majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:12472665.csml convertedTime:2009.07.01.10:41

Entity

e1: e10: e11:PI-3kinase e12:Kallikrein e13:FactorXIa e14:FctorXIIa e15:MSP e16:EGFBP e17:NGF-gamma e18:Cell surface proteases e19:RON receptor{active}:MSP e2: e20:inos e21:iNOS e22:cox-2 e23:IFN-gamma e24:PKR e25:PKR{active} e26:STAT1 e27:STAT1{p} e28:IRF-1 e29:IRF-2 e3: e30:NFKB:IKB e31:NFKappB{active} e32:DNA e33:NFKappaB:DNA e34:NFKB{active} e35:protein remnants e36:NFKB:IKB{p} e37:IKKalpha:beta:gamma e38:RON receptor:MSP:PI-3kinase e39:RON e4: e40:TNF-alpha e41:GSNO e42:SNAP e43:NO e44:SP-1 e45:unknown protein e46:IFN-gamma receptor e47:IFN-gamma:receptor e48:receptor e49:cytokine:receptor e5:Pro-MSP e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:RON receptor e60: e61: e62: e64:TLR4 e65:LPS:TLR4 e66:TGFbeta e67:wortmannin e68:TNF-alpha receptor e69:TNF_alpha:receptor e7: e70:receptor e71:TGFbeta:receptor e72:MyD88 e73:LPS:TLR4:MyD88 e74:IRAK e75:IRAK{active} e76:IKK{active} e77:IRF-1 e78:IRF-1{active} e8:LPS e9:cytokine

Process

p1 p10 p12 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p24 p25 p3 p31 p32 p33 p34 p35 p36 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p49 p5 p50 p51 p6 p7 p8 p9
164.03288610123087, 146.97413031427192
976.8345100619148, 1418.363708609902

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
182.8496935675846, 201.69863873573567
930.1279045547263, 1308.4284240936668

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
903.0, 216.5
49.84503924330851, 30.73777420004025

PI-3kinase

--

e11

cso30:c:Protein

cso30:i:CC_Cell

--

--

p1

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
963.0, 534.5
57.48842825518213, 35.45119742402898

Kallikrein

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
971.0, 610.5
57.48842825518213, 35.45119742402898

FactorXIa

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
971.0, 682.5
57.48842825518213, 35.45119742402898

FctorXIIa

--

e14

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1228.5, 267.0
30.81223586234655, 49.9657878848863

MSP

--

e15

cso30:c:Protein

cso30:i:CC_Extracellular

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1173.0, 786.5
46.400000000000006, 34.8

EGFBP

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p5

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1157.0, 666.5
46.400000000000006, 34.8

NGF-gamma

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1151.0, 834.0
26.0, 60.0

Cell surface proteases

--

e18

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p7

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1090.5, 317.0
34.887521968365554, 53.67311072056239

RON receptor{active}:MSP

--

e19

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
164.03288610123087, 146.97413031427192
976.8345100619148, 1418.363708609902

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
458.0, 936.0
60.0, 32.0

inos

--

e20

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
812.0, 433.5
48.009659891326216, 29.6059569329845

iNOS

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

p9 p10

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
818.0, 964.0
60.0, 32.0

cox-2

--

e22

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p12

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
318.0, 41.0
20.004677268475206, 46.164639850327404

IFN-gamma

--

e23

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p34

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
461.5, 232.0
29.09961762930168, 47.18856912859731

PKR

--

e24

cso30:c:Protein

cso30:i:CC_Cell

--

--

p14

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
484.5, 415.0
30.87180519219158, 50.062386798148516

PKR{active}

--

e25

cso30:c:Protein

cso30:i:CC_Cell

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
240.0, 281.5
47.055745622861735, 29.017709800764738

STAT1

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

p16

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
257.0, 342.0
54.26829268292682, 43.41463414634146

STAT1{p}

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

p16

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
374.0, 1012.0
60.0, 32.0

IRF-1

--

e28

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p17

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
286.0, 1044.0
60.0, 32.0

IRF-2

--

e29

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p18

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
183.56957630246916, 166.5108205155103
937.7611296594383, 1379.2903282074253

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
246.0, 415.0
44.204419889502766, 49.11602209944751

NFKB:IKB

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p25

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
691.0, 933.5
49.44, 37.08

NFKappB{active}

--

e31

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
706.0, 1045.5
60.0, 13.0

DNA

--

e32

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p21

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
642.0, 1079.5
60.0, 17.0

NFKappaB:DNA

--

e33

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p21

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
254.0, 559.5
43.99999999999999, 33.00000000000001

NFKB{active}

--

e34

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
362.0, 619.0
40.442274554853526, 39.094198736358415

protein remnants

--

e35

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p22

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
507.0, 548.0
50.36585365853658, 40.29268292682927

NFKB:IKB{p}

--

e36

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
646.5, 402.0
43.0, 60.0

IKKalpha:beta:gamma

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p47

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1050.5, 235.0
35.36905854285191, 49.35217471095615

RON receptor:MSP:PI-3kinase

--

e38

cso30:c:Complex

cso30:i:CC_Cell

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
338.0, 1192.0
60.0, 32.0

RON

--

e39

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p32 p33

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
219.71245317476007, 200.70002836767708
865.475375914857, 1310.911912503091

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
816.0, 57.0
23.446211412535078, 54.106641721234794

TNF-alpha

--

e40

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p43

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
1213.922624053827, 1113.4894869638351
52.07737594617325, 29.510513036164845

GSNO

--

e41

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p32 p33

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1218.0, 1179.0
60.0, 34.0

SNAP

--

e42

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p32 p33

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1014.774600504626, 767.3389402859543
59.09167367535745, 33.48528174936923

NO

--

e43

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p31 p41 p42

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
893.0, 1287.5
53.41919903401086, 32.941839404306705

SP-1

--

e44

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p33

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
837.5, 1336.0
29.062386798148527, 47.128194807808406

unknown protein

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p32

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
216.5, 157.0
30.22671353251318, 46.50263620386642

IFN-gamma receptor

--

e46

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p34

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
338.5, 149.0
27.737557553168166, 53.68559526419645

IFN-gamma:receptor

--

e47

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
408.5, 156.0
31.391915641476277, 48.29525483304042

receptor

--

e48

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p35

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
485.5, 148.0
28.76386757290068, 55.672001754001315

cytokine:receptor

--

e49

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1316.5, 371.0
30.81223586234655, 49.9657878848863

Pro-MSP

--

e5

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p2 p3 p4 p5 p6 p7

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
261.0, 753.0
685.3228786500682, 621.5125547534147

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
335.0199757201192, 767.7289440105208
400.7288340709897, 602.3694575844181

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
269.93344534553165, 761.2953421065653
667.4559879590056, 604.921870540284

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
271.2096518234648, 762.571548584498
664.9035750031388, 602.3694575844181

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
261.0, 753.0
685.3228786500682, 621.5125547534147

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
261.0, 753.0
685.3228786500682, 621.5125547534147

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
271.2096518234648, 762.571548584498
664.9035750031388, 602.3694575844181

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
761.2729393497693, 1008.241295586618
42.81520794870761, 38.759030353566956

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
648.9667692916587, 1186.9102024972503
121.2396154036433, 109.7537571022458

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
261.0, 753.0
685.3228786500682, 621.5125547534147

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1038.5, 149.0
34.887521968365554, 53.67311072056239

RON receptor

--

e6

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p8

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
422.52674645140036, 1029.1950437318992
21.703168590654133, 10.449673765870537

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
421.80201621956894, 998.0316437631533
74.2848487627089, 133.7127277728763

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
452.96541618831606, 1084.9992715829108
11.595683709300895, 11.595683709300914

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
579.5, 150.0
33.173989455184525, 51.036906854130045

TLR4

--

e64

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p36

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
700.1840605130454, 141.0
32.067090550317914, 62.06533654900241

LPS:TLR4

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1235.0, 928.5
41.919999999999995, 31.439999999999994

TGFbeta

--

e66

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p44

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1178.0, 1287.0
60.0, 34.0

wortmannin

--

e67

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p1 p41 p42

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
950.5, 149.0
34.68189806678382, 53.35676625659052

TNF-alpha receptor

--

e68

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p43

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
876.5, 143.0
30.395088796316596, 58.82920412190309

TNF_alpha:receptor

--

e69

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
219.20423998515156, 213.69704885082206
833.5859744586843, 1181.1697940669178

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1085.5, 915.0
37.926186291739896, 58.347978910369065

receptor

--

e70

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p44

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
1084.5, 1018.0
33.582766937075206, 64.99890374917781

TGFbeta:receptor

--

e71

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
807.0, 288.5
42.239999999999995, 31.680000000000003

MyD88

--

e72

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p45

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
798.5, 138.0
43.0, 60.0

LPS:TLR4:MyD88

--

e73

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
964.0, 413.0
23.762394761459305, 54.83629560336763

IRAK

--

e74

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p46

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
909.0, 523.0
21.780168381665106, 50.26192703461178

IRAK{active}

--

e75

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
630.5, 490.0
43.0, 60.0

IKK{active}

--

e76

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
253.5, 713.0
28.92835580599718, 46.9108472529684

IRF-1

--

e77

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p49

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
337.5, 780.0
29.92614208090159, 48.52887905011069

IRF-1{active}

--

e78

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
578.3086627417997, 43.6761984861228
58.63751051303615, 33.22792262405382

LPS

--

e8

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p36

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false false false

--

Go back
464.0, 49.0
23.446211412535078, 54.106641721234794

cytokine

--

e9

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p35

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false false false

--

Go back
985.0, 237.0
30.0, 30.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cell

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c3 : 1
stoichiometry:c32 : 1
stoichiometry:c21 : 1

m19*m11*0.1

nodelay

--

true

0

false

PMID: 12472665, 9794431 Wortmannin, a specific inhibitor of PI-3 kinase, prevented the inhibitory effect of RON on iNOS gene transcription activity and NO production induced by LPS and IFN-¦Ã

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581.0, 361.0
30.0, 30.0

p10

p10

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c31 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1

m20*m49*0.1

nodelay

--

true

0

false

The inhibitory effect of MSP on macrophages was first demonstrated in vitro, in which treatment of mouse peritoneal macrophages with physiological concentrations of MSP inhibits lipopolysaccharides (LPS)- or cytokine-induced inducible NO synthase (iNOS) and NO production

Go back
761.0, 877.0
30.0, 30.0

p12

p12

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c40 : 1
stoichiometry:c36 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 12472665, LPS-induced cyclooxygenase-2 (Cox-2) expression and prostaglandin E2 (PGE2) production by macrophages was also inhibited by MSP

Go back
637.0, 273.0
30.0, 30.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c81 : 1
stoichiometry:c42 : 1

m24*m65*0.1

nodelay

--

true

0

false

PMID: 12472665, 10557102, 10878375 Recently, it was shown that double-stranded RNA-regulated protein kinase (PKR) also plays a critical role in LPS-induced iNOS expression. Inactivation of PKR gene results in the failure of iNOS induction by LPS

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397.0, 861.0
30.0, 30.0

p15

p15

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c82 : 1
stoichiometry:c44 : 1

m25*0.1

nodelay

--

true

0

false

PMID: 12472665, 10878375 Inactivation of PKR gene results in the failure of iNOS induction by LPS

Go back
285.0, 233.0
30.0, 30.0

p16

p16

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 12472665, 10586055 RON activation affect IFN-¦Ã-induced STAT1 phosphorylation and IRF-1 or IRF-2 expression

Go back
365.0, 921.0
30.0, 30.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c50 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 12472665, 10586055 RON activation affect IFN-¦Ã-induced STAT1 phosphorylation and IRF-1 or IRF-2 expression

Go back
305.0, 937.0
30.0, 30.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c51 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 12472665, 10586055 RON activation affect IFN-¦Ã-induced STAT1 phosphorylation and IRF-1 or IRF-2 expression

Go back
473.0, 673.0
30.0, 30.0

p19

p19

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c66 : 1
stoichiometry:c53 : 1
stoichiometry:c56 : 1

m34*m47*0.1

nodelay

--

true

0

false

PMID: 12472665, 10586055 After LPS and IFN-¦Ã stimulation, nuclear translocation of NF¦ÊB was significantly reduced upon RON activation

Go back
1149.0, 373.0
30.0, 30.0

p2

p2

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c4 : 1
stoichiometry:c10 : 1

m5*m12*0.1

nodelay

--

true

0

false

PMID: 12472665, 7508914 Three enzymes, kallikrein, factor XIa and XIIa, in the blood clotting system have the ability to cleave pro-MSP

Go back
569.0, 637.0
30.0, 30.0

p20

p20

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c67 : 1
stoichiometry:c77 : 1
stoichiometry:c57 : 1

m34*m65*0.1

nodelay

--

true

0

false

PMID: 12472665, 10586055 After LPS and IFN-¦Ã stimulation, nuclear translocation of NF¦ÊB was significantly reduced upon RON activation

Go back
573.0, 1017.0
30.0, 30.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c63 : 1
stoichiometry:c60 : 1

m31*m32*0.1

nodelay

--

true

0

false

PMID: 12472665, 10586055 RON activation also caused decreased binding of NF¦ÊB to its consensus sequence [

Go back
357.0, 445.0
30.0, 30.0

p22

p22

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c108 : 1
stoichiometry:c54 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m65*m36*0.1

nodelay

--

true

0

false

PMID: 12472665,10837071,10847627, 11521070 In mouse macrophages, two separate but cooperative signalling pathways are involved in the induction of iNOS expression: LPS-induced TRL4 > MyD88 > IRAK > IKK > nuclear factor kappa-B (NF¦ÊB) pathway [54, 55] and interferon-¦Ã (IFN-¦Ã)-induced JAK/STAT/IFN-response factor-1 (IRF-1) pathway [54?56] NF¦ÊB is normally sequestered in the cytoplasm by NF¦ÊB inhibitor protein I¦ÊBs such as I¦ÊB¦Á[64]. LPS stimulation causes the degradation of I¦ÊB¦Á, which releases NF¦ÊB, leading to its nuclear translocation [64] Using Raw264.7 cells expressing RON, we demonstrated that MSP treatment significantly prevents the decrease of LPS-induced I¦ÊB¦Á degradationFirst, we found that MSP inhibits LPS-induced I¦ÊB¦Á degradation in macrophages

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381.0, 685.0
30.0, 30.0

p24

p24

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c34 : 1
stoichiometry:c74 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 12472665, 10837071 LPS stimulation causes the degradation of I¦ÊB¦Á, which releases NF¦ÊB, leading to its nuclear translocation

Go back
381.0, 541.0
30.0, 30.0

p25

p25

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c55 : 1
stoichiometry:c129 : 1
stoichiometry:c33 : 1
stoichiometry:c79 : 1

m65*m30*m76*0.1

nodelay

--

true

0

false

PMID: 12472665, 9804806 IKK¦Â, also known as IKK1, is the intermediate upstream kinase responsible for the phosphorylation of I¦ÊBs including I¦ÊB¦Á[65]. Reduced phosphorylation and decreased degradation of I¦ÊB¦Á suggest that MSP may affect LPS-induced IKK¦Â activity

Go back
1161.0, 449.0
30.0, 30.0

p2

p3

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c5 : 1
stoichiometry:c11 : 1

m5*m13*0.1

nodelay

--

true

0

false

PMID: 12472665, 7508914 Three enzymes, kallikrein, factor XIa and XIIa, in the blood clotting system have the ability to cleave pro-MSP

Go back
905.0, 733.0
30.0, 30.0

p31

p31

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c105 : 1
stoichiometry:c160 : 1
stoichiometry:c93 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 12472665, 7514598, 9794431 The inhibitory effect of MSP on macrophages was first demonstrated in vitro, in which treatment of mouse peritoneal macrophages with physiological concentrations of MSP inhibits lipopolysaccharides (LPS)- or cytokine-induced inducible NO synthase (iNOS) and NO production PMID: 12472665, 10725742 Blocking NO production by transforming growth factor-¦Â and MSP prevented LPS-induced inhibition of RON expression

Go back
493.0, 1253.0
30.0, 30.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c39 : 1
stoichiometry:c52 : 1
stoichiometry:c84 : 1
stoichiometry:c86 : 1
stoichiometry:c98 : 1

m45*0.1

nodelay

--

true

0

false

Studies of deletion of successive regions, which encompass potential SP-1 sites, suggested that SP-1 or a protein with a binding specificity similar to SP-1 may be involved in the positive regulation of the RON gene transcription PMID: 12472665, 10725742 We have shown that a chemical NO donor, S-nitroglutathione (GSNO) or S-nitroso-N-acetylpenicillamine (SNAP), directly inhibits the RON expression when added to cell culture PMID: 12472665, 10725742 We have shown that in mice injected intraperitoneally with LPS, RON expression is significantly reduced or lost in the peritoneal macrophages [72]. The levels of RON mRNA and protein were also diminished in cultured macrophages following LPS stimulation PMID: 12472665, 10725742 Interestingly, tumour necrosis factor-¦Á together with IFN-¦Ã abrogated the macrophage RON expression, although each individual cytokine alone had no effect

Go back
537.0, 1197.0
30.0, 30.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c35 : 1
stoichiometry:c38 : 1
stoichiometry:c70 : 1
stoichiometry:c80 : 1
stoichiometry:c85 : 1
stoichiometry:c96 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 12472665, 9467940, 7632741 Studies of deletion of successive regions, which encompass potential SP-1 sites, suggested that SP-1 or a protein with a binding specificity similar to SP-1 may be involved in the positive regulation of the RON gene transcription PMID: 12472665, 10725742 We have shown that a chemical NO donor, S-nitroglutathione (GSNO) or S-nitroso-N-acetylpenicillamine (SNAP), directly inhibits the RON expression when added to cell culture PMID: 12472665, 10725742 We have shown that in mice injected intraperitoneally with LPS, RON expression is significantly reduced or lost in the peritoneal macrophages [72]. The levels of RON mRNA and protein were also diminished in cultured macrophages following LPS stimulation PMID: 12472665, 10725742 Interestingly, tumour necrosis factor-¦Á together with IFN-¦Ã abrogated the macrophage RON expression, although each individual cytokine alone had no effect

Go back
230.0, 58.0
27.0, 27.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m46*m23*0.1

nodelay

--

true

0

false

PMID: 12472665 IFN-gamma binds its receptor.

Go back
389.0, 85.0
30.0, 30.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m48*m9*0.1

nodelay

--

true

0

false

PMID: 12472665 cytokine binds its receptor

Go back
665.0, 73.0
30.0, 30.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m8*m64*0.1

nodelay

--

true

0

false

PMID: 12472665 LPS binds its receptor.

Go back
605.0, 937.0
30.0, 30.0

p39

p39

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c121 : 1
stoichiometry:c119 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 12472665, 9794431 Wortmannin, a specific inhibitor of PI-3 kinase, prevented the inhibitory effect of RON on iNOS gene transcription activity and NO production induced by LPS and IFN-¦Ã[

Go back
1161.0, 525.0
30.0, 30.0

p2

p4

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c6 : 1
stoichiometry:c12 : 1

m5*m14*0.1

nodelay

--

true

0

false

PMID: 12472665, 7508914 Three enzymes, kallikrein, factor XIa and XIIa, in the blood clotting system have the ability to cleave pro-MSP

Go back
573.0, 901.0
30.0, 30.0

p40

p40

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c120 : 1
stoichiometry:c118 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 12472665, 9794431 Wortmannin, a specific inhibitor of PI-3 kinase, prevented the inhibitory effect of RON on iNOS gene transcription activity and NO production induced by LPS and IFN-¦Ã[

Go back
893.0, 789.0
30.0, 30.0

p41

p41

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c133 : 1
stoichiometry:c163 : 1
stoichiometry:c27 : 1
stoichiometry:c130 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 12472665, 9794431 Wortmannin, a specific inhibitor of PI-3 kinase, prevented the inhibitory effect of RON on iNOS gene transcription activity and NO production induced by LPS and IFN-¦Ã PMID: 12472665, 10725742 Blocking NO production by transforming growth factor-¦Â and MSP prevented LPS-induced inhibition of RON expression PMID: 12472665, 7514598, 9794431 The inhibitory effect of MSP on macrophages was first demonstrated in vitro, in which treatment of mouse peritoneal macrophages with physiological concentrations of MSP inhibits lipopolysaccharides (LPS)- or cytokine-induced inducible NO synthase (iNOS) and NO production

Go back
869.0, 833.0
30.0, 30.0

p42

p42

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c128 : 1
stoichiometry:c164 : 1
stoichiometry:c125 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 12472665, 9794431 Wortmannin, a specific inhibitor of PI-3 kinase, prevented the inhibitory effect of RON on iNOS gene transcription activity and NO production induced by LPS and IFN-¦Ã PMID: 12472665, 10725742 Blocking NO production by transforming growth factor-¦Â and MSP prevented LPS-induced inhibition of RON expression

Go back
889.0, 65.0
30.0, 30.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m40*m68*0.1

nodelay

--

true

0

false

PMID: 12472665 TNF-alpha binds its receptor.

Go back
1181.0, 985.0
30.0, 30.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c76 : 1
stoichiometry:c139 : 1

m66*m70*0.1

nodelay

--

true

0

false

Go back
769.0, 237.0
30.0, 30.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c140 : 1
stoichiometry:c142 : 1

m72*m65*0.1

nodelay

--

true

0

false

PMID: 12472665, 10847627, 11521070 In mouse macrophages, two separate but cooperative signalling pathways are involved in the induction of iNOS expression: LPS-induced TRL4 > MyD88 > IRAK > IKK > nuclear factor kappa-B (NF¦ÊB) pathway [54, 55] and interferon-¦Ã (IFN-¦Ã)-induced JAK/STAT/IFN-response factor-1 (IRF-1) pathway [54?56]

Go back
869.0, 361.0
30.0, 30.0

p46

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c143 : 1
stoichiometry:c145 : 1

m74*m73*0.1

nodelay

--

true

0

false

PMID: 12472665, 10847627, 11521070 In mouse macrophages, two separate but cooperative signalling pathways are involved in the induction of iNOS expression: LPS-induced TRL4 > MyD88 > IRAK > IKK > nuclear factor kappa-B (NF¦ÊB) pathway [54, 55] and interferon-¦Ã (IFN-¦Ã)-induced JAK/STAT/IFN-response factor-1 (IRF-1) pathway [54?56]

Go back
741.0, 509.0
30.0, 30.0

p47

p47

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c75 : 1
stoichiometry:c148 : 1

m75*m37*0.1

nodelay

--

true

0

false

PMID: 12472665, 10847627, 11521070 In mouse macrophages, two separate but cooperative signalling pathways are involved in the induction of iNOS expression: LPS-induced TRL4 > MyD88 > IRAK > IKK > nuclear factor kappa-B (NF¦ÊB) pathway [54, 55] and interferon-¦Ã (IFN-¦Ã)-induced JAK/STAT/IFN-response factor-1 (IRF-1) pathway [54?56]

Go back
277.0, 641.0
30.0, 30.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c156 : 1

m47*m77*0.1

nodelay

--

true

0

false

In mouse macrophages, two separate but cooperative signalling pathways are involved in the induction of iNOS expression: LPS-induced TRL4 > MyD88 > IRAK > IKK > nuclear factor kappa-B (NF¦ÊB) pathway [54, 55] and interferon-¦Ã (IFN-¦Ã)-induced JAK/STAT/IFN-response factor-1 (IRF-1) pathway [54?56]

Go back
1193.0, 597.0
30.0, 30.0

p5

p5

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c15 : 1
stoichiometry:c17 : 1

m16*m5*0.1

nodelay

--

true

0

false

PMID: 12472665, 8188657, 8609228 Pro-MSP activation was also observed in wound fluids collected from surgical patients [32], presumably mediated by tissue proteases such as epidermal growth factor-binding protein and nerve growth factor-¦Ã[32], or by cell-surface proteases located on tissue macrophages [28].

Go back
533.0, 973.0
30.0, 30.0

p50

p50

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c91 : 1
stoichiometry:c155 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 12472665, 10847627, 11521070 In mouse macrophages, two separate but cooperative signalling pathways are involved in the induction of iNOS expression: LPS-induced TRL4 > MyD88 > IRAK > IKK > nuclear factor kappa-B (NF¦ÊB) pathway [54, 55] and interferon-¦Ã (IFN-¦Ã)-induced JAK/STAT/IFN-response factor-1 (IRF-1) pathway [54?56]

Go back
337.0, 1137.0
30.0, 30.0

p51

p51

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c90 : 1
stoichiometry:c158 : 1

m78*0.1

nodelay

--

true

0

false

PMID: 12472665, 10847627, 11521070, 11536325 In mouse macrophages, two separate but cooperative signalling pathways are involved in the induction of iNOS expression: LPS-induced TRL4 > MyD88 > IRAK > IKK > nuclear factor kappa-B (NF¦ÊB) pathway [54, 55] and interferon-¦Ã (IFN-¦Ã)-induced JAK/STAT/IFN-response factor-1 (IRF-1) pathway [54?56]

Go back
1241.0, 769.0
30.0, 30.0

p6

p6

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c16 : 1
stoichiometry:c159 : 1

m17*m5*0.1

nodelay

--

true

0

false

PMID: 12472665, 8188657, 8609228 Pro-MSP activation was also observed in wound fluids collected from surgical patients [32], presumably mediated by tissue proteases such as epidermal growth factor-binding protein and nerve growth factor-¦Ã[32], or by cell-surface proteases located on tissue macrophages [28].

Go back
1317.0, 861.0
30.0, 30.0

p7

p7

cso30:i:ME_Cleavage

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m18*m5*0.1

nodelay

--

true

0

false

PMID: 12472665, 8188657, 8609228 Pro-MSP activation was also observed in wound fluids collected from surgical patients [32], presumably mediated by tissue proteases such as epidermal growth factor-binding protein and nerve growth factor-¦Ã[32], or by cell-surface proteases located on tissue macrophages [28].

Go back
1181.0, 161.0
30.0, 30.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c1 : 1
stoichiometry:c23 : 1

m15*m6*0.1

nodelay

--

true

0

false

PMID: 12472665, 7939629, 7732008, 8062829 MSP binds the RON receptor.

Go back
789.0, 633.0
30.0, 30.0

p9

p9

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c89 : 1
stoichiometry:c26 : 1
stoichiometry:c25 : 1

m20*m65*0.1

nodelay

--

true

0

false

PMID: 12472665, 7514598, 9794431 The inhibitory effect of MSP on macrophages was first demonstrated in vitro, in which treatment of mouse peritoneal macrophages with physiological concentrations of MSP inhibits lipopolysaccharides (LPS)- or cytokine-induced inducible NO synthase (iNOS) and NO production

Go back
1073.0, 176.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1177.0, 317.12953234500634

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
264.9615792869974, 65.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
257.0, 84.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
409.89564944152806, 122.77216271026504

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
426.5894663844041, 80.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
419.0, 112.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
514.0, 195.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
613.0, 108.81034719847815

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
687.0, 103.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
393.1345100515665, 185.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1182.0, 324.44326714253674

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
361.0, 203.0

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
622.9736346150183, 203.0

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
525.5183473879075, 921.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.0, 952.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1180.0, 324.71553678492415

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
601.3638672917036, 284.0

c120

c120

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
632.171084887073, 284.0

c121

c121

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
899.0, 798.949005762265

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
366.0, 194.0

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
897.3154830940157, 866.2616771822679

c128

c128

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
290.0, 460.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1197.0, 634.9844206278631

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
923.0, 789.2035359758917

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
725.0, 203.0

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
919.0590605109518, 822.4293249790941

c133

c133

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
839.0, 81.31974430679097

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
918.4654135385309, 101.63777688160008

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.9922778767136, 95.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1125.0866522822412, 1008.0

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1193.0, 701.0

c14

c14

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
732.0, 191.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
801.0659023220582, 273.19165839362654

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
790.0, 205.3335677176674

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
829.0, 198.0

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
905.5775375331502, 391.55367983064247

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
887.0, 391.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
778.9172847920029, 527.1474325785512

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
681.9964381120229, 521.2386996451351

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1220.9818418753885, 421.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
294.9967386482519, 203.0

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
275.0, 678.6422871255307

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
570.8152001391701, 957.0

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
521.8262546692157, 972.1716000756318

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
298.0, 671.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
352.0, 829.0

c157

c157

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
362.0, 974.6139558513813

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1245.1946326379727, 324.99763203306054

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1260.5342032419733, 421.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
931.0638166276589, 766.4264647856645

c160

c160

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
922.4712862077276, 822.1452733552896

c163

c163

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
901.9289295721458, 864.7242194407592

c164

c164

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1210.0, 324.95141558249236

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1177.0, 865.0

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1332.0, 421.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1021.1192895849364, 270.1530859662622

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1249.1924119657963, 324.910635480404

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1015.0, 254.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1205.104456000465, 198.37308300110453

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1125.7120559573646, 191.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
505.0, 667.554585028684

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
806.0, 470.89364692462556

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
816.2471648710894, 284.0

c26

c26

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
916.5894439354698, 371.0

c27

c27

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
491.0, 398.8634670816072

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
611.0, 381.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
953.0, 239.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
513.0, 204.0

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
614.9922103139315, 345.0

c31

c31

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1003.7770653411825, 270.92379528715924

c32

c32

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
418.9217419845493, 523.0

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
414.5777087639997, 353.0

c34

c34

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
570.998938603502, 1197.0

c35

c35

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
788.0, 907.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
787.0748542594214, 371.0

c37

c37

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
570.9705115226135, 1131.0

c38

c38

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
526.9289555724598, 1133.0

c39

c39

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1010.0, 407.5307252610301

c4

c4

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
719.0, 203.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
491.0, 259.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.6568542494924, 303.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
416.58415841584156, 465.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
427.0, 891.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
315.7455923043988, 195.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
279.7455923043988, 263.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
288.10328023956595, 263.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
353.0, 203.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
321.32670270981214, 203.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1019.0, 483.4687928795244

c5

c5

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
384.0, 951.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
317.3114520150781, 967.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.9809903691487, 1199.0

c52

c52

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
359.0, 203.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
393.6307893926052, 474.4757828400085

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
413.12492706846785, 191.0

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
501.0, 703.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
591.0, 667.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
609.7839864320407, 968.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
610.9271089302845, 1035.0774711167378

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1019.0, 559.3793064530703

c6

c6

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
603.0, 1042.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
602.4489976616852, 354.0

c61

c61

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
506.4983116143568, 354.0

c62

c62

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
601.4141079617551, 367.0

c63

c63

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
295.0856580228888, 475.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
373.0, 475.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
298.0, 588.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
298.0, 581.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
390.9511882865769, 347.0

c68

c68

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1216.8623479330104, 960.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1186.9924492668404, 389.3474977942105

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
554.624054407946, 203.0

c70

c70

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
292.0, 593.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
411.0, 712.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
690.0, 454.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1123.0, 956.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
590.115466760049, 203.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
414.8328529947432, 349.0

c78

c78

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
411.0, 557.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1198.3319271481682, 403.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
558.2419594912491, 202.0

c80

c80

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
663.885143449429, 201.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
429.9158162229679, 276.0

c82

c82

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
514.3250800499557, 202.0

c84

c84

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
357.0, 203.0

c85

c85

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
356.0, 203.0

c86

c86

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
722.0, 203.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1196.8855857826945, 410.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
366.5054457169712, 282.0

c90

c90

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
561.3245058308328, 284.0

c91

c91

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
637.0, 71.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
935.0, 752.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
928.6920899642465, 371.0

c94

c94

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
574.7639337618484, 1217.9290755665943

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
405.9981373931012, 1209.1726216703546

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
530.72987951681, 1274.0613012044826

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
405.345138220817, 1224.1700070216157

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
235.0, 92.95106987738895

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back