PMID: 10380893, 9427712 In monocytic THP-1 cells LPS was able to activate caspase-1, a cysteine protease involved in different apoptotic processes.

PMID: 10380893 It was pointed out that reactive oxygen intermediates (ROI) play a central role as downstream mediators of Fasinduced monocyte apoptosis.

PMID: 10380893, 1698311 In 1990 CD14 putative main function as a receptor for LPS was discovered with the help of specific monoclonal antibodies (mAb). PMID: 10380893, 2402637 LPS binds to CD14 in a native state or in aggregates and a 60-kDa serum glycoprotein, named LPS-binding protein (LBP), highly enhances binding to the CD14 receptor.

PMID: 10380893, 1375269 In murine 70 Z/3 B cells, LPS responsiveness was enhanced 1000-fold as measured by nuclear factor-kB (NF-kB) -regulated rise of IgM expression.

PMID: 10380893, 7534294 Gregner et al. could show that LPS signal transduction and LPS clearance or internalization utilized both membrane-bound CD14 (mCD14) and LBP but signal transduction pathways, e.g., NF-kB activation, diverged after the initial complex was formed.

PMID: 10380893, 2466895 Ca2+ mobilization in activated monocytes can be induced by the CD14 molecule via cross-linking of anti-CD14 antibody Fc receptors or F(ab)¡Ç2 fragments of secondary antibodies.

PMID: 10380893, 2466895 Ca2+ mobilization in activated monocytes can be induced by the CD14 molecule via cross-linking of anti-CD14 antibody Fc receptors or F(ab)¡Ç2 fragments of secondary antibodies.

PMID: 10380893 This was shown by blocking IL-8 and IL-1b secretion induced by IL-2 with anti-CD14 mAbs as well as by transfecting U937 cells with CD14 cDNA and thus up-regulating monokine synthesis in response to IL-2.

PMID: 10380893 This was shown by blocking IL-8 and IL-1b secretion induced by IL-2 with anti-CD14 mAbs as well as by transfecting U937 cells with CD14 cDNA and thus up-regulating monokine synthesis in response to IL-2.

PMID: 10380893 This was shown by blocking IL-8 and IL-1b secretion induced by IL-2 with anti-CD14 mAbs as well as by transfecting U937 cells with CD14 cDNA and thus up-regulating monokine synthesis in response to IL-2. PMID: 10380893 Only IL-4 blocked CD40-dependent rescue from apoptosis, although both cytokines decreased IL-1b synthesis after receptor ligation.

PMID: 10380893 Cleavage of the IL-1b precursor protein was followed by release of mature IL-1b with putative secondary consequences for the antagonism of cell death.

PMID: 10380893, 7534618 purified lipophilic or polysaccharide components such as muramyl dipeptide, peptidoglycan, lipoarabinomannan, or phospholipids interact with CD14, suggesting that CD14 acts not only as a surface receptor for LPS but might function as a polyspecific receptor with broad recognition properties.

PMID: 10380893, 7534618 purified lipophilic or polysaccharide components such as muramyl dipeptide, peptidoglycan, lipoarabinomannan, or phospholipids interact with CD14, suggesting that CD14 acts not only as a surface receptor for LPS but might function as a polyspecific receptor with broad recognition properties.

PMID: 10380893, 7534618 purified lipophilic or polysaccharide components such as muramyl dipeptide, peptidoglycan, lipoarabinomannan, or phospholipids interact with CD14, suggesting that CD14 acts not only as a surface receptor for LPS but might function as a polyspecific receptor with broad recognition properties.

PMID: 10380893, 7534618 purified lipophilic or polysaccharide components such as muramyl dipeptide, peptidoglycan, lipoarabinomannan, or phospholipids interact with CD14, suggesting that CD14 acts not only as a surface receptor for LPS but might function as a polyspecific receptor with broad recognition properties.

PMID: 10380893, 7914033, 7992057 Monocyte activation by LPS induces a rapid increase of tyrosine phosphorylation in different proteins belonging to the MAP kinase family such as p38 or ERK.

PMID: 10380893, 7914033, 7992057 Monocyte activation by LPS induces a rapid increase of tyrosine phosphorylation in different proteins belonging to the MAP kinase family such as p38 or ERK.

PMID: 10380893 wild-type LPS activated the cytokine production (e.g., TNF-a) and translocated NF-kB in a TLR2-dependent manner.

PMID: 10380893 wild-type LPS activated the cytokine production (e.g., TNF-a) and translocated NF-kB in a TLR2-dependent manner.

PMID: 10380893 wild-type LPS activated the cytokine production (e.g., TNF-a) and translocated NF-kB in a TLR2-dependent manner.

PMID: 10380893 wild-type LPS activated the cytokine production (e.g., TNF-a) and translocated NF-kB in a TLR2-dependent manner.

PMID: 10380893 Parallel to increased CD14 expression due to LPS administration, apoptosis was inhibited, whereas decreased expression after IL-4 treatment was associated with induction of apoptosis.

PMID: 10380893, 7682078 Cytokines such as TNF-a or IL-1 with their well-known effects of enhancing survival of monocytes also increase CD14 expression.

PMID: 10380893, 7682078 Cytokines such as TNF-a or IL-1 with their well-known effects of enhancing survival of monocytes also increase CD14 expression. PMID: 10380893 Parallel to increased CD14 expression due to LPS administration, apoptosis was inhibited, whereas decreased expression after IL-4 treatment was associated with induction of apoptosis.

PMID: 10380893, 7682078 Cytokines such as TNF-a or IL-1 with their well-known effects of enhancing survival of monocytes also increase CD14 expression.

PMID: 10380893, 7682078 Cytokines such as TNF-a or IL-1 with their well-known effects of enhancing survival of monocytes also increase CD14 expression. PMID: 10380893 Parallel to increased CD14 expression due to LPS administration, apoptosis was inhibited, whereas decreased expression after IL-4 treatment was associated with induction of apoptosis.

PMID: 10380893, 7545713 IL-13 can evoke apoptosis consecutively to down-regulation of CD14

PMID: 10380893, 1545126, 7595231 Phagocyte receptors for phosphatidylserine (PS) have been further described that bind this phospholipid when it comes from the inner to the outer leaflet of the membranes of cells undergoing apoptosis.

PMID: 10380893 Activation of monocytes can also be achieved through the interaction between monocytic CD40 with the CD40 ligand present on activated lymphocytes.

PMID: 10380893, 1688647, 7536797 The first and best established receptor complex comprises the avb3 vitronectin receptor integrin and CD36, which belongs to class B scavenger receptors and can bind thrombospondin.

PMID: 10380893 Only IL-4 blocked CD40-dependent rescue from apoptosis, although both cytokines decreased IL-1b synthesis after receptor ligation.

PMID: 10380893 Only IL-4 blocked CD40-dependent rescue from apoptosis, although both cytokines decreased IL-1b synthesis after receptor ligation.

PMID: 10380893 Only IL-4 blocked CD40-dependent rescue from apoptosis, although both cytokines decreased IL-1b synthesis after receptor ligation.

PMID: 10380893, 7532907 The Fas (APO-1,CD95)/Fas ligand (FasL) system has been established as a central pathway for the induction of lymphocyte apoptosis acting from the cell surface site