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PMID:11257452
LPS induction of NF-kB-dependent gene expression in THP-1 cells was blocked by the protein tyrosine kinase inhibitor genistein without affecting nuclear translocation of NF-kB.<svg contentScriptType="text/ecmascript" width="250" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 431.413 43.583" contentStyleType="text/css" height="250" viewBox="0 0 250 250" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0">
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<svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" style="overflow:visible;enable-background:new 0 0 431.413 43.583" viewBox="0 0 117.6 191.2" preserveAspectRatio="xMidYMid meet" zoomAndPan="magnify" width="117.6" height="191.2" contentScriptType="text/ecmascript" contentStyleType="text/css" version="1.0"><defs><linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" id="color2" gradientUnits="objectBoundingBox" gradientTransform="" x1="0%" y1="0%" x2="100%" y2="0%" spreadMethod="pad"><stop style="stop-color:#000000;stop-opacity:1;" offset="0%"></stop></linearGradient><linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" id="color3" gradientUnits="objectBoundingBox" gradientTransform="" x1="0%" y1="0%" x2="100%" y2="0%" spreadMethod="pad"><stop style="stop-color:#0000ff;stop-opacity:1;" offset="0%"></stop></linearGradient><linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" id="stroke1" gradientUnits="objectBoundingBox" gradientTransform="" x1="0%" y1="0%" x2="100%" y2="0%" spreadMethod="pad"><stop style="stop-color:#808080;stop-opacity:1;" offset="0%"></stop></linearGradient><linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" id="stroke2" gradientUnits="objectBoundingBox" gradientTransform="" x1="0%" y1="0%" x2="100%" y2="0%" spreadMethod="pad"><stop style="stop-color:#008000;stop-opacity:1;" offset="0%"></stop></linearGradient><linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" id="stroke3" gradientUnits="objectBoundingBox" gradientTransform="" x1="0%" y1="0%" x2="100%" y2="0%" spreadMethod="pad"><stop style="stop-color:#00ff00;stop-opacity:1;" offset="0%"></stop></linearGradient><radialGradient xmlns:xlink="http://www.w3.org/1999/xlink" id="color1" gradientUnits="objectBoundingBox" gradientTransform="" cx="50%" cy="50%" r="50%" fx="50%" fy="50%" spreadMethod="pad"><stop style="stop-color:white;stop-opacity:1;" offset="0%"></stop><stop style="stop-color:green;stop-opacity:1;" offset="100%"></stop></radialGradient></defs><ellipse style="fill:url(#color1);stroke:none;" cx="58.8" cy="95.6" rx="58.8" ry="95.6"></ellipse></svg>PMID: 11257452
LPS binds to the serum protein LBP and is transferred to the CD14 at the cell surface.
PMID: 11257452
LPS and LPS-containing particles (including intact bacteria) form complexes with a plasma protein known as LPS-binding protein (LBP).PMID:11257452
LPS binds to the serum protein LBP and is transferred to the CD14 at the cell surface. PMID: 11257452
MD-2 physically associated with TLR4 in a similar manner to MD-1 binding to RP105.PMID: 11257452
LPS binds to LPS-binding protein (LBP) in plasma and is delivered to the cell surface receptor CD14. Next, LPS is transferred to the transmembrane signaling receptor toll-like receptor 4 (TLR4) and its accessory protein MD2.
PMID: 11257452
TLR4-MD2 complex functions as the LPS signaling receptor on the surface of monocytes.
PMID: 11257452
LPS then interacts with the signaling receptor TLR4 and the accessory protein MD-2.PMID: 11257452
LPS activates the IKK pathway via MyD88, IRAK, and TRAF6.PMID: 11257452
LPS activates the IKK pathway via MyD88, IRAK, and TRAF6.PMID: 11257452
LPS activates the IKK pathway via MyD88, IRAK, and TRAF6.PMID: 11257452
Adaptor protein called TAB2 that mediates activation of TAK1 by linking TAK1 to TRAF6PMID: 11257452
a novel protein linking TRAF-6 to MEKK1 that was called evolutionarily conserved signaling intermediate in Toll pathways (ECSIT).PMID: 11257452
TAK1–TAB2 and MEKK1–ECSIT complexes phosphorylate IKKβ.PMID: 11257452
IKKβ phosphorylates IκBs.PMID: 11257452
The PI3K–Akt pathway phosphorylates and activates p65 via an unknown kinase. PMID: 11257452
Degradation of IκBs permits nuclear translocation of NF-κB/Rel complexes, such as p50/p65. PMID: 11257452
LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines.
The transcription factors that bind to these LPS response elements include NF-κB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS.
PMID: 11257452, 78
The N-terminal region (amino acids 1-450) of CBP, a protein highly homologous to p300, specifically interacts with the C-terminal region (amino acids 286-551) of p65 both in vitro and in vivo.PMID: 11257452, 8610116
LPS stimulation of THP-1 cells and RAW 264.7 cells rapidly activates the JNK pathway.
PMID: 11257452, 9891090, 10207617, 9096336
The MAPKKs, MKK4, and MKK7 are direct activators of JNK.PMID: 11257452
LPS stimulation of THP-1 cells and RAW 264.7 cells rapidly activates the JNK pathway.
The MAPKKs, MKK4, and MKK7 are direct activators of JNK.indirectPMID: 11257452
LPS stimulation of THP-1 cells and RAW 264.7 cells rapidly activates the JNK pathway.
The MAPKKs, MKK4, and MKK7 are direct activators of JNK.
PMID: 11257452, 9343388
The immunosuppressant dexamethasone reduced LPS-induced translation of TNFα mRNA by selectively inhibiting the JNK pathway.PMID: 11257452
Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1.PMID: 11257452
LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines.
The transcription factors that bind to these LPS response elements include NF-κB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS.PMID: 11257452
MAPKKKs involved in the p38 signaling cascade include protein kinase RNA-regulated (PKR).PMID: 11257452
The MAPKKs involved in p38 activation include the dual specificity kinases MKK3 and MKK6.PMID: 11257452
The MAPKKs involved in p38 activation include the dual specificity kinases MKK3 and MKK6.
PMID: 11257452, 7839144
There is some evidence that MKK4 also phosphorylates the p38.
PMID: 11257452, 7997261
One of these compounds, SB203580, specifically inhibited p38 activation and reduced LPS induction of IL-1 and TNFa expression without affecting the mRNA accumulation [149].PMID: 11257452
Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1.
p38 phosphorylates and activates various transcription factors that include ATF-2, Elk-1.PMID: 11257452
LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines.
The transcription factors that bind to these LPS response elements include NF-κB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS.PMID: 11257452
LPS activation of tyrosine kinases leads to activation of the MEK–ERK1/2 pathway in a Raf-1-dependent manner.PMID: 11257452
LPS activation of tyrosine kinases leads to activation of the MEK–ERK1/2 pathway in a Raf-1-dependent manner.PMID: 11257452
LPS activation of tyrosine kinases leads to activation of the MEK–ERK1/2 pathway in a Raf-1-dependent manner.
PMID: 11257452, 99
Inhibition of MEK in monocytes by U0126 reduced LPS induction of several inflammatory cytokines, including IL-1, IL-8, and TNFα, as well as prostaglandin E2.PMID: 11257452
LPS activation of tyrosine kinases leads to activation of the MEK–ERK1/2 pathway in a Raf-1-dependent manner.PMID: 11257452
Phosphorylation of Elk-1 in its C-terminal domain induces a conformational change that promotes binding of Elk-1 to Ets sites via its N terminal Ets-domain and to SRF dimers via its B box domain. This results in the assembly of inducible ternary complex consisting of Elk-1 and SRF.Phosphorylation and activation of Elk-1 was inhibited by PD98059, suggesting that Elk-1 is a downstream target of the MEK-ERK1/2 pathway.
PMID: 11257452
Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1.
PMID: 11257452, 10417144
PD98059 inhibited LPS induction of TNFα in human monocytes.
PMID: 11257452
PD98059 also inhibits LPS induction of tissue factor gene expression in human moncytes.
PMID: 11257452
One of the downstream targets of the MEK-ERK1/2 pathway is the transcription factor Elk-1.PMID: 11257452
LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines.
The transcription factors that bind to these LPS response elements include NF-κB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS.PMID: 11257452, 9687510
p38 also phosphorylates numerous downstream kinases, including MNK1/2, MAPKAPK2 (MK2), MSK1, and PRAK, which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.PMID: 11257452
p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.PMID: 11257452
LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines.
The transcription factors that bind to these LPS response elements include NF-κB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS.PMID: 11257452
Phosphorylation of Elk-1 in its C-terminal domain induces a conformational change that promotes binding of Elk-1 to Ets sites via its N terminal Ets-domain and to SRF dimers via its B box domain. This results in the assembly of inducible ternary complex consisting of Elk-1 and SRF.Phosphorylation and activation of Elk-1 was inhibited by PD98059, suggesting that Elk-1 is a downstream target of the MEK-ERK1/2 pathway.
PMID: 11257452
Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1.
PMID: 11257452, 10417144
PD98059 inhibited LPS induction of TNFα in human monocytes.
PMID: 11257452
PD98059 also inhibits LPS induction of tissue factor gene expression in human moncytes.
PMID: 11257452
One of the downstream targets of the MEK-ERK1/2 pathway is the transcription factor Elk-1.
PMID: 11257452, 8622669
p38 phosphorylates and activates various transcription factors that include ATF-2, Elk-1, CHOP, MEF2C, and Sap1a.PMID: 11257452
Phosphorylation of Elk-1 in its C-terminal domain induces a conformational change that promotes binding of Elk-1 to Ets sites via its N terminal Ets-domain and to SRF dimers via its B box domain. This results in the assembly of inducible ternary complex consisting of Elk-1 and SRF.Phosphorylation and activation of Elk-1 was inhibited by PD98059, suggesting that Elk-1 is a downstream target of the MEK-ERK1/2 pathway.
PMID: 11257452
Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1.
PMID: 11257452, 10417144
PD98059 inhibited LPS induction of TNFα in human monocytes.
PMID: 11257452
PD98059 also inhibits LPS induction of tissue factor gene expression in human moncytes.
PMID: 11257452
One of the downstream targets of the MEK-ERK1/2 pathway is the transcription factor Elk-1.PMID: 11257452
Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1.
PMID: 11257452, 9422727
p38 phosphorylates and activates various transcription factors that include ATF-2, Elk-1.PMID: 11257452
TAK1–TAB2 and MEKK1–ECSIT complexes phosphorylate IKKβ.PMID: 11257452, 9195953
PKCζ is a downstream target of the LPS-activated PI3K-Akt pathway in human moncytic cells and may be involved in this process. However, the specific site(s) of phosphorylation of p65 was not identified.
PMID: 11257452, 9548485
The N-terminal region (amino acids 1-450) of CBP, a protein highly homologous to p300, specifically interacts with the C-terminal region (amino acids 286-551) of p65 both in vitro and in vivo.PMID: 11257452, 7691802, 8521300, 7519214
LPS stimulation of monocytes/macrophages induces the rapid tyrosine phosphorylation of proteins, including the src tyrosine kinase family members p53/56lyn, p58/64c-fgr. PMID: 11257452, 7691802, 8521300, 7519214
LPS stimulation of monocytes/macrophages induces the rapid tyrosine phosphorylation of proteins, including the src tyrosine kinase family members p53/56lyn, p58/64c-fgr. indirectPMID: 11257452, 9195953, 7519214
LPS also activates typical (PKCbeta) and a typical (PKCζ) isoforms of protein kinase CPMID: 11257452, 7799956, 8513862, 7477354
There is also evidence for LPS activation of the MEK-ERK1/2 pathway via c-Raf-independent pathways.
PMID: 11257452, 9820549
Inhibition of MEK in monocytes by U0126 reduced LPS induction of several inflammatory cytokines, including IL-1, IL-8, and TNFα, as well as prostaglandin E2.PMID: 11257452
Phosphorylation of Elk-1 in its C-terminal domain induces a conformational change that promotes binding of Elk-1 to Ets sites via its N terminal Ets-domain and to SRF dimers via its B box domain. This results in the assembly of inducible ternary complex consisting of Elk-1 and SRF.Phosphorylation and activation of Elk-1 was inhibited by PD98059, suggesting that Elk-1 is a downstream target of the MEK-ERK1/2 pathway.
PMID: 11257452
Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1.
PMID: 11257452
PD98059 inhibited LPS induction of TNFα in human monocytes.
PMID: 11257452
PD98059 also inhibits LPS induction of tissue factor gene expression in human moncytes.
PMID: 11257452
One of the downstream targets of the MEK-ERK1/2 pathway is the transcription factor Elk-1.
PMID: 11257452, 8621675
p38 phosphorylates and activates various transcription factors that include ATF-2, Elk-1, CHOP, MEF2C, and Sap1a.PMID: 11257452
Phosphorylation of Elk-1 in its C-terminal domain induces a conformational change that promotes binding of Elk-1 to Ets sites via its N terminal Ets-domain and to SRF dimers via its B box domain. This results in the assembly of inducible ternary complex consisting of Elk-1 and SRF.Phosphorylation and activation of Elk-1 was inhibited by PD98059, suggesting that Elk-1 is a downstream target of the MEK-ERK1/2 pathway.
PMID: 11257452
Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1.
PMID: 11257452
PD98059 inhibited LPS induction of TNFα in human monocytes.
PMID: 11257452
PD98059 also inhibits LPS induction of tissue factor gene expression in human moncytes.
PMID: 11257452
One of the downstream targets of the MEK-ERK1/2 pathway is the transcription factor Elk-1.
PMID: 11257452, 9130707
p38 phosphorylates and activates various transcription factors that include ATF-2, Elk-1, CHOP, MEF2C, and Sap1a.PMID: 11257452
Phosphorylation of Elk-1 in its C-terminal domain induces a conformational change that promotes binding of Elk-1 to Ets sites via its N terminal Ets-domain and to SRF dimers via its B box domain. This results in the assembly of inducible ternary complex consisting of Elk-1 and SRF.Phosphorylation and activation of Elk-1 was inhibited by PD98059, suggesting that Elk-1 is a downstream target of the MEK-ERK1/2 pathway.
PMID: 11257452
Many of the downstream targets of the JNK pathway are transcription factors that include c-Jun, ATF-2, and Elk-1.
PMID: 11257452
PD98059 inhibited LPS induction of TNFα in human monocytes.
PMID: 11257452
PD98059 also inhibits LPS induction of tissue factor gene expression in human moncytes.
PMID: 11257452
One of the downstream targets of the MEK-ERK1/2 pathway is the transcription factor Elk-1.
PMID: 11257452, 8650547
p38 phosphorylates and activates various transcription factors that include ATF-2, Elk-1, CHOP, MEF2C, and Sap1a.PMID: 11257452
LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines.
The transcription factors that bind to these LPS response elements include NF-κB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS.
PMID: 11257452, 78
The N-terminal region (amino acids 1-450) of CBP, a protein highly homologous to p300, specifically interacts with the C-terminal region (amino acids 286-551) of p65 both in vitro and in vivo.PMID: 11257452
LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines.
The transcription factors that bind to these LPS response elements include NF-κB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS.
PMID: 11257452, 78
The N-terminal region (amino acids 1-450) of CBP, a protein highly homologous to p300, specifically interacts with the C-terminal region (amino acids 286-551) of p65 both in vitro and in vivo.PMID: 11257452
LPS stimulation of monocytes and macrophages induces many genes that express inflammatory mediators, such as cytokines and chemokines.
The transcription factors that bind to these LPS response elements include NF-κB/Rel proteins, AP-1 proteins, and NF-IL-6. These transcription factors are activated by phosphorylation, which permits the rapid induction of gene expression in response to LPS.
PMID: 11257452, 78
The N-terminal region (amino acids 1-450) of CBP, a protein highly homologous to p300, specifically interacts with the C-terminal region (amino acids 286-551) of p65 both in vitro and in vivo.PMID: 11257452, 9155018
p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.PMID: 11257452, 1327754
p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.PMID: 11257452, 9628874
p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.PMID: 11257452, 10391889
p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.PMID: 11257452, 10391889
p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.PMID: 11257452, 10391889
p38 also phosphorylates downstream kinases, including MNK1/2, MAPKAPK2(MK2), MSK1 and PRAK which regulate gene expression by phosphorylating transcription factors such as CREB and ATF-1.indirect