_enti_e78
_enti_e2
_enti_e82
_enti_e79
_enti_e84
_enti_e80
_enti_e83
_enti_e81
_enti_e36
_enti_e74
_enti_e70
_enti_e46
_enti_e69
_enti_e75
_enti_e28
_enti_e77
_enti_e76
_enti_e73
_enti_e68
_enti_e71
_enti_e72
g2_fact_g2
g2_fact_g12
g2_fact_g13
g1_fact_g1
g1_fact_g14
p1_propro_p1
PMID: 11257452
LPS binds to the serum protein LBP and is transferred to the CD14 at the cell surface.
PMID: 11257452
LPS and LPS-containing particles (including intact bacteria) form complexes with a plasma protein known as LPS-binding protein (LBP).
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID:11257452
LPS binds to the serum protein LBP and is transferred to the CD14 at the cell surface.
c4 cso30:c:InputProcess connector
c5 cso30:c:InputProcess connector
c6 cso30:c:OutputProcess connector
c104 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 11257452
MD-2 physically associated with TLR4 in a similar manner to MD-1 binding to RP105.
c11 cso30:c:InputProcess connector
c7 cso30:c:InputProcess connector
c12 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 11257452
LPS binds to LPS-binding protein (LBP) in plasma and is delivered to the cell surface receptor CD14. Next, LPS is transferred to the transmembrane signaling receptor toll-like receptor 4 (TLR4) and its accessory protein MD2.
PMID: 11257452
TLR4-MD2 complex functions as the LPS signaling receptor on the surface of monocytes.
PMID: 11257452
LPS then interacts with the signaling receptor TLR4 and the accessory protein MD-2.
c8 cso30:c:InputProcess connector
c9 cso30:c:InputProcess connector
c10 cso30:c:OutputProcess connector
c105 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 11257452
LPS activates the IKK pathway via MyD88, IRAK, and TRAF6.
c13 cso30:c:InputProcess connector
c15 cso30:c:InputAssociation connector
c14 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 11257452
LPS activates the IKK pathway via MyD88, IRAK, and TRAF6.
c16 cso30:c:InputProcess connector
c18 cso30:c:InputAssociation connector
c17 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 11257452
LPS activates the IKK pathway via MyD88, IRAK, and TRAF6.
c19 cso30:c:InputProcess connector
c21 cso30:c:InputAssociation connector
c20 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 11257452
Adaptor protein called TAB2 that mediates activation of TAK1 by linking TAK1 to TRAF6
c22 cso30:c:InputProcess connector
c23 cso30:c:InputProcess connector
c24 cso30:c:InputAssociation connector
c25 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 11257452
a novel protein linking TRAF-6 to MEKK1 that was called evolutionarily conserved signaling intermediate in Toll pathways (ECSIT).
c26 cso30:c:InputProcess connector
c27 cso30:c:InputProcess connector
c29 cso30:c:InputAssociation connector
c28 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 11257452
TAK1TAB2 and MEKK1ECSIT complexes phosphorylate IKKβ.
c30 cso30:c:InputProcess connector
c32 cso30:c:InputAssociation connector
c31 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 11257452
IKKβ phosphorylates IκBs.
c36 cso30:c:InputAssociation connector
c33 cso30:c:InputProcess connector
c34 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 11257452
The PI3KAkt pathway phosphorylates and activates p65 via an unknown kinase.
c39 cso30:c:InputProcess connector
c120 cso30:c:InputAssociation connector
c40 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 11257452
Degradation of IκBs permits nuclear translocation of NF-κB/Rel complexes, such as p50/p65.
c41 cso30:c:InputProcess connector
c42 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 11257452
LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines.
The transcription factors that bind to these LPS response elements include NF-κB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS.
PMID: 11257452, 78
The N-terminal region (amino acids 1-450) of CBP, a protein highly homologous to p300, specifically interacts with the C-terminal region (amino acids 286-551) of p65 both in vitro and in vivo.
c117 cso30:c:InputInhibitor connector
c44 cso30:c:InputAssociation connector
p16_propro_p16
c45 cso30:c:InputProcess connector
c47 cso30:c:InputAssociation connector
c46 cso30:c:OutputProcess connector
p17_propro_p17
c48 cso30:c:InputProcess connector
c50 cso30:c:InputAssociation connector
c49 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 11257452, 8610116
LPS stimulation of THP-1 cells and RAW 264.7 cells rapidly activates the JNK pathway.
PMID: 11257452, 9891090, 10207617, 9096336
The MAPKKs, MKK4, and MKK7 are direct activators of JNK.
c52 cso30:c:InputProcess connector
c54 cso30:c:InputAssociation connector
c53 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 11257452
LPS stimulation of THP-1 cells and RAW 264.7 cells rapidly activates the JNK pathway.
The MAPKKs, MKK4, and MKK7 are direct activators of JNK.
c55 cso30:c:InputProcess connector
c57 cso30:c:InputAssociation connector
c56 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 11257452
LPS stimulation of THP-1 cells and RAW 264.7 cells rapidly activates the JNK pathway.
The MAPKKs, MKK4, and MKK7 are direct activators of JNK.
PMID: 11257452, 9343388
The immunosuppressant dexamethasone reduced LPS-induced translation of TNFα mRNA by selectively inhibiting the JNK pathway.
c58 cso30:c:InputProcess connector
c60 cso30:c:InputAssociation connector
c138 cso30:c:InputInhibitor connector
c59 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 11257452
Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1.
c61 cso30:c:InputProcess connector
c63 cso30:c:InputAssociation connector
c62 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 11257452
LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines.
The transcription factors that bind to these LPS response elements include NF-κB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS.
c65 cso30:c:InputProcess connector
p24_propro_p24
PMID: 11257452
MAPKKKs involved in the p38 signaling cascade include protein kinase RNA-regulated (PKR).
c67 cso30:c:InputProcess connector
c107 cso30:c:InputAssociation connector
c68 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 11257452
The MAPKKs involved in p38 activation include the dual specificity kinases MKK3 and MKK6.
c70 cso30:c:InputProcess connector
c72 cso30:c:InputAssociation connector
c71 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 11257452
The MAPKKs involved in p38 activation include the dual specificity kinases MKK3 and MKK6.
PMID: 11257452, 7839144
There is some evidence that MKK4 also phosphorylates the p38.
PMID: 11257452, 7997261
One of these compounds, SB203580, specifically inhibited p38 activation and reduced LPS induction of IL-1 and TNFa expression without affecting the mRNA accumulation [149].
c73 cso30:c:InputProcess connector
c75 cso30:c:InputAssociation connector
c139 cso30:c:InputAssociation connector
c170 cso30:c:InputInhibitor connector
c74 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 11257452
Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1.
p38 phosphorylates and activates various transcription factors that include ATF-2, Elk-1.
c76 cso30:c:InputProcess connector
c66 cso30:c:InputAssociation connector
c77 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 11257452
LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines.
The transcription factors that bind to these LPS response elements include NF-κB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS.
c64 cso30:c:InputProcess connector
p30_propro_p30
PMID: 11257452
LPS activation of tyrosine kinases leads to activation of the MEKERK1/2 pathway in a Raf-1-dependent manner.
c82 cso30:c:InputProcess connector
c106 cso30:c:InputAssociation connector
c83 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 11257452
LPS activation of tyrosine kinases leads to activation of the MEKERK1/2 pathway in a Raf-1-dependent manner.
c85 cso30:c:InputProcess connector
c87 cso30:c:InputAssociation connector
c86 cso30:c:OutputProcess connector
p32_propro_p32
PMID: 11257452
LPS activation of tyrosine kinases leads to activation of the MEKERK1/2 pathway in a Raf-1-dependent manner.
PMID: 11257452, 99
Inhibition of MEK in monocytes by U0126 reduced LPS induction of several inflammatory cytokines, including IL-1, IL-8, and TNFα, as well as prostaglandin E2.
c88 cso30:c:InputProcess connector
c90 cso30:c:InputAssociation connector
c136 cso30:c:InputInhibitor connector
c89 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 11257452
LPS activation of tyrosine kinases leads to activation of the MEKERK1/2 pathway in a Raf-1-dependent manner.
c91 cso30:c:InputProcess connector
c93 cso30:c:InputAssociation connector
c92 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 11257452
Phosphorylation of Elk-1 in its C-terminal domain induces a conformational change that promotes binding of Elk-1 to Ets sites via its N terminal Ets-domain and to SRF dimers via its B box domain. This results in the assembly of inducible ternary complex consisting of Elk-1 and SRF.Phosphorylation and activation of Elk-1 was inhibited by PD98059, suggesting that Elk-1 is a downstream target of the MEK-ERK1/2 pathway.
PMID: 11257452
Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1.
PMID: 11257452, 10417144
PD98059 inhibited LPS induction of TNFα in human monocytes.
PMID: 11257452
PD98059 also inhibits LPS induction of tissue factor gene expression in human moncytes.
PMID: 11257452
One of the downstream targets of the MEK-ERK1/2 pathway is the transcription factor Elk-1.
c94 cso30:c:InputProcess connector
c96 cso30:c:InputAssociation connector
c43 cso30:c:InputInhibitor connector
c95 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 11257452
LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines.
The transcription factors that bind to these LPS response elements include NF-κB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS.
c97 cso30:c:InputProcess connector
p21_propro_p21
PMID: 11257452, 9687510
p38 also phosphorylates numerous downstream kinases, including MNK1/2, MAPKAPK2 (MK2), MSK1, and PRAK, which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.
c79 cso30:c:InputProcess connector
c81 cso30:c:InputAssociation connector
c80 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 11257452
p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.
c100 cso30:c:InputProcess connector
c102 cso30:c:InputAssociation connector
c101 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 11257452
LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines.
The transcription factors that bind to these LPS response elements include NF-κB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS.
c103 cso30:c:InputProcess connector
p37_propro_p37
PMID: 11257452
Phosphorylation of Elk-1 in its C-terminal domain induces a conformational change that promotes binding of Elk-1 to Ets sites via its N terminal Ets-domain and to SRF dimers via its B box domain. This results in the assembly of inducible ternary complex consisting of Elk-1 and SRF.Phosphorylation and activation of Elk-1 was inhibited by PD98059, suggesting that Elk-1 is a downstream target of the MEK-ERK1/2 pathway.
PMID: 11257452
Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1.
PMID: 11257452, 10417144
PD98059 inhibited LPS induction of TNFα in human monocytes.
PMID: 11257452
PD98059 also inhibits LPS induction of tissue factor gene expression in human moncytes.
PMID: 11257452
One of the downstream targets of the MEK-ERK1/2 pathway is the transcription factor Elk-1.
PMID: 11257452, 8622669
p38 phosphorylates and activates various transcription factors that include ATF-2, Elk-1, CHOP, MEF2C, and Sap1a.
c69 cso30:c:InputProcess connector
c98 cso30:c:InputAssociation connector
c115 cso30:c:InputInhibitor connector
c84 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 11257452
Phosphorylation of Elk-1 in its C-terminal domain induces a conformational change that promotes binding of Elk-1 to Ets sites via its N terminal Ets-domain and to SRF dimers via its B box domain. This results in the assembly of inducible ternary complex consisting of Elk-1 and SRF.Phosphorylation and activation of Elk-1 was inhibited by PD98059, suggesting that Elk-1 is a downstream target of the MEK-ERK1/2 pathway.
PMID: 11257452
Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1.
PMID: 11257452, 10417144
PD98059 inhibited LPS induction of TNFα in human monocytes.
PMID: 11257452
PD98059 also inhibits LPS induction of tissue factor gene expression in human moncytes.
PMID: 11257452
One of the downstream targets of the MEK-ERK1/2 pathway is the transcription factor Elk-1.
c108 cso30:c:InputProcess connector
c110 cso30:c:InputAssociation connector
c116 cso30:c:InputInhibitor connector
c109 cso30:c:OutputProcess connector
p27_propro_p39
PMID: 11257452
Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1.
PMID: 11257452, 9422727
p38 phosphorylates and activates various transcription factors that include ATF-2, Elk-1.
c99 cso30:c:InputProcess connector
c112 cso30:c:InputAssociation connector
c111 cso30:c:OutputProcess connector
p10_propro_p40
PMID: 11257452
TAK1TAB2 and MEKK1ECSIT complexes phosphorylate IKKβ.
c78 cso30:c:InputAssociation connector
c113 cso30:c:InputProcess connector
c114 cso30:c:OutputProcess connector
p12_propro_p12
c35 cso30:c:InputProcess connector
c37 cso30:c:OutputProcess connector
c38 cso30:c:OutputProcess connector
p17_propro_p41
PMID: 11257452, 9195953
PKCζ is a downstream target of the LPS-activated PI3K-Akt pathway in human moncytic cells and may be involved in this process. However, the specific site(s) of phosphorylation of p65 was not identified.
c51 cso30:c:InputProcess connector
c119 cso30:c:InputAssociation connector
c118 cso30:c:OutputProcess connector
p42_propro_p42
PMID: 11257452, 9548485
The N-terminal region (amino acids 1-450) of CBP, a protein highly homologous to p300, specifically interacts with the C-terminal region (amino acids 286-551) of p65 both in vitro and in vivo.
c121 cso30:c:InputProcess connector
c122 cso30:c:InputProcess connector
c123 cso30:c:OutputProcess connector
p43_propro_p43
PMID: 11257452, 7691802, 8521300, 7519214
LPS stimulation of monocytes/macrophages induces the rapid tyrosine phosphorylation of proteins, including the src tyrosine kinase family members p53/56lyn, p58/64c-fgr.
c124 cso30:c:InputProcess connector
c128 cso30:c:InputAssociation connector
c125 cso30:c:OutputProcess connector
p43_propro_p44
PMID: 11257452, 7691802, 8521300, 7519214
LPS stimulation of monocytes/macrophages induces the rapid tyrosine phosphorylation of proteins, including the src tyrosine kinase family members p53/56lyn, p58/64c-fgr.
c126 cso30:c:InputProcess connector
c129 cso30:c:InputAssociation connector
c127 cso30:c:OutputProcess connector
p6_propro_p45
PMID: 11257452, 9195953, 7519214
LPS also activates typical (PKCbeta) and a typical (PKCζ) isoforms of protein kinase C
c130 cso30:c:InputProcess connector
c132 cso30:c:InputAssociation connector
c131 cso30:c:OutputProcess connector
p46_propro_p46
PMID: 11257452, 7799956, 8513862, 7477354
There is also evidence for LPS activation of the MEK-ERK1/2 pathway via c-Raf-independent pathways.
PMID: 11257452, 9820549
Inhibition of MEK in monocytes by U0126 reduced LPS induction of several inflammatory cytokines, including IL-1, IL-8, and TNFα, as well as prostaglandin E2.
c133 cso30:c:InputProcess connector
c135 cso30:c:InputAssociation connector
c137 cso30:c:InputInhibitor connector
c134 cso30:c:OutputProcess connector
p38_propro_p47
PMID: 11257452
Phosphorylation of Elk-1 in its C-terminal domain induces a conformational change that promotes binding of Elk-1 to Ets sites via its N terminal Ets-domain and to SRF dimers via its B box domain. This results in the assembly of inducible ternary complex consisting of Elk-1 and SRF.Phosphorylation and activation of Elk-1 was inhibited by PD98059, suggesting that Elk-1 is a downstream target of the MEK-ERK1/2 pathway.
PMID: 11257452
Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1.
PMID: 11257452
PD98059 inhibited LPS induction of TNFα in human monocytes.
PMID: 11257452
PD98059 also inhibits LPS induction of tissue factor gene expression in human moncytes.
PMID: 11257452
One of the downstream targets of the MEK-ERK1/2 pathway is the transcription factor Elk-1.
PMID: 11257452, 8621675
p38 phosphorylates and activates various transcription factors that include ATF-2, Elk-1, CHOP, MEF2C, and Sap1a.
c140 cso30:c:InputProcess connector
c146 cso30:c:InputAssociation connector
c141 cso30:c:OutputProcess connector
p38_propro_p48
PMID: 11257452
Phosphorylation of Elk-1 in its C-terminal domain induces a conformational change that promotes binding of Elk-1 to Ets sites via its N terminal Ets-domain and to SRF dimers via its B box domain. This results in the assembly of inducible ternary complex consisting of Elk-1 and SRF.Phosphorylation and activation of Elk-1 was inhibited by PD98059, suggesting that Elk-1 is a downstream target of the MEK-ERK1/2 pathway.
PMID: 11257452
Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1.
PMID: 11257452
PD98059 inhibited LPS induction of TNFα in human monocytes.
PMID: 11257452
PD98059 also inhibits LPS induction of tissue factor gene expression in human moncytes.
PMID: 11257452
One of the downstream targets of the MEK-ERK1/2 pathway is the transcription factor Elk-1.
PMID: 11257452, 9130707
p38 phosphorylates and activates various transcription factors that include ATF-2, Elk-1, CHOP, MEF2C, and Sap1a.
c144 cso30:c:InputProcess connector
c148 cso30:c:InputAssociation connector
c145 cso30:c:OutputProcess connector
p38_propro_p49
PMID: 11257452
Phosphorylation of Elk-1 in its C-terminal domain induces a conformational change that promotes binding of Elk-1 to Ets sites via its N terminal Ets-domain and to SRF dimers via its B box domain. This results in the assembly of inducible ternary complex consisting of Elk-1 and SRF.Phosphorylation and activation of Elk-1 was inhibited by PD98059, suggesting that Elk-1 is a downstream target of the MEK-ERK1/2 pathway.
PMID: 11257452
Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1.
PMID: 11257452
PD98059 inhibited LPS induction of TNFα in human monocytes.
PMID: 11257452
PD98059 also inhibits LPS induction of tissue factor gene expression in human moncytes.
PMID: 11257452
One of the downstream targets of the MEK-ERK1/2 pathway is the transcription factor Elk-1.
PMID: 11257452, 8650547
p38 phosphorylates and activates various transcription factors that include ATF-2, Elk-1, CHOP, MEF2C, and Sap1a.
c142 cso30:c:InputProcess connector
c147 cso30:c:InputAssociation connector
c143 cso30:c:OutputProcess connector
p15_propro_p50
PMID: 11257452
LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines.
The transcription factors that bind to these LPS response elements include NF-κB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS.
PMID: 11257452, 78
The N-terminal region (amino acids 1-450) of CBP, a protein highly homologous to p300, specifically interacts with the C-terminal region (amino acids 286-551) of p65 both in vitro and in vivo.
c149 cso30:c:InputAssociation connector
p15_propro_p51
PMID: 11257452
LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines.
The transcription factors that bind to these LPS response elements include NF-κB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS.
PMID: 11257452, 78
The N-terminal region (amino acids 1-450) of CBP, a protein highly homologous to p300, specifically interacts with the C-terminal region (amino acids 286-551) of p65 both in vitro and in vivo.
c150 cso30:c:InputAssociation connector
p15_propro_p52
PMID: 11257452
LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines.
The transcription factors that bind to these LPS response elements include NF-κB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS.
PMID: 11257452, 78
The N-terminal region (amino acids 1-450) of CBP, a protein highly homologous to p300, specifically interacts with the C-terminal region (amino acids 286-551) of p65 both in vitro and in vivo.
c151 cso30:c:InputAssociation connector
p28_propro_p53
PMID: 11257452, 9155018
p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.
c152 cso30:c:InputProcess connector
c158 cso30:c:InputAssociation connector
c153 cso30:c:OutputProcess connector
p28_propro_p54
PMID: 11257452, 1327754
p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.
c154 cso30:c:InputProcess connector
c159 cso30:c:InputAssociation connector
c155 cso30:c:OutputProcess connector
p28_propro_p55
PMID: 11257452, 9628874
p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.
c156 cso30:c:InputProcess connector
c160 cso30:c:InputAssociation connector
c157 cso30:c:OutputProcess connector
p28_propro_p56
PMID: 11257452, 10391889
p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.
c163 cso30:c:InputAssociation connector
c164 cso30:c:InputProcess connector
c165 cso30:c:OutputProcess connector
p28_propro_p57
PMID: 11257452, 10391889
p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.
c162 cso30:c:InputAssociation connector
c166 cso30:c:InputProcess connector
c167 cso30:c:OutputProcess connector
p28_propro_p58
PMID: 11257452, 10391889
p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.
c161 cso30:c:InputAssociation connector
c168 cso30:c:InputProcess connector
c169 cso30:c:OutputProcess connector
p59_propro_p59
c172 cso30:c:InputAssociation connector
c171 cso30:c:OutputProcess connector
LPS_enti_e1
LPS
LBP_enti_e3
LBP
TLR4_enti_e8
TLR4
LPS:LBP_enti_e4
LPS:LBP
CD14_enti_e5
CD14
CD14:LPS_enti_e6
CD14:LPS
MD2_enti_e7
MD2
TLR4:MD2_enti_e10
TLR4:MD2
LPS: TLR4:MD2_enti_e9
LPS: TLR4:MD2
MYD88_enti_e11
MYD88
IRAK_enti_e15
IRAK
MYD88{active}_enti_e12
MYD88{active}
IRAK{active}_enti_e13
IRAK{active}
TRAF6{active}_enti_e14
TRAF6{active}
TRAF6_enti_e16
TRAF6
TAB2_enti_e17
TAB2
TAK1_enti_e18
TAK1
TAB2:TAK1_enti_e19
TAB2:TAK1
MEKK1_enti_e20
MEKK1
ECSIT_enti_e21
ECSIT
ECSIT:MEKK1_enti_e22
ECSIT:MEKK1
IKK-beta_enti_e23
IKK-beta
IKK-beta{p}_enti_e24
IKK-beta{p}
p50:p65_enti_e29
p50:p65
p50:p65{p}_enti_e30
p50:p65{p}
p50:p65{p}_enti_e31
p50:p65{p}
PI3K{active}_enti_e32
PI3K{active}
PI3K_enti_e33
PI3K
AKT_enti_e34
AKT
AKT{active}_enti_e35
AKT{active}
MEKK1/4{active}_enti_e37
MEKK1/4{active}
MEKK1/4_enti_e38
MEKK1/4
MKK4/7{active}_enti_e39
MKK4/7{active}
MKK4/7_enti_e40
MKK4/7
JNK_enti_e41
JNK
JNK{active}_enti_e42
JNK{active}
c-fos{p}:c-jun{p}_enti_e43
c-fos{p}:c-jun{p}
_enti_e44
PKR_enti_e47
PKR
PKR{active}_enti_e48
PKR{active}
MKK3/6_enti_e49
MKK3/6
MKK3/6{active}_enti_e50
MKK3/6{active}
p38_enti_e51
p38
p38{active}_enti_e52
p38{active}
c-jun:ATF2_enti_e53
c-jun:ATF2
c-jun{p}:ATF2{p}_enti_e54
c-jun{p}:ATF2{p}
Ras_enti_e56
Ras
Ras{active}_enti_e57
Ras{active}
c-Raf_enti_e58
c-Raf
c-Raf{active}_enti_e59
c-Raf{active}
MEK1/2_enti_e60
MEK1/2
MEK1/2{active}_enti_e61
MEK1/2{active}
ERK1/2_enti_e62
ERK1/2
ERK1/2{active}_enti_e63
ERK1/2{active}
ELK1:SRF_enti_e64
ELK1:SRF
ELK1{p}:SRF{p}_enti_e65
ELK1{p}:SRF{p}
MSK1_enti_e45
MSK1
MSK1{active}_enti_e55
MSK1{active}
CREB:ATF1_enti_e66
CREB:ATF1
CREB{p}:ATF1{p}_enti_e67
CREB{p}:ATF1{p}
p50:p65:Ikappa-Balpha_enti_e85
p50:p65:Ikappa-Balpha
p50:p65:Ikappa-Balpha{p}_enti_e25
p50:p65:Ikappa-Balpha{p}
protein reminant of Ikappa-Balpha_enti_e27
PD98059_enti_e26
PD98059
genistein_enti_e86
PMID:11257452
LPS induction of NF-kB-dependent gene expression in THP-1 cells was blocked by the protein tyrosine kinase inhibitor genistein without affecting nuclear translocation of NF-kB.
genistein
PKCζ_enti_e87
PKCζ
PKCζ{active}_enti_e88
PKCζ{active}
p50:p65{p}:CBP_enti_e89
p50:p65{p}:CBP
CBP_enti_e90
CBP
p53/56lyn_enti_e91
p53/56lyn
p58/64c-fgr_enti_e92
p58/64c-fgr
p53/64c-fgr{p}_enti_e93
p53/64c-fgr{p}
p53/56lyn{p}_enti_e94
p53/56lyn{p}
PKCbeta_enti_e95
PKCbeta
PKCbeta{active}_enti_e96
PKCbeta{active}
unknown_enti_e97
unknown
U0126_enti_e98
U0126
dexamethasone_enti_e99
dexamethasone
CHOP_enti_e100
CHOP
MEF2C_enti_e101
MEF2C
Sap1a_enti_e102
Sap1a
Sap1a{p}_enti_e103
Sap1a{p}
CHOP{p}_enti_e104
CHOP{p}
MEF2C{p}_enti_e105
MEF2C{p}
MNK1/2_enti_e106
MNK1/2
MAPKAPK2(MK2)_enti_e107
MAPKAPK2(MK2)
PRAK_enti_e109
PRAK
PRAK{p}_enti_e108
PRAK{p}
MAPKAPK2(MK2){p}_enti_e110
MAPKAPK2(MK2){p}
MNK1/2{p}_enti_e111
MNK1/2{p}
SB203580_enti_e112
SB203580
Egr-1_enti_e113
Egr-1