c 2.9003 6.5545 -3.4678 5.7125 6.1033 4.2315 l 0.5754 27.7424 c 0.6872 4.3954 3.2779 5.4255 10.4523 -10.8951 c 6.5545 -2.9003 5.7125 3.4678 4.2315 -6.1033 l 27.7424 -0.5754 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="MO000000079" name="ASK1" refUnificationXrefID="ref823;ref824;ref825;ref826;ref827;ref828;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m71">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="974.0" y="710.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="28.0" outlineColor="0 0 0 0" width="28.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_3cc3af" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#3cc3af;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_3cc3af);stroke:none;" d="M 47.9547 46.6051 c -3.6097 -2.0562 2.853 -8.4259 4.8183 -8.1992 c -4.312 -5.4627 4.0855 -10.3128 -5.9493 -6.1515 c 3.5523 -2.1894 11.1716 -7.328 13.1763 -8.4744 c 5.6331 -2.585 5.0806 -3.2383 -12.0453 -4.821 c -2.9972 2.9326 -6.8295 -5.4236 -6.0146 -7.2963 c -6.3314 2.5738 -8.175 -7.2247 -7.4682 3.9793 c -0.9057 -4.1878 -3.2542 -13.3065 -3.6833 -15.6421 c -0.6247 -6.3667 -1.3937 -6.0221 -8.1341 10.4157 c 1.7575 3.8686 -7.0735 5.0742 -8.5356 3.6899 c 0.3987 7.0532 -9.1378 5.8476 1.3337 8.6109 c -4.1121 -0.399 -13.1827 -0.8957 -15.4527 -1.1933 c -6.0192 -1.3499 -5.9417 -0.4837 7.0182 11.2581 c 4.0834 -0.5415 2.4576 8.5594 0.7392 9.5767 c 6.5779 1.7855 2.5275 10.8386 8.2924 1.3425 c -1.6359 3.9413 -4.8933 12.7528 -5.8671 14.9048 c -3.0956 5.5325 -2.2785 5.7234 12.4716 -3.458 c 0.7664 -4.2034 8.5923 0.2159 8.9924 2.2289 c 3.6664 -5.9498 10.7001 0.8514 3.791 -7.7811 c 3.1013 2.8345 10.1582 8.7772 11.8268 10.4049 c 4.1064 4.7691 4.5337 4.0207 0.6897 -13.3953 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e33" name="ASK1{p}" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m35">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="954.0" y="829.4390243902438"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="29.560975609756095" outlineColor="0 0 0 0" resourceID="32" width="36.95121951219513"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol"/>
</csml:entity>
<csml:entity id="e34" name="MEKK3" refUnificationXrefID="ref829;ref830;ref831;ref832;ref833;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m36">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="822.0" y="1086.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="28.0" outlineColor="0 0 0 0" width="28.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_74b2b1" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#74b2b1;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_74b2b1);stroke:none;" d="M 58.2321 48.608 c 2.4836 -10.1813 2.4454 -2.8183 -9.4386 -7.3298 c -2.6271 -1.7676 4.6702 -16.8723 11.2065 -25.3691 c -4.0856 -15.1425 -17.5887 -1.2995 -1.7685 -4.1665 c -9.1716 -5.4476 -1.9961 -3.1363 -10.072 6.4801 c -2.5377 1.8879 -15.0275 -9.5408 -21.3033 -18.2227 c -16.0455 -0.8938 -6.7033 15.8954 -4.6138 0.3506 c -8.1519 6.8147 -3.6787 0.8801 3.2135 11.3347 c 1.0586 2.9347 -13.9577 10.9754 -24.3726 14.1066 c -5.8306 14.5902 13.4455 11.1227 -1.0833 4.3831 c 4.1333 9.6588 -0.2776 3.6806 12.0581 0.5254 c 3.1917 -0.0745 6.401 16.3239 6.2399 26.9413 c 12.4416 9.9109 15.0134 -9.0205 3.9445 2.3583 c 10.7066 -0.8451 3.5069 1.3946 4.2391 -11.0098 c 0.9139 -2.9805 17.914 -0.8869 28.2289 2.5439 c 13.5202 -8.4648 -4.1668 -16.6981 3.521 -2.9261 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="MO000000193" name="RelA-p65" refUnificationXrefID="ref834;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m166">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1119.0" y="811.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="26.0" outlineColor="0 0 0 0" width="26.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_2dba73" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#2dba73;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_2dba73);stroke:none;" d="M 51.9614 51.9613 c 2.0554 -1.43 -4.5487 -7.9459 2.0928 -10.7024 c -2.3065 -8.6059 -8.9448 -2.7239 2.2109 -7.3301 c -3.7433 -8.9875 -14.8657 -1.1754 3.7349 -11.9673 c -0.2109 -2.4953 -9.1557 -0.0333 -8.2222 -7.1638 c -8.6062 -2.3053 -6.8311 6.3845 -5.2429 -5.5795 c -9.655 -1.2521 -8.4507 12.2866 -8.4965 -9.2181 c -2.2663 -1.0653 -4.607 7.9126 -10.315 3.5389 c -6.2997 6.3006 2.1133 9.1084 -7.4534 1.7506 c -5.9117 7.7354 6.415 13.462 -12.2315 2.7492 c -2.0554 1.43 4.5487 7.9459 -2.0928 10.7024 c 2.3065 8.6059 8.9448 2.7239 -2.2109 7.3301 c 3.7433 8.9875 14.8657 1.1754 -3.7349 11.9673 c 0.2109 2.4953 9.1557 0.0333 8.2222 7.1638 c 8.6062 2.3053 6.8311 -6.3845 5.2429 5.5795 c 9.655 1.2521 8.4507 -12.2866 8.4965 9.2181 c 2.2663 1.0653 4.607 -7.9126 10.315 -3.5389 c 6.2997 -6.3006 -2.1133 -9.1084 7.4534 -1.7506 c 5.9117 -7.7354 -6.415 -13.462 12.2315 -2.7492 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e35" name="RelA-p65" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m37">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1170.0" y="953.9268292682926"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="29.073170731707318" outlineColor="0 0 0 0" resourceID="32" width="36.34146341463415"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol"/>
</csml:entity>
<csml:entity id="e36" name="IkappaB-alpha:NF-kappaB" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m38">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="835.0" y="1003.0939226519336"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="26.9060773480663" outlineColor="0 0 0 0" resourceID="29" width="24.215469613259668"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol"/>
</csml:entity>
<csml:entity id="e37" name="IkappaB-alpha{p}:NF-kappaB" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m39">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="975.0" y="1037.1602209944751"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="28.83977900552486" outlineColor="0 0 0 0" resourceID="29" width="25.955801104972377"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol"/>
</csml:entity>
<csml:entity id="MO000019479" name="protein remnants" refUnificationXrefID="ref835;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m360980">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="872.0" y="1164.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="24.0" outlineColor="0 0 0 0" width="24.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_ab834f" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#ab834f;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_ab834f);stroke:none;" d="M 60 30 l -34.9569 -27.9966 l -17.8713 -2.0034 l -7.1718 43.775 l 7.1718 16.225 l 42.128 -15.7784 l 10.7001 -14.2216 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e38" name="NF-kappaB{active}" refUnificationXrefID="ref836;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m40">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="836.0" y="1316.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="internal" height="24.0" outlineColor="0 0 0 0" width="24.0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_c0a85b" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#c0a85b;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_c0a85b);stroke:none;" d="M 59.9987 30 c -33.2435 0.7613 5.9036 22.2992 -25.8364 -16.4278 l -1.8953 25.5774 c -14.6426 13.9063 -31.9178 -9.3883 -29.5118 -39.1497 c 17.3491 25.7524 18.323 -15.7914 -2.7553 28.5239 l 25.3495 -11.2984 c 20.5888 4.5578 7.0015 29.7852 -22.5942 42.7745 c 15.8957 -26.5149 -24.2266 -6.5088 28.5917 -12.0961 l -23.4542 -14.2779 c -5.9449 -18.4641 24.9151 -20.397 52.1072 -3.6249 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:entity>
<csml:entity id="e39" name="IL-12p40" type="cso30:c:mRNA">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m41">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="843.0" y="1522.840830449827"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="26.15916955017301" outlineColor="0 0 0 0" resourceID="37" width="49.048442906574394"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Nucleoplasm"/>
</csml:entity>
<csml:entity id="e40" name="IL-12p35" type="cso30:c:mRNA">
<csml:entitySimulationProperty>
<csml:variable type="csml-variable:Double" variableID="m42">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="954.0" y="1508.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="32.0" outlineColor="0 0 0 0" resourceID="37" width="60.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Nucleoplasm"/>
</csml:entity>
</csml:entitySet>
<csml:processSet>
<csml:process id="p1" name="p1" type="cso30:c:ProcessBiological">
<csml:connector id="c1" name="c1" refID="MO000016882" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="907.0" y="79.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" name="default" points="907.0 79.0 935.1294497188876 115.65352539127778" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="937.5093776971585 113.82706903586063 932.7495217406168 117.47998174669493 940.0 122.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:connector>
<csml:connector id="c2" name="c2" refID="MO000019394" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="953.8905685420692" y="148.45953172146886"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" name="default" points="982.0 221.0 953.8905685420692 148.45953172146886" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="951.0932441465184 149.5434949247448 956.6878929376201 147.37556851819292 951.0 141.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:connector>
<csml:connector id="c3" name="c3" refID="e5" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="932.4743082804015" y="141.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" name="default" points="946.0 141.0 932.4743082804015 213.13702250452542" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="935.4229248412045 213.68988810967596 929.5256917195985 212.58415689937485 931.0 220.99999999999997" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="938.0" y="122.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="19.0" outlineColor="0 0 0 0" resourceID="10005" width="19.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 7612223, 10973276
Stimulation through TLRs by PAMPs, such as lipopolysaccharide (LPS) (endotoxin), triggers production of various cytokines, including interleukin-12 (IL-12), which is a crucial inducer of Th1 responses.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p2" name="p2" type="cso30:c:ProcessBiological">
<csml:connector id="c7" name="c7" refID="e5" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="928.0" y="260.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" name="default" points="928.0 260.0 935.9375019072613 1276.0002441294496" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="938.9374103587177 1275.9768073446726 932.937593455805 1276.0236809142266 936.0 1283.9999999999998" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c4" name="c4" refID="e6" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="936.0" y="1307.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" name="default" points="936.0 1307.0 936.0 1329.0" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="939.0 1329.0 933.0 1329.0 936.0 1337.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="924.0" y="1284.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="23.0" outlineColor="0 0 0 0" resourceID="10068" width="23.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_GeneExpression" refCellComponentID="cso30:i:CC_Nucleoplasm"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 7612223, 10973276
Stimulation through TLRs by PAMPs, such as lipopolysaccharide (LPS) (endotoxin), triggers production of various cytokines, including interleukin-12 (IL-12), which is a crucial inducer of Th1 responses.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p3" name="p3" type="cso30:c:ProcessBiological">
<csml:connector id="c5" name="c5" refID="e6" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="958.0" y="1229.406376290639"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" name="default" points="958.0 1338.0 1188.761450382392 1229.406376290639" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1187.4840592734024 1226.691920184036 1190.0388414913816 1232.1208323972419 1196.0 1226.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:connector>
<csml:connector id="c8" name="c8" refID="e5" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="934.0" y="260.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" name="default" points="934.0 260.0 1202.8011593637789 1200.308114674769" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1205.6856163607404 1199.4835494361862 1199.9167023668172 1201.132679913352 1204.9999999999998 1208.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c6" name="c6" refID="MO000017265" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1219.0" y="1220.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" name="default" points="1219.0 1220.0 1498.0 1220.0" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1498.0 1217.0 1498.0 1223.0 1506.0 1220.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1196.0" y="1208.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="23.0" outlineColor="0 0 0 0" resourceID="10031" width="23.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Translation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 7612223, 10973276
Stimulation through TLRs by PAMPs, such as lipopolysaccharide (LPS) (endotoxin), triggers production of various cytokines, including interleukin-12 (IL-12), which is a crucial inducer of Th1 responses.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p4" name="p4" type="cso30:c:ProcessBiological">
<csml:connector id="c9" name="c9" refID="MO000017608" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1102.0" y="434.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" name="default" points="1102.0 434.0 1113.9373361106832 523.0708925181744" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1116.9107514163677 522.6723935596806 1110.9639208049985 523.4693914766682 1115.0 531.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:connector>
<csml:connector id="c11" name="c11" refID="e12" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1117.6548003536773" y="117.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" name="default" points="1151.0 117.0 1117.6548003536773 523.0268427522828" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1120.6447343215711 523.2723928849118 1114.6648663857834 522.7812926196539 1117.0 531.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c10" name="c10" refID="e11" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1116.0" y="550.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" name="default" points="1116.0 550.0 1116.0 626.0" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1119.0 626.0 1113.0 626.0 1116.0 634.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1106.0" y="530.5"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="19.5" outlineColor="0 0 0 0" resourceID="10003" width="19.5"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 12154357, 11101877, 9195953, 10635328, 7507510, 11509631
PI3Ks are activated in DCs by many distinct stimuli, including LPS, peptidoglycan, CpG-oligodeoxynucleotide (CpG-ODN), CD40L and RANKL (receptor activator of NF-κB ligand), all of which induce IL-12 production.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p5" name="p5" type="cso30:c:ProcessBiological">
<csml:connector id="c12" name="c12" refID="e13" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1192.3878542440334" y="444.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" name="default" points="1522.0 444.0 1192.3878542440334 580.9308617383838" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1193.5387810921395 583.7013070798963 1191.2369273959273 578.1604163968713 1185.0 584.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c13" name="c13" refID="MO000017608" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1106.0" y="434.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" name="default" points="1106.0 434.0 1167.7086629885496 570.7084226207867" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1170.4430045057545 569.4741712414927 1164.9743214713444 571.9426740000806 1171.0 578.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:connector>
<csml:connector id="c14" name="c14" refID="e11" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1135.6568542494924" y="597.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" name="default" points="1167.0 597.0 1135.6568542494924 628.3431457505076" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1137.778174593052 630.4644660940672 1133.5355339059327 626.2218254069479 1130.0 634.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1166.0" y="578.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="19.0" outlineColor="0 0 0 0" resourceID="10003" width="19.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 12154357, 11101877, 9195953, 10635328, 7507510, 11509631
PI3Ks are activated in DCs by many distinct stimuli, including LPS, peptidoglycan, CpG-oligodeoxynucleotide (CpG-ODN), CD40L and RANKL (receptor activator of NF-κB ligand), all of which induce IL-12 production.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p6" name="p6" type="cso30:c:ProcessBiological">
<csml:connector id="c15" name="c15" refID="MO000017608" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1086.0626638893168" y="434.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" name="default" points="1098.0 434.0 1086.0626638893168 523.0708925181744" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1089.0360791950013 523.4693914766683 1083.089248583632 522.6723935596807 1085.0 531.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:connector>
<csml:connector id="c17" name="c17" refID="e14" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1100.6463112182357" y="262.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" name="default" points="1500.0 262.0 1100.6463112182357 529.5472988882755" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1102.3160741351323 532.0396655951139 1098.9765483013389 527.054932181437 1093.9999999999998 534.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c16" name="c16" refID="e11" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1087.0" y="550.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" name="default" points="1087.0 550.0 1109.7179712418065 626.3323833724697" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1112.5933274771303 625.4766225881472 1106.8426150064827 627.1881441567923 1112.0 634.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1074.0" y="530.5"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="19.5" outlineColor="0 0 0 0" resourceID="10003" width="19.5"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 12154357, 11101877, 9195953, 10635328, 7507510, 11509631
PI3Ks are activated in DCs by many distinct stimuli, including LPS, peptidoglycan, CpG-oligodeoxynucleotide (CpG-ODN), CD40L and RANKL (receptor activator of NF-κB ligand), all of which induce IL-12 production.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p7" name="p7" type="cso30:c:ProcessBiological">
<csml:connector id="c18" name="c18" refID="MO000017608" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1112.0" y="434.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" name="default" points="1112.0 434.0 1180.6761642728218 511.0286707384352" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1182.9154127459085 509.03223234074335 1178.4369157997348 513.0251091361271 1186.0 517.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:connector>
<csml:connector id="c20" name="c20" refID="MO000018743" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1213.855840053257" y="531.5118786517589"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" name="default" points="1471.0 581.0 1213.855840053257 531.5118786517589" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1213.2888855588474 534.4578186717303 1214.4227945476666 528.5659386317875 1206.0 530.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c19" name="c19" refID="e11" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1129.437601569802" y="538.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" name="default" points="1189.0 538.0 1129.437601569802 627.3435976452972" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1131.9337524528155 629.0076982339729 1126.9414506867884 625.6794970566215 1125.0000000000002 633.9999999999999" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1185.0" y="517.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="21.0" outlineColor="0 0 0 0" resourceID="10003" width="21.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 12154357, 11101877, 9195953, 10635328, 7507510, 11509631
PI3Ks are activated in DCs by many distinct stimuli, including LPS, peptidoglycan, CpG-oligodeoxynucleotide (CpG-ODN), CD40L and RANKL (receptor activator of NF-κB ligand), all of which induce IL-12 production.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p8" name="p8" type="cso30:c:ProcessBiological">
<csml:connector id="c21" name="c21" refID="e6" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="958.0" y="1291.5254450313403"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" name="default" points="958.0 1344.0 1228.1467829868036 1291.5254450313403" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1227.574741100051 1288.5804886513915 1228.718824873556 1294.470401411289 1236.0 1290.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:connector>
<csml:connector id="c23" name="c23" refID="MO000018743" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1254.5802492992138" y="601.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" name="default" points="1482.0 601.0 1254.5802492992138 1268.4275292305676" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1257.419925837751 1269.395122717773 1251.7405727606767 1267.4599357433624 1252.0 1276.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c22" name="c22" refID="MO000017265" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1259.0" y="1225.9180813318717"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" name="default" points="1259.0 1285.0 1498.233342803733 1225.9180813318717" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1497.5140623042812 1223.0055848832715 1498.952623303185 1228.8305777804717 1506.0 1224.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1236.0" y="1276.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="23.0" outlineColor="0 0 0 0" resourceID="10031" width="23.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Translation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 12154357, 11101877, 9195953, 10635328, 7507510, 11509631
PI3Ks are activated in DCs by many distinct stimuli, including LPS, peptidoglycan, CpG-oligodeoxynucleotide (CpG-ODN), CD40L and RANKL (receptor activator of NF-κB ligand), all of which induce IL-12 production.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p9" name="p9" type="cso30:c:ProcessBiological">
<csml:connector id="c24" name="c24" refID="e6" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="952.0" y="1155.7144114488897"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" name="default" points="952.0 1337.0 1200.536693981361 1155.7144114488897" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1198.7687896880273 1153.2906716919 1202.3045982746946 1158.1381512058792 1207.0 1150.9999999999998" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:connector>
<csml:connector id="c26" name="c26" refID="e13" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1223.3343310936464" y="448.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" name="default" points="1535.0 448.0 1223.3343310936464 1127.7279826624283" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1226.0613375952357 1128.9783568225457 1220.607324592057 1126.4776085023109 1220.0 1135.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c25" name="c25" refID="MO000017265" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1224.0" y="1146.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" name="default" points="1224.0 1146.0 1498.2356316116989 1214.0726745135423" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1498.9583786691205 1211.1610363679295 1497.5128845542772 1216.9843126591554 1506.0 1216.0000000000002" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1207.0" y="1135.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="17.0" outlineColor="0 0 0 0" resourceID="10031" width="17.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Translation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:process>
<csml:process id="p10" name="p10" type="cso30:c:ProcessBiological">
<csml:connector id="c27" name="c27" refID="e6" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="958.0" y="1350.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" name="default" points="958.0 1350.0 1185.0317520141637 1370.2879437970105" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1185.2987730902848 1367.2998508023218 1184.7647309380427 1373.276036791699 1193.0 1371.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:connector>
<csml:connector id="c29" name="c29" refID="e14" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1209.106721800948" y="262.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" name="default" points="1507.0 262.0 1209.106721800948 1353.2823758025277" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1212.000830875 1354.072396477883 1206.2126127268957 1352.4923551271722 1207.0 1361.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c28" name="c28" refID="MO000017265" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1216.0" y="1232.4375346821403"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" name="default" points="1216.0 1367.0 1498.7761952331834 1232.4375346821403" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1497.4871197273808 1229.728607894584 1500.065270738986 1235.1464614696965 1506.0 1229.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1193.0" y="1360.5"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="22.5" outlineColor="0 0 0 0" resourceID="10031" width="22.5"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Translation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 12154357, 11101877, 9195953, 10635328, 7507510, 11509631
PI3Ks are activated in DCs by many distinct stimuli, including LPS, peptidoglycan, CpG-oligodeoxynucleotide (CpG-ODN), CD40L and RANKL (receptor activator of NF-κB ligand), all of which induce IL-12 production.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p11" name="p11" type="cso30:c:ProcessBiological">
<csml:connector id="c30" name="c30" refID="MO000016573" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="840.0" y="339.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="840.0 367.0 840.0 339.0" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="837.0 339.0 843.0 339.0 840.0 331.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c31" name="c31" refID="e5" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="856.9596035747526" y="250.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="918.0 250.0 856.9596035747526 304.6630415748484" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="858.9609629841844 306.8978929153806 854.9582441653208 302.42819023431616 851.0 310.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c32" name="c32" refID="e15" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="840.0" y="266.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="840.0 308.0 840.0 266.0" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="837.0 266.0 843.0 266.0 840.0 258.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="828.0" y="308.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="23.0" outlineColor="0 0 0 0" resourceID="10005" width="23.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 16924467, 12524386
PI3K is activated after triggering of many TLR members, suggesting the presence of ‘shared’ signaling pathway(s) for TLR-mediated activation of PI3K. MyD88, TOLLIP (Toll-interacting protein), IRAK and TRAF6 [tumor necrosis factor (TNF) receptor-associated factor 6] are involved in such ‘shared’ signaling pathway(s).</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p12" name="p12" type="cso30:c:ProcessBiological">
<csml:connector id="c33" name="c33" refID="MO000000213" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="772.0" y="347.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="772.0 393.0 772.0 347.0" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="769.0 347.0 775.0 347.0 772.0 339.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c34" name="c34" refID="e15" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="785.9189245967844" y="257.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="827.0 257.0 785.9189245967844 309.6909445389069" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="788.2848203946944 311.53554126270103 783.5530287988746 307.84634781511267 781.0 315.99999999999994" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c35" name="c35" refID="e16" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="772.0" y="269.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="772.0 316.0 772.0 269.0" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="769.0 269.0 775.0 269.0 772.0 261.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="760.0" y="316.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="23.0" outlineColor="0 0 0 0" resourceID="10005" width="23.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 16924467, 12524386
PI3K is activated after triggering of many TLR members, suggesting the presence of ‘shared’ signaling pathway(s) for TLR-mediated activation of PI3K. MyD88, TOLLIP (Toll-interacting protein), IRAK and TRAF6 [tumor necrosis factor (TNF) receptor-associated factor 6] are involved in such ‘shared’ signaling pathway(s).
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p13" name="p13" type="cso30:c:ProcessBiological">
<csml:connector id="c36" name="c36" refID="e16" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="712.8" y="257.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="759.0 257.0 712.8 318.6" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="715.1999999999999 320.40000000000003 710.4 316.8 707.9999999999999 325.00000000000006" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c37" name="c37" refID="e17" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="700.0" y="270.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="700.0 325.0 700.0 270.0" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="697.0 270.0 703.0 270.0 700.0 262.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="689.0" y="325.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="21.0" outlineColor="0 0 0 0" resourceID="10001" width="21.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Phosphorylation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 16924467, 12524386
PI3K is activated after triggering of many TLR members, suggesting the presence of ‘shared’ signaling pathway(s) for TLR-mediated activation of PI3K. MyD88, TOLLIP (Toll-interacting protein), IRAK and TRAF6 [tumor necrosis factor (TNF) receptor-associated factor 6] are involved in such ‘shared’ signaling pathway(s).
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p14" name="p14" type="cso30:c:ProcessBiological">
<csml:connector id="c38" name="c38" refID="e17" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="669.6240935117632" y="153.5573893138783"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="692.0 218.0 669.6240935117632 153.5573893138783" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="666.7900725190589 154.54142438078955 672.4581145044676 152.57335424696709 666.9999999999999 146.00000000000003" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c39" name="c39" refID="MO000019406" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="664.0" y="154.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="664.0 303.0 664.0 154.0" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="661.0 154.0 667.0 154.0 664.0 146.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c40" name="c40" refID="e18" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="633.7263945889712" y="146.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="660.0 146.0 633.7263945889712 218.47891147870013" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="636.5468027844586 219.50130944956433 630.9059863934837 217.45651350783592 630.9999999999999 226.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="653.0" y="125.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="21.0" outlineColor="0 0 0 0" resourceID="10005" width="21.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 16924467, 12524386
PI3K is activated after triggering of many TLR members, suggesting the presence of ‘shared’ signaling pathway(s) for TLR-mediated activation of PI3K. MyD88, TOLLIP (Toll-interacting protein), IRAK and TRAF6 [tumor necrosis factor (TNF) receptor-associated factor 6] are involved in such ‘shared’ signaling pathway(s).
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p15" name="p15" type="cso30:c:ProcessBiological">
<csml:connector id="c41" name="c41" refID="e18" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="584.2751338252662" y="155.29886966773606"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="616.0 226.0 584.2751338252662 155.29886966773606" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="581.5380576998651 156.52704485221088 587.0122099506672 154.07069448326124 581.0 148.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c42" name="c42" refID="MO000000212" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="577.944398901614" y="155.94406134887126"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="594.0 291.0 577.944398901614 155.94406134887126" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="574.9653758957872 156.29821093697655 580.9234219074407 155.589911760766 576.9999999999999 148.00000000000003" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c43" name="c43" refID="e19" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="533.7259714626609" y="148.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="570.0 148.0 533.7259714626609 216.92065422094413" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="536.3807261298069 218.317893519442 531.071216795515 215.52341492244628 530.0 224.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="563.0" y="123.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="25.0" outlineColor="0 0 0 0" resourceID="10005" width="25.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 16924467, 12524386
PI3K is activated after triggering of many TLR members, suggesting the presence of ‘shared’ signaling pathway(s) for TLR-mediated activation of PI3K. MyD88, TOLLIP (Toll-interacting protein), IRAK and TRAF6 [tumor necrosis factor (TNF) receptor-associated factor 6] are involved in such ‘shared’ signaling pathway(s).
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p16" name="p16" type="cso30:c:ProcessBiological">
<csml:connector id="c44" name="c44" refID="MO000016574" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="664.0" y="517.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="664.0 517.0 699.63654623974 544.1516542778971" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="701.4546758855286 541.7653591177997 697.8184165939514 546.5379494379947 706.0 549.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c46" name="c46" refID="e19" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="532.0" y="263.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" points="532.0 263.0 705.7406675844114 539.22814003589" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="708.2801150709527 537.6308903800442 703.2012200978702 540.8253896917357 710.0 546.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c45" name="c45" refID="e20" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="716.0" y="565.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="716.0 565.0 716.0 609.0" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="719.0 609.0 713.0 609.0 716.0 617.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="706.0" y="546.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="19.0" outlineColor="0 0 0 0" resourceID="10003" width="19.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 11129660, 11460167 
In TLR4 signaling, TAK1 (transforming growth factor β-activated kinase 1) and TRAF6 pathways are operative in PI3K activation downstream of TLR4.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p17" name="p17" type="cso30:c:ProcessBiological">
<csml:connector id="c47" name="c47" refID="MO000017608" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1048.7175610316242" y="434.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="1090.0 434.0 1048.7175610316242 490.53899250016684" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1051.1404388440617 492.30807788702595 1046.2946832191867 488.7699071133078 1044.0 497.00000000000006" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c49" name="c49" refID="e20" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="735.0" y="514.9711254108329"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" points="735.0 628.0 1017.5721864729179 514.9711254108329" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1016.4580144438556 512.1856953381771 1018.6863585019803 517.7565554834887 1025.0 512.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c48" name="c48" refID="e11" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1042.0" y="518.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="1042.0 518.0 1104.0438060059596 627.0466893438077" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1106.6512975020316 625.5631165960425 1101.4363145098873 628.5302620915728 1108.0 634.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1025.0" y="497.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="21.0" outlineColor="0 0 0 0" resourceID="10003" width="21.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 11129660, 11460167 
In TLR4 signaling, TAK1 (transforming growth factor β-activated kinase 1) and TRAF6 pathways are operative in PI3K activation downstream of TLR4.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p18" name="p18" type="cso30:c:ProcessBiological">
<csml:connector id="c50" name="c50" refID="MO000000248" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="767.2719439311038" y="762.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="787.0 762.0 767.2719439311038 793.2360887757523" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="769.8084106401967 794.8380677499161 764.7354772220109 791.6341098015882 763.0 800.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c52" name="c52" refID="e20" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="720.0" y="655.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" points="720.0 655.0 751.2247060451267 792.1994659558598" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="754.1499063116793 791.5337307227823 748.2995057785741 792.8652011889372 753.0 799.9999999999999" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c51" name="c51" refID="e21" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="762.0" y="823.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="762.0 823.0 790.8840339565797 871.1400565942996" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="793.4565127337173 869.596569328017 788.311555179442 872.6835438605822 794.9999999999999 878.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="744.0" y="800.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="23.0" outlineColor="0 0 0 0" resourceID="10003" width="23.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525
confirmed pathway from fig.1</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p19" name="p19" type="cso30:c:ProcessBiological">
<csml:connector id="c53" name="c53" refID="e22" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="106.0" y="338.7339445046936"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="106.0 384.0 230.4816526120925 338.7339445046936" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="229.4564234228324 335.9145642342283 231.50688180135262 341.5533247751589 238.0 335.99999999999994" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c54" name="c54" refID="MO000019397" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="264.6626102817692" y="337.2987830845308"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="337.0 359.0 264.6626102817692 337.2987830845308" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="263.8005666250702 340.17226194019423 265.52465393846825 334.42530422886733 257.0 335.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c55" name="c55" refID="e23" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="256.0" y="341.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="256.0 341.0 328.8914202432215 428.8435064469592" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="331.2001053256118 426.9277890381673 326.5827351608312 430.7592238557512 334.0 435.00000000000006" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="238.0" y="322.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="19.0" outlineColor="0 0 0 0" resourceID="10005" width="19.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525
TLR2 binds TLR2 ligand</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p20" name="p20" type="cso30:c:ProcessBiological">
<csml:connector id="c56" name="c56" refID="MO000000166" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="462.0" y="580.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="462.0 580.0 498.0 580.0" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="498.0 577.0 498.0 583.0 506.0 580.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c58" name="c58" refID="e23" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="355.0" y="457.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" points="355.0 457.0 499.635578825915 567.1529242713922" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="501.4532322241429 564.7662663311103 497.81792542768704 569.539582211674 505.99999999999994 571.9999999999999" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c57" name="c57" refID="e24" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="516.0" y="589.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="516.0 589.0 516.0 642.0" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="519.0 642.0 513.0 642.0 516.0 650.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="506.0" y="570.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="19.0" outlineColor="0 0 0 0" resourceID="10003" width="19.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 11101877
activation of PI3K downstream of TLR2 is mediated in a Rac1-dependent manner.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p21" name="p21" type="cso30:c:ProcessBiological">
<csml:connector id="c59" name="c59" refID="MO000017608" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1060.4961229707417" y="430.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="1086.0 430.0 1060.4961229707417 448.3309116147794" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1062.2470311151994 450.76695772880754 1058.745214826284 445.8948655007513 1054.0 453.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c61" name="c61" refID="e24" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="530.0" y="466.89169666546536"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" points="530.0 659.0 1025.5409055244663 466.89169666546536" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1024.456519274917 464.09453623714023 1026.625291774016 469.6888570937905 1033.0 464.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c60" name="c60" refID="e11" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1048.0" y="470.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="1048.0 470.0 1108.1312190006058 626.5320621603072" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1110.9316956904906 625.4562692855344 1105.330742310721 627.60785503508 1111.0 634.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1033.0" y="449.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="21.0" outlineColor="0 0 0 0" resourceID="10003" width="21.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 11101877
activation of PI3K downstream of TLR2 is mediated in a Rac1-dependent manner.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p22" name="p22" type="cso30:c:ProcessBiological">
<csml:connector id="c62" name="c62" refID="e15" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="847.0" y="258.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="847.0 258.0 889.1703499226735 369.5171475732922" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="891.9764195826889 368.4560287942948 886.3642802626581 370.57826635228963 892.0 377.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c63" name="c63" refID="MO000017608" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="913.9049317516391" y="391.22965605025496"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="1086.0 418.0 913.9049317516391 391.22965605025496" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="913.4438107327935 394.1940054571196 914.3660527704848 388.2653066433903 906.0000000000001 390.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c64" name="c64" refID="e25" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="906.0" y="257.65685424949237"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="906.0 378.0 1026.3431457505076 257.65685424949237" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1024.221825406948 255.53553390593274 1028.4644660940673 259.77817459305203 1032.0 252.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="885.0" y="377.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="21.0" outlineColor="0 0 0 0" resourceID="10005" width="21.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 12616480
interaction of PI3K with MyD88 in response to LPS has been reported, demonstrating the importance of such ‘shared’ signaling in the PI3K pathway</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p23" name="p23" type="cso30:c:ProcessBiological">
<csml:connector id="c65" name="c65" refID="MO000000058" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1032.0" y="906.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="1032.0 906.0 1047.5675454834536 938.7737799651657" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1050.2773779965164 937.4866095214608 1044.8577129703906 940.0609504088704 1050.9999999999998 946.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c67" name="c67" refID="e21" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="818.0" y="896.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" points="818.0 896.0 1038.2388599988374 951.0597149997093" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1038.9664668739463 948.1492874992733 1037.5112531237282 953.9701425001454 1046.0 953.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c66" name="c66" refID="e26" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1042.3151160102107" y="965.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="1053.0 965.0 1042.3151160102107 1000.3423085816112" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1045.1867502921066 1001.2104770854402 1039.443481728315 999.4741400777822 1040.0000000000002 1008.0000000000001" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1046.0" y="946.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="19.0" outlineColor="0 0 0 0" resourceID="10003" width="19.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525
confirmed pathway from fig.1
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p24" name="p24" type="cso30:c:ProcessBiological">
<csml:connector id="c68" name="c68" refID="e27" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="555.0" y="806.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="555.0 806.0 591.9359130097366 837.7820646827967" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="593.8926387536878 835.5080320614479 589.9791872657853 840.0560973041455 598.0 843.0000000000001" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c70" name="c70" refID="e20" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="616.5623785035427" y="655.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" points="706.0 655.0 616.5623785035427 834.8369378477151" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="619.2485268106495 836.1728297865437 613.8762301964358 833.5010459088867 612.9999999999999 842.0000000000001" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c69" name="c69" refID="e28" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="526.0" y="852.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="598.0 852.0 526.0 852.0" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="526.0 855.0 526.0 849.0 518.0 852.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="598.0" y="842.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="19.0" outlineColor="0 0 0 0" resourceID="10003" width="19.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol"/>
</csml:process>
<csml:process id="p25" name="p25" type="cso30:c:ProcessBiological">
<csml:connector id="c71" name="c71" refID="MO000016966" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="682.0" y="895.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="682.0 895.0 708.046442685443 960.5651833116325" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="710.8344989435808 959.4575993186736 705.2583864273053 961.6727673045913 710.9999999999999 967.9999999999999" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c73" name="c73" refID="e28" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="518.0" y="863.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" points="518.0 863.0 697.1140622695762 968.9276712346956" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="698.6411855565653 966.3454445857867 695.5869389825871 971.5098978836046 704.0 973.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c89" name="c89" refID="e33" type="cso30:c:InputInhibitor">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="730.5362878125189" y="854.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<inhibitoryConnector depth="0" points="954.0 854.0 730.5362878125189 972.1305967510913" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<bioInhibitoryConnectorArrow pointsInAbsoluteCoordinate="733.8077434981091 978.3191004229993 727.2648321269287 965.9420930791832 723.7285443144098 967.8114963280918 730.2714556855901 980.188503671908" size="4.0 14.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c72" name="c72" refID="e29" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="691.8776860867976" y="991.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="707.0 991.0 691.8776860867976 1010.6590080871632" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="694.2555580541114 1012.4881403697123 689.4998141194837 1008.8298758046141 687.0 1017.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="704.0" y="968.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="23.0" outlineColor="0 0 0 0" resourceID="10003" width="23.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525
confirmed pathway from fig.1

PMID: 12860525, 11154276
Protein kinase B (PKB)-mediated phosphorylation of apoptosis signal-regulating kinase 1 (ASK1), one of the MAPK kinase kinases (MAPKK-Ks), blocks ASK1 kinase activity, leading to suppression of MAPK kinase 3 (MKK3) or MKK6, upstream regulators of p38
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p28" name="p28" type="cso30:c:ProcessBiological">
<csml:connector id="c79" name="c79" refID="MO000019005" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="428.0" y="914.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="428.0 914.0 428.0 949.0" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="431.0 949.0 425.0 949.0 428.0 957.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c81" name="c81" refID="e28" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="439.20085861637284" y="863.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" points="493.0 863.0 439.20085861637284 950.1917118976027" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="441.7539666547719 951.7670338787425 436.64775057797385 948.6163899164628 435.0 957.0000000000001" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c90" name="c90" refID="e33" type="cso30:c:InputInhibitor">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="441.89934020347215" y="848.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<inhibitoryConnector depth="0" points="954.0 848.0 441.89934020347215 965.1082904185859" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<bioInhibitoryConnectorArrow pointsInAbsoluteCoordinate="443.45983197094694 971.9321357746621 440.33884843599736 958.2844450625096 436.4395082325252 959.1761546439238 439.5604917674748 972.8238453560763" size="4.0 14.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c80" name="c80" refID="e31" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="433.0" y="978.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="433.0 978.0 449.4222912360003 1010.8445824720006" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="452.1055728090001 1009.5029416855008 446.73900966300056 1012.1862232585005 453.0 1018.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="417.0" y="957.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="21.0" outlineColor="0 0 0 0" resourceID="10003" width="21.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 11154276
Protein kinase B (PKB)-mediated phosphorylation of apoptosis signal-regulating kinase 1 (ASK1), one of the MAPK kinase kinases (MAPKK-Ks), blocks ASK1 kinase activity, leading to suppression of MAPK kinase 3 (MKK3) or MKK6, upstream regulators of p38
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p29" name="p29" type="cso30:c:ProcessBiological">
<csml:connector id="c83" name="c83" refID="MO000000048" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="866.8311367793272" y="636.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="878.0 636.0 866.8311367793272 665.5177099403497" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="869.636995551696 666.5793862325974 864.0252780069584 664.456033648102 864.0 673.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c85" name="c85" refID="e11" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="877.9202772896064" y="650.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" points="1102.0 650.0 877.9202772896064 681.873408833806" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="878.3427489769291 684.8435128174084 877.4978056022836 678.9033048502037 870.0 683.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c84" name="c84" refID="e32" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="864.0" y="694.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="864.0 694.0 877.733071519534 724.6974539848406" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="880.4715262752187 723.4723558046659 874.9946167638492 725.9225521650154 881.0 732.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="849.0" y="673.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="21.0" outlineColor="0 0 0 0" resourceID="10003" width="21.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 9192891
activation of PKB is positively regulated by PI3K.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p30" name="p30" type="cso30:c:ProcessBiological">
<csml:connector id="c74" name="c74" refID="MO000000022" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="554.0" y="1096.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="554.0 1096.0 570.6261540022754 1131.7462311048919" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="573.346317337941 1130.481038855745 567.9059906666099 1133.0114233540385 574.0000000000001 1138.9999999999998" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c76" name="c76" refID="e29" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="595.014069158532" y="1047.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" points="664.0 1047.0 595.014069158532 1132.7662923975006" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="597.3517095094693 1134.6465683319502 592.6764288075948 1130.8860164630512 590.0 1139.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c75" name="c75" refID="e30" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="557.734068956465" y="1164.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="573.0 1164.0 557.734068956465 1192.9249219772241" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="560.3872232150059 1194.3251978358985 555.0809146979241 1191.5246461185498 554.0 1200.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="567.0" y="1139.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="25.0" outlineColor="0 0 0 0" resourceID="10001" width="25.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Phosphorylation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525
confirmed pathway from fig.1
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p26" name="p26" type="cso30:c:ProcessBiological">
<csml:connector id="c77" name="c77" refID="MO000000022" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="521.7647058823529" y="1096.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="542.0 1096.0 521.7647058823529 1133.9411764705883" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="524.4117647058823 1135.3529411764707 519.1176470588235 1132.529411764706 518.0 1141.0000000000002" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c82" name="c82" refID="e31" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="466.0" y="1046.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" points="466.0 1046.0 503.8299929783842 1133.654861779183" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="506.58441981119057 1132.466109146077 501.0755661455778 1134.8436144122888 506.99999999999994 1141.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c78" name="c78" refID="e30" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="518.0" y="1162.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="518.0 1162.0 536.8575785647538 1193.155999367854" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="539.4240788018085 1191.6025913296367 534.2910783276991 1194.7094074060713 541.0 1199.9999999999998" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="501.0" y="1141.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="21.0" outlineColor="0 0 0 0" resourceID="10001" width="21.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Phosphorylation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525
confirmed pathway from fig.1
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p27" name="p27" type="cso30:c:ProcessBiological">
<csml:connector id="c86" name="c86" refID="MO000000079" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="988.0" y="738.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="988.0 738.0 988.0 762.0" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="991.0 762.0 985.0 762.0 988.0 770.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c88" name="c88" refID="e32" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="904.0" y="753.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" points="904.0 753.0 970.3902174484099 774.5319624157005" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="971.3157315425221 771.6782939588542 969.4647033542975 777.3856308725467 977.9999999999999 777.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c87" name="c87" refID="e33" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="977.9402850002907" y="789.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="986.0 789.0 977.9402850002907 821.2388599988374" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="980.8507125007267 821.9664668739464 975.0298574998546 820.5112531237284 976.0 829.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="978.0" y="770.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="19.0" outlineColor="0 0 0 0" resourceID="10001" width="19.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Phosphorylation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 11154276
Protein kinase B (PKB)-mediated phosphorylation of apoptosis signal-regulating kinase 1 (ASK1), one of the MAPK kinase kinases (MAPKK-Ks), blocks ASK1 kinase activity, leading to suppression of MAPK kinase 3 (MKK3) or MKK6, upstream regulators of p38</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p32" name="p32" type="cso30:c:ProcessBiological">
<csml:connector id="c94" name="c94" refID="MO000000022" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="560.0" y="1091.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="560.0 1091.0 625.2160135679593 1131.7600084799747" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="626.8060103879689 1129.2160135679594 623.6260167479497 1134.30400339199 632.0 1136.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c96" name="c96" refID="e34" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="662.8006037422365" y="1103.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" points="822.0 1103.0 662.8006037422365 1139.2250123221258" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="663.4662241214393 1142.1502387254645 662.1349833630336 1136.2997859187872 654.9999999999999 1141.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c91" name="c91" refID="e33" type="cso30:c:InputInhibitor">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="657.9530922221818" y="859.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<inhibitoryConnector depth="0" points="956.0 859.0 657.9530922221818 1131.3019921558139" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<bioInhibitoryConnectorArrow pointsInAbsoluteCoordinate="662.6746059495074 1136.469903544632 653.2315784948563 1126.1340807669956 650.2784862726745 1128.8320886111817 659.7215137273256 1139.167911388818" size="4.0 14.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c95" name="c95" refID="e30" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="566.5281958488132" y="1152.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="632.0 1152.0 566.5281958488132 1198.3758612737572" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="568.2622478711542 1200.8239347170622 564.7941438264721 1195.9277878304522 559.9999999999999 1203.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="632.0" y="1132.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="23.0" outlineColor="0 0 0 0" resourceID="10001" width="23.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Phosphorylation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 11387313
PKB blocks kinase activity of MEKK3, another MAPKK-K upstream of p38.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p31" name="p31" type="cso30:c:ProcessBiological">
<csml:connector id="c92" name="c92" refID="MO000000193" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1142.0" y="837.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="1142.0 837.0 1175.097411845649 879.6782415904421" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1177.4680712492334 877.8397710325604 1172.726752442065 881.5167121483237 1180.0000000000002 886.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c97" name="c97" refID="e11" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1120.0" y="662.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" points="1120.0 662.0 1182.7705388844238 878.3169340017065" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1185.6516886337838 877.4808860833654 1179.8893891350638 879.1529819200475 1185.0 886.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c93" name="c93" refID="e35" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1188.0" y="905.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="1188.0 905.0 1188.0 946.0" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1191.0 946.0 1185.0 946.0 1188.0 954.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1178.0" y="886.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="19.0" outlineColor="0 0 0 0" resourceID="10001" width="19.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Phosphorylation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 11101877, 10373529
NF-κB transactivation by the PI3K cascade in TLR2-mediated signaling is independent of IκBα (inhibitor of NF-κBα) degradation and triggered by PI3K-pathway-mediated p65 phosphorylation.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p33" name="p33" type="cso30:c:ProcessBiological">
<csml:connector id="c98" name="c98" refID="e36" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="859.0" y="1024.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="859.0 1024.0 893.9133477177587 1042.2879440426354" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="895.3053687017704 1039.630449436795 892.5213267337471 1044.945438648476 900.9999999999999 1046.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c100" name="c100" refID="e21" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="813.0" y="906.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" points="813.0 906.0 900.4948250204723 1034.3891454104755" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="902.9738954915439 1032.6997047931527 898.0157545494005 1036.0785860277986 905.0 1041.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c106" name="c106" refID="e11" type="cso30:c:InputInhibitor">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="919.8001553201204" y="662.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<inhibitoryConnector depth="0" points="1109.0 662.0 919.8001553201204 1037.4279640506509" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<bioInhibitoryConnectorArrow pointsInAbsoluteCoordinate="926.0512182314812 1040.5782358608617 913.5490924087596 1034.27769224044 911.7489370886391 1037.849728189789 924.2510629113608 1044.1502718102108" size="4.0 14.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c99" name="c99" refID="e37" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="922.0" y="1052.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="922.0 1052.0 967.0 1052.0" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="967.0 1049.0 967.0 1055.0 975.0 1052.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="901.0" y="1041.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="21.0" outlineColor="0 0 0 0" resourceID="10001" width="21.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Phosphorylation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 12052830
inhibition of PI3K augments the phosphorylation and degradation of IκBα, resulting in nuclear localization of NF-κB in monocytes.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p34" name="p34" type="cso30:c:ProcessBiological">
<csml:connector id="c102" name="c102" refID="e37" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="989.0" y="1066.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="989.0 1066.0 994.1165477914012 1112.048930122611" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="997.0981989954221 1111.7176355443864 991.1348965873804 1112.3802247008355 995.0 1120.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c107" name="c107" refID="e11" type="cso30:c:InputInhibitor">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="999.9661537370597" y="662.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<inhibitoryConnector depth="0" points="1113.0 662.0 999.9661537370597 1116.1184349861987" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<bioInhibitoryConnectorArrow pointsInAbsoluteCoordinate="1006.7588925112118 1117.8092040260533 993.1734149629076 1114.4276659463444 992.2072612258479 1118.3092309601457 1005.7927387741521 1121.6907690398546" size="4.0 14.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c101" name="c101" refID="MO000019479" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="903.4623850752448" y="1137.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="984.0 1137.0 903.4623850752448 1168.1168057663826" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="904.5435829128513 1170.9152001695995 902.3811872376383 1165.318411363166 896.0000000000001 1171.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c103" name="c103" refID="e26" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1000.0" y="1039.5183473879074"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="1000.0 1120.0 1029.2660554953063 1039.5183473879074" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1026.446675224841 1038.4931181986474 1032.0854357657718 1040.5435765771676 1032.0 1032.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="984.0" y="1120.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="23.0" outlineColor="0 0 0 0" resourceID="10012" width="23.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownDegradation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 12052830
inhibition of PI3K augments the phosphorylation and degradation of IκBα, resulting in nuclear localization of NF-κB in monocytes.
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p35" name="p35" type="cso30:c:ProcessBiological">
<csml:connector id="c104" name="c104" refID="e26" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1036.0" y="1032.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="1036.0 1032.0 1039.7867424780882 1174.0028429283059" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="1042.7856763799734 1173.922871357589 1036.787808576203 1174.0828144990228 1040.0 1182.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c108" name="c108" refID="e11" type="cso30:c:InputInhibitor">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1041.5560855737954" y="662.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<inhibitoryConnector depth="0" points="1114.0 662.0 1041.5560855737954 1178.0388424880325" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<bioInhibitoryConnectorArrow pointsInAbsoluteCoordinate="1048.4881112197386 1179.0119922421745 1034.6240599278524 1177.0656927338905 1034.0679743540568 1181.026850245858 1047.9320256459432 1182.973149754142" size="4.0 14.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c105" name="c105" refID="e38" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="866.5357429061181" y="1199.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="1030.0 1199.0 866.5357429061181 1314.3865344192106" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="868.265792498914 1316.837438009005 864.8056933133221 1311.9356308294164 860.0 1319.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="1030.0" y="1182.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="19.0" outlineColor="0 0 0 0" resourceID="10027" width="19.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Translocation" refCellComponentID="cso30:i:CC_Cytosol"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 12052830
inhibition of PI3K augments the phosphorylation and degradation of IκBα, resulting in nuclear localization of NF-κB in monocytes.
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p36" name="p36" type="cso30:c:ProcessBiological">
<csml:connector id="c111" name="c111" refID="e38" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="850.0" y="1340.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" points="850.0 1340.0 864.5689164944001 1420.1290407192007" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="867.5205262246999 1419.5923844046008 861.6173067641005 1420.6656970338006 866.0 1428.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c109" name="c109" refID="e39" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="868.0" y="1451.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="868.0 1451.0 868.0 1515.0" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="871.0 1515.0 865.0 1515.0 868.0 1523.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="856.0" y="1428.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="23.0" outlineColor="0 0 0 0" resourceID="10068" width="23.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_GeneExpression" refCellComponentID="cso30:i:CC_Nucleoplasm"/>
</csml:process>
<csml:process id="p37" name="p37" type="cso30:c:ProcessBiological">
<csml:connector id="c112" name="c112" refID="e38" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="860.0" y="1336.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<associationConnector depth="0" points="860.0 1336.0 965.3801938048659 1407.507988653302" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="967.0646980598777 1405.0255613301267 963.6956895498541 1409.9904159764774 972.0 1412.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c110" name="c110" refID="e40" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="984.0" y="1431.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<figure xmlns="http://www.csml.org/csml/cigraphics">
<processConnector depth="0" points="984.0 1431.0 984.0 1500.0" visible="true"/>
</figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="987.0 1500.0 981.0 1500.0 984.0 1508.0" size="8.0 6.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingOnce="false" firingStyle="csml-firingStyle:and" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" fast="false" kineticStyle="csml-kineticStyle:mass">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty viewID="">
<csml:position position="auto" positionID="default" x="972.0" y="1408.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image fileFormat="svg" filePath="" fileType="resourceFile" height="23.0" outlineColor="0 0 0 0" resourceID="10068" width="23.0"/>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_GeneExpression" refCellComponentID="cso30:i:CC_Nucleoplasm"/>
<csml:comments>
<csml:comment type="text">PMID: 12860525, 7612223, 10973276
NF-κB activation is required for the transcription of both IL-12 p35 and p40</csml:comment>
</csml:comments>
</csml:process>
</csml:processSet>
<csml:factSet>
<csml:fact id="g2" name="g2" type="cso30:c:FactViewGroup">
<csml:participant id="participant-e9" name="participant-e9" refID="e9" type="csml-element:participant"/>
<csml:participant id="participant-e7" name="participant-e7" refID="e7" type="csml-element:participant"/>
<csml:participant id="participant-g14" name="participant-g14" refID="g14" type="csml-element:participant"/>
<csml:participant id="participant-e10" name="participant-e10" refID="e10" type="csml-element:participant"/>
<csml:participant id="participant-g1" name="participant-g1" refID="g1" type="csml-element:participant"/>
<csml:participant id="participant-g12" name="participant-g12" refID="g12" type="csml-element:participant"/>
<csml:participant id="participant-e8" name="participant-e8" refID="e8" type="csml-element:participant"/>
</csml:fact>
<csml:fact id="g14" name="g1" type="cso30:c:FactViewGroup"/>
<csml:fact id="g1" name="g1" type="cso30:c:FactViewGroup">
<csml:participant id="participant-e2" name="participant-e2" refID="e2" type="csml-element:participant"/>
<csml:participant id="participant-e3" name="participant-e3" refID="e3" type="csml-element:participant"/>
<csml:participant id="participant-e1" name="participant-e1" refID="e1" type="csml-element:participant"/>
<csml:participant id="participant-e4" name="participant-e4" refID="e4" type="csml-element:participant"/>
</csml:fact>
<csml:fact id="g12" name="g2" type="cso30:c:FactViewGroup">
<csml:participant id="participant-e54" name="participant-e54" refID="e54" type="csml-element:participant"/>
<csml:participant id="participant-e50" name="participant-e50" refID="e50" type="csml-element:participant"/>
<csml:participant id="participant-e56" name="participant-e56" refID="e56" type="csml-element:participant"/>
<csml:participant id="participant-g13" name="participant-g13" refID="g13" type="csml-element:participant"/>
<csml:participant id="participant-e59" name="participant-e59" refID="e59" type="csml-element:participant"/>
<csml:participant id="participant-e53" name="participant-e53" refID="e53" type="csml-element:participant"/>
<csml:participant id="participant-e55" name="participant-e55" refID="e55" type="csml-element:participant"/>
<csml:participant id="participant-e52" name="participant-e52" refID="e52" type="csml-element:participant"/>
<csml:participant id="participant-e51" name="participant-e51" refID="e51" type="csml-element:participant"/>
<csml:participant id="participant-e57" name="participant-e57" refID="e57" type="csml-element:participant"/>
<csml:participant id="participant-e58" name="participant-e58" refID="e58" type="csml-element:participant"/>
</csml:fact>
<csml:fact id="g13" name="g2" type="cso30:c:FactViewGroup">
<csml:participant id="participant-e62" name="participant-e62" refID="e62" type="csml-element:participant"/>
<csml:participant id="participant-e60" name="participant-e60" refID="e60" type="csml-element:participant"/>
<csml:participant id="participant-e61" name="participant-e61" refID="e61" type="csml-element:participant"/>
</csml:fact>
</csml:factSet>
<csml:modelSimulationProperty>
<csml:parameter key="enhancedFiring" value="true"/>
<csml:parameter key="discreteWeakFiring" value="false"/>
<csml:parameter key="continousWeakFiring" value="false"/>
<csml:parameter key="samplingInterval" value="0.1"/>
<csml:parameter key="plotUpdateInterval" value="1.0"/>
<csml:parameter key="logUpdateInterval" value="1.0"/>
<csml:parameter key="simulationTime" value="1000.0"/>
<csml:parameter key="firingAccuracy" value="1.0E-10"/>
</csml:modelSimulationProperty>
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:model>
<csml:subModelSet/>
<csml:viewSet>
<csml:view name="Default View" refAnimationID="default" refModelID="undef" refPositionID="default" refShapeID="default" viewID="default"/>
</csml:viewSet>
<csml:references>
<csml:unificationXref db="TRANSPATH" name="MO000016882" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000016882" unificationXrefID="ref748">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR000157" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000157" unificationXrefID="ref749">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR003591" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR003591" unificationXrefID="ref750">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR000887" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000887" unificationXrefID="ref751">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR000483" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000483" unificationXrefID="ref752">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR001611" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001611" unificationXrefID="ref753">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000019394" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000019394" unificationXrefID="ref754">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000017265" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000017265" unificationXrefID="ref755">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000017608" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000017608" unificationXrefID="ref756">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000017608" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000017608" unificationXrefID="ref757">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR003636" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR003636" unificationXrefID="ref758">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR008983" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR008983" unificationXrefID="ref759">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR006052" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR006052" unificationXrefID="ref760">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000018743" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000018743" unificationXrefID="ref761">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR000157" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000157" unificationXrefID="ref762">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR004075" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR004075" unificationXrefID="ref763">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR000488" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000488" unificationXrefID="ref764">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000016573" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000016573" unificationXrefID="ref765">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR000719" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000719" unificationXrefID="ref766">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR008271" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR008271" unificationXrefID="ref767">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR000488" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000488" unificationXrefID="ref768">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000000213" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000000213" unificationXrefID="ref769">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR000008" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000008" unificationXrefID="ref770">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR003892" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR003892" unificationXrefID="ref771">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR008973" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR008973" unificationXrefID="ref772">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000019406" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000019406" unificationXrefID="ref773">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR001841" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001841" unificationXrefID="ref774">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR002083" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR002083" unificationXrefID="ref775">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR000504" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000504" unificationXrefID="ref776">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR001293" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001293" unificationXrefID="ref777">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR008974" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR008974" unificationXrefID="ref778">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000000212" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000000212" unificationXrefID="ref779">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR000719" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000719" unificationXrefID="ref780">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR008271" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR008271" unificationXrefID="ref781">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR001245" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001245" unificationXrefID="ref782">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000016574" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000016574" unificationXrefID="ref783">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR000719" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000719" unificationXrefID="ref784">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR008271" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR008271" unificationXrefID="ref785">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR001245" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001245" unificationXrefID="ref786">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000016574" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000016574" unificationXrefID="ref787">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000000248" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000000248" unificationXrefID="ref788">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000000248" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000000248" unificationXrefID="ref789">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR000157" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000157" unificationXrefID="ref790">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR002086" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR002086" unificationXrefID="ref791">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR003591" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR003591" unificationXrefID="ref792">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR000483" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000483" unificationXrefID="ref793">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR004075" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR004075" unificationXrefID="ref794">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR001611" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001611" unificationXrefID="ref795">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000019397" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000019397" unificationXrefID="ref796">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000000166" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000000166" unificationXrefID="ref797">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000000166" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000000166" unificationXrefID="ref798">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000000058" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000000058" unificationXrefID="ref799">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000000058" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000000058" unificationXrefID="ref800">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR000719" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000719" unificationXrefID="ref801">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR008271" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR008271" unificationXrefID="ref802">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR002290" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR002290" unificationXrefID="ref803">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR001245" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001245" unificationXrefID="ref804">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000016966" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000016966" unificationXrefID="ref805">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR000719" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000719" unificationXrefID="ref806">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR008271" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR008271" unificationXrefID="ref807">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR002290" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR002290" unificationXrefID="ref808">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR001245" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001245" unificationXrefID="ref809">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000016966" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000016966" unificationXrefID="ref810">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000000022" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000000022" unificationXrefID="ref811">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000000022" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000000022" unificationXrefID="ref812">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR000719" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000719" unificationXrefID="ref813">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR008271" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR008271" unificationXrefID="ref814">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR002290" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR002290" unificationXrefID="ref815">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000019005" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000019005" unificationXrefID="ref816">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR000719" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000719" unificationXrefID="ref817">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR008271" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR008271" unificationXrefID="ref818">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR002290" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR002290" unificationXrefID="ref819">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000019005" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000019005" unificationXrefID="ref820">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000000048" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000000048" unificationXrefID="ref821">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000000048" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000000048" unificationXrefID="ref822">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR000719" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000719" unificationXrefID="ref823">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR001179" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001179" unificationXrefID="ref824">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR008271" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR008271" unificationXrefID="ref825">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR002290" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR002290" unificationXrefID="ref826">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR001245" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001245" unificationXrefID="ref827">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000000079" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000000079" unificationXrefID="ref828">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR000719" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000719" unificationXrefID="ref829">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR000270" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000270" unificationXrefID="ref830">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR002290" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR002290" unificationXrefID="ref831">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="INTERPRO" name="IPR001245" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001245" unificationXrefID="ref832">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000009093" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000009093" unificationXrefID="ref833">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000000193" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000000193" unificationXrefID="ref834">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000019479" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000019479" unificationXrefID="ref835">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref db="TRANSPATH" name="MO000000058" xmlns:p1="http://www.w3.org/1999/xlink" p1:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000000058" unificationXrefID="ref836">
<csml:comments>
<csml:comment type="text"/>
</csml:comments>
</csml:unificationXref>
</csml:references>
</csml:project>
