Entity
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
LPS
--
e11
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m11
0
infinite
0
--
csml-variable:Double
m12
0
infinite
0
--
csml-variable:Double
m13
0
infinite
0
--
csml-variable:Double
m14
0
infinite
0
--
csml-variable:Double
m15
0
infinite
0
--
Iron
--
e16
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m16
0
infinite
0
--
csml-variable:Double
m17
0
infinite
0
--
csml-variable:Double
m18
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
csml-variable:Double
m20
0
infinite
0
--
NFkappaB{activated}
--
e21
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m21
0
infinite
0
--
zinc protoporphyrin
--
e22
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m22
0
infinite
0
--
deferiprone
--
e23
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m23
0
infinite
0
--
csml-variable:Double
m24
0
infinite
0
--
csml-variable:Double
m25
0
infinite
0
--
NO
--
e26
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m26
0
infinite
0
--
csml-variable:Double
m27
0
infinite
0
--
IKK{activated}
--
e28
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m28
0
infinite
0
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
iNOS{activated}
--
e30
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m30
0
infinite
0
--
csml-variable:Double
m31
0
infinite
0
--
csml-variable:Double
m32
0
infinite
0
--
NADPH oxidase{activated}
--
e33
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m33
0
infinite
0
--
O2-
--
e34
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m34
0
infinite
0
--
csml-variable:Double
m35
0
infinite
0
--
csml-variable:Double
m36
0
infinite
0
--
csml-variable:Double
m37
0
infinite
0
--
OH-
--
e38
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m38
0
infinite
0
--
H2O2
--
e39
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m39
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
ONOO-
--
e40
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m40
0
infinite
0
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c20 : 1
stoichiometry:c3 : 1
m11*0.1
nodelay
--
0
PMID: 11841920 Addition of LPS to cultured HM results in induced expression of TNF-alpha with its mRNA and protein expression peaking at 2?4 and 6?8 h, respectively. PMID: 11841920, 8386517 IL-10 inhibits TNF-alpha expression at both transcriptional and posttranscriptional levels.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1
m34*m36*0.1
nodelay
--
0
PMID: 11841920 iron may be released from ferritin via reduction of iron by O2-.
p11
p11
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c31 : 1
stoichiometry:c21 : 1
stoichiometry:c35 : 1
stoichiometry:c27 : 1
m20*m16*0.1
nodelay
--
0
PMID: 11841920 increased iron content may promote NF-kappaB activation and TNF-alpha expression. PMID: 11841920 When the cells were pretreated with deferiprone, both the transient rise of iron and NF-kappaB activation were abrogated. PMID: 11841920, 9710205, 8626684 In fact, low, physiological concentrations of NO are known to increase TNFalpha- or PMA-induced IKK activity, NF-kappaB binding, and promoter transactivation even though high pharmacological concentrations suppress activation of NF-kappaB.
p12
p12
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c30 : 1
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c25 : 1
m20*m11*0.1
nodelay
--
0
PMID: 11841920, 10600822 LPS treatment results in accentuated NF-kappaB activation, the effect which is abrogated by zinc protoporphyrin, a hemeoxygenase inhibitor. iNOS abolishes LPS-mediated transient rise in LMW iron and NF-kappaB activation. PMID: 11841920 When the cells were pretreated with deferiprone, both the transient rise of iron and NF-kappaB activation were abrogated. PMID: 11841920, 9710205, 8626684 In fact, low, physiological concentrations of NO are known to increase TNFalpha- or PMA-induced IKK activity, NF-kappaB binding, and promoter transactivation even though high pharmacological concentrations suppress activation of NF-kappaB.
p15
p15
cso30:i:ME_ChangeInMaterialConcentration
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c32 : 1
stoichiometry:c5 : 1
stoichiometry:c39 : 1
m11*0.1
nodelay
--
0
PMID: 11841920 This study demonstrated a transient rise in the intracellular chelatable pool of iron at 10 min following LPS stimulation. iNOS abolishes LPS-mediated transient rise in LMW iron and NF-kappaB activation. PMID: 11841920 When the cells were pretreated with deferiprone, both the transient rise of iron and NF-kappaB activation were abrogated.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1
m24*m16*m11*0.1
nodelay
--
0
PMID: 118420, 2153975, 2154196 formation of nonheme iron-nitrosyl complex was previously demonstrated in LPS-stimulated macrophages.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c50 : 1
stoichiometry:c45 : 1
m29*m6*0.1
nodelay
--
0
PMID: 11841920, 9710205 In fact, low, physiological concentrations of NO are known to increase TNF-alpha- or PMA-induced IKK activity, NF-kappaB binding.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c51 : 1
stoichiometry:c47 : 1
m29*m27*0.1
nodelay
--
0
PMID: 11841920, 9710205 In fact, low, physiological concentrations of NO are known to increase TNF-alpha- or PMA-induced IKK activity, NF-kappaB binding.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c18 : 1
stoichiometry:c49 : 1
m29*m26*0.1
nodelay
--
0
PMID: 11841920, 9710205 In fact, low, physiological concentrations of NO are known to increase TNF-alpha- or PMA-induced IKK activity, NF-kappaB binding.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c4 : 1
m11*0.1
nodelay
--
0
PMID: 11841920 Addition of LPS to cultured HM results in induced expression of TNF-alpha with its mRNA and protein expression peaking at 2?4 and 6?8 h, respectively. Induction of IL-10 lags slightly behind that of TNF-alpha.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c82 : 1
stoichiometry:c77 : 1
m36*m38*0.1
nodelay
--
0
PMID: 11841920 iron may be released from ferritin via reduction of iron by O2- or oxidative destruction of ferritin proteins by OH.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c85 : 1
stoichiometry:c84 : 1
m39*m16*0.1
nodelay
--
0
PMID: 11841920, 9512778, 10391125, 10678585 iron may produce OH from H2O2 generated from O2-.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c66 : 1
stoichiometry:c65 : 1
m31*m11*0.1
nodelay
--
0
PMID: 11841920 LPS stimulates activities of iNOS and NADPH oxidase.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c69 : 1
stoichiometry:c68 : 1
m32*m11*0.1
nodelay
--
0
PMID: 11841920 LPS stimulates activities of iNOS and NADPH oxidase.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
m30*0.1
nodelay
--
0
PMID: 11841920 LPS stimulates activities of iNOS and NADPH oxidase resulting in generation of NO and O2-.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
m33*0.1
nodelay
--
0
PMID: 11841920 LPS stimulates activities of iNOS and NADPH oxidase resulting in generation of NO and O2-.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c13 : 1
stoichiometry:c75 : 1
stoichiometry:c33 : 1
m35*m26*0.1
nodelay
--
0
PMID: 11841920, 7557022 NO may target and release iron sulfur clusters from enzymes containing them. One such enzyme is iron regulatory protein-1 (IRP-1).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c17 : 1
stoichiometry:c79 : 1
m29*m16*0.1
nodelay
--
0
PMID: 11841920 A transiently raised LMW-iron may directly provide redox modifications of signaling proteins for IKK activation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c34 : 1
m37*0.1
nodelay
--
0
PMID: 11841920, 7557022 NO may target and release iron sulfur clusters from enzymes containing them. One such enzyme is iron regulatory protein-1 (IRP-1).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c90 : 1
stoichiometry:c89 : 1
m5*m11*0.1
nodelay
--
0
PMID: 11841920 Addition of LPS to cultured HM results in induced expression of TNF-alpha with its mRNA and protein expression peaking at 2?4 and 6?8 h, respectively.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
m34*0.1
nodelay
--
0
PMID: 11841920, 9512778, 10391125, 10678585 iron may produce OH from H2O2 generated from O2-.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c95 : 1
m26*0.1
nodelay
--
0
PMID: 11841920 OH is also produced from ONOO- generated from NO and O2.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c96 : 1
m40*0.1
nodelay
--
0
PMID: 11841920 OH is also produced from ONOO- generated from NO and O2.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
m34*0.1
nodelay
--
0
PMID: 11841920 OH is also produced from ONOO- generated from NO and O2.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c11 : 1
stoichiometry:c8 : 1
m12*m16*0.1
nodelay
--
0
PMID: 11841920, 9180188 Iron overloading in mice causes suppressed candidacidal activity by macrophages and reduced release of NO and IL-12 and enhanced production of IL-4 and IL-10 by splenic CD4+ T cells.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c12 : 1
stoichiometry:c10 : 1
m13*m16*0.1
nodelay
--
0
PMID: 11841920, 9180188 Iron overloading in mice causes suppressed candidacidal activity by macrophages and reduced release of NO and IL-12 and enhanced production of IL-4 and IL-10 by splenic CD4+ T cells.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c19 : 1
stoichiometry:c22 : 1
m16*0.1
nodelay
--
0
PMID: 11841920 increased iron content may promote NF-kappaB activation and TNF-alpha expression.
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
1
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
1
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--