Entity
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
LPS:CD14
--
e11
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
csml-variable:Double
m11
0
infinite
0
--
CD14
--
e12
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m12
0
infinite
0
--
LPS:CD14
--
e13
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m13
0
infinite
0
--
TLR4
--
e14
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m14
0
infinite
0
--
MD2
--
e15
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m15
0
infinite
0
--
TLR4:MD2
--
e16
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m16
0
infinite
0
--
LPS:CD14:TLR4:MD2
--
e17
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m17
0
infinite
0
--
CD11b:CD18
--
e18
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m18
0
infinite
0
--
LPS:CD11b:CD18
--
e19
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
CD11c:CD18
--
e20
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m20
0
infinite
0
--
LPS:CD11c:CD18
--
e21
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
csml-variable:Double
m21
0
infinite
0
--
csml-variable:Double
m22
0
infinite
0
--
Nod1
--
e23
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m23
0
infinite
0
--
LPS:Nod1
--
e24
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m24
0
infinite
0
--
CXCR4:GDF5:HSP90:HSP70
--
e25
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m25
0
infinite
0
--
LPS:CXCXR4:GDF5:HSP90:HSP70
--
e26
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m26
0
infinite
0
--
TNF-alpha
--
e27
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m27
0
infinite
0
--
ERK2
--
e28
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m28
0
infinite
0
--
ERK2{active}
--
e29
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
NF-kappaB:
--
e30
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m30
0
infinite
0
--
NF-kappaB{active}
--
e31
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m31
0
infinite
0
--
AP-1
--
e32
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m32
0
infinite
0
--
AP-1{active}
--
e33
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m33
0
infinite
0
--
NF-kappaB{active}
--
e34
cso30:c:Protein
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m34
0
infinite
0
--
IL-12p40
--
e35
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m35
0
infinite
0
--
MCP-5
--
e36
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m36
0
infinite
0
--
IFN-gamma
--
e37
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m37
0
infinite
0
--
TLR2
--
e38
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m38
0
infinite
0
--
csml-variable:Double
m39
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
LAM:TLR2
--
e40
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m40
0
infinite
0
--
csml-variable:Double
m41
0
infinite
0
--
STF:TLR2
--
e42
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m42
0
infinite
0
--
IL-8
--
e43
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m43
0
infinite
0
--
csml-variable:Double
m44
0
infinite
0
--
LPS:TLR2
--
e45
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m45
0
infinite
0
--
cox2
--
e46
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m46
0
infinite
0
--
csml-variable:Double
m47
0
infinite
0
--
IP-10
--
e48
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m48
0
infinite
0
--
csml-variable:Double
m49
0
infinite
0
--
LPS
--
e5
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
CD14
--
e6
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
ICSBP
--
e63
cso30:c:mRNA
cso30:i:CC_Nucleolus
--
--
csml-variable:Double
m63
0
infinite
0
--
IKKalpha:IKKbeta:IKKgamma
--
e64
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m64
0
infinite
0
--
IKKalpha:Ikkbeta:IKKgamma{active}
--
e65
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m65
0
infinite
0
--
Ikappa-B:NF-kappaB
--
e66
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m66
0
infinite
0
--
csml-variable:Double
m67
0
infinite
0
--
Ikappa-B{ub}{NF-kappaB
--
e68
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m68
0
infinite
0
--
protein remnants
--
e69
cso30:c:EntityBiological
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m69
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
I-kappaB
--
e70
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m70
0
infinite
0
--
csml-variable:Double
m71
0
infinite
0
--
csml-variable:Double
m72
0
infinite
0
--
csml-variable:Double
m73
0
infinite
0
--
csml-variable:Double
m74
0
infinite
0
--
csml-variable:Double
m75
0
infinite
0
--
csml-variable:Double
m76
0
infinite
0
--
csml-variable:Double
m77
0
infinite
0
--
csml-variable:Double
m78
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m6*m5*0.1
nodelay
--
0
PMID: 12106783 LPS is bound by CD14 and/or CD11/18 at the cell surface and facilitates an interaction with the TLR4-MD2 complex.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1
m25*m5*0.1
nodelay
--
0
PMID: 12106783 The CD14-independent cluster able to bind to LPS and represented by Hsp70, Hsp-90, CXCR4, and GDF5 may also contribute to LPS-induced TNF-¦Á production by as yet unknown mechanism(s).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c29 : 1
m17*0.1
nodelay
--
0
PMID: 12106783 Induction of a panel of inflammatory genes including COX-2, IL-12 p35, IL-12 p40, TNF-¦Á, IP-10, IRF-1, and ICSBP by low concentrations of LPS required both CD14 and TLR4.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c54 : 1
stoichiometry:c32 : 1
m28*m42*0.1
nodelay
--
0
PMID: 12106783 E. coli LPS and the TLR2 agonists, lipoarabinomannan (LAM) and soluble tuberculosis factor (STF), rapidly activated mitogen activated (MAP) kinases, as well as NF-¦ÊB and AP-1 transactivation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c37 : 1
stoichiometry:c36 : 1
m32*m17*0.1
nodelay
--
0
PMID: 12106783 E. coli LPS and the TLR2 agonists, lipoarabinomannan (LAM) and soluble tuberculosis factor (STF), rapidly activated mitogen activated (MAP) kinases, as well as NF-¦ÊB and AP-1 transactivation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c41 : 1
stoichiometry:c39 : 1
m31*m21*0.1
nodelay
--
0
PMID: 12106783, 9200483, 7535339, 9820516 CD18 in complex with CD11b or CD11c, activates signaling cascades leading to NF-¦ÊB translocation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c42 : 1
m17*0.1
nodelay
--
0
PMID: 12106783 IFN-¦Ã, IL-12 p40, and MCP-5 were induced only by E. coli LPS. Induction of a panel of inflammatory genes including COX-2, IL-12 p35, IL-12 p40, TNF-¦Á, IP-10, IRF-1, and ICSBP by low concentrations of LPS required both CD14 and TLR4.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c44 : 1
m17*0.1
nodelay
--
0
PMID: 12106783 IFN-¦Ã, IL-12 p40, and MCP-5 were induced only by E. coli LPS.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c46 : 1
m17*0.1
nodelay
--
0
PMID: 12106783 IFN-¦Ã, IL-12 p40, and MCP-5 were induced only by E. coli LPS
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1
m38*m39*0.1
nodelay
--
0
PMID: 12106783 E. coli LPS and the TLR2 agonists, lipoarabinomannan (LAM) and soluble tuberculosis factor (STF), rapidly activated mitogen activated (MAP) kinases, as well as NF-¦ÊB and AP-1 transactivation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1
m41*m38*0.1
nodelay
--
0
PMID: 12106783 E. coli LPS and the TLR2 agonists, lipoarabinomannan (LAM) and soluble tuberculosis factor (STF), rapidly activated mitogen activated (MAP) kinases, as well as NF-¦ÊB and AP-1 transactivation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m5*m12*0.1
nodelay
--
0
PMID: 12106783, 1698311, 7534290, 7534291 soluble form (sCD14) or a glycosylphosphatidylinositol (GPI)-linked form (mCD14) on myeloid lineage cells bound enterobacterial LPS with high affinity.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c60 : 1
m42*0.1
nodelay
--
0
PMID: 12106783 Activation of DC through TLR2 also led to preferential induction of IL-8 and p19/IL-23.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c62 : 1
m42*0.1
nodelay
--
0
PMID: 12106783 Activation of DC through TLR2 also led to preferential induction of IL-8 and p19/IL-23.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1
m38*m5*0.1
nodelay
--
0
PMID: 12106783, 9751057 LPS binding ability of TLRs revealed that 3H-labeled LPS bound TLR2. However, the kinetics of association was slow and the Kd low (500?700 nM).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c69 : 1
m17*0.1
nodelay
--
0
PMID: 12106783 Induction of a panel of inflammatory genes including COX-2, IL-12 p35, IL-12 p40, TNF-¦Á, IP-10, IRF-1, and ICSBP by low concentrations of LPS required both CD14 and TLR4.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
m17*0.1
nodelay
--
0
PMID: 12106783 Induction of a panel of inflammatory genes including COX-2, IL-12 p35, IL-12 p40, TNF-¦Á, IP-10, IRF-1, and ICSBP by low concentrations of LPS required both CD14 and TLR4.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c73 : 1
m17*0.1
nodelay
--
0
PMID: 12106783 Induction of a panel of inflammatory genes including COX-2, IL-12 p35, IL-12 p40, TNF-¦Á, IP-10, IRF-1, and ICSBP by low concentrations of LPS required both CD14 and TLR4.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c75 : 1
m17*0.1
nodelay
--
0
PMID: 12106783 Induction of a panel of inflammatory genes including COX-2, IL-12 p35, IL-12 p40, TNF-¦Á, IP-10, IRF-1, and ICSBP by low concentrations of LPS required both CD14 and TLR4.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c77 : 1
m17*0.1
nodelay
--
0
PMID: 12106783 Induction of a panel of inflammatory genes including COX-2, IL-12 p35, IL-12 p40, TNF-¦Á, IP-10, IRF-1, and ICSBP by low concentrations of LPS required both CD14 and TLR4.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c34 : 1
stoichiometry:c80 : 1
m17*m64*0.1
nodelay
--
0
PMID: 12106783 Stimulation of cells with LPS or other inflammatory stimuli leads to the activation of the I¦ÊB kinase complex (IKK).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c102 : 1
stoichiometry:c101 : 1
m75*m17*0.1
nodelay
--
0
PMID: 12106783 In addition to NF-¦ÊB, LPS also activates MAP kinases, including JNK-1/2, ERK-1/2, and p38, in macrophages.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
m14*m15*0.1
nodelay
--
0
PMID: 12106783 LPS is bound by CD14 and/or CD11/18 at the cell surface and facilitates an interaction with the TLR4-MD2 complex.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c84 : 1
stoichiometry:c83 : 1
m66*m65*0.1
nodelay
--
0
PMID: 12106783 Stimulation of cells with LPS or other inflammatory stimuli leads to the activation of the I¦ÊB kinase complex (IKK), which phosphorylates I¦ÊB on two N-terminal serine residues.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
m67*0.1
nodelay
--
0
PMID: 12106783 Phosphorylated I¦ÊB becomes a substrate for ubiquitin ligase and finally undergoes degradation by the 26S proteasome.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1
m68*0.1
nodelay
--
0
PMID: 12106783 Phosphorylated I¦ÊB becomes a substrate for ubiquitin ligase and finally undergoes degradation by the 26S proteasome.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
m34*0.1
nodelay
--
0
PMID: 12106783 Released NF-¦ÊB then moves to the nucleus, where it activates the transcription of many ¦ÊB-dependent genes, including TNF-¦Á and I¦ÊB¦Á.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c94 : 1
stoichiometry:c93 : 1
m71*m17*0.1
nodelay
--
0
PMID: 12106783 In addition to NF-¦ÊB, LPS also activates MAP kinases, including JNK-1/2, ERK-1/2, and p38, in macrophages.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c96 : 1
stoichiometry:c95 : 1
m73*m17*0.1
nodelay
--
0
PMID: 12106783 In addition to NF-¦ÊB, LPS also activates MAP kinases, including JNK-1/2, ERK-1/2, and p38, in macrophages.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c106 : 1
stoichiometry:c105 : 1
m77*m17*0.1
nodelay
--
0
PMID: 12106783 In addition to NF-¦ÊB, LPS also activates MAP kinases, including JNK-1/2, ERK-1/2, and p38, in macrophages.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c19 : 1
stoichiometry:c109 : 1
m28*m17*0.1
nodelay
--
0
PMID: 12106783 In addition to NF-¦ÊB, LPS also activates MAP kinases, including JNK-1/2, ERK-1/2, and p38, in macrophages.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c110 : 1
m26*0.1
nodelay
--
0
PMID: 12106783 The CD14-independent cluster able to bind to LPS and represented by Hsp70, Hsp-90, CXCR4, and GDF5 may also contribute to LPS-induced TNF-¦Á production by as yet unknown mechanism(s). Induction of a panel of inflammatory genes including COX-2, IL-12 p35, IL-12 p40, TNF-¦Á, IP-10, IRF-1, and ICSBP by low concentrations of LPS required both CD14 and TLR4. Released NF-¦ÊB then moves to the nucleus, where it activates the transcription of many ¦ÊB-dependent genes, including TNF-¦Á and I¦ÊB¦Á. MAP kinases have been shown to be important for both TNF-¦Á and IL-1 synthesis
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c30 : 1
m34*0.1
nodelay
--
0
PMID: 12106783 Released NF-¦ÊB then moves to the nucleus, where it activates the transcription of many ¦ÊB-dependent genes, including TNF-¦Á and I¦ÊB¦Á.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1
m11*m16*0.1
nodelay
--
0
PMID: 12106783 LPS is bound by CD14 and/or CD11/18 at the cell surface and facilitates an interaction with the TLR4-MD2 complex.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c79 : 1
m78*0.1
nodelay
--
0
PMID: 12106783 Induction of a panel of inflammatory genes including COX-2, IL-12 p35, IL-12 p40, TNF-¦Á, IP-10, IRF-1, and ICSBP by low concentrations of LPS required both CD14 and TLR4. MAP kinases have been shown to be important for both TNF-¦Á and IL-1 synthesis
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c107 : 1
m76*0.1
nodelay
--
0
PMID: 12106783 Induction of a panel of inflammatory genes including COX-2, IL-12 p35, IL-12 p40, TNF-¦Á, IP-10, IRF-1, and ICSBP by low concentrations of LPS required both CD14 and TLR4. MAP kinases have been shown to be important for both TNF-¦Á and IL-1 synthesis
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c103 : 1
m72*0.1
nodelay
--
0
PMID: 12106783 Induction of a panel of inflammatory genes including COX-2, IL-12 p35, IL-12 p40, TNF-¦Á, IP-10, IRF-1, and ICSBP by low concentrations of LPS required both CD14 and TLR4. MAP kinases have been shown to be important for both TNF-¦Á and IL-1 synthesis
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c115 : 1
m29*0.1
nodelay
--
0
PMID: 12106783 Induction of a panel of inflammatory genes including COX-2, IL-12 p35, IL-12 p40, TNF-¦Á, IP-10, IRF-1, and ICSBP by low concentrations of LPS required both CD14 and TLR4. MAP kinases have been shown to be important for both TNF-¦Á and IL-1 synthesis
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c97 : 1
m74*0.1
nodelay
--
0
PMID: 12106783 Induction of a panel of inflammatory genes including COX-2, IL-12 p35, IL-12 p40, TNF-¦Á, IP-10, IRF-1, and ICSBP by low concentrations of LPS required both CD14 and TLR4. MAP kinases have been shown to be important for both TNF-¦Á and IL-1 synthesis
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c122 : 1
stoichiometry:c118 : 1
m32*m42*0.1
nodelay
--
0
PMID: 12106783 E. coli LPS and the TLR2 agonists, lipoarabinomannan (LAM) and soluble tuberculosis factor (STF), rapidly activated mitogen activated (MAP) kinases, as well as NF-¦ÊB and AP-1 transactivation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c121 : 1
stoichiometry:c120 : 1
m32*m40*0.1
nodelay
--
0
PMID: 12106783 E. coli LPS and the TLR2 agonists, lipoarabinomannan (LAM) and soluble tuberculosis factor (STF), rapidly activated mitogen activated (MAP) kinases, as well as NF-¦ÊB and AP-1 transactivation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c123 : 1
stoichiometry:c59 : 1
m31*m19*0.1
nodelay
--
0
PMID: 12106783, 9200483, 7535339, 9820516 CD18 in complex with CD11b or CD11c, activates signaling cascades leading to NF-¦ÊB translocation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c127 : 1
stoichiometry:c124 : 1
m30*m40*0.1
nodelay
--
0
PMID: 12106783 E. coli LPS and the TLR2 agonists, lipoarabinomannan (LAM) and soluble tuberculosis factor (STF), rapidly activated mitogen activated (MAP) kinases, as well as NF-¦ÊB and AP-1 transactivation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c128 : 1
stoichiometry:c126 : 1
m30*m24*0.1
nodelay
--
0
PMID: 12106783 Nod 1 binds to 3H?LPS and activates NF-¦ÊB in a TLR4-independent fashion.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1
m18*m5*0.1
nodelay
--
0
PMID: 12106783, 2462607 CD11b/CD18 (Mac-1) and CD11c/CD18, obligate heterodimers share a common molecule, CD18, which was shown to be necessary for LPS binding on the surface of cells expressing integrins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1
m5*m20*0.1
nodelay
--
0
PMID: 12106783, 2462607 CD11b/CD18 (Mac-1) and CD11c/CD18, obligate heterodimers share a common molecule, CD18, which was shown to be necessary for LPS binding on the surface of cells expressing integrins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c56 : 1
stoichiometry:c33 : 1
m30*m42*0.1
nodelay
--
0
PMID: 12106783 E. coli LPS and the TLR2 agonists, lipoarabinomannan (LAM) and soluble tuberculosis factor (STF), rapidly activated mitogen activated (MAP) kinases, as well as NF-¦ÊB and AP-1 transactivation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
m5*0.1
nodelay
--
0
PMID: 12106783 LPS can also be internalized through an as yet unknown mechanism.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1
m23*m22*0.1
nodelay
--
0
PMID: 12106783 LPS can also be internalized through an as yet unknown mechanism, and may bind to intracellular Nod1.
cso30:c:InputProcess
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cso30:c:InputAssociation
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cso30:c:OutputProcess
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cso30:c:InputAssociation
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:OutputProcess
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cso30:c:InputAssociation
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cso30:c:OutputProcess
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cso30:c:InputAssociation
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cso30:c:InputAssociation
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cso30:c:InputAssociation
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--