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indirect
PMID: 10473535, 8663020
Cp markedly enhanced LDL oxidation by both cell types.
PMID: 10473535
Cell-derived superoxide anion (Obardot 2) was essential for the enhancement of LDL oxidation by Cp under these conditions.
PMID: 10473535, 8609249
Exogenous Cp added to unactivated U937 cells caused LDL oxidation to an extent similar to that by zymosan in the absence of exogenous Cp.
indirect
PMID: 10473535, 8609249
Zymosan induced Cp mRNA and (after a 5-6-h lag following activation) Cp protein synthesis.
indirect
PMID: 10473535, 1996664, 9257859
Factors that stimulate monocyte-macrophage Cp production and could contribute to Cp accumulation in vivo include endotoxin and interferon (IFN)-gamma.
indirect
PMID: 10473535, 1996664, 9257859
Factors that stimulate monocyte-macrophage Cp production and could contribute to Cp accumulation in vivo include endotoxin and interferon (IFN)-gamma.
PMID: 10473535, 3139813, 1901344
Incubation of LDL with 15-LO plus phospholipase A2 led to LDL oxidation in a cell-free system; however, 15-LO alone was also shown to oxidize LDL significantly in the absence of cells.
indirect
PMID: 10473535, 3139813, 1901344
Incubation of LDL with 15-LO plus phospholipase A2 led to LDL oxidation in a cell-free system; however, 15-LO alone was also shown to oxidize LDL significantly in the absence of cells.
PMID: 10473535, 9261183
Angiotensin II enhanced both LO activity and LDL oxidation in mouse peritoneal macrophages and J774 cells.
PMID: 10473535
They catalyze the direct insertion of molecular oxygen into polyenoic fatty acids, forming hydroperoxides.
PMID: 10473535
MPO can catalyze the one-electron oxidation of L-tyrosine, generating the tyrosyl radical.
PMID: 10473535
MPO catalyzes the two-electron oxidation of chloride forming the powerful oxidant, hypochlorous acid (HOCl).
PMID: 10473535, 3139813, 1901344
Incubation of LDL with 15-LO plus phospholipase A2 led to LDL oxidation in a cell-free system; however, 15-LO alone was also shown to oxidize LDL significantly in the absence of cells.