_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e3
_enti_e2
_enti_e4
_enti_e55
_enti_e59
_enti_e53
_enti_e52
_enti_e50
_enti_e51
_enti_e56
_enti_e54
_enti_e57
_enti_e58
_enti_e61
_enti_e60
_enti_e62
g1_fact_g1
g1_fact_g14
g2_fact_g12
g2_fact_g13
p1_propro_p1
PMID: 10534111
LPS binds its receptor TLR4.
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 10534111, 2786204, 2120129, 2785566, 9558115, 10427971, 9558115, 10427971 2114443
IL-4 inhibited the production of lipopolysaccharide
(LPS)-stimulated tumor necrosis factor a (TNF-a),
IL-1b, IL-6, IL-10, and prostaglandin E2 (PGE2) [14] by monocytes and this regulation occurred for the peptides, at least
in part, at the mRNA level.
Furthermore, in kinetic studies
of mRNA levels for gc and IL-13Ra1 with increasing time of
culture for monocytes, as mRNA levels were reduced so too was
the ability of IL-4 and IL-13 to suppress LPS-induced TNF-a
production [16, 17].
c4 cso30:c:InputAssociation connector
c21 cso30:c:InputInhibitor connector
c8 cso30:c:OutputProcess connector
p2_propro_p3
PMID: 10534111, 2786204, 2120129, 2785566, 2114443
IL-4 inhibited the production of lipopolysaccharide
(LPS)-stimulated tumor necrosis factor a (TNF-a),
IL-1b, IL-6, IL-10, and prostaglandin E2 (PGE2) [14] by monocytes and this regulation occurred for the peptides, at least
in part, at the mRNA level.
c5 cso30:c:InputAssociation connector
c23 cso30:c:InputInhibitor connector
c9 cso30:c:OutputProcess connector
p2_propro_p4
PMID: 10534111, 2786204, 2120129, 2785566, 2114443
IL-4 inhibited the production of lipopolysaccharide
(LPS)-stimulated tumor necrosis factor a (TNF-a),
IL-1b, IL-6, IL-10, and prostaglandin E2 (PGE2) [14] by monocytes and this regulation occurred for the peptides, at least
in part, at the mRNA level.
c6 cso30:c:InputAssociation connector
c24 cso30:c:InputInhibitor connector
c10 cso30:c:OutputProcess connector
p2_propro_p5
PMID: 10534111, 2786204, 2120129, 2785566, 2114443
IL-4 inhibited the production of lipopolysaccharide
(LPS)-stimulated tumor necrosis factor a (TNF-a),
IL-1b, IL-6, IL-10, and prostaglandin E2 (PGE2) [14] by monocytes and this regulation occurred for the peptides, at least
in part, at the mRNA level.
c7 cso30:c:InputAssociation connector
c22 cso30:c:InputInhibitor connector
c82 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 10534111, 9573026
It is believed that a site within the A/C helices of IL-4 first
binds the IL-4Ra chain with high affinity. A site located near
the end of helix D then binds gc, creating an active receptor
dimer; mutations of the tyrosine at position 124 greatly reduces
this interaction.
There
is strong evidence particularly on non-hematopoietic cells that
the IL-4Ra chain on binding to IL-4 can heterodimerize with
the IL-13Ra1 chain forming the type II IL-4 receptor [28].
c12 cso30:c:InputProcess connector
c13 cso30:c:InputProcess connector
c14 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 10534111
It is believed that a site within the A/C helices of IL-4 first
binds the IL-4Ra chain with high affinity. A site located near
the end of helix D then binds gc, creating an active receptor
dimer; mutations of the tyrosine at position 124 greatly reduces
this interaction.
c15 cso30:c:InputProcess connector
c16 cso30:c:InputProcess connector
c17 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 10534111, 7843245
Western blots of
gc on monocytes suggested proteins of 58 and 64 kDa but only
the 64 kDa protein could associate with the IL-2Rb chain [23].
c18 cso30:c:InputProcess connector
c19 cso30:c:InputProcess connector
c20 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 10534111, 2786204, 2120129, 2785566, 2114443
IL-4 inhibited the production of lipopolysaccharide
(LPS)-stimulated tumor necrosis factor a (TNF-a),
IL-1b, IL-6, IL-10, and prostaglandin E2 (PGE2) [14] by monocytes and this regulation occurred for the peptides, at least
in part, at the mRNA level.
c25 cso30:c:InputAssociation connector
c26 cso30:c:InputInhibitor connector
c49 cso30:c:InputAssociation connector
c27 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 10534111, 8910586, 9013879
The IL-13Ra1 chain has weak IL-13 binding capacity on
its own but binds IL-13 strongly on complexing with the IL-4Ra
chain [26, 27].
c28 cso30:c:InputProcess connector
c29 cso30:c:InputProcess connector
c30 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 10534111, 8910586, 9013879
The IL-13Ra1 chain has weak IL-13 binding capacity on
its own but binds IL-13 strongly on complexing with the IL-4Ra
chain [26, 27].
c31 cso30:c:InputProcess connector
c32 cso30:c:InputProcess connector
c33 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 10534111
For IL-13, the second bound receptor chain
(IL-4Ra) functions to recruit JAK1 to the receptor complex,
and to provide a docking site for STAT6 on its intracellular
domain and thus provides a mechanism by which the biological
effects of IL-4 and IL-13 on monocytes are very similar.
c34 cso30:c:InputProcess connector
c36 cso30:c:OutputProcess connector
c35 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 10534111
For IL-13, the second bound receptor chain
(IL-4Ra) functions to recruit JAK1 to the receptor complex,
and to provide a docking site for STAT6 on its intracellular
domain and thus provides a mechanism by which the biological
effects of IL-4 and IL-13 on monocytes are very similar.
c37 cso30:c:InputProcess connector
c38 cso30:c:InputProcess connector
c39 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 10534111, 9573026
There
is strong evidence particularly on non-hematopoietic cells that
the IL-4Ra chain on binding to IL-4 can heterodimerize with
the IL-13Ra1 chain forming the type II IL-4 receptor [28].
c40 cso30:c:InputProcess connector
c41 cso30:c:InputProcess connector
c42 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 10534111, 8663118
A second
IL-13-specific receptor chain, IL-13Ra2, has been cloned from
a human renal carcinoma cell line and binds IL-13 with much
higher affinity [29].
c43 cso30:c:InputProcess connector
c44 cso30:c:InputProcess connector
c45 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 10534111, 9558115, 10427971
The loss of IL-4- and IL-13-induced STAT6
activation with monocyte differentiation was unique because STATs activated by IFN-g, GM-CSF, and IL-10 were not altered
with monocyte culture [16, 17].
c46 cso30:c:InputProcess connector
c47 cso30:c:OutputProcess connector
c48 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 10534111, 9558115, 10427971
The loss of IL-4- and IL-13-induced STAT6
activation with monocyte differentiation was unique because STATs activated by IFN-g, GM-CSF, and IL-10 were not altered
with monocyte culture [16, 17].
c50 cso30:c:InputAssociation connector
c51 cso30:c:InputProcess connector
c52 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 10534111
IFN-gamma binds its corresponding receptor.
c53 cso30:c:InputProcess connector
c54 cso30:c:InputProcess connector
c55 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 10534111
GM-CSF binds its corresponding receptor.
c56 cso30:c:InputProcess connector
c57 cso30:c:InputProcess connector
c58 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 10534111
IL-10 binds its corresponding receptor.
c59 cso30:c:InputProcess connector
c60 cso30:c:InputProcess connector
c61 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 10534111, 9558115, 10427971
The loss of IL-4- and IL-13-induced STAT6
activation with monocyte differentiation was unique because STATs activated by IFN-g, GM-CSF, and IL-10 were not altered
with monocyte culture [16, 17].
c62 cso30:c:InputProcess connector
c63 cso30:c:InputAssociation connector
c64 cso30:c:OutputProcess connector
p21_propro_p22
PMID: 10534111, 9558115, 10427971
The loss of IL-4- and IL-13-induced STAT6
activation with monocyte differentiation was unique because STATs activated by IFN-g, GM-CSF, and IL-10 were not altered
with monocyte culture [16, 17].
c65 cso30:c:InputAssociation connector
c66 cso30:c:InputProcess connector
c67 cso30:c:OutputProcess connector
p21_propro_p23
PMID: 10534111, 9558115, 10427971
The loss of IL-4- and IL-13-induced STAT6
activation with monocyte differentiation was unique because STATs activated by IFN-g, GM-CSF, and IL-10 were not altered
with monocyte culture [16, 17].
c68 cso30:c:InputProcess connector
c70 cso30:c:InputAssociation connector
c69 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 10534111, 9558115, 10427971
Furthermore, in kinetic studies
of mRNA levels for gc and IL-13Ra1 with increasing time of
culture for monocytes, as mRNA levels were reduced so too was
the ability of IL-4 and IL-13 to suppress LPS-induced TNF-a
production [16, 17].
c71 cso30:c:InputAssociation connector
c73 cso30:c:InputInhibitor connector
c72 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 10534111, 10227996
It was recently shown
that IL-4 could regulate TNF-a and IL-12 production by
IFN-g-activated murine bone marrow-derived macrophages
from STAT6-/- mice [31].
c75 cso30:c:InputAssociation connector
c76 cso30:c:InputInhibitor connector
c74 cso30:c:OutputProcess connector
p25_propro_p26
PMID: 10534111, 10227996
It was recently shown
that IL-4 could regulate TNF-a and IL-12 production by
IFN-g-activated murine bone marrow-derived macrophages
from STAT6-/- mice [31].
c77 cso30:c:InputAssociation connector
c79 cso30:c:InputInhibitor connector
c78 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 10534111
First, a
neutralizing antibody to gc blocked IL-4 regulation of LPSinduced
TNF-a, but not IL-1b, production.
c80 cso30:c:InputAssociation connector
c81 cso30:c:InputInhibitor connector
c93 cso30:c:InputInhibitor connector
c83 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 10534111
Second, a mutant
IL-4 molecule that was able to bind the IL-4Ra chain but not gc
suppressed LPS-induced monocyte IL-1b, but not TNF-a,
production.
c84 cso30:c:InputProcess connector
c85 cso30:c:InputProcess connector
c86 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 10534111
Second, a mutant
IL-4 molecule that was able to bind the IL-4Ra chain but not gc
suppressed LPS-induced monocyte IL-1b, but not TNF-a,
production.
c87 cso30:c:InputAssociation connector
c88 cso30:c:InputInhibitor connector
c89 cso30:c:OutputProcess connector
p30_propro_p30
PMID: 10534111, 10427971
From studies using an antibody to the IL-4Ra chain, we know
that this chain is a component of the receptor by which IL-4 and
IL-13 signal suppression of LPS-induced IL-1b production by
MDMac [17].
c91 cso30:c:InputAssociation connector
c92 cso30:c:InputInhibitor connector
c90 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 10534111, 2786204, 2120129, 2785566, 9558115, 10427971, 9558115, 10427971 2114443
IL-4 inhibited the production of lipopolysaccharide
(LPS)-stimulated tumor necrosis factor a (TNF-a),
IL-1b, IL-6, IL-10, and prostaglandin E2 (PGE2) [14] by monocytes and this regulation occurred for the peptides, at least
in part, at the mRNA level.
c11 cso30:c:InputAssociation connector
c95 cso30:c:InputInhibitor connector
c94 cso30:c:OutputProcess connector
LPS:TLR4_enti_e11
LPS:TLR4
IL-6_enti_e14
IL-6
TLR4_enti_MO000019394
TLR4
LPS_enti_MO000016882
LPS
IL-4_enti_MO000017053
IL-4
IL-4Ralpha_enti_MO000017058
IL-4Ralpha
IL-4:IL-4Ralpha_enti_MO000034134
IL-4:IL-4Ralpha
IL-2Rgamma_enti_e5
IL-2Rgamma
IL4:IL-4Ralpha:IL-2Rgamma_enti_e6
IL4:IL-4Ralpha:IL-2Rgamma
TNF-alpha_enti_G010329
TNF-alpha
IL-1beta_enti_G010389
IL-1beta
IL-2Rbeta_enti_MO000017215
IL-2Rbeta
IL-2Rgamma:IL-2Rbeta_enti_e12
IL-2Rgamma:IL-2Rbeta
t-PA_enti_e13
t-PA
t-PA_enti_e16
t-PA
IL-13Ralpha1_enti_MO000045621
IL-13Ralpha1
IL-13_enti_MO000007321
IL-13
IL-13:IL-13Ralpha1_enti_e17
IL-13:IL-13Ralpha1
IL-13:IL-13Ralpha1:IL-4Ralpha_enti_e18
IL-13:IL-13Ralpha1:IL-4Ralpha
IL-13:IL-13Ralpha1:IL-4Ralpha:JAK1_enti_e20
IL-13:IL-13Ralpha1:IL-4Ralpha:JAK1
Jak1_enti_MO000000145
Jak1
STAT6_enti_MO000013130
STAT6
IL-13:IL-13Ralpha1:IL-4Ralpha:JAK1:STAT6_enti_e19
IL-13:IL-13Ralpha1:IL-4Ralpha:JAK1:STAT6
IL-4:IL-4Ralpha:IL-13Ralpha1_enti_e21
IL-4:IL-4Ralpha:IL-13Ralpha1
IL-13Ralpha2_enti_MO000045622
IL-13Ralpha2
Il-13:IL-13Ralpha2_enti_e22
Il-13:IL-13Ralpha2
STAT6{active}_enti_e23
STAT6{active}
IL-13:IL-13Ralpha1:IL-4Ralpha:JAK1_enti_e24
IL-13:IL-13Ralpha1:IL-4Ralpha:JAK1
IFNgamma_enti_MO000016665
IFNgamma
IFNgammaR_enti_e25
IFNgammaR
IFNgamma:receptor_enti_e26
IFNgamma:receptor
GM-CSF_enti_MO000000099
GM-CSF
GM-CSFR_enti_MO000000090
GM-CSFR
GM-CSF:GM-CSFR_enti_e27
GM-CSF:GM-CSFR
IL-10_enti_MO000017247
IL-10
IL-10R_enti_MO000017252
IL-10R
IL-10:IL-10R_enti_e28
IL-10:IL-10R
STATs_enti_MO000016656
STATs
STATs_enti_e29
STATs
IL-12_enti_e30
IL-12
IL-4{mutant}_enti_e32
IL-4{mutant}
IL-4{mutant}:IL-4Ralpha_enti_e33
IL-4{mutant}:IL-4Ralpha
Neutralizing antibiody_enti_e34
Neutralizing antibiody
IL10_enti_G011345
IL10
PGE2_enti_e15
PGE2