Entity
NF-kappaB
--
MO000000058
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m17
10
infinite
0
TRANSPATH | MO000000058 |
--
TRAF6{active}
--
MO000000212
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m183
10
infinite
0
InterPro | IPR001841 |
TRANSPATH | MO000000212 |
--
IRAK{active}
--
MO000000213
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m184
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000000213 |
--
ERK1
--
MO000004670
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m549
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000004670 |
--
ERK2
--
MO000004676
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m554
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000004676 |
--
M-CSF-1-R
--
MO000007995
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1031
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000007995 |
--
MyD88{active}
--
MO000016573
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1572
10
infinite
0
InterPro | IPR000157 |
TRANSPATH | MO000016573 |
--
LPS
--
MO000016882
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m155666
10
infinite
0
TRANSPATH | MO000016882 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
IFNgamma:R
--
e11
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m11
0
infinite
0
--
CpGDNA
--
e12
cso30:c:Dna
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m12
0
infinite
0
--
CpG DNA receptor
--
e13
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m13
0
infinite
0
--
PAI-2
--
e14
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m14
0
infinite
0
--
csml-variable:Double
m15
0
infinite
0
--
Il-12
--
e16
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m16
0
infinite
0
--
LPS:TLR4
--
e17
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m18
0
infinite
0
--
JNK
--
e18
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m19
0
infinite
0
--
p38
--
e19
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m20
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
NF-kappaB{active}
--
e20
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m21
10
infinite
0
TRANSPATH | MO000000058 |
--
ERK2{active}
--
e21
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m22
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000004676 |
--
ERK1{active}
--
e22
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m23
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000004670 |
--
p38{active}
--
e23
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m24
0
infinite
0
--
JNK{active}
--
e24
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m25
0
infinite
0
--
Ras
--
e28
cso30:c:Protein
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m30
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
M-CSF:M-CSF-1-R
--
e30
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m33
0
infinite
0
--
Ras{active}
--
e31
cso30:c:Protein
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m34
0
infinite
0
--
Ets2
--
e33
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m36
0
infinite
0
--
csml-variable:Double
m37
0
infinite
0
--
--
e35
cso30:c:EntityBiologicalCompartment
cso30:i:CC_GolgiTransFace
--
--
--
csml-variable:Double
m38
0
infinite
0
--
--
e36
cso30:c:EntityBiologicalCompartment
cso30:i:CC_GolgiMembrane
--
--
--
csml-variable:Double
m39
0
infinite
0
--
--
e37
cso30:c:EntityBiologicalCompartment
cso30:i:CC_GolgiApparatus
--
--
--
csml-variable:Double
m40
0
infinite
0
--
--
e38
cso30:c:EntityBiologicalCompartment
cso30:i:CC_GolgiLumen
--
--
--
csml-variable:Double
m41
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
M-CSF-1-R{p}
--
e40
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m43
0
infinite
0
--
IL-12:IL-12R
--
e5
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
IFNgammaR
--
e6
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c5 : 1
m15*m13*0.1
nodelay
--
0
PMID: 10534106 To activate cells, CpG DNA probably needs to be internalized via the endosomes. Although internalization of DNA appears to be essential for the biological response, the possibility that a co-stimulatory signal comes from a membrane receptor during the process of internalization should not be discounted.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c31 : 1
m1639*m6*0.1
nodelay
--
0
PMID: 10534106 Interferon-g in turn primes murine macrophages to respond to CpG DNA with expression of iNOS and nitric oxide production as well as increasing a number of other responses, creating a potential self-amplifying loop with NK cells PMID: 10534106, 1401905 Baccarini et al reported an increase in serine phosphorylation of the receptor in Bac1.2F5 cells treated with interferon-g plus LPS.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
m93479*0.1
nodelay
--
0
PMID: 10534106, 9568729, 8757335 In comparison to the response to LPS, CpG DNA was as effective at increasing TNF-a mRNA in bone marrow-derived murine macrophages, whereas it was a less effective inducer of IL-1b and plasminogen activator inhibitor type-2 and did not, by itself, lead to production of inducible nitric oxide synthase (iNOS) Interferon-g in turn primes murine macrophages to respond to CpG DNA with expression of iNOS and nitric oxide production as well as increasing a number of other responses, creating a potential self-amplifying loop with NK cells
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1
m93323*m12*0.1
nodelay
--
0
PMID: 10534106, 9568729, 8757335 In comparison to the response to LPS, CpG DNA was as effective at increasing TNF-a mRNA in bone marrow-derived murine macrophages, whereas it was a less effective inducer of IL-1b and plasminogen activator inhibitor type-2 and did not, by itself, lead to production of inducible nitric oxide synthase (iNOS)
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1
m155666*m3961*0.1
nodelay
--
0
PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
p14
p14
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c65 : 1
stoichiometry:c52 : 1
m1572*m17*0.1
nodelay
--
0
PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1
m12*m19*0.1
nodelay
--
0
PMID: 10534106, 9799232, 9568729 The latter (MAP kinases) are also activated by CpG DNA in myeloid cells
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1
m12*m20*0.1
nodelay
--
0
PMID: 10534106, 9799232, 9568729 The latter (MAP kinases) are also activated by CpG DNA in myeloid cells
p17
p17
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c40 : 1
stoichiometry:c39 : 1
m549*m12*0.1
nodelay
--
0
PMID: 10534106, 9799232, 9568729 The latter (MAP kinases) are also activated by CpG DNA in myeloid cells PMID: 10534106, 10586047 More recently, we confirmed that CpG DNA can mimic the ability of CSF-1 to activate phosphorylation of the MAP kinases ERK-1 and ERK-2 in macrophages
p17
p18
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c162 : 1
m12*m554*0.1
nodelay
--
0
PMID: 10534106, 9799232, 9568729 The latter (MAP kinases) are also activated by CpG DNA in myeloid cells PMID: 10534106, 10586047 More recently, we confirmed that CpG DNA can mimic the ability of CSF-1 to activate phosphorylation of the MAP kinases ERK-1 and ERK-2 in macrophages
p14
p19
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c66 : 1
stoichiometry:c55 : 1
m1572*m19*0.1
nodelay
--
0
PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c4 : 1
m12*0.1
nodelay
--
0
PMID: 10534106, 9568729, 8757335 In comparison to the response to LPS, CpG DNA was as effective at increasing TNF-a mRNA in bone marrow-derived murine macrophages, whereas it was a less effective inducer of IL-1b and plasminogen activator inhibitor type-2 and did not, by itself, lead to production of inducible nitric oxide synthase (iNOS)
p14
p20
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c67 : 1
stoichiometry:c58 : 1
m1572*m20*0.1
nodelay
--
0
PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
p14
p21
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c68 : 1
stoichiometry:c61 : 1
m1572*m549*0.1
nodelay
--
0
PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
p14
p22
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c69 : 1
stoichiometry:c64 : 1
m1572*m554*0.1
nodelay
--
0
PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
p14
p23
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c73 : 1
stoichiometry:c72 : 1
m184*m17*0.1
nodelay
--
0
PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
p14
p24
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c77 : 1
stoichiometry:c76 : 1
m184*m19*0.1
nodelay
--
0
PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
p14
p25
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c81 : 1
stoichiometry:c80 : 1
m184*m20*0.1
nodelay
--
0
PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
p14
p26
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c85 : 1
stoichiometry:c84 : 1
m184*m549*0.1
nodelay
--
0
PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
p14
p27
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c89 : 1
stoichiometry:c88 : 1
m184*m554*0.1
nodelay
--
0
PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
p14
p28
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c93 : 1
stoichiometry:c92 : 1
m183*m17*0.1
nodelay
--
0
PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
p14
p29
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c97 : 1
stoichiometry:c96 : 1
m183*m19*0.1
nodelay
--
0
PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1
stoichiometry:c8 : 1
m12*m16*0.1
nodelay
--
0
PMID: 10534106, 9245551, 10689778, 9464831 CpG DNA induces a range of cytokines in macrophages/ dendritic cells, including interleukin-12 (IL-12), tumor necrosis factor a (TNF-a), IL-1b, and IL-6.
p14
p30
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c101 : 1
stoichiometry:c100 : 1
m183*m20*0.1
nodelay
--
0
PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
p14
p31
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c105 : 1
stoichiometry:c104 : 1
m183*m549*0.1
nodelay
--
0
PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
p14
p32
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c109 : 1
stoichiometry:c108 : 1
m183*m554*0.1
nodelay
--
0
PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).
p33
p33
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1
stoichiometry:c133 : 1
m89*m1031*0.1
nodelay
--
0
PMID: 10534106, 9710599 We have demonstrated the constitutive activation of this pathway in response to CSF-1, and its role in phosphorylation of the transcription factor Ets2 PMID: 10534106 CSF-1 can activate Raf-1 in a ras-independent manner.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c114 : 1
1.0*0.1
nodelay
--
0
PMID: 10534106, 10354505, 6092475, 1401905, 2548952 LPS has been shown previously to cause rapid down-regulation of CSF-1 binding to murine macrophages
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c113 : 1
m95036*0.1
nodelay
--
0
PMID: 10534106, 10354505, 6092475, 1401905, 2548952 LPS has been shown previously to cause rapid down-regulation of CSF-1 binding to murine macrophages
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c43 : 1
stoichiometry:c112 : 1
1.0*0.1
nodelay
--
0
PMID: 10534106 Both LPS and bacterial DNA or CpG oligonucleotides cause rapid down-modulation of the CSF-1R from the cell surface. PMID: 10534106, 8497248 Indeed, down-modulation of the receptor from the cell surface is followed, at least in the case of LPS, by specific repression of c-fms (CSF-1R) mRNA transcription and RAW264 macrophage cells treated with LPS or CpG DNA for a prolonged period deplete both their cell surface and intracellular Golgi-associated pool of CSF-1R
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
m26*0.1
nodelay
--
0
PMID: 10534106 Both LPS and bacterial DNA or CpG oligonucleotides cause rapid down-modulation of the CSF-1R from the cell surface.
p38
p38
cso30:i:ME_UnknownActivation
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c137 : 1
stoichiometry:c119 : 1
m46*m155666*0.1
nodelay
--
0
--
p39
p39
cso30:i:ME_Internalization
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c122 : 1
stoichiometry:c121 : 1
m1031*m18*0.1
nodelay
--
0
PMID: 10534106 The biological importance of the specific internalization of the CSF-1R in response to CpG DNA and LPS is not known.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c11 : 1
stoichiometry:c10 : 1
m93309*m12*0.1
nodelay
--
0
PMID: 10534106, 9245551, 10689778, 9464831 CpG DNA induces a range of cytokines in macrophages/ dendritic cells, including interleukin-12 (IL-12), tumor necrosis factor a (TNF-a), IL-1b, and IL-6.
p39
p40
cso30:i:ME_Internalization
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1
stoichiometry:c125 : 1
m12*m1031*0.1
nodelay
--
0
PMID: 10534106 The biological importance of the specific internalization of the CSF-1R in response to CpG DNA and LPS is not known.
p41
p41
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c127 : 1
stoichiometry:c128 : 1
m18*m28*0.1
nodelay
--
0
PMID: 10534106, 7799956 More recently the same group claimed that activation of Raf in LPS-stimulated cells was ras-independent
p42
p42
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c143 : 1
stoichiometry:c132 : 1
m31*m33*0.1
nodelay
--
0
PMID: 10534106 CSF-1 can activate Raf-1 in a ras-independent manner.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1
m33*m30*0.1
nodelay
--
0
PMID: 10534106, 9710599 We have demonstrated the constitutive activation of this pathway in response to CSF-1, and its role in phosphorylation of the transcription factor Ets2
p44
p44
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c140 : 1
stoichiometry:c139 : 1
m47*m155666*0.1
nodelay
--
0
--
p45
p45
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c163 : 1
stoichiometry:c142 : 1
m48*m155666*0.1
nodelay
--
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c145 : 1
stoichiometry:c146 : 1
m33*m36*0.1
nodelay
--
0
PMID: 10534106, 9710599 We have demonstrated the constitutive activation of this pathway in response to CSF-1, and its role in phosphorylation of the transcription factor Ets2
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1
m26*0.1
nodelay
--
0
PMID: 10534106 Both LPS and bacterial DNA or CpG oligonucleotides cause rapid down-modulation of the CSF-1R from the cell surface. PMID: 10534106, 8497248 Indeed, down-modulation of the receptor from the cell surface is followed, at least in the case of LPS, by specific repression of c-fms (CSF-1R) mRNA transcription and RAW264 macrophage cells treated with LPS or CpG DNA for a prolonged period deplete both their cell surface and intracellular Golgi-associated pool of CSF-1R
p48
p48
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c151 : 1
stoichiometry:c152 : 1
stoichiometry:c150 : 1
m1031*m18*m11*0.1
nodelay
--
0
PMID: 10534106, 1401905 Baccarini et al reported an increase in serine phosphorylation of the receptor in Bac1.2F5 cells treated with interferon-g plus LPS.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c154 : 1
stoichiometry:c155 : 1
m27*m30*0.1
nodelay
--
0
PMID:10534106 One possibility is that after internalization the receptor provides a CSF-1-independent signal to the ras-raf-MAP kinase pathway.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c14 : 1
stoichiometry:c13 : 1
m93364*m12*0.1
nodelay
--
0
PMID: 10534106, 9245551, 10689778, 9464831 CpG DNA induces a range of cytokines in macrophages/ dendritic cells, including interleukin-12 (IL-12), tumor necrosis factor a (TNF-a), IL-1b, and IL-6.
p49
p50
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1
m34*m28*0.1
nodelay
--
0
PMID:10534106 One possibility is that after internalization the receptor provides a CSF-1-independent signal to the ras-raf-MAP kinase pathway.
p49
p51
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1
stoichiometry:c161 : 1
m29*m69*0.1
nodelay
--
0
PMID:10534106 One possibility is that after internalization the receptor provides a CSF-1-independent signal to the ras-raf-MAP kinase pathway.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c17 : 1
m12*m93248*0.1
nodelay
--
0
PMID: 10534106, 9245551, 10689778, 9464831 CpG DNA induces a range of cytokines in macrophages/ dendritic cells, including interleukin-12 (IL-12), tumor necrosis factor a (TNF-a), IL-1b, and IL-6.
p7
p7
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1
m12340*m2121*0.1
nodelay
--
0
PMID: 10534106, 9245551, 8648098 In mixed spleen cell culture, CpG DNA-induced macrophage IL-12 promotes interferon-g production by NK cells
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1
m5*m93423*0.1
nodelay
--
0
PMID: 10534106, 9245551, 8648098 In mixed spleen cell culture, CpG DNA-induced macrophage IL-12 promotes interferon-g production by NK cells
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1
m11*m12*0.1
nodelay
--
0
PMID: 10534106, 9568729, 8757335 In comparison to the response to LPS, CpG DNA was as effective at increasing TNF-a mRNA in bone marrow-derived murine macrophages, whereas it was a less effective inducer of IL-1b and plasminogen activator inhibitor type-2 and did not, by itself, lead to production of inducible nitric oxide synthase (iNOS) Interferon-g in turn primes murine macrophages to respond to CpG DNA with expression of iNOS and nitric oxide production as well as increasing a number of other responses, creating a potential self-amplifying loop with NK cells
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--