PMID: 11890659 The guanylyl cyclases NPR-A and NPR-B contain an extracellular, ligand binding domain whereby NPR-A binds ANP and BNP.

PMID: 11890659 NPR-C has the potency to internalise and clear the natriuretic peptides

PMID: 11890659 NPR-C has the potency to internalise and clear the natriuretic peptides.

PMID: 11890659 NPR-C has the potency to internalise and clear the natriuretic peptides

PMID: 11890659, 8532063, 10865843 In the organism nitric oxide is synthesised by nitric oxide synthases (NOS) from the amino acid L-arginine. Two constitutive nitric oxide synthases, the endothelial NOS (eNOS, NOS I) and the neuronal NOS (nNOS; NOS III), produce NO that mainly serves as vasodilator.

PMID: 11890659, 8532063, 10865843 In the organism nitric oxide is synthesised by nitric oxide synthases (NOS) from the amino acid L-arginine. Two constitutive nitric oxide synthases, the endothelial NOS (eNOS, NOS I) and the neuronal NOS (nNOS; NOS III), produce NO that mainly serves as vasodilator.

PMID: 11890659, 8532063, 9303203 NO produced by the inducible isoform of the enzyme (iNOS) is an important mediator of host defence.

PMID: 11890659, 8532063, 1429562 Induction occurs after exposure of cells to cytokines and bacterial products, such as lipopolysaccharides (LPS).

PMID: 11890659, 8532063, 1429562 Induction occurs after exposure of cells to cytokines and bacterial products, such as lipopolysaccharides (LPS).

PMID: 11890659, 9593677, 11257311 ANP was shown to inhibit markedly the activation of the transcription factor NF-kappaB. The LPS-induced expression of TNF-alpha is inhibited by ANP through binding to the NPR-A. The inhibitory action involves transcriptional processes with a reduced activation of NF-kappaB and AP1.

PMID: 11890659, 7508926 ANP was shown to inhibit markedly the activation of the transcription factor NF-kappaB which is crucial for the induction of iNOS in murine macrophages.

PMID: 11890659 The guanylyl cyclases NPR-A and NPR-B contain an extracellular, ligand binding domain whereby NPR-A binds ANP and BNP.

PMID: 11890659, 1429562 TNF-alpha is a central proinflammatory cytokine and is regulated transcriptionally; the two transcription factors NF-kappaB and AP1 are involved.

PMID: 11890659, 10861050 Besides the reduced activation of NF-kappaB, ANP markedly inhibited AP1 activity in LPS activated macrophages.

PMID: 11890659, 1429562 TNF-alpha is a central proinflammatory cytokine and is regulated transcriptionally; the two transcription factors NF-kappaB and AP1 are involved.

PMID: 11890659, 11257311 The inhibitory action of ANP on the interferon-gamma mediated activation of the p38 mitogen activated protein kinase was suggested to be the upstream step responsible for the attenuated activation of NF-kappaB in macrophages.

PMID: 11890659, 11257311 The inhibitory action of ANP on the interferon-gamma mediated activation of the p38 mitogen activated protein kinase was suggested to be the upstream step responsible for the attenuated activation of NF-kappaB in macrophages.

PMID: 11890659, 7508926 ANP was shown to inhibit markedly the activation of the transcription factor NF-kappaB, which is crucial for the induction of iNOS in murine macrophages.

PMID: 11890659 NPR-B binds CNP.

PMID: 11890659 NPR-C has the potency to internalise and clear the natriuretic peptides.

PMID: 11890659 NPR-C has the potency to internalise and clear the natriuretic peptides.Moreover, an increasing number of reports show that several biological effects of ANP are mediated through this ¡Èclearance¡É receptor (NPR-C).

PMID: 11890659 NPR-C has the potency to internalise and clear the natriuretic peptides.

PMID: 11890659 NPR-C has the potency to internalise and clear the natriuretic peptides.

PMID: 11890659 NPR-C has the potency to internalise and clear the natriuretic peptides

PMID: 11890659 NPR-C has the potency to internalise and clear the natriuretic peptides.