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Indirect
PMID: 10080535
cPLA2 is regulated by an increase in intracellular calcium, which binds to an aminoterminal C2 domain and induces its translocation to the nuclear envelope and endoplasmic reticulum.
Indirect
PMID: 10080535
cPLA2 is regulated by an increase in intracellular calcium, which binds to an aminoterminal C2 domain and induces its translocation to the nuclear envelope and endoplasmic reticulum.
PMID: 10080535
cPLA2 is regulated by an increase in intracellular calcium, which binds to an aminoterminal C2 domain and induces its translocation to the nuclear envelope and endoplasmic reticulum.
Indirect
Indirect
PMID: 10080535
cPLA2 can be fully activated by both an increase in intracellular calcium, which drives its translocation to membrane, and phosphorylation on S505.
Indirect
PMID: 10080535, 8751717
Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT),
PMID: 10080535
Some lysophospholipids,such as lysophosphatidic acid (lyso-PA), can also mediate cellular activation, and alkyl-lysophosphatidylcholine (lyso-PAF) can be acetylated to produce plateletactivating factor (PAF)
Indirect
PMID: 10080535, 8751717
Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT),
PMID: 10080535, 8751717
Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT)
PMID: 10080535, 8751717
Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT), 8751717
PMID: 10080535
Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT), 8751717
PMID: 10080535, 8294398
group I pancreatic sPLA2 is primarily involved in the digestion of dietary lipid and may play additional roles in other tissues through its binding to M-type receptors
Indirect
PMID: 10080535, 8034717
Zymosan activates protein kinase C (PKC)
Indirect
PMID: 10080535, 8034717
Zymosan activates protein kinase C (PKC), which initiates a kinase cascade leading to activation of p42/p44 MAPK.
treatment of macrophages with the MAPK kinase (MEK) inhibitor, PD98059 together with the p38 inhibitor, SB 203580, quantitatively suppresses zymosan-induced arachidonic acid release and cPLA2 phosphorylation on S505.
Indirect
PMID: 10080535
Zymosan also activates the MAPK homologs, Jun kinase and p38, which can phosphorylate cPLA2 in vitro and induce a gel shift, suggesting phosphorylation on S505
treatment of macrophages with the MAPK kinase (MEK) inhibitor, PD98059 together with the p38 inhibitor, SB 203580, quantitatively suppresses zymosan-induced arachidonic acid release and cPLA2 phosphorylation on S505.
Indirect
PMID: 10080535
Zymosan also activates the MAPK homologs, Jun kinase and p38, which can phosphorylate cPLA2 in vitro and induce a gel shift, suggesting phosphorylation on S505
PMID: 10080535, 9202883
PLA2 hydrolyzes phospholipid and produces lysophospholipid and fatty acid.
PMID: 10080535, 8751717
Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT)
PMID: 10080535
Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT), 8751717
PMID: 10080535
Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT), 8751717
PMID: 10080535
Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT), 8751717
PMID: 10080535
Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT), 8751717
Indirect
PMID: 10080535
Zymosan also activates the MAPK homologs, Jun kinase and p38, which can phosphorylate cPLA2 in vitro and induce a gel shift, suggesting phosphorylation on S505
Indirect
PMID: 10080535
Zymosan also activates the MAPK homologs, Jun kinase and p38, which can phosphorylate cPLA2 in vitro and induce a gel shift, suggesting phosphorylation on S505
Indirect
PMID: 10080535
Treatment of Sf9 cells with A23187 induces translocation of GFP-cPLA2 but not GFP to the nuclear envelope in living Sf9 cells as observed by digital confocal microscopy. Similar results are observed using okadaic acid
Indirect
PMID: 10080535
Treatment of Sf9 cells with A23187 induces translocation of GFP-cPLA2 but not GFP to the nuclear envelope in living Sf9 cells as observed by digital confocal microscopy. Similar results are observed using okadaic acid
Indirect
PMID: 10080535, 9525925
colony-stimulating factor 1 (CSF1) is a strong MAPK activator.
treatment of macrophages with the MAPK kinase (MEK) inhibitor, PD98059 together with the p38 inhibitor, SB 203580, quantitatively suppresses zymosan-induced arachidonic acid release and cPLA2 phosphorylation on S505.
Indirect
PMID: 10080535
PMA and okadaic acid are strong activators of MAPK leading to cPLA2 phosphorylation.
treatment of macrophages with the MAPK kinase (MEK) inhibitor, PD98059 together with the p38 inhibitor, SB 203580, quantitatively suppresses zymosan-induced arachidonic acid release and cPLA2 phosphorylation on S505.
Indirect
PMID: 10080535
PMA and okadaic acid are strong activators of MAPK leading to cPLA2 phosphorylation.
treatment of macrophages with the MAPK kinase (MEK) inhibitor, PD98059 together with the p38 inhibitor, SB 203580, quantitatively suppresses zymosan-induced arachidonic acid release and cPLA2 phosphorylation on S505.
Indirect
PMID: 10080535
calcium ionophore A23187 is sufficient for cPLA2 activation and arachidonic acid release.
Indirect
PMID: 10080535, 8227003, 8034717, 9525925
Phosphorylation of cPLA2 on S505 by mitogenactivated protein kinases (MAPK) also contributes to activation.
Indirect
PMID: 10080535
Okadaic acid preferentially induces an increase in phosphorylation on S727.
PMID: 10080535, 8751717
Free arachidonic acid can be metabolized by 5-lipoxygenase (5-LO) or cyclooxygenases 1 and 2 (COX1 and COX2) to generate numerous lipid mediators, such as prostaglandins (PG), leukotrienes (LT),
PMID: 10080535
In human platelets, thrombin promotes phosphorylation of cPLA2 on S505 by the MAPK homolog, p38.
treatment of macrophages with the MAPK kinase (MEK) inhibitor, PD98059 together with the p38 inhibitor, SB 203580, quantitatively suppresses zymosan-induced arachidonic acid release and cPLA2 phosphorylation on S505.