Entity
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
PI-3kinase
--
e11
cso30:c:Protein
cso30:i:CC_Cell
--
--
csml-variable:Double
m11
0
infinite
0
--
Kallikrein
--
e12
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m12
0
infinite
0
--
FactorXIa
--
e13
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m13
0
infinite
0
--
FctorXIIa
--
e14
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m14
0
infinite
0
--
MSP
--
e15
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m15
0
infinite
0
--
csml-variable:Double
m16
0
infinite
0
--
csml-variable:Double
m17
0
infinite
0
--
Cell surface proteases
--
e18
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m18
0
infinite
0
--
RON receptor{active}:MSP
--
e19
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
inos
--
e20
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m20
0
infinite
0
--
iNOS
--
e21
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m21
0
infinite
0
--
csml-variable:Double
m22
0
infinite
0
--
IFN-gamma
--
e23
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m23
0
infinite
0
--
PKR
--
e24
cso30:c:Protein
cso30:i:CC_Cell
--
--
csml-variable:Double
m24
0
infinite
0
--
PKR{active}
--
e25
cso30:c:Protein
cso30:i:CC_Cell
--
csml-variable:Double
m25
0
infinite
0
--
STAT1
--
e26
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m26
0
infinite
0
--
STAT1{p}
--
e27
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m27
0
infinite
0
--
csml-variable:Double
m28
0
infinite
0
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
NFKB:IKB
--
e30
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m30
0
infinite
0
--
NFKappB{active}
--
e31
cso30:c:Protein
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m31
0
infinite
0
--
csml-variable:Double
m32
0
infinite
0
--
csml-variable:Double
m33
0
infinite
0
--
NFKB{active}
--
e34
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m34
0
infinite
0
--
protein remnants
--
e35
cso30:c:EntityBiological
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m35
0
infinite
0
--
NFKB:IKB{p}
--
e36
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m36
0
infinite
0
--
csml-variable:Double
m37
0
infinite
0
--
RON receptor:MSP:PI-3kinase
--
e38
cso30:c:Complex
cso30:i:CC_Cell
--
csml-variable:Double
m38
0
infinite
0
--
csml-variable:Double
m39
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
TNF-alpha
--
e40
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m40
0
infinite
0
--
GSNO
--
e41
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
csml-variable:Double
m41
0
infinite
0
--
csml-variable:Double
m42
0
infinite
0
--
NO
--
e43
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m43
0
infinite
0
--
SP-1
--
e44
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m44
0
infinite
0
--
unknown protein
--
e45
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m45
0
infinite
0
--
IFN-gamma receptor
--
e46
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m46
0
infinite
0
--
IFN-gamma:receptor
--
e47
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m47
0
infinite
0
--
receptor
--
e48
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m48
0
infinite
0
--
cytokine:receptor
--
e49
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m49
0
infinite
0
--
Pro-MSP
--
e5
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
RON receptor
--
e6
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
TLR4
--
e64
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m64
0
infinite
0
--
LPS:TLR4
--
e65
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m65
0
infinite
0
--
TGFbeta
--
e66
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m66
0
infinite
0
--
wortmannin
--
e67
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
csml-variable:Double
m67
0
infinite
0
--
TNF-alpha receptor
--
e68
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m68
0
infinite
0
--
TNF_alpha:receptor
--
e69
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
csml-variable:Double
m69
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
receptor
--
e70
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m70
0
infinite
0
--
TGFbeta:receptor
--
e71
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m71
0
infinite
0
--
MyD88
--
e72
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m72
0
infinite
0
--
LPS:TLR4:MyD88
--
e73
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
csml-variable:Double
m73
0
infinite
0
--
IRAK
--
e74
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m74
0
infinite
0
--
IRAK{active}
--
e75
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m75
0
infinite
0
--
csml-variable:Double
m76
0
infinite
0
--
IRF-1
--
e77
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m77
0
infinite
0
--
IRF-1{active}
--
e78
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m78
0
infinite
0
--
LPS
--
e8
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m8
0
infinite
0
--
cytokine
--
e9
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c3 : 1
stoichiometry:c32 : 1
stoichiometry:c21 : 1
m19*m11*0.1
nodelay
--
0
PMID: 12472665, 9794431 Wortmannin, a specific inhibitor of PI-3 kinase, prevented the inhibitory effect of RON on iNOS gene transcription activity and NO production induced by LPS and IFN-¦Ã
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c31 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1
m20*m49*0.1
nodelay
--
0
The inhibitory effect of MSP on macrophages was first demonstrated in vitro, in which treatment of mouse peritoneal macrophages with physiological concentrations of MSP inhibits lipopolysaccharides (LPS)- or cytokine-induced inducible NO synthase (iNOS) and NO production
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c40 : 1
stoichiometry:c36 : 1
m65*0.1
nodelay
--
0
PMID: 12472665, LPS-induced cyclooxygenase-2 (Cox-2) expression and prostaglandin E2 (PGE2) production by macrophages was also inhibited by MSP
p14
p14
cso30:i:ME_UnknownActivation
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c81 : 1
stoichiometry:c42 : 1
m24*m65*0.1
nodelay
--
0
PMID: 12472665, 10557102, 10878375 Recently, it was shown that double-stranded RNA-regulated protein kinase (PKR) also plays a critical role in LPS-induced iNOS expression. Inactivation of PKR gene results in the failure of iNOS induction by LPS
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c82 : 1
stoichiometry:c44 : 1
m25*0.1
nodelay
--
0
PMID: 12472665, 10878375 Inactivation of PKR gene results in the failure of iNOS induction by LPS
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1
m47*0.1
nodelay
--
0
PMID: 12472665, 10586055 RON activation affect IFN-¦Ã-induced STAT1 phosphorylation and IRF-1 or IRF-2 expression
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c50 : 1
m47*0.1
nodelay
--
0
PMID: 12472665, 10586055 RON activation affect IFN-¦Ã-induced STAT1 phosphorylation and IRF-1 or IRF-2 expression
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c51 : 1
m47*0.1
nodelay
--
0
PMID: 12472665, 10586055 RON activation affect IFN-¦Ã-induced STAT1 phosphorylation and IRF-1 or IRF-2 expression
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c66 : 1
stoichiometry:c53 : 1
stoichiometry:c56 : 1
m34*m47*0.1
nodelay
--
0
PMID: 12472665, 10586055 After LPS and IFN-¦Ã stimulation, nuclear translocation of NF¦ÊB was significantly reduced upon RON activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c4 : 1
stoichiometry:c10 : 1
m5*m12*0.1
nodelay
--
0
PMID: 12472665, 7508914 Three enzymes, kallikrein, factor XIa and XIIa, in the blood clotting system have the ability to cleave pro-MSP
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c67 : 1
stoichiometry:c77 : 1
stoichiometry:c57 : 1
m34*m65*0.1
nodelay
--
0
PMID: 12472665, 10586055 After LPS and IFN-¦Ã stimulation, nuclear translocation of NF¦ÊB was significantly reduced upon RON activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c63 : 1
stoichiometry:c60 : 1
m31*m32*0.1
nodelay
--
0
PMID: 12472665, 10586055 RON activation also caused decreased binding of NF¦ÊB to its consensus sequence [
p22
p22
cso30:i:ME_UnknownDegradation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c108 : 1
stoichiometry:c54 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1
m65*m36*0.1
nodelay
--
0
PMID: 12472665,10837071,10847627, 11521070 In mouse macrophages, two separate but cooperative signalling pathways are involved in the induction of iNOS expression: LPS-induced TRL4 > MyD88 > IRAK > IKK > nuclear factor kappa-B (NF¦ÊB) pathway [54, 55] and interferon-¦Ã (IFN-¦Ã)-induced JAK/STAT/IFN-response factor-1 (IRF-1) pathway [54?56] NF¦ÊB is normally sequestered in the cytoplasm by NF¦ÊB inhibitor protein I¦ÊBs such as I¦ÊB¦Á[64]. LPS stimulation causes the degradation of I¦ÊB¦Á, which releases NF¦ÊB, leading to its nuclear translocation [64] Using Raw264.7 cells expressing RON, we demonstrated that MSP treatment significantly prevents the decrease of LPS-induced I¦ÊB¦Á degradationFirst, we found that MSP inhibits LPS-induced I¦ÊB¦Á degradation in macrophages
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c34 : 1
stoichiometry:c74 : 1
m34*0.1
nodelay
--
0
PMID: 12472665, 10837071 LPS stimulation causes the degradation of I¦ÊB¦Á, which releases NF¦ÊB, leading to its nuclear translocation
p25
p25
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c55 : 1
stoichiometry:c129 : 1
stoichiometry:c33 : 1
stoichiometry:c79 : 1
m65*m30*m76*0.1
nodelay
--
0
PMID: 12472665, 9804806 IKK¦Â, also known as IKK1, is the intermediate upstream kinase responsible for the phosphorylation of I¦ÊBs including I¦ÊB¦Á[65]. Reduced phosphorylation and decreased degradation of I¦ÊB¦Á suggest that MSP may affect LPS-induced IKK¦Â activity
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c5 : 1
stoichiometry:c11 : 1
m5*m13*0.1
nodelay
--
0
PMID: 12472665, 7508914 Three enzymes, kallikrein, factor XIa and XIIa, in the blood clotting system have the ability to cleave pro-MSP
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c105 : 1
stoichiometry:c160 : 1
stoichiometry:c93 : 1
m49*0.1
nodelay
--
0
PMID: 12472665, 7514598, 9794431 The inhibitory effect of MSP on macrophages was first demonstrated in vitro, in which treatment of mouse peritoneal macrophages with physiological concentrations of MSP inhibits lipopolysaccharides (LPS)- or cytokine-induced inducible NO synthase (iNOS) and NO production PMID: 12472665, 10725742 Blocking NO production by transforming growth factor-¦Â and MSP prevented LPS-induced inhibition of RON expression
p32
p32
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c39 : 1
stoichiometry:c52 : 1
stoichiometry:c84 : 1
stoichiometry:c86 : 1
stoichiometry:c98 : 1
m45*0.1
nodelay
--
0
Studies of deletion of successive regions, which encompass potential SP-1 sites, suggested that SP-1 or a protein with a binding specificity similar to SP-1 may be involved in the positive regulation of the RON gene transcription PMID: 12472665, 10725742 We have shown that a chemical NO donor, S-nitroglutathione (GSNO) or S-nitroso-N-acetylpenicillamine (SNAP), directly inhibits the RON expression when added to cell culture PMID: 12472665, 10725742 We have shown that in mice injected intraperitoneally with LPS, RON expression is significantly reduced or lost in the peritoneal macrophages [72]. The levels of RON mRNA and protein were also diminished in cultured macrophages following LPS stimulation PMID: 12472665, 10725742 Interestingly, tumour necrosis factor-¦Á together with IFN-¦Ã abrogated the macrophage RON expression, although each individual cytokine alone had no effect
p33
p33
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c35 : 1
stoichiometry:c38 : 1
stoichiometry:c70 : 1
stoichiometry:c80 : 1
stoichiometry:c85 : 1
stoichiometry:c96 : 1
m44*0.1
nodelay
--
0
PMID: 12472665, 9467940, 7632741 Studies of deletion of successive regions, which encompass potential SP-1 sites, suggested that SP-1 or a protein with a binding specificity similar to SP-1 may be involved in the positive regulation of the RON gene transcription PMID: 12472665, 10725742 We have shown that a chemical NO donor, S-nitroglutathione (GSNO) or S-nitroso-N-acetylpenicillamine (SNAP), directly inhibits the RON expression when added to cell culture PMID: 12472665, 10725742 We have shown that in mice injected intraperitoneally with LPS, RON expression is significantly reduced or lost in the peritoneal macrophages [72]. The levels of RON mRNA and protein were also diminished in cultured macrophages following LPS stimulation PMID: 12472665, 10725742 Interestingly, tumour necrosis factor-¦Á together with IFN-¦Ã abrogated the macrophage RON expression, although each individual cytokine alone had no effect
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1
m46*m23*0.1
nodelay
--
0
PMID: 12472665 IFN-gamma binds its receptor.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1
m48*m9*0.1
nodelay
--
0
PMID: 12472665 cytokine binds its receptor
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1
m8*m64*0.1
nodelay
--
0
PMID: 12472665 LPS binds its receptor.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c121 : 1
stoichiometry:c119 : 1
m65*0.1
nodelay
--
0
PMID: 12472665, 9794431 Wortmannin, a specific inhibitor of PI-3 kinase, prevented the inhibitory effect of RON on iNOS gene transcription activity and NO production induced by LPS and IFN-¦Ã[
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c6 : 1
stoichiometry:c12 : 1
m5*m14*0.1
nodelay
--
0
PMID: 12472665, 7508914 Three enzymes, kallikrein, factor XIa and XIIa, in the blood clotting system have the ability to cleave pro-MSP
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c120 : 1
stoichiometry:c118 : 1
m47*0.1
nodelay
--
0
PMID: 12472665, 9794431 Wortmannin, a specific inhibitor of PI-3 kinase, prevented the inhibitory effect of RON on iNOS gene transcription activity and NO production induced by LPS and IFN-¦Ã[
p41
p41
cso30:i:ME_UnknownProduction
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c133 : 1
stoichiometry:c163 : 1
stoichiometry:c27 : 1
stoichiometry:c130 : 1
m65*0.1
nodelay
--
0
PMID: 12472665, 9794431 Wortmannin, a specific inhibitor of PI-3 kinase, prevented the inhibitory effect of RON on iNOS gene transcription activity and NO production induced by LPS and IFN-¦Ã PMID: 12472665, 10725742 Blocking NO production by transforming growth factor-¦Â and MSP prevented LPS-induced inhibition of RON expression PMID: 12472665, 7514598, 9794431 The inhibitory effect of MSP on macrophages was first demonstrated in vitro, in which treatment of mouse peritoneal macrophages with physiological concentrations of MSP inhibits lipopolysaccharides (LPS)- or cytokine-induced inducible NO synthase (iNOS) and NO production
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c128 : 1
stoichiometry:c164 : 1
stoichiometry:c125 : 1
m47*0.1
nodelay
--
0
PMID: 12472665, 9794431 Wortmannin, a specific inhibitor of PI-3 kinase, prevented the inhibitory effect of RON on iNOS gene transcription activity and NO production induced by LPS and IFN-¦Ã PMID: 12472665, 10725742 Blocking NO production by transforming growth factor-¦Â and MSP prevented LPS-induced inhibition of RON expression
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1
m40*m68*0.1
nodelay
--
0
PMID: 12472665 TNF-alpha binds its receptor.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c76 : 1
stoichiometry:c139 : 1
m66*m70*0.1
nodelay
--
0
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c140 : 1
stoichiometry:c142 : 1
m72*m65*0.1
nodelay
--
0
PMID: 12472665, 10847627, 11521070 In mouse macrophages, two separate but cooperative signalling pathways are involved in the induction of iNOS expression: LPS-induced TRL4 > MyD88 > IRAK > IKK > nuclear factor kappa-B (NF¦ÊB) pathway [54, 55] and interferon-¦Ã (IFN-¦Ã)-induced JAK/STAT/IFN-response factor-1 (IRF-1) pathway [54?56]
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c143 : 1
stoichiometry:c145 : 1
m74*m73*0.1
nodelay
--
0
PMID: 12472665, 10847627, 11521070 In mouse macrophages, two separate but cooperative signalling pathways are involved in the induction of iNOS expression: LPS-induced TRL4 > MyD88 > IRAK > IKK > nuclear factor kappa-B (NF¦ÊB) pathway [54, 55] and interferon-¦Ã (IFN-¦Ã)-induced JAK/STAT/IFN-response factor-1 (IRF-1) pathway [54?56]
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c75 : 1
stoichiometry:c148 : 1
m75*m37*0.1
nodelay
--
0
PMID: 12472665, 10847627, 11521070 In mouse macrophages, two separate but cooperative signalling pathways are involved in the induction of iNOS expression: LPS-induced TRL4 > MyD88 > IRAK > IKK > nuclear factor kappa-B (NF¦ÊB) pathway [54, 55] and interferon-¦Ã (IFN-¦Ã)-induced JAK/STAT/IFN-response factor-1 (IRF-1) pathway [54?56]
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c156 : 1
m47*m77*0.1
nodelay
--
0
In mouse macrophages, two separate but cooperative signalling pathways are involved in the induction of iNOS expression: LPS-induced TRL4 > MyD88 > IRAK > IKK > nuclear factor kappa-B (NF¦ÊB) pathway [54, 55] and interferon-¦Ã (IFN-¦Ã)-induced JAK/STAT/IFN-response factor-1 (IRF-1) pathway [54?56]
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c15 : 1
stoichiometry:c17 : 1
m16*m5*0.1
nodelay
--
0
PMID: 12472665, 8188657, 8609228 Pro-MSP activation was also observed in wound fluids collected from surgical patients [32], presumably mediated by tissue proteases such as epidermal growth factor-binding protein and nerve growth factor-¦Ã[32], or by cell-surface proteases located on tissue macrophages [28].
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c91 : 1
stoichiometry:c155 : 1
m31*0.1
nodelay
--
0
PMID: 12472665, 10847627, 11521070 In mouse macrophages, two separate but cooperative signalling pathways are involved in the induction of iNOS expression: LPS-induced TRL4 > MyD88 > IRAK > IKK > nuclear factor kappa-B (NF¦ÊB) pathway [54, 55] and interferon-¦Ã (IFN-¦Ã)-induced JAK/STAT/IFN-response factor-1 (IRF-1) pathway [54?56]
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c90 : 1
stoichiometry:c158 : 1
m78*0.1
nodelay
--
0
PMID: 12472665, 10847627, 11521070, 11536325 In mouse macrophages, two separate but cooperative signalling pathways are involved in the induction of iNOS expression: LPS-induced TRL4 > MyD88 > IRAK > IKK > nuclear factor kappa-B (NF¦ÊB) pathway [54, 55] and interferon-¦Ã (IFN-¦Ã)-induced JAK/STAT/IFN-response factor-1 (IRF-1) pathway [54?56]
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c16 : 1
stoichiometry:c159 : 1
m17*m5*0.1
nodelay
--
0
PMID: 12472665, 8188657, 8609228 Pro-MSP activation was also observed in wound fluids collected from surgical patients [32], presumably mediated by tissue proteases such as epidermal growth factor-binding protein and nerve growth factor-¦Ã[32], or by cell-surface proteases located on tissue macrophages [28].
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1
m18*m5*0.1
nodelay
--
0
PMID: 12472665, 8188657, 8609228 Pro-MSP activation was also observed in wound fluids collected from surgical patients [32], presumably mediated by tissue proteases such as epidermal growth factor-binding protein and nerve growth factor-¦Ã[32], or by cell-surface proteases located on tissue macrophages [28].
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c1 : 1
stoichiometry:c23 : 1
m15*m6*0.1
nodelay
--
0
PMID: 12472665, 7939629, 7732008, 8062829 MSP binds the RON receptor.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c89 : 1
stoichiometry:c26 : 1
stoichiometry:c25 : 1
m20*m65*0.1
nodelay
--
0
PMID: 12472665, 7514598, 9794431 The inhibitory effect of MSP on macrophages was first demonstrated in vitro, in which treatment of mouse peritoneal macrophages with physiological concentrations of MSP inhibits lipopolysaccharides (LPS)- or cytokine-induced inducible NO synthase (iNOS) and NO production
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--