majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:10080535.csml convertedTime:2009.07.01.10:37

Entity

e1: e10: e11: e12: e13: e14: e15: e16: e17:PLA2{endoplasmic reticulum} e18:cPLA2{nuclear envelope} e19:calcium:cPLA2 e2: e20:p42/p44MAPK{activated} e22:cPLA2{phosphorylated} e23:Phospholipid e24:Fatty Acids (Arachidonic acid) e25:Lysophospholipids (Lyso-PAF) e26:PAF e27:Leukotrine A4 e28:Leucotrine B4 e29:5-lipoxygenase e3: e30:Leukotrine C4 e31:COX1 e32:Prostaglandin (PGG2) e33:Prostaglandin (PGH2) e34:PGI2 e35:PGD2 e36:PGE2 e37:PGF2alpha e38:thromboxanes e39:M-type receptor e4: e40:Group I sPLA2 e41:Group I sPLA2:M-type receptor e42:Thrombin e43:p38{activated} e44:zymosan e45:PKC{activated} e46:PKC e47:p42/p44MAPK e48:p38 e49:JNK{activated} e5:cPLA2 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:Calcium e60: e61: e62: e63:JNK e64:PD98059 e65:SB 203580 e66:Okadaic acid e67:PMA e68:A23187 e69:CSF1 e7: e70:COX2 e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p3 p30 p31 p32 p33 p34 p35 p5 p6 p7 p8 p9
120.92213024984474, 110.836383917035
812.087300926608, 1241.4492181602911

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
128.74653485049186, 129.811360370424
787.1612772342116, 1165.817692243212

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
186.94003476794614, 845.7730491582748
154.84333109125959, 44.67610864272413

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
185.41698560967131, 844.25
157.88942940780893, 47.72220695927354

--

e12

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToExternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false true false

--

Go back
185.41698560967131, 844.25
157.88942940780893, 47.72220695927354

--

e13

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_IntegralToMembrane_

--

--

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false true false

--

Go back
188.20924239984151, 847.0422567901702
152.30491582746842, 42.13769337893301

--

e14

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulumLumen

--

--

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false true false

--

Go back
185.41698560967131, 844.25
157.88942940780893, 47.72220695927354

--

e15

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_Membrane_

--

--

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false true false

--

Go back
187.70155934708328, 846.5345737374122
153.3202819329849, 43.15305948444946

--

e16

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false true false

--

Go back
245.5, 858.125
45.0, 27.75

PLA2{endoplasmic reticulum}

--

e17

cso30:c:Protein

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToExternalSideOfMembrane_

--

p2

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
513.5, 814.125
45.0, 27.75

cPLA2{nuclear envelope}

--

e18

cso30:c:Protein

cso30:i:CC_NuclearEnvelopeLumen

--

p1 p27 p28

p18

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
184.5, 719.125
55.79492855705373, 34.406872610183136

calcium:cPLA2

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

p3

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
120.92213024984474, 110.836383917035
812.087300926608, 1241.4492181602911

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
285.5, 399.125
45.0, 33.75

p42/p44MAPK{activated}

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

p15 p30 p32 p33

p26

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
433.5, 562.0
45.0, 36.0

cPLA2{phosphorylated}

--

e22

cso30:c:Protein

cso30:i:CC_Cytosol

--

p5 p24 p25 p34 p26 p35

p1 p2 p27 p28

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
634.0, 863.0
60.0, 34.0

Phospholipid

--

e23

cso30:c:SmallMolecule

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p18

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
761.5, 491.25
45.0, 25.5

Fatty Acids (Arachidonic acid)

--

e24

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p18

p7 p9 p6

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
765.5, 319.25
45.0, 25.5

Lysophospholipids (Lyso-PAF)

--

e25

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p18

p8

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
769.5, 203.25
45.0, 25.5

PAF

--

e26

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p8

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
705.5, 643.25
45.0, 25.5

Leukotrine A4

--

e27

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p7

p10 p19

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
605.5, 739.25
45.0, 25.5

Leucotrine B4

--

e28

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p10

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
701.5, 499.125
45.0, 33.75

5-lipoxygenase

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
137.16387626837684, 127.93623540684621
779.6038088895438, 1207.2495151806697

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
701.5, 763.25
45.0, 25.5

Leukotrine C4

--

e30

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p19

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
833.5, 479.125
45.0, 33.75

COX1

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
833.5, 627.25
45.0, 25.5

Prostaglandin (PGG2)

--

e32

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p9 p6

p11

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
833.5, 743.25
45.0, 25.5

Prostaglandin (PGH2)

--

e33

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p11

p12 p20 p21 p22 p23

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
697.5, 819.25
45.0, 25.5

PGI2

--

e34

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
725.5, 879.25
45.0, 25.5

PGD2

--

e35

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p20

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
745.5, 943.25
45.0, 25.5

PGE2

--

e36

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p21

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
765.5, 1007.25
45.0, 25.5

PGF2alpha

--

e37

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p22

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
777.5, 1067.25
45.0, 25.5

thromboxanes

--

e38

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p23

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
772.375, 105.5
40.17091388400703, 61.80140597539543

M-type receptor

--

e39

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p13

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
167.21110640266144, 157.8609755140156
719.509348620975, 1147.4000349663295

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
597.5, 42.125
45.0, 27.75

Group I sPLA2

--

e40

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p13

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
645.375, 99.5
36.28617627713221, 70.2313089234817

Group I sPLA2:M-type receptor

--

e41

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p13

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
534.125, 361.5
27.75, 45.0

Thrombin

--

e42

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p31

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
485.5, 323.125
45.0, 33.75

p38{activated}

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

p16 p31

p24

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
481.5, 179.25
45.0, 25.5

zymosan

--

e44

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p14 p16 p17

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
201.5, 235.125
45.0, 33.75

PKC{activated}

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

p14

p15

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
201.5, 179.125
45.0, 33.75

PKC

--

e46

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p14

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
281.5, 235.125
45.0, 33.75

p42/p44MAPK

--

e47

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p15 p30 p32 p33

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
449.5, 275.125
45.0, 33.75

p38

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p16 p31

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
613.5, 323.125
45.0, 33.75

JNK{activated}

--

e49

cso30:c:Protein

cso30:i:CC_Cytosol

--

p17

p25

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
321.5, 566.125
45.0, 27.75

cPLA2

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3 p5 p24 p25 p34 p26 p35

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
292.8219282943646, 826.7786523679687
441.62843122758227, 421.6686601145594

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
340.5210884641965, 836.7715866028738
258.23338436771115, 408.680919043269

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
298.5787234872754, 832.4066734988611
430.114840841761, 410.41261785277425

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
299.40112280054836, 833.2725229036138
428.4700422152149, 408.680919043269

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
292.8219282943646, 826.7786523679687
441.62843122758227, 421.6686601145594

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
292.8219282943646, 826.7786523679687
441.62843122758227, 421.6686601145594

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
299.40112280054836, 833.2725229036138
428.4700422152149, 408.680919043269

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
615.2024590973668, 999.9485333185062
27.590517853884823, 26.296280375241

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
542.831319529346, 1121.1674499838828
78.12793476093167, 74.46304880873126

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
292.8219282943646, 826.7786523679687
441.62843122758227, 421.6686601145594

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
248.875, 692.5
37.81757520124276, 38.45855105211128

Calcium

--

e6

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p1 p2 p3 p5

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
396.91126466256077, 1014.1647206460564
13.985723512161313, 7.089639463899636

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
396.44424176675824, 993.0217380804849
47.86984681975654, 90.71814612437123

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
416.5262262862663, 1052.025410356499
7.472366332840038, 7.867156303468504

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
693.5, 175.125
45.0, 33.75

JNK

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p17

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
373.5, 367.25
45.0, 25.5

PD98059

--

e64

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p15 p30 p32 p33

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
553.5, 207.25
45.0, 25.5

SB 203580

--

e65

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p16 p31

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
185.5, 467.25
45.0, 25.5

Okadaic acid

--

e66

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p27 p32 p35

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
177.5, 347.25
45.0, 25.5

PMA

--

e67

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p33

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
205.5, 551.25
45.0, 25.5

A23187

--

e68

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p28 p34

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
370.125, 229.5
27.75, 45.0

CSF1

--

e69

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p30

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
131.59177288709083, 115.83207371144746
796.4046374899931, 1188.1064059398927

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
777.5, 631.125
45.0, 33.75

COX2

--

e70

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
134.43701092368974, 136.8010036999123
764.0004585189324, 1167.9381894289104

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
142.0243123546203, 157.7699336883771
760.5123773452655, 1152.6209727333803

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
469.0, 721.0
30.0, 30.0

p1

p1

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e6 e22

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c98 : 1
stoichiometry:c6 : 1

m6*m22*0.1

nodelay

--

true

0

false

PMID: 10080535 cPLA2 is regulated by an increase in intracellular calcium, which binds to an aminoterminal C2 domain and induces its translocation to the nuclear envelope and endoplasmic reticulum.

Go back
665.0, 689.0
30.0, 30.0

p10

p10

cso30:i:ME_MetabolicReaction

cso30:i:CC_Cytosol

--

e27

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c26 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 10080535, 8751717 Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT)

Go back
841.0, 677.0
30.0, 30.0

p11

p11

cso30:i:ME_MetabolicReaction

cso30:i:CC_Cytosol

--

e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 10080535, 8751717 Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT), 8751717

Go back
773.0, 785.0
30.0, 30.0

p12

p12

cso30:i:ME_MetabolicReaction

cso30:i:CC_Cytosol

--

e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 10080535 Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT), 8751717

Go back
717.0, 41.0
30.0, 30.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e40 e39

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m40*m39*0.1

nodelay

--

true

0

false

PMID: 10080535, 8294398 group I pancreatic sPLA2 is primarily involved in the digestion of dietary lipid and may play additional roles in other tissues through its binding to M-type receptors

Go back
329.0, 181.0
30.0, 30.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e46 e44

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c49 : 1
stoichiometry:c45 : 1

m46*m44*0.1

nodelay

--

true

0

false

PMID: 10080535, 8034717 Zymosan activates protein kinase C (PKC)

Go back
293.0, 297.0
30.0, 30.0

p15

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e47 e45 e64

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c48 : 1
stoichiometry:c103 : 1
stoichiometry:c47 : 1

m47*m45*0.1

nodelay

--

true

0

false

PMID: 10080535, 8034717 Zymosan activates protein kinase C (PKC), which initiates a kinase cascade leading to activation of p42/p44 MAPK. treatment of macrophages with the MAPK kinase (MEK) inhibitor, PD98059 together with the p38 inhibitor, SB 203580, quantitatively suppresses zymosan-induced arachidonic acid release and cPLA2 phosphorylation on S505.

Go back
493.0, 229.0
30.0, 30.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e48 e44 e65

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c51 : 1
stoichiometry:c101 : 1
stoichiometry:c50 : 1

m48*m44*0.1

nodelay

--

true

0

false

PMID: 10080535 Zymosan also activates the MAPK homologs, Jun kinase and p38, which can phosphorylate cPLA2 in vitro and induce a gel shift, suggesting phosphorylation on S505 treatment of macrophages with the MAPK kinase (MEK) inhibitor, PD98059 together with the p38 inhibitor, SB 203580, quantitatively suppresses zymosan-induced arachidonic acid release and cPLA2 phosphorylation on S505.

Go back
621.0, 177.0
30.0, 30.0

p17

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e63 e44

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c54 : 1
stoichiometry:c53 : 1

m63*m44*0.1

nodelay

--

true

0

false

PMID: 10080535 Zymosan also activates the MAPK homologs, Jun kinase and p38, which can phosphorylate cPLA2 in vitro and induce a gel shift, suggesting phosphorylation on S505

Go back
581.0, 833.0
30.0, 30.0

p18

p18

cso30:i:ME_Hydrolysis

cso30:i:CC_Cytosol

--

e23 e18

e25 e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c15 : 1

m23*m18*0.1

nodelay

--

true

0

false

PMID: 10080535, 9202883 PLA2 hydrolyzes phospholipid and produces lysophospholipid and fatty acid.

Go back
709.0, 701.0
30.0, 30.0

p19

p19

cso30:i:ME_MetabolicReaction

cso30:i:CC_Cytosol

--

e27

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c69 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 10080535, 8751717 Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT)

Go back
253.0, 769.0
30.0, 30.0

p2

p2

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e6 e22

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c84 : 1
stoichiometry:c5 : 1

m6*m22*0.1

nodelay

--

true

0

false

PMID: 10080535 cPLA2 is regulated by an increase in intracellular calcium, which binds to an aminoterminal C2 domain and induces its translocation to the nuclear envelope and endoplasmic reticulum.

Go back
797.0, 829.0
30.0, 30.0

p20

p20

cso30:i:ME_MetabolicReaction

cso30:i:CC_Cytosol

--

e33

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c70 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 10080535 Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT), 8751717

Go back
809.0, 893.0
30.0, 30.0

p21

p21

cso30:i:ME_MetabolicReaction

cso30:i:CC_Cytosol

--

e33

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c71 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 10080535 Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT), 8751717

Go back
825.0, 949.0
30.0, 30.0

p22

p22

cso30:i:ME_MetabolicReaction

cso30:i:CC_Cytosol

--

e33

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c72 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 10080535 Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT), 8751717

Go back
849.0, 1029.0
30.0, 30.0

p23

p23

cso30:i:ME_MetabolicReaction

cso30:i:CC_Cytosol

--

e33

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c73 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 10080535 Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT), 8751717

Go back
429.0, 433.0
30.0, 30.0

p24

p24

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e43 e5

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m43*m5*0.1

nodelay

--

true

0

false

PMID: 10080535 Zymosan also activates the MAPK homologs, Jun kinase and p38, which can phosphorylate cPLA2 in vitro and induce a gel shift, suggesting phosphorylation on S505

Go back
513.0, 477.0
30.0, 30.0

p25

p25

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e5 e49

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c78 : 1
stoichiometry:c77 : 1

m5*m49*0.1

nodelay

--

true

0

false

PMID: 10080535 Zymosan also activates the MAPK homologs, Jun kinase and p38, which can phosphorylate cPLA2 in vitro and induce a gel shift, suggesting phosphorylation on S505

Go back
373.0, 417.0
30.0, 30.0

p26

p26

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e5 e20

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c14 : 1
stoichiometry:c95 : 1

m5*m20*0.1

nodelay

--

true

0

false

PMID: 10080535, 8227003, 8034717, 9525925 Phosphorylation of cPLA2 on S505 by mitogenactivated protein kinases (MAPK) also contributes to activation.

Go back
421.0, 757.0
30.0, 30.0

p27

p27

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e66 e22

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c94 : 1
stoichiometry:c80 : 1

m66*m22*0.1

nodelay

--

true

0

false

PMID: 10080535 Treatment of Sf9 cells with A23187 induces translocation of GFP-cPLA2 but not GFP to the nuclear envelope in living Sf9 cells as observed by digital confocal microscopy. Similar results are observed using okadaic acid

Go back
365.0, 797.0
30.0, 30.0

p28

p28

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e68 e22

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c88 : 1
stoichiometry:c81 : 1

m68*m22*0.1

nodelay

--

true

0

false

PMID: 10080535 Treatment of Sf9 cells with A23187 induces translocation of GFP-cPLA2 but not GFP to the nuclear envelope in living Sf9 cells as observed by digital confocal microscopy. Similar results are observed using okadaic acid

Go back
197.0, 605.0
30.0, 30.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 e5

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m6*m5*0.1

nodelay

--

true

0

false

PMID: 10080535 cPLA2 is regulated by an increase in intracellular calcium, which binds to an aminoterminal C2 domain and induces its translocation to the nuclear envelope and endoplasmic reticulum.

Go back
341.0, 293.0
30.0, 30.0

p30

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e47 e69 e64

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c55 : 1
stoichiometry:c102 : 1
stoichiometry:c85 : 1

m47*m69*0.1

nodelay

--

true

0

false

PMID: 10080535, 9525925 colony-stimulating factor 1 (CSF1) is a strong MAPK activator. treatment of macrophages with the MAPK kinase (MEK) inhibitor, PD98059 together with the p38 inhibitor, SB 203580, quantitatively suppresses zymosan-induced arachidonic acid release and cPLA2 phosphorylation on S505.

Go back
545.0, 265.0
30.0, 30.0

p29

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e48 e42 e65

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c87 : 1
stoichiometry:c41 : 1
stoichiometry:c86 : 1

m48*m42*0.1

nodelay

--

true

0

false

PMID: 10080535 In human platelets, thrombin promotes phosphorylation of cPLA2 on S505 by the MAPK homolog, p38. treatment of macrophages with the MAPK kinase (MEK) inhibitor, PD98059 together with the p38 inhibitor, SB 203580, quantitatively suppresses zymosan-induced arachidonic acid release and cPLA2 phosphorylation on S505.

Go back
245.0, 297.0
30.0, 30.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e47 e66 e64

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c93 : 1
stoichiometry:c104 : 1
stoichiometry:c90 : 1

m47*m66*0.1

nodelay

--

true

0

false

PMID: 10080535 PMA and okadaic acid are strong activators of MAPK leading to cPLA2 phosphorylation. treatment of macrophages with the MAPK kinase (MEK) inhibitor, PD98059 together with the p38 inhibitor, SB 203580, quantitatively suppresses zymosan-induced arachidonic acid release and cPLA2 phosphorylation on S505.

Go back
193.0, 297.0
30.0, 30.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e47 e67 e64

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c58 : 1
stoichiometry:c105 : 1
stoichiometry:c92 : 1

m47*m67*0.1

nodelay

--

true

0

false

PMID: 10080535 PMA and okadaic acid are strong activators of MAPK leading to cPLA2 phosphorylation. treatment of macrophages with the MAPK kinase (MEK) inhibitor, PD98059 together with the p38 inhibitor, SB 203580, quantitatively suppresses zymosan-induced arachidonic acid release and cPLA2 phosphorylation on S505.

Go back
293.0, 625.0
30.0, 30.0

p34

p34

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e68 e5

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m68*m5*0.1

nodelay

--

true

0

false

PMID: 10080535 calcium ionophore A23187 is sufficient for cPLA2 activation and arachidonic acid release.

Go back
329.0, 453.0
30.0, 30.0

p35

p35

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e5 e66

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c62 : 1
stoichiometry:c97 : 1

m5*m66*0.1

nodelay

--

true

0

false

PMID: 10080535 Okadaic acid preferentially induces an increase in phosphorylation on S727.

Go back
249.0, 481.0
30.0, 30.0

p5

p5

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e5 e6

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c67 : 1
stoichiometry:c13 : 1

m5*m6*0.1

nodelay

--

true

0

false

PMID: 10080535 cPLA2 can be fully activated by both an increase in intracellular calcium, which drives its translocation to membrane, and phosphorylation on S505.

Go back
793.0, 569.0
30.0, 30.0

p9

p6

cso30:i:ME_MetabolicReaction

cso30:i:CC_Cytosol

--

e24 e70

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c100 : 1
stoichiometry:c59 : 1

m24*m70*0.1

nodelay

--

true

0

false

PMID: 10080535, 8751717 Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT),

Go back
713.0, 577.0
30.0, 30.0

p7

p7

cso30:i:ME_MetabolicReaction

cso30:i:CC_Cytosol

--

e29 e24

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c21 : 1
stoichiometry:c27 : 1

m29*m24*0.1

nodelay

--

true

0

false

PMID: 10080535, 8751717 Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT),

Go back
773.0, 257.0
30.0, 30.0

p8

p8

cso30:i:ME_Acetylation

cso30:i:CC_Cytosol

--

e25

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m25*0.1

nodelay

--

true

0

false

PMID: 10080535 Some lysophospholipids,such as lysophosphatidic acid (lyso-PA), can also mediate cellular activation, and alkyl-lysophosphatidylcholine (lyso-PAF) can be acetylated to produce plateletactivating factor (PAF)

Go back
841.0, 565.0
30.0, 30.0

p9

p9

cso30:i:ME_MetabolicReaction

cso30:i:CC_Cytosol

--

e31 e24

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c22 : 1
stoichiometry:c29 : 1

m31*m24*0.1

nodelay

--

true

0

false

PMID: 10080535, 8751717 Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT),

Go back
321.1804964634343, 594.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
802.0, 606.9382230137094

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
526.769710981925, 228.0

c101

c101

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
365.9760376304381, 326.47782622957106

c102

c102

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
326.16636128389274, 325.44420871037335

c103

c103

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
278.5849217092839, 321.77435518944355

c104

c104

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
226.75844643648023, 318.36897055633386

c105

c105

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
323.0, 592.0056408699137

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
283.55114592832746, 516.76062313317

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
279.0, 503.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
331.0, 420.0

c14

c14

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
604.0, 524.0172155789631

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
559.0, 835.0

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
602.0, 352.5006914159311

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
788.0, 517.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
788.0, 295.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
789.0, 236.97966959864587

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
742.2804166494748, 517.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
796.0, 517.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
725.0, 533.0

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
700.6568542494924, 669.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
725.4990262892414, 669.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
647.907883951425, 718.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
728.0, 607.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
856.0, 513.0

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
856.0, 595.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
268.0, 731.0

c3

c3

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
856.0, 653.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
856.0, 707.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
809.7492919018569, 769.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
750.2494651199621, 807.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
823.5777087639997, 769.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
828.6417187543783, 769.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
841.6203486880655, 769.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
856.0, 769.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
643.0, 56.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
747.7736221307565, 77.41969872756907

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
287.0, 714.0

c4

c4

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
687.2179353172033, 71.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
565.0829823076731, 233.0

c41

c41

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
457.07593605334216, 357.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
484.0, 265.4

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
247.0, 196.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
254.22451187705678, 203.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
305.0, 269.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
308.0, 327.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
247.0, 268.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
366.9976215251444, 193.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
268.0, 799.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
508.0, 259.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
505.0, 205.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
659.0, 192.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
636.0, 207.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
527.0, 192.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
366.5777087639997, 275.0

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
495.0, 283.10918275627523

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
241.0, 577.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
202.0, 334.9114908229464

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
821.0, 599.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.0, 751.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
320.0, 269.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.0, 454.6572767717404

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
231.0, 469.7316151395658

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
264.1757817267227, 518.998068565882

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
618.2170737730852, 858.451643978432

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
724.0, 731.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
225.13331974307533, 641.8495012885248

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
771.4, 855.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
789.1070902829529, 921.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
805.4436087949382, 979.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
828.9932582089723, 1052.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
355.0, 469.37764020735796

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
445.0, 463.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
367.0, 502.4586356432362

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
476.0659023220581, 507.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
543.6241387262427, 357.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
234.6514375283176, 587.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
451.0, 780.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
395.0, 814.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
236.0, 577.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
218.0, 493.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
287.41047690551835, 598.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
318.26692848046605, 323.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
528.2063309876478, 295.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
551.0, 302.95669194279526

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
387.48391898249804, 598.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
275.8, 269.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
212.0, 635.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
267.0, 327.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
229.77752501735145, 266.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
222.0, 327.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
212.0, 334.64741217382164

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
438.80098619559806, 598.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
395.0, 447.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.0, 491.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
359.0, 483.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
459.0, 598.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back